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Oriented cellulose hydrogel:Directed tissue regeneration for reducing corneal leukoplakia and managing fungal corneal ulcers

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Bioactive Materials 2024年第11期41卷 15-29页

作者： Lina Dong Zixin Fan Bixing Fang xiaoyu zhao Hongyi Yao Gangpei Cai Shuo Yang Guoming Zhang Xiaoqi Cheng Yun Feng Shengli Mi Wei Sun Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen518055China Department of Burns The Second Affiliated HospitalZhejiang University School of MedicineZhejiangChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhenGuangdong518040China Department of Otolaryngology The Second Affiliated HospitalZhejiang University School of MedicineZhejiangChina Department of Mechanical Engineering Biomanufacturing CenterTsinghua UniversityBeijingChina Department of Mechanical Engineering Drexel UniversityPhiladelphiaPAUSA Department of Ophthalmology Peking University Third HospitalBeijing100191China

Fungal corneal ulcer is one of the leading causes of corneal blindness in developing *** scars such as leukoplakia are formed due to inflammation,oxidative stress and non-directed repair,which seriously affect the patients'subsequent visual and life *** this study,drawing inspiration from the oriented structure of collagen fibers within the corneal stroma,we first proposed the directional arrangement of CuTA-CMHT hydrogel system at micro and macro scales based on the 3D printing extrusion method combined with secondary *** played an antifungal role and induced oriented repair in therapy of fungal corneal *** results showed that it effectively inhibited Candida albicans,Aspergillus Niger,Fusarium sapropelum,which mainly affects TNF,NF-kappa B,and HIF-1 signaling pathways,achieving effective antifungal *** importantly,the fibroblasts interacted with extracellular matrix(ECM)of corneal stroma through formation of focal adhesions,promoted the proliferation and directional migration of cells in vitro,induced the directional alignment of collagen fibers and corneal stromal orthogonally oriented repair in *** process is mainly associated with MYLK,MYL9,and ITGA3 ***,the downregulation the growth factors TGF-βand PDGF-βinhibits myofibroblast development and reduces scar-type ECM production,thereby reducing corneal *** also activates the PI3K-AKT signaling pathway,promoting corneal *** conclusion,the oriented CuTA-CMHT hydrogel system mimics the orthogonal arrangement of collagen fibers,inhibits inflammation,eliminates reactive oxygen species,and reduces corneal leukoplakia,which is of great significance in the treatment of fungal corneal ulcer and is expected to write a new chapter in corneal tissue engineering.

关键词： Corneal leukoplakia Fungal corneal ulcers Oriented tissue regeneration Nanozyme Cellulose hydrogel

Theoretical Investigating Mechanisms of Drug-Resistance Generated by Mutation-Induced Changes in Influenza Viruses

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Chinese Journal of Chemical Physics 2021年第6期34卷 785-796,I0003,I0061-I0067页

作者： Song Luo xiaoyu zhao Yihui Wang Lili Duan School of Physics and Electronics Shandong Normal UniversityJinan250014China

Influenza A(A/H_(x)N_(y))is a significant public health concern due to its high infectiousness and ***,which interacts with sialic acid(SIA)in host cells,has become an essential target since its highly conserved catalytic center structure,while resistance mutations have already ***,a detailed investigation of the drug resistance mechanism caused by mutations was performed for subtype N9(A/H7N9).Molecular dynamics simulation and alanine-scanning-interaction-entropy method(ASIE)were used to explore the critical differences between N9 and Zanamivir(ZMR)before and after R294K *** results showed that the mutation caused the hydrogen bond between Arg294 and ZMR to break,then the hydrogen bonding network was disrupted,leading to weakened binding ability and *** in wild type(A/H7N9^(WT)),this hydrogen bond was initially ***,N9 derived from A/H11N9 was obtained as an R292K *** the relative binding free energy of N9 with five inhibitors(SIA,DAN,ZMR,G28,and G39)was predicted,basically consistent with experimental values,indicating that the calculated results were reliable by *** addition,Arg292 and Tyr406 were hot spots in the A/H11N9^(WT)-***,Lys292 was not observed as a favorable contributing residue in A/H11N9^(R292K),which may promote *** comparison,Tyr406 remained the hotspot feature when SIA,ZMR,and G28 binding to A/H11N9^(R292K).Combining the two groups,we speculate that the resistance was mainly caused by the disruption of the hydrogen bonding network and the transformation of *** study could guide novel drug delivery of drug-resistant mutations in the treatment of A/H_(x)N9.

