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Multi-component Levi Hierarchy and Its Multi-component Integrable Coupling System

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Communications in Theoretical Physics 2005年第6X期44卷 990-996页

作者： XIA Tie-Cheng YOU Fu-Cai zhao wen-ying Department of Mathematics Shanghai University Shanghai 200444 China Department of Mathematics Bohai University Jinzhou 121000 China

A simple 3M-dimensional loop algebra X is produced, whose commutation operation defined by us is A1 as simple and straightforward as that in the loop algebra A1. It follows that a general scheme for generating multi-component integrable hierarchy is proposed. By taking advantage of X, a new isospectral problem is established, and then by making use of the Tu scheme the well-known multi-component Levi hierarchy is obtained. Finally, an expanding loop algebra FM of the loop algebra .X is presented, based on the FM, the multi-component integrable coupling system of the multi-component Levi hierarchy is worked out. The method in this paper can be applied to other nonlinear evolution equation hierarchies.

关键词： loop algebra multi-component Levi hierarchy multi-component integrable coupling system

Three-Dimensional Analysis of Rolling by Twin Shear Stress Yield Criterion

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Journal of Iron and Steel Research International 2006年第6期13卷 21-26页

作者： zhao De-wen XIE ying-jie LIU Xiang-hua WANG Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

Using the twin shear stress yield criterion, the surface integral of the co-line vectors, and the integration depending on upper limit, Kobayashi＇s three-dimensional velocity field of rolling was analyzed and an analytical expression of rolling torque and single force was obtained. Through redoing the same experiment of rolling pure lead as Sims, the calculated results by the above expression were compared with those of Kobayashi and Sims formulae. The results show that the twin shear stress yield criterion is available for rolling analysis and the calculated results by the new formula are a little higher than those by Kobayashi and Sims ones if the reduction ratio is less than 30%.

关键词： twin shear stress yield criterion co-line vector integral three-dimensional rolling analytical solution

An adpA homologue in Streptomyces avermitilis is involved in regulation of morphogenesis and melanogenesis

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Chinese Science Bulletin 2007年第5期52卷 623-630页

作者： zhao JinLei wen ying CHEN Zhi SONG Yuan LI JiLun Department of Microbiology and Immunology College of Biological Sciences China Agricultural University and Key Laboratory of Agro-Microbial Resource and Application Ministry of Agriculture Beijing 100094 China

In Streptomyces griseus, AdpA, the key transcriptional activator in the A-factor regulatory cascade, switches on the transcription of multiple genes required for secondary metabolism and morphological differentiation. Streptomyces avermitilis also contains an ortholog of adpA, which is named adpA-a. To clarify the in vivo function of adpA-a, an adpA-a-disrupted strain was constructed by double crossover recombination. No difference in avermectin production was found between the adpA-a-disruptant and the wild-type strain. However, this disruptant neither formed spores nor produced melanin and its phenotype was restored to the original wild-type by a single copy of the adpA-a gene integrated into the chromosome. This report shows that adpA-a is involved in regulation of morphological differentiation and melanin production in S. avermitilis.

关键词：灰色链霉菌除虫链霉菌黑素生成 AdpA同族体转化致活因子形态发生次级代谢

The Effect of Acid Stress Treatment on Viability and Membrane Fatty Acid Composition of Oenococcus oeni SD-2a

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Agricultural Sciences in China 2009年第3期8卷 311-316页

作者： zhao wen-ying LI Hua WANG Hua LI Zhong-chao WANG Ai-lian College of Enology Northwest A＆F University Yangling 712100 P.R.China College of Chemical Engineering and Environment North University of China Taiyuan 030051 P.R.China

To obtain ready-to-use wine malolactic starter cultures with high viability, the effects of acid stress treatments on the growth, inoculation viability, freeze-drying viability, and membrane fatty acid composition of the native Oenococcus oeni SD-2a strain were studied. The results showed that pH 3.5 and 3.2 adaptive treatments did not strongly decrease cell biomass but increased distinctly inoculation viability and freeze-drying viability. Concerning the membrane fatty acid composition, it was observed that acid stress conditions increased significantly the relative concentration of lactobacillic acid （C19cycl 1） and the unsaturated：saturated fatty acid ratio in cell membrane lipids. We assumed that acid-induced cross protective responses could be used in preparing ready-to-use O. oeni SD-2a malolactic starter cultures, and the accumulation of lactobacillic acid in the membrane of O. oeni SD-2a cells appears as an acid stress response mechanism, which might be related with the enhanced viability.

