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Stay in touch with the endoplasmic reticulum

Science China(Life Sciences) 2024年第2期67卷 230-257页

作者： Sha Sun Gan zhao Mingkang Jia Qing Jiang Shulin Li Haibin Wang wenjing Li Yunyun Wang Xin Bian Yan G.zhao Xun Huang Ge Yang Huaqing Cai Jose C.Pastor-Pareja Liang Ge Chuanmao Zhang Junjie Hu National Laboratory of Biomacromolecules Institute of BiophysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China The Ministry of Education Key Laboratory of Cell Proliferation and Differentiation College of Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Laboratory of Computational Biology&Machine Intelligence School of Artificial IntelligenceUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin 300071China Brain Research Center Department of BiologySchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Neurosciences Consejo Superior de Investigaciones Científicas-Universidad Miguel HernándezSan Juan de Alicante 03550Spain

The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic *** a result,it engages a variety of organelles by establishing membrane contact sites(MCSs).These contacts regulate organelle positioning and remodeling,including fusion and fission,facilitate precise lipid exchange,and couple vital signaling ***,we systematically review recent advances and converging themes on ER-involved organellar *** molecular basis,cellular influence,and potential physiological functions for ER/nuclear envelope contacts with mitochondria,Golgi,endosomes,lysosomes,lipid droplets,autophagosomes,and plasma membrane are summarized.

关键词： endoplasmic reticulum nuclear envelope mitochondria Golgi apparatus endosome lysosome lipid droplets autophagosome plasma membrane membrane contact site

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Present development of NiMH battery industry in China

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China Rare Earth Information 2015年第11期21卷 1-5页

作者： zhao wenjing

Reproduced by zhao wenjing from China Rare Earth Information Center,according to presentation of Cao Guoqing,from State Quafity Supervision and Inspection Center of Chemical Power Products,at 2015 China Rare Earth Hydrogen Storage Forum Battery is the key to develop energy technology for it can improve energy yield and energy use efficiency.

关键词： battery Battery presentation lithium disadvantages exported monomer accounting Jiangsu cadmium

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2015 Rare earth situation in China and the US

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China Rare Earth Information 2016年第5期22卷 1-4页

作者： zhao wenjing China Rare Earth Information Center

*** earth industry(1)China China cancelled rare earth export quota and adjusted rare earth tariff during *** with the sluggish rare earth market at home and abroad,Chinese government vigorously promoted rare earth res... 详细信息

关键词：稀土产业中国政府美国稀土市场违法行为稀土应用国内外资源税

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基于自适应虚拟阻抗的新能源微电网功率控制系统

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电源学报 2023年第5期21卷 75-82页

作者：刘强赵文晶晋能电力集团有限公司太原030002 太原理工大学工程训练中心太原030024

传统新能源微电网功率控制系统因忽略虚拟阻抗而不利于随机位置分布式电源的结合,导致容易发生电网故障,致使微电网整体瘫痪。为了解决上述问题,本文提出基于自适应虚拟阻抗的新能源微电网功率控制系统的研究。引入虚拟阻抗,降低逆变器... 详细信息

传统新能源微电网功率控制系统因忽略虚拟阻抗而不利于随机位置分布式电源的结合,导致容易发生电网故障,致使微电网整体瘫痪。为了解决上述问题,本文提出基于自适应虚拟阻抗的新能源微电网功率控制系统的研究。引入虚拟阻抗,降低逆变器输出功率的耦合程度。通过逆变器额定容量比值确定虚拟电阻取值范围,计算微电网输出电压,保障微电网输出电能质量。在积分控制器下控制虚拟阻抗电阻数值,使逆变器输出功率趋近于积分控制器计算得到的功率参考值,保障输出功率的稳定性,实现对新能源微电网的功率控制。设计仿真实验,结果显示:本文方法控制的逆变器在同容量逆变器并联条件下,输出的有功功率最为稳定,无功功率保持均分状态;不同容量逆变器并联条件下,输出的有功功率稳定用时最短、无功功率基本与额定容量比匹配,充分说明提出方法对新能源微电网的功率控制及运行具备较好的控制效果。

关键词：自适应虚拟阻抗新能源微电网功率控制

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A hybrid heterogeneous Pythagorean fuzzy group decision modelling for crowdfunding development process pathways of fintech‑based clean energy investment projects

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Financial Innovation 2021年第1期7卷 689-721页

作者： Yue Meng Haoyue Wu wenjing zhao Wenkuan Chen Hasan Dincer Serhat Yuksel College of Tourism Sichuan Agricultural UniversityChengdu 611830China College of Management Sichuan Agricultural UniversityChengdu 611830China School of Business İstanbul Medipol UniversityKavacık Mah.Ekinciler Cad.No:19Kavacık Kavşağı34810 BeykozIstanbulTurkey

