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Short-term efficacy of early percutaneous cholecystostomy for pancreatitis and factors associated with recurrence and mortality

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World Journal of Gastroenterology 2025年第6期31卷 20-33页

作者： Xin Yan Feng Xie xiao-dan zhao liang li Jia-Xian meng Department of Nuclear Medicine The People’s Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina Department of Interventional Medicine Jin Qiu Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina Department of General Surgery The People’s Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina Department of Science and Education The People’s Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina

BACKGROUND Percutaneous cholecystostomy(PC)can be used as a bridging therapy for moderately severe acute biliary pancreatitis(MSABP).Currently,there are only a limited number of reports of MSABP using *** To assess the short-term outcomes of early PC in MSABP and factors associated with recurrence and death in *** Patients who received conservative treatment or PC for acute biliary pancreatitis(ABP)in liaoning Provincial People’s Hospital from January 2017 to July 2022 were collected.A total of 54 patients with MSABP who received early-stage PC and 29 patients who received conservative *** short-term efficacy of PC was *** on whether there is a recurrence,compare the characteristics of the pre-PC and explore the factors of ***-PC features were compared and predictors were discussed,depending on the *** After 3 days of PC treatment,patients experienced a reduction in inflammatory markers compared to the conservative *** PC,patients were divided into non-recurrence(n=37)and recurrence(n=10)groups,and the results showed that age was an independent correlation affecting ABP recurrence[odds ratio(OR)=0.937,95%confidence interval(CI):0.878-0.999;P=0.047lity(OR=2.397,95%CI:1.139-5.047;P=0.0210.7).When the Youden index maximum was 0.565,the cut-off value was 5.5,the sensitivity was 71.4%,and the specificity was 85.1%.CONCLUSION PC is an important method in the early years(lity.

关键词： Acute biliary pancreatitis Percutaneous cholecystostomy The revised Atlanta classification Charleson Comorbidity Index Yoden index

Double[5]carbohelicene:facile synthesis,chiroptical properties,isomerization study,and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei liu Yantong li meng-Xiang Wu Hao Kang xiao-li zhao lin Xu linlin liu xiaodong li Junfeng Fang Zhiwei Fang Ya Cheng Hai-Bo Yang Huakang yu Xueliang Shi State Key Laboratory of Petroleum Molecular&Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Physics and Electronic Science Engineering Research Center of Nanophotonics&Advanced InstrumentMinistry of EducationEast China Normal UniversityShanghai 200241China State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Institute of Polymer Optoelectronic Materials&Devices State Key Laboratory of Luminescent Materials&DevicesSouth China University of TechnologyGuangzhou 510640China

Double carbohelicenes have attracted considerable attention due to their aesthetic structures,distinctπ-conjugation extension,inherent chirality,and intriguing optical and electronic ***,the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties,isomerization process and lasing application is presented.1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key *** is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM,which were successfully isolated and unambiguously confirmed by Xray *** optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography(HPLC),and 1-PP and 1-MM were characterized by circular ***,it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating,and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated.1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%.Consequently,we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously,which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm^(-2).We believe that our studies,including the facile synthesis methodology,detailed isomerization studies,and lasing application,will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction

Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3) Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： Yingjie zhao Yicheng Sun Chaoxin Pei Xing Yin Xinyi li Yi Hao mengru Zhang meng yuan Jinglin Zhou yu Chen Yanlin Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabilityhinders further ***,all-inorganic perovskites possessexcellent thermal stability,but black-phase all-inorganic perovskite filmusually requires high-temperature annealing steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yielding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fidelity imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

Achievable dual-strategy to stabilize li-rich layered oxide interface by a one-step wet chemical reaction towards long oxygen redox reversibility

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Journal of Energy Chemistry 2025年第2期101卷 120-131页

作者： Bin He yujie Dai Shuai Jiang Dawei Chen Xilong Wang Jie Song dan xiao Qian zhao Yan meng Wei Feng School of Mechanical Engineering Chengdu University Chongqing Institute of Metrology and Quality Inspection Institute of New Energy and Low-Carbon Technology Sichuan University

Oxygen release and electrolyte decomposition under high voltage endlessly exacerbate interfacial ramifications and structu ral degradation of high energy-density li-rich layered oxide（LLO）,leading to voltage and capacity ***,the dual-strategy of Cr,B complex coating and local gradient doping is simultaneously achieved on LLO surface by a one-step wet chemical reaction at room *** functional theory（DFT） calculations prove that stable B-O and Cr-O bonds through the local gradient doping can significantly reduce the high-energy O 2p states of interfacial lattice O,which is also effective for the near-surface lattice O,thus greatly stabilizing the LLO surface,Besides,differential electrochemical mass spectrometry（DEMS） indicates that the CrxB complex coating can adequately inhibit oxygen release and prevents the migration or dissolution of transition metal ions,including allowing speedy li+migration,The voltage and capacity fading of the modified cathode（LLO-CrB） are adequately suppressed,which are benefited from the uniformly dense cathode electrolyte interface（CEI） composed of balanced organic/inorganic ***,the specific capacity of LLO-CrB after 200 cycles at 1C is 209.3 mA h g-1（with a retention rate of 95.1%）.This dual-strategy through a one-step wet chemical reaction is expected to be applied in the design and development of other anionic redox cathode materials.