关键词： Oenococcus oeni acid stress response membrane fatty acid composition

中国不同地区猪轮状病毒的分离鉴定及分子流行病学分析

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中国预防兽医学报 2024年第2期46卷 201-205页

作者：燕贺孙玉洁赵文影谢莉敏黄柏成田克恭张云静逄文强国家兽用药品工程技术研究中心河南洛阳471000 普莱柯生物工程股份有限公司河南洛阳471000

为鉴定国内不同地区猪轮状病毒(Porcine rotavirus,PRo V)并分析其分子流行病学特征,本研究将从我国不同地区收集病料中检测到的16份PRoV阳性仔猪粪便样品和小肠内容物处理后接种MA-104细胞,传代后进行荧光定量PCR (qPCR)和间接免疫荧... 详细信息

为鉴定国内不同地区猪轮状病毒(Porcine rotavirus,PRo V)并分析其分子流行病学特征,本研究将从我国不同地区收集病料中检测到的16份PRoV阳性仔猪粪便样品和小肠内容物处理后接种MA-104细胞,传代后进行荧光定量PCR (qPCR)和间接免疫荧光试验(IFA)鉴定,并经电镜观察。结果显示,其中7份样品F1~F3代病毒液qPCR Ct值均随着传代次数的升高而逐渐降低,IFA鉴定结果显示均能在细胞中观察到特异性荧光,电镜观察到直径约70 nm无囊膜的病毒粒子,表明本实验分离到7株PRoV。利用RT-PCR扩增7株分离株和其余9份PRoV的阳性样品的VP7基因并测序分析基因型,基于VP7基因进行同源性和遗传进化分析。结果显示,16份阳性样品包含3种G型,即G9(7/16)、G4 (6/16)和G3 (3/16),同时G9型FJ-2021分离株和G4型JS01-2021分离株与近两年流行株亲缘关系较近。统计16份样品中G型PRoV的地域分布,结果显示华东地区有G9、G4和G3型的流行,四川有G3和G9型流行,广东有G9型的流行,分别与华东地区、四川地区和广西地区报道的流行G型一致;除此之外,G9型在云南、辽宁、湖南均有流行,G4基因型在广西、广东、陕西、黑龙江、河南均有流行。本研究首次收集了来自我国12个省市的PRoV阳性临床样品并进行PRoV的分离鉴定,丰富了PRoV在国内的流行资料,对不同地区针对性的防控PRoV的感染提供了流行病学数据,同时为进一步研究不同G型PRoV的致病机制和疫苗研发奠定了基础。

关键词：猪轮状病毒分离鉴定

Numerical investigation of the coupled aero-hydrodynamic performances of a semi-submersible floating offshore wind turbine with inclined columns

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Journal of Hydrodynamics 2024年第2期36卷 316-330页

作者： ying-jie Xue Xiao-long Yang Wei-wen zhao De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Offshore Oil Engineering Co.Ltd. Tianjin300461China

Numerical investigations of floating platforms with different outer column inclined angles under two operating conditions of regular wave and irregular wave are presented in this paper.A coupled aero-hydrodynamic computational fluid dynamics in-house solver FOWT-UALM-SJTU is applied for the ***,the validation for wave and wind generation are conducted to determine mesh distribution *** on these,the hydrodynamic motion response,aerodynamic performance and wake flow are analyzed to explore the impact of inclined *** spectral analysis on the motion response under wave action,discuss the aerodynamic attack angle and inflow wind velocity along the blade spanwise direction in detail,reveal different trends in wake development and *** results show that for the regular wave condition with the increase of inclined angles,the equilibrium position of surge motion is constantly rising,while pitch is *** maximum root mean square(rms)value occurs at angle=30°,compared with the original OC4 FOWT,the rms in power and thrust increase 0.35%,0.71%.And there are two low regions of attack angle and high regions of axial inflow velocity,corresponding to aerodynamic *** spectral analysis indicates that the natural frequency of pitch motion will increase with inclined ***,from the middle to far region of wake flow,the velocity recovery of FOWT with inclined angle will become faster,which is beneficial for downstream turbines to enhance more wind energy.