This study aims to evaluate the crowdfunding alternatives regarding new service development process pathways of clean energy investment *** this framework,a new model has been generated by considering the consensus-based group decisionmaking with incomplete preferences,Pythagorean fuzzy decision-making trial and evaluation laboratory(DEMATEL)and technique for order preference by similarity to ideal solution(TOPSIS).Moreover,a comparative evaluation has been performed with Vise Kriterijumska Optimizacija *** Resenje methodology and sensitivity analysis has been made by considering 4 different *** main contribution is to identify appropriate crowdfunding-based funding alternatives for the improvement of the clean energy investments with a novel MCDM *** considering the iteration technique and consensus-based analysis,the missing parts in the evaluations can be completed and opposite opinion problems can be ***,with the help of hybrid MCDM model by combining DEMATEL and TOPSIS,more objective results can be *** is concluded that the analysis results are coherent and *** findings indicate that the full launch is the most significant criterion for equity and debt-based crowdfunding *** the other side,the analysis has the highest weight for reward and donation-based alternatives whereas design is the most essential item regarding the royalty-based ***,it is also defined that equity-based crowdfunding alternative is the most significant for the service development process of clean energy investment *** this way,it will be possible to provide a continuous resource for clean energy investment *** the other hand,by providing financing with equity,there will be no fixed financing cost for clean energy *** these investors make a profit,they distribute dividends with the decision of their authorized bodies.

关键词： Crowdfunding Project financing Clean energy investments New service development PERT Group decision making Pythagorean fuzzy sets DEMATEL TOPSIS VIKOR

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累加平均提升点扩散函数信噪比实现透过散射介质三维成像

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光学学报 2022年第14期42卷 85-91页

作者：李元铖翟爱平张腾赵文静王东太原理工大学物理与光电工程学院山西太原030024 太原理工大学新型传感器与智能控制教育部重点实验室山西太原030024

光学三维成像在医学诊断、空间遥感、人工智能等领域具有广泛且重要的应用。然而,在散射环境中,入射光的波前相位会发生严重畸变,导致传统光学三维成像性能劣化,甚至失效。目前,研究透过散射介质成像大多使用的是昂贵的科研相机。为了... 详细信息

光学三维成像在医学诊断、空间遥感、人工智能等领域具有广泛且重要的应用。然而,在散射环境中,入射光的波前相位会发生严重畸变,导致传统光学三维成像性能劣化,甚至失效。目前,研究透过散射介质成像大多使用的是昂贵的科研相机。为了降低成本,本团队提出了一种采用普通工业相机进行数据采集的透过散射介质的三维成像方法。针对普通工业相机采集的低信噪比图像,本文对代表成像系统点扩散函数的点光源散斑进行多次累加平均,获得了可与科研相机相媲美的高信噪比点扩散函数;然后,将该点扩散函数与单次曝光获得的结构光散斑进行反卷积运算,得到受物体面形调制的变形条纹;最后,基于傅里叶变换轮廓术恢复物体的三维信息。实验结果表明,该方法可以获得与科研相机相媲美的成像效果,为透过散射介质的三维成像提供了一种可行的低成本方案。

关键词：成像系统三维成像散射成像结构光照明累加平均

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Mulberry Biomass-Derived Nanomedicines Mitigate Colitis through Improved Inflamed Mucosa Accumulation and Intestinal Microenvironment Modulation

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Research 2024年第1期2023卷 791-807页

作者： wenjing Yang Ya Ma Haiting Xu Zhenhua Zhu Jiaxue Wu Cheng Xu Wei Sun Erhu zhao Min Wang Rui L.Reis Subhas C.Kundu Xiaoxiao Shi Bo Xiao State Key Laboratory of Silkworm Genome Biology College of SericultureTextileand Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing Faculty of Materials and EnergySouthwest UniversityChongqing 400715China Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarco 4805-017GuimaraesPortugal ICVS/3B’s-PT Government Associate Laboratory BragaGuimarãesPortugal

The therapeutic outcomes of conventional oral medications against ulcerative colitis(UC)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory ***,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles(MLNs)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-MLNs possessed exosome-like morphologies,desirable particle sizes(around 171.4 nm),and negatively charged surfaces(−14.8 mV).The introduction of FP127 to RN-MLNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.

