检索结果-南通市图书馆

Aneurysmal Bone Cyst of the Orbit

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2015年第4期128卷 562-563页

作者： Jian-Cang Wang Meng Zhang xin-xin zhao Department of Ophthalmology Children's Hospital of Hebei Province Shijiazhuang Hebei 050000 China Department of Ophthalmology Fourth Hospital of Hebei Medical University Shijiazhuang Hebei 050011 China

Aneurysmal bone cyst （ABC） is an uncommon benign lesion with a reported incidence rate of 0.14 cases for every 1,000,000 *** can occur in any part of the skeletal system but is mainly detected in the long *** involvement is rare （〈1% of all ABCs）.In this article,we presented two female patients aged 49 and 33 years old respectively who suffered from *** successful surgical removal of the cyst via frontal craniotomy and simple curettage,the patients recovered well and have been in good health throughout the 2.5-4.5 years of follow-up.

关键词： Aneurysmal Bone Cyst Cranium Tumors Orbital Tumors Proptosis

Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing Fan Ruimin Li xin Zhang Wanyu zhao Zhenghui Pan Xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

The codon-optimized capsid gene of duck circovirus can be highly expressed in yeast and self-assemble into virus-like particles

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2017年第7期16卷 1601-1608页

作者： YANG Cui XU Yu JIA Ren-yong LIU Si-yang WANG Ming-shu ZHU De-kang CHEN Shun LIU Ma-feng zhao xin-xin SUN Kun-feng JING Bo YIN Zhong-qiong CHENG An-chun Avian Disease Research Centre Sichuan Agricultural UniversityChengdu 611130P.R.China Institute of Preventive Veterinary Medicine Sichuan Agricultural UniversityChengdu 611130P.R.China Key Laboratory of Animal Disease and Human Health of Sichuan Province Chengdu 611130P.R.China

The capsid （Cap） protein, which is the only structural protein of duck circovirus （DuCV）, is the most important antigen for the development of vaccines against DuCV and the virus＇s serological diagnostic methods. In order to use yeast expression system to produce a large quantities of DuCVCap protein which is close to its natural form to display the antigen peptides perfectly, the Cap gene was optimized into the codon-optimized capsid （Opt-Cap） gene towards the preference of yeast firstly. Then, the genes of Cap and Opt-Cap were separately cloned into pPIC9K plasmid and transformed into Picha pas- toris GSl15. The strains that displayed the phenotype of Mut~ and contained multiple inserts of expression cassette were selected from those colonies. After the induction expression, the secretory type of Cap protein, which was about 43 kDa, was best expressed under 0.5% （v/v） methanol and sorbitol induction. Compared with the Cap gene, the expression level of Opt-Cap gene was much higher. What＇s more, the purified Cap protein had a good reactivity to its specific polyclone antibody and DuCV-positive serum, and it was able to self-assemble into virus-like particles （VLPs）. These VLPs, with a diameter of 15-20 nm and without a nucleic acid structure, showed a high level of similarity to DuCV particles in size and shape. All of the resultsdemonstrated that, based on the codon-optimization, it is suitable to use the P. pastoris expression system to produce DuCV VLPs on a large scale. It is the first time that a large amounts of DuCV VLPs were produced successfully in P. pastoris, which might be particularly useful for the further studies of serological diagnosis and vaccines of DuCV.

关键词： capsid gene codon'optimization duck circovirus virus-like particles

在线全文

学校读者我要写书评

暂无评论

基于实测荷载的铁路钢桁梁桥疲劳可靠性评估

计算力学学报 2020年第2期37卷 254-260页

作者：肖鑫赵欣欣中国铁道科学研究院集团有限公司铁道建筑研究所北京100081 高速铁路轨道技术国家重点实验室北京100081

为了对钢桁梁桥疲劳进行评估,引入可靠性理论,提出了基于实测荷载的桥梁疲劳可靠性评估方法。根据某铁路钢桁梁桥实测车辆荷载数据,建立了随机车辆荷载模型。并在考虑车辆荷载随机性的基础上,结合Monte-Carlo法与有限元,分析了钢桁梁桥... 详细信息