关键词： N9 Drug resistance Alanine-scanning-interaction-entropy method Binding free energy

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赞比亚经济与坦赞铁路未来的发展

国际经济合作 2006年第3期 61-63页

作者：张小瑜商务部国际贸易经济合作研究院

一、赞比亚境内路网建设状况

关键词：坦赞铁路赞比亚经济路网建设勘测设计坦桑尼亚成套项目民主刚果津巴布韦省会城市

The research of feet pressing energy collection and utilization device --based on piezoelectric ceramics

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International Journal of Technology Management 2015年第9期 107-109页

作者： Chen RUAN Dengjin WU Niu LIU xiaoyu zhao North China Electric Power University Beijing 102206 China

After people or vehicles press, piezoelectric ceramics can send a weak and unstable alternating current. According to this characteristic, we made feet pressing energy collection and utilization device based on piezoelectric ceramics. The two parts of this device includes energy storage and utilization. In terms of storage, the energy collection module, can deposit AC sent by piezoelectric ceramics in the super capacitor after rectification. In terms of utilization of energy, the device achieve a variety of usage： through the USB interface, it can supply power for different equipments, replace the mobile station of train stations and realize the function of saving the electricity as the night corridor induction lamp, combined with vibration module design and programmable timer. The whole structure is supported by an acrylic plate, which saves cost and have good durability. This device implements the storage and usage of idle feet pressing energy. In conclusion, it is helpful to provide a new idea for people＇ s low carbon lives and has a quite broad application prospect.

关键词： piezoelectric ceramic acrylic plate energy collection module super capacitor vibration module timer.

乳化沥青冷再生混合料强度特征与失效断裂演变机制研究进展

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浙江师范大学学报（自然科学版） 2025年第1期48卷 12-20页

作者：邱欣张丁川郭群英项震宇陈军金钟声赵晓瑜吕会军浙江师范大学道路与交通工程研究中心浙江金华321004 永康市公路与运输管理中心浙江永康321399 金华市公路与运输管理中心浙江金华321000 金华市婺城区公路与运输管理中心浙江金华321004 浙江正达检测科技有限公司浙江金华321000 浙江正方交通建设有限公司浙江金华321025

“双碳”背景下,将乳化沥青冷再生混合料作为冷拌路面材料已受到道路工程界的广泛关注.针对乳化沥青冷再生混合料设计与应用中关键技术问题的研究进展进行了综述,系统地汇总了乳化沥青冷再生混合料在施工控制、强度发展机理和损伤行为特... 详细信息

“双碳”背景下,将乳化沥青冷再生混合料作为冷拌路面材料已受到道路工程界的广泛关注.针对乳化沥青冷再生混合料设计与应用中关键技术问题的研究进展进行了综述,系统地汇总了乳化沥青冷再生混合料在施工控制、强度发展机理和损伤行为特征3个方面的研究成果.混合料制备工艺方面,总结了目前国内外乳化沥青冷再生混合料生产工艺的相关技术,阐述了乳化沥青冷再生混合料的材料特性、拌和工艺、成型方式和养生条件等对其施工和易性的影响;混合料强度发展机理方面,阐明了乳化沥青冷再生混合料在不同影响因素下的微观结构特征,凝练了材料强度形成过程中的内部界面行为;混合料断裂失效行为特征方面,归纳了研究断裂行为和断裂机理的理论方法和实验手段,探讨了乳化沥青冷再生混合料的断裂机制与疲劳特性.研究表明:构建全面的材料组成特性认知体系,利用多尺度手段揭示乳化沥青冷再生混合料强度形成机理,实时动态感知混合料疲劳损伤过程的阶段性演化规律,将对改善乳化沥青冷再生混合料的力学性能和延长冷再生路面的使用寿命具有重要意义.