关键词： Interfacial oxygen lithium-rich layered oxide cathode Local gradient doping One-step wet chemical reaction Surface coating

RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China(life Sciences) 2025年第2期68卷 441-453页

作者： Xue Pang lin Gu Qiu-Ying Han Jia-qing Xing Ming zhao Shao-Yi Huang Jun-Xi Yi Jie Pan Hao Hong Wen Xue Xue-qing Zhou Zhi-Hui Su Xin-Ran Zhang li-Ming Sun Shao-Zhen Jiang dan Luo ling Chen zheng-Jie Wang yu yu Tian Xia Xue-Min Zhang Ai-ling li Tao Zhou Hong Cai Tao li Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100039China School of Basic Medical Sciences Fudan UniversityShanghai 200032China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia *** ependymal denudation or ciliary dysfunction causes ***,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and ***,RGS22 is specifically expressed in ependymal cells within the *** conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce ***,we show that Rgs22 deficiency leads to the ependymal denudation and impaired *** phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)***,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词： RGS22 hydrocephalus ependymal cells

SkullcapflavoneⅡsuppresses TGF-β-induced corneal epithelial mesenchymal transition in vitro

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 209-215页

作者： meng-Xi li Zhen Zhang yue Zhang Fan-Ru zhao yu-Fan li yu-Fei dang Yang-Yang yue li li Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Xi’an People’s Hospital(Xi’an Fourth Hospital) Shaanxi Eye HospitalAffiliated Xi’an Fourth HospitalNorthwestern Polytechnical UniversityXi’an 710000Shaanxi ProvinceChina Department of Vascular Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

AIM:To investigate the effect of skullcapflavone II(SCF-II)on the epithelial-mesenchymal transition(EMT)induced by transforming growth factor beta(TGF-β)in human corneal epithelial cells(HCECs),as well as to identify the signaling pathways that may be ***:HCECs were cultured in *** a SCFII(5,10μmol/L)dose,cell viability was analysed with a cell counting kit-8(CCK-8)assay,and cell migration was monitored with wound healing and Transwell migration *** were 4 groups:SCF-II,TGF-β,SCF-II+TGF-βand *** blotting and immunofluorescence were performed to show the expression of EMT markers and the translocation of nuclear factor kappa-B(NF-κB)into the nucleus in the 4 ***:Treatment with SCF-II decreased HCEC viability in a dose-dependent manner.A concentration below 10μmol/L did not present obvious cell toxicity,and survival rates were more than 70%at *** with SCF-II(5 and 10μmol/L)significantly impeded migration in wound healing and Transwell migration assays(Pling ***,SCF-II represents a candidate putative therapeutic agent in corneal fibrotic diseases.

关键词： skullcapflavone II epithelial-mesenchymal transition transforming growth factor nuclear factor kappa-B human corneal epithelial cells

Pulsed dynamic electrolysis enhanced PEMWE hydrogen production:Revealing the effects of pulsed electric fields on protons mass transport and hydrogen bubble escape

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Journal of Energy Chemistry 2025年第1期100卷 201-214页

作者： Xuewei Zhang Wei Zhou yuming Huang liang Xie Tonghui li Huimin Kang lijie Wang Yang yu Yani Ding Junfeng li Jiaxiang Chen Miaoting Sun Shuo Cheng xiaoxiao meng Jihui Gao Guangbo zhao School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001HeilongjiangChina China Datang Technology Innovation Co. LtdXiong’an 071799HebeiChina

The transition of hydrogen sourcing from carbon-intensive to water-based methodologies is underway,with renewable energy-powered proton exchange membrane water electrolysis(PEMWE)emerging as the preeminent pathway for hydrogen *** remarkable advancements in this field,confronting the sluggish electrochemical kinetics and inherent high-energy consumption arising from deteriorated mass transport within PEMWE systems remains a formidable *** impediment stems primarily from the hindered protons mass transfer and the untimely hydrogen bubbles *** address these challenges,we harness the inherent variability of electrical energy and introduce an innovative pulsed dynamic water electrolysis *** to constant voltage electrolysis(hydrogen production rate:51.6 m L h^(-1),energy consumption:5.37 kWh Nm-^(3)H_(2)),this strategy(hydrogen production rate:66 m L h^(-1),energy consumption:3.83 kWh Nm-^(3)H_(2))increases the hydrogen production rate by approximately 27%and reduces the energy consumption by about 28%.Furthermore,we demonstrate the practicality of this system by integrating it with an off-grid photovoltaic(PV)system designed for outdoor operation,successfully driving a hydrogen production current of up to 500 mA under an average voltage of approximately 2 *** combined results of in-situ characterization and finite element analysis reveal the performance enhancement mechanism:pulsed dynamic electrolysis(PDE)dramatically accelerates the enrichment of protons at the electrode/solution interface and facilitates the release of bubbles on the electrode *** such,PDE-enhanced PEMWE represents a synergistic advancement,concurrently enhancing both the hydrogen generation reaction and associated transport *** promising technology not only redefines the landscape of electrolysis-based hydrogen production but also holds immense potential for broadening its application across a diverse spectrum of electrocatalytic end