关键词： fluorine sizes Biomass

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Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development

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Acta Pharmaceutica Sinica B 2021年第10期11卷 2957-2972页

作者： Yuli Wang Xingyan Zhang Yuyan Wang wenjing zhao Huling Li Lixing Zhang Xinping Li Tiejun Zhang Hongbing Zhang He Huang Changxiao Liu Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemistry Engineering and TechnologyTianjin UniversityTianjin 300072China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical ResearchTianjin 300193 China Tianjin Key Laboratory of Quality-Marker of Traditional Chinese Medicines Tianjin Institute of Pharmaceutical ResearchTianjin 300193 China Tianjin University of Traditional Chinese Medicine Tianjin 300193 China The Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Thoracic Medical OncologyBeijing Institute of Cancer ResearchBeijing 100142 China Department of Pharmacology Tianjin Medical UniversityTianjin 300070China MITRO Biotech Co. Ltd.Nanjing 211100China

Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance,preventing autoimmune responses,and minimizing tissue damage by regulating the duration and intensity of the immune ***,immune checkpoints are usually overexpressed in cancer cells or noninvasive cells in tumor tissues and are capable of suppressing the antitumor *** on substantial physiological analyses as well as preclinical and clinical studies,checkpoint molecules have been evaluated as potential therapeutic targets for the treatment of multiple types of *** the last few years,extensive evidence has supported the immunoregulatory effects of traditional Chinese medicines(TCMs).The main advantage of TCMs and natural medicine is that they usually contain multiple active components,which can act on multiple targets at the same time,resulting in additive or synergistic *** strong immune regulation function of traditional Chinese medicine on immune checkpoints has also been of great *** example,Astragalus membranaceus polysaccharides can induce anti-PD-1 antibody responses in animals,and these antibodies can overcome the exhaustion of immune cells under tumor immune ***,many other TCM molecules could also be novel and effective drug candidates for the treatment of ***,it is essential to assess the application of immune checkpoints in the development of new drugs and *** this review,we focus on research progress in the field of immune checkpoints based on three topics:(1)immune checkpoint targets and pathways,(2)development of novel immune checkpoint-based drugs,and(3)application of immune checkpoints in the development of TCMs.

关键词： Immune checkpoint Therapeutic target Signaling pathway Drug development Traditional Chinese medicine Immunoregulatory Cancer immunity

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基于AI/物联网的高校智慧实验室建设

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实验室研究与探索 2022年第12期41卷 163-167页

作者：赵文静刘葵广州大学实验中心网络与现代教育技术中心广州510006

高校实验室是学校培养学生实践和创新能力的重要场所,承担着科学实验和实践教学任务。然而,目前实验室管理呈现出安全防范难保障、设备管控太烦琐、教学资源管理难等问题。以人工智能和物联网技术为基础,利用分布式协同和集中式统筹的... 详细信息

高校实验室是学校培养学生实践和创新能力的重要场所,承担着科学实验和实践教学任务。然而,目前实验室管理呈现出安全防范难保障、设备管控太烦琐、教学资源管理难等问题。以人工智能和物联网技术为基础,利用分布式协同和集中式统筹的思想提出高校智慧实验室建设方案。通过建设物联网控制系统和智慧实验室综合管理平台,实现实验环境的安全控制、实验业务的全面管理、实验数据的建设和共享。高校实验室的数字化转型和智能化改造,有利于推动学校的实践教学优化改革,改善师生的实验教学体验,为学校的科学管理和决策提供高效、准确的数据和技术支撑,进而助力学校智慧校园建设和人才培养模式的创新。

关键词：人工智能物联网智慧实验室物联网控制系统

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Efficient X-ray luminescence imaging with ultrastable and eco-friendly copper(Ⅰ)-iodide cluster microcubes

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光:科学与应用(英文版) 2023年第8期12卷 1595-1603页

作者： Yanze Wang wenjing zhao Yuanyuan Guo Wenbo Hu Chenxi Peng Lei Li Yuan Wei Zhongbin Wu Weidong Xu Xiyan Li Yung Doug Suh Xiaowang Liu Wei Huang Frontiers Science Centre for Flexible Electronics(FSCFE) MIT Key Laboratory of Flexible Electronics(KLoFE)Shaanxi Key Laboratory of Flexible ElectronicsXian Key Laboratory of Flexible ElectronicsXian Key Laboratory of Biomedical Materials&EngineeringXian Institute of Flexible ElectronicsInstitute of Flexible Electronics(IFE)Northwestern Polytechnical UniversityXi'an 710072 ShaanxiChina Key Laboratory of Magnetic Materials Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Institute of Photoelectronic Thin Film Devices and Technology Solar Energy Conversion CenterNankai UniversityTianjin 300350China Department of Chemistry and School of Energy and Chemical Engineering UNISTUlsan 44919Korea State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)Nanjing Tech University(Nanjing Tech)30 South Puzhu RoadNanjing 211816China

The advancement of contemporary X-ray imaging heavily depends on discovering scintillators that possess high sensitivity,robust stability,low toxicity,and a uniform size *** significant progress in this field,the discovery of a material that satisfies all of these criteria remains a *** this study,we report the synthesis of monodisperse copper(Ⅰ)-iodide cluster microcubes as a new class of X-ray *** as-prepared microcubes exhibit remarkable sensitivity to X-rays and exceptional stability under moisture and X-ray *** uniform size distribution and high scintillation performance of the copper(Ⅰ)-iodide cluster microcubes make them suitable for the fabrication of large-area,flexible scintillating films for X-ray imaging applications in both static and dynamic settings.

关键词： iodide cluster stability

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