关键词：乳化沥青冷再生混合料施工强度发展损伤行为

A Distributed Strategy for Defensing Objective Function Attack in Large-scale Cognitive Networks

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国际计算机前沿大会会议论文集 2015年第1期 4-5页

作者： Guangsheng Feng Junyu Lin Huiqiang Wang xiaoyu zhao Hongwu Lv Qiao zhao College of Computer Science and Technology Harbin Engineering UniversityHarbin150001China School of Computer and Information Engineering Harbin University of CommerceHarbin150028China

Most of existed strategies for defending OFA (Objective Function Attack)are centralized, only suitable for small-scale networks and stressed on the computation complexity and traffic load are usually neglected. In this paper, we pay more attentions on the OFA problem in large-scale cognitive networks, where the big data generated from the network must be considered and the traditional methods could be of helplessness. In this paper, we first analyze the interactive processes between attacker and defender in detail, and then a defense strategy for OFA based on differential game is proposed, abbreviated as DSDG. Secondly, the game saddle point and optimal defense strategy have proved to be existed simultaneously. Simulation results show that the proposed DSDG has a less influence on network performance and a lower rate of packet *** importantly, it can cope with the large range

关键词： cognitive networks objective function attack game model

加权紧致非线性格式在热化学非平衡流数值模拟中的应用

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国防科技大学学报 2016年第5期38卷 163-169页

作者：葛明明曾明赵小宇国防科技大学航天科学与工程学院湖南长沙410073

高精度格式因其在较低的计算资源消耗下仍能保持足够的精度而在精细流动结构的模拟中具有独特优势。将显式5阶加权紧致非线性格式（WCNS-E-5)引人二维高温非平衡流计算，进行自由流速度5.0~5.7km/s的高焓风洞和高空条件下的圆柱非平衡... 详细信息

高精度格式因其在较低的计算资源消耗下仍能保持足够的精度而在精细流动结构的模拟中具有独特优势。将显式5阶加权紧致非线性格式（WCNS-E-5)引人二维高温非平衡流计算，进行自由流速度5.0~5.7km/s的高焓风洞和高空条件下的圆柱非平衡流场数值模拟，得到正确的流场参数分布、壁面压力和壁面热流等结果与实验值吻合较好。计算结果表明,WCNS-E-5格式较2阶的MUSCL格式具有更好的热流网格收敛特性。分析并针对算例条件初步解决了高阶格式在刚性化学反应流模拟中的鲁棒性问题，为进一步采用高阶格式开展流场结构更加复杂的热化学非平衡流数值研究奠定了良好基础。

关键词：高精度格式热化学非平衡流数值模拟

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电动车复合材料电池盒轻量化设计方法

中国机械工程 2018年第9期29卷 1044-1049页

作者：赵晓昱张树仁长春理工大学机电工程学院长春130022 上海工程技术大学汽车工程学院上海201620

为了减小电动汽车车体的质量,分析了电动汽车电池盒的承载特点,基于刚度等效的设计方法,采用复合材料替代金属材料。应用复合材料的叠层结构力学理论对电池盒体进行叠层结构构建,建立了力学方程和优化方程,确定了复合材料电池盒的结构... 详细信息

为了减小电动汽车车体的质量,分析了电动汽车电池盒的承载特点,基于刚度等效的设计方法,采用复合材料替代金属材料。应用复合材料的叠层结构力学理论对电池盒体进行叠层结构构建,建立了力学方程和优化方程,确定了复合材料电池盒的结构参数。为了验证轻量化效果,运用理论解析和有限元数值分析相结合的方法,对比了金属材料和复合材料的刚度和形变,研究结果表明:采用复合材料利用刚度等效设计法是对电动汽车零部件进行轻量化设计的有效途径,也可为汽车板型零件承载结构的轻量化设计提供借鉴。

关键词：轻量化电池盒复合材料刚度分析有限元分析

Analysis of F, Al, Mn, Zn, Fe, Cu, Ca and Mg concentrations in brick teas from main producing areas in China

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Chinese Journal Of Geochemistry 2006年第B8期25卷 80-81页

作者： xiaoyu zhao Wuyi WANG Hairong LI Fujian FENG Lizhen WANG Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China