关键词： Water electrolysis Hydrogen production Pulsed dynamic electrolysis Proton exchange membrane water electrolysis Mass transport

Conjunctival microbiota variations in a subset of middleaged and elderly individuals from Beijing,China

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 237-243页

作者： Tian-Yao zhao yu-Chen Wang Ying-Juan Sun Jun-yue Wang xiao-dan Jiang Xue-Min li Ai-Hua Deng Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NerveBeijing 100191China Fangshan Hospital Beijing University of Chinese Medicine Beijing 102400China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Animal Nutrition and Feeding Ministry of Agriculture and Rural Affairs Feed Industry CentreAgricultural UniversityBeijing 100193China

AIM:To isolate and identify the conjunctival microbiota of cataract patients and analyze the associated influencing ***:This study recruited 216 participants(216 eyes)from April 2022 to July *** the condition of no antibiotic use prior to cataract surgery,sterile swabs were used to collect samples from the lower conjunctival *** cultures were then conducted,followed by species identification through 16S rDNA gene *** factors associated with positive or negative bacterial isolation rates were analyzed,including age,gender,meibomian gland dysfunction(MGD),history of hypertension,history of diabetes,history of cancer,history of infectious diseases and the habit of wearing ***:Among the 216 eyes,78 eyes yielded isolates,with an isolation rate of 36.11%,detecting a total of 122 ***-positive rods accounted for 49.18%(60 strains),gram-positive cocci accounted for 45.08%(55 strains),gram-negative bacteria accounted for 4.92%(6 strains),and fungi accounted for 0.82%(1 strain).This study found that the most abundant genera in the conjunctival sac were Corynebacterium(42.62%),Staphylococcus(31.15%),Micrococcus(9.84%),Acinetobacter(4.10%),and Bacillus(3.28%).Furthermore,age(P=0.006),gender(P=0.039),diabetes(P=0.003),history of infectious diseases(P=0.02),and duration of mask replacement(P<0.001)were important factors influencing the positive bacterial culture of the conjunctival *** hypertensive patients exhibited a higher isolation rate of conjunctival bacteria,it did not reach statistical significance,and the history of cancer did not affect the isolation rate of the conjunctival microbial community in cataract patients before ***:Potential changes are observed in the conjunctival microbiota among a sample of middleaged and elderly individuals from Beijing,***,an increased isolation rate of Corynebacterium and Micrococcus is detected,suggesting a possible change in the mic

关键词： conjunctival microbiota 16S rDNA middle-aged and elderly population mask cataract surgery

A rethinking of nitrate， nitrite， and nitric oxide for food preservation and human health

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Food Science and Human Wellness 2025年

作者： xiaojing Tian Yanan Tian Shaohua meng Jiansheng zhao Lele Shao yu li Wenhang Wang Tianjin Key Laboratory of Food Quality and Health， Tianjin University of Science & Technology College of Food Science and Engineering， Tianjin University of Science & Technology Henan Shuanghui Investment & Development Co.， Ltd. Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization， Ministry of Agriculture and Rural Affairs， Anhui Engineering Research Center for High Value Utilization of Characteristic Agricultural Products， College of Tea & Food Science and Technology， Anhui Agricultural University College of Biotechnology， Tianjin University of Science & Technology

Nitrate and nitrite， as long-standing additives used in food industry and particularly prevalent in meat products， are often perceived negatively by consumers due to their potential to produce carcinogenic nitrosamines. Within the past decades， the importance of nitric oxide (NO) has been established for human health， including cardiovascular health， immunizing and defending system， skeletal muscle contraction and relaxation， nervous system， and cognitive function. Gradually， nitrate and nitrite， as the main NO donors， have also been demonstrated to have numerous health benefits in clinical studies. likewise， NO has showed positive effect on postharvest fruits and vegetables. In view of different controversies， this review comprehensively discussed the effect of nitrate， nitrite on meat products and NO on fruits and vegetables， the intake of nitrate and nitrite by diet， the physiological functions， synthesis and metabolism of nitrate， nitrite， and NO in human body. It is hoped to provide some new understanding for nitrate， nitrite， and NO in food preservation and human health.

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