关键词： Floating offshore wind turbine numerical simulation aero-hydrodynamic coupled analysis floating platform with inclinedcolumns wake flow recovery

Involvement of CD4^＋CD25^＋ regulatory T cells in the pathogenesis of polycythaemia vera

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Chinese Medical Journal 2008年第18期 1781-1786页

作者： zhao wen-bo LI ying LIU Xin ZHANG Ling-yan WANG Xin Department of Hematology Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China

Background Regulatory T cells （mreg） have been shown to play an important role in the regulation of hematopoietic activity. However, there is no information about the effect of Treg cells in the pathogenesis of polycythaemia vera （PV）. Methods In this study, we investigated the percentage and function of Treg cells in the peripheral blood of 21 PV patients and 25 healthy donors, mreg cells were identified and characterized as CD4^＋CD25^＋FOXP3^＋ by flow cytometry. The suppressive activity of CD4^＋CD25^＋ Treg cells was assessed by the proliferation and cytokine secretion of the co-cultured CD4^＋CD25^- fractions. Results The results showed that the percentage of Treg cells in the peripheral blood of PV patients significantly increased compared to healthy controls （（10.93±4.02）% vs （5.86±1.99）%, P 〈0.05）. Moreover, the mRNA and protein expression of FOXP3 was higher in CD4^＋CD25^＋ Treg cells. Coordinately, when co-cultured with the activated CD4^＋CD25^- cells, the CD4^＋CD25^＋ Treg cells showed enhanced suppressive function in PV. Yet, the underlying mechanism for the increased frequency and function of CD4^＋CD25^＋ Treg cells is still to be clarified. Conclusion Treg cells expansion might account for the abnormal T cell immunity in PV patients and thus contribute to the pathogenesis of PV.

关键词： polycythaemia vera regulatory T cells pathogenesis

Advanced Progress on Adaptive Stress Response of Oenococcus oeni

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Journal of Northeast Agricultural University(English Edition) 2013年第1期20卷 91-96页

作者： zhao wen-ying Kang Zhen-kui College of Chemical Engineering and Environment North University of China Tianjiaohong Biotechnology Company

Oenoccoccus oeni is an alcohol-tolerant, acidophilic lactic acid bacterium with its ability to perform malolactic fermentation in wine, which is of fundamental importance in oenology. As a representative of the wine bacterium with remarkable adaptability to the very harsh physicochemical conditions of wine, many studies were carded out for its applied interest and focused mainly on its stress response mechanisms of O. oeni. on both physiological and molecular levels. In this review, three main stress response mechanisms in O. oeni during culturing process were addressed. Of them, various solute transporters and secondary metabolic energy-generating systems were utilized to control the intracellular environment and the energetic status of O. oeni. The changes in cell membrane fatty acid composition profiles and synthesis of stress proteins, especially small heat shock proteins were required for active cell response to maintain membrane integrity and function under stress conditions. The study on stress response of O. oeni played an important role on culture bacteria selection, making inoculation culture and construction of other engineering bacteria.

关键词： Oenococcus oeni stress response acid stress alcohol stress

Advances in the differentiation of pluripotent stem cells into vascular cells

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World Journal of Stem Cells 2024年第2期16卷 137-150页

作者： Yi-Chang Jiao ying-Xin Wang wen-Zhu Liu Jing-wen Xu Yu-ying zhao Chuan-Zhu Yan Fu-Chen Liu Department of Neurology Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Research Institute of Neuromuscular and Neurodegenerative Diseases Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Mitochondrial Medicine Laboratory Qilu Hospital(Qingdao)of Shandong UniversityQingdao 266103Shandong ProvinceChina Brain Science Research Institute Shandong UniversityJinan 250012Shandong ProvinceChina

Blood vessels constitute a closed pipe system distributed throughout the body,transporting blood from the heart to other organs and delivering metabolic waste products back to the lungs and *** in blood vessels are related to many disorders like stroke,myocardial infarction,aneurysm,and diabetes,which are important causes of death *** research for new appro-aches to disease modeling and effective treatment is needed due to the huge socio-economic burden on healthcare *** mice or rats have been widely used,applying data from animal studies to human-specific vascular physiology and pathology is *** rise of induced pluripotent stem cells(iPSCs)provides a reliable in vitro resource for disease modeling,regenerative medicine,and drug discovery because they carry all human genetic information and have the ability to directionally differentiate into any type of human *** review summarizes the latest progress from the establishment of iPSCs,the strategies for differentiating iPSCs into vascular cells,and the in vivo trans-plantation of these vascular *** also introduces the application of these technologies in disease modeling,drug screening,and regenerative ***,the application of high-tech tools,such as omics analysis and high-throughput sequencing,in this field is reviewed.

关键词： Induced pluripotent stem cell Blood vessels Vascular organoids Endothelial cells Smooth muscle cells Pericytes Tissue engineering vascular graft