为了对钢桁梁桥疲劳进行评估,引入可靠性理论,提出了基于实测荷载的桥梁疲劳可靠性评估方法。根据某铁路钢桁梁桥实测车辆荷载数据,建立了随机车辆荷载模型。并在考虑车辆荷载随机性的基础上,结合Monte-Carlo法与有限元,分析了钢桁梁桥构件疲劳应力谱,计算了构件疲劳可靠性随时间的变化,并探讨了车辆荷载及荷载效应变异性对构件疲劳可靠性的影响,最后采用β约界法与静力分析法对钢桁梁桥系统疲劳可靠性进行了研究。结果表明,基于随机车辆荷载的构件疲劳应力谱呈现单峰分布;构件疲劳可靠性随运营时间的增加而减小;车辆荷载的增长及荷载效应变异性的增加对构件疲劳可靠性影响较大,当车辆荷载增长率和等效应力变异系数分别增加到5%时,构件疲劳寿命大幅减小;β约界法结合静力分析法可快速确定钢桁梁桥失效模式,桥梁系统疲劳寿命小于构件疲劳寿命。总的来看,基于实测荷载的钢桁梁桥疲劳可靠性评估方法能有效地利用监测数据,对桥梁疲劳评估具有良好的适用性。

关键词：铁路钢桥随机车辆荷载疲劳可靠性评估 β约界法系统疲劳可靠性

Immunogenicity and protective efficacy of DHBV DNA vaccines expressing envelope and capsid fusion proteins in ducks delivered by attenuated Salmonella typhimurium

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2018年第4期17卷 928-939页

作者： LIU Si-yang JIA Ren-yong LI Qing-qing FENG Dai-shen SHEN Hao-yue YANG Cui WANG Ming-shu ZHU De-kang CHEN Shun LIU Ma-feng zhao xin-xin YIN Zhong-qiong JING Bo CHENG An-chun Avian Disease Research Center Sichuan Agricultural University Chengdu 611130 P.R. China Institute of Preventive Veterinary Medicine Sichuan Agricultural University Chengdu 611130 P.R. China Key Laboratory of Animal Disease and Human Health of Sichuan Province Chengdu 611130 P.R.China

Duck hepatitis B virus(DHBV) shares many basic characteristics with hepatitis B virus(HBV) and is an attractive model for vaccine development. In this study, DHBV DNA vaccines were designed to express envelope and capsid fusion proteins to enhance the breadth of immune response in ducks. Attenuated Salmonella typhimurium(SL7207) was used as a carrier and adjuvant to boost the magnitude of immune response. Based on this strategy, novel DNA vaccines(SL7207-p VAX1-LC and SL7207-p VAX1-SC) were generated. Growth kinetics, genetic stabilities and relative transcription levels of the L, S and C genes introduced by these vaccine strains were measured before inoculation to guarantee safety and efficacy. The relative transcript levels of the CD4 and CD8 T genes and the antibody levels(Ig Y) in ducks receiving the vaccines were higher than those in single gene delivered groups. Additionally, the copy number of covalently closed circular DNA in hepatocytes after DHBV challenge also provided evidence that our fusion vaccines could enhance the protective efficiency against DHBV infection in ducks.

关键词： fusion DNA genes attenuated Salmonella typhimurium(SL7207) hepatitis B virus(HBV) duck hepatitis B virus(DHBV) oral immunization

在线全文

学校读者我要写书评

暂无评论

聚酰亚胺无机杂化薄膜疲劳性能研究

工程力学 2008年第5期25卷 67-72页

作者：赵欣欣王正道北京交通大学工程力学所北京100044

现有报道较少涉及有机薄膜疲劳特性的研究。基于应力幅控制,对聚酰亚胺/二氧化硅(PI/SiO_2)复合薄膜的疲劳性能进行了实验研究,给出了不同应力幅值下材料的疲劳寿命,以及阻尼角、储能模量、耗能模量等随疲劳周次增加的变化规律。在此基... 详细信息

现有报道较少涉及有机薄膜疲劳特性的研究。基于应力幅控制,对聚酰亚胺/二氧化硅(PI/SiO_2)复合薄膜的疲劳性能进行了实验研究,给出了不同应力幅值下材料的疲劳寿命,以及阻尼角、储能模量、耗能模量等随疲劳周次增加的变化规律。在此基础上,基于疲劳模量的概念,提出了一种改进型的针对聚合物及基体控制聚合物复合材料的疲劳寿命预测模型,其理论预测值与实验测试结果具有很好的一致性。

关键词：聚合物聚酰亚胺薄膜粘弹性疲劳模量疲劳寿命

Cu(001)表面CO吸附单层结构和电子态的第一性原理研究

在线全文

学校读者我要写书评

暂无评论

物理化学学报 2008年第1期24卷 127-132页

作者：赵新新宓一鸣上海工程技术大学上海201620

用密度泛函理论(DFT)研究了Cu(001)表面CO吸附单层的表面性质.总能计算结果表明,顶位结构总能最低,相应位置的CO分子吸附能最大.谷位吸附结构的衬底原子层间距相对于清洁表面的膨胀量约为10%,从而导致了谷位吸附的不稳定性.在顶位、桥... 详细信息

用密度泛函理论(DFT)研究了Cu(001)表面CO吸附单层的表面性质.总能计算结果表明,顶位结构总能最低,相应位置的CO分子吸附能最大.谷位吸附结构的衬底原子层间距相对于清洁表面的膨胀量约为10%,从而导致了谷位吸附的不稳定性.在顶位、桥位和谷位三个吸附结构中,C和Cu原子之间的距离dC-Cu分别为0.1868、0.1975和0.2231nm,对应的CO分子键长为0.1154、0.1165和0.1175nm.计算了CO分子的态密度(DOS).结果表明,衬底与分子的作用主要是分子和金属轨道的杂化.在吸附过程中,电荷主要从碳原子的s轨道向p轨道转移.在顶位、桥位和谷位吸附结构中,每个碳原子内电荷的转移量分别为0.45e、0.54e和0.55e.衬底向吸附分子的电荷转移量不大,CO吸附分子层为一绝缘层.

关键词： Cu(001) CO吸附单层原子结构态密度

基于宽板拉伸试验的Q690qE高性能桥梁钢断裂韧性研究

在线全文

学校读者我要写书评

暂无评论

桥梁建设 2022年第1期52卷 56-63页

作者：左照坤鞠晓臣赵欣欣刘晓光中国铁道科学研究院北京100081 中国铁道科学研究院集团有限公司铁道建筑研究所北京100081

为研究应用于桥梁钢结构的Q690qE钢防脆断性能,以主跨408 m的汉江湾桥为背景,设计、制作Q690qE钢32 mm板厚母材、32 mm板厚焊缝、50 mm板厚母材、50 mm板厚焊缝4组试件,进行不同温度下的宽板拉伸试验,分析其断裂韧性。将宽板拉伸试验值... 详细信息

为研究应用于桥梁钢结构的Q690qE钢防脆断性能,以主跨408 m的汉江湾桥为背景,设计、制作Q690qE钢32 mm板厚母材、32 mm板厚焊缝、50 mm板厚母材、50 mm板厚焊缝4组试件,进行不同温度下的宽板拉伸试验,分析其断裂韧性。将宽板拉伸试验值作为断裂抗力,采用有限元法计算汉江湾桥典型受拉杆件在较不利工作应力下的断裂驱动力,评价桥梁钢结构采用Q690qE钢时的低温防脆断性能。结果表明:Q690qE钢32 mm板厚母材具有良好的低温防脆断性能,50 mm板厚母材的断裂韧性随温度降低具有明显下降趋势;在温度低于-20℃时,Q690qE钢32 mm、50 mm板厚焊缝的断裂韧性随温度降低具有下降趋势;与Q500qE钢相比,Q690qE钢母材和焊缝均具有较好的断裂韧性;汉江湾桥典型受拉杆件采用Q690qE钢时能够满足低温防脆断的要求。

关键词：桥梁钢结构 Q690qE桥梁钢板厚温度断裂韧性宽板拉伸试验有限元法

在线全文

学校读者我要写书评

暂无评论

3种生物聚合物改良粉土的持水特性研究

岩土力学 2022年第8期43卷 2157-2164页

作者：张俊然赵鑫鑫姜彤华北水利水电大学河南省岩土力学与结构工程重点实验室河南郑州450046

针对黄河流域水土流失防治,以往多采用水泥等灰色材料进行加固筑堤,但生态环境破坏严重。为响应黄河流域生态保护和高质量发展的国家战略,采用环境友好的生物聚合物对黄河流域典型粉土进行改良,通过WP4C仪测量生物聚合物改良粉土的持水... 详细信息

针对黄河流域水土流失防治,以往多采用水泥等灰色材料进行加固筑堤,但生态环境破坏严重。为响应黄河流域生态保护和高质量发展的国家战略,采用环境友好的生物聚合物对黄河流域典型粉土进行改良,通过WP4C仪测量生物聚合物改良粉土的持水特性,并从微观角度分析了生物聚合物改良粉土持水特性的机制。研究结果表明,与未改良土相比,生物聚合物改良粉土饱和含水率增大,孔隙比增大,持水能力显著提高。黄原胶、结冷胶、瓜尔胶改良粉土的持水能力均随着掺量的增加而增加,结冷胶改良的效果优于黄原胶、瓜尔胶。其机制为生物聚合物颗粒经过水合作用形成水凝胶,填充颗粒间孔隙,增加颗粒之间的黏结性。而且黄原胶、结冷胶改良粉土中形成类似蜂巢结构的孔隙空间,为其提供储水空间,进而提高改良土的持水特性。上述研究结果可为生物聚合物安全、科学地应用于黄河流域水土流失的防治提供科学依据。

关键词：粉土黄原胶结冷胶瓜尔胶持水特性