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佛山市南海区汛期降水特征的分析

广东气象 2016年第5期38卷 25-28页

作者：庞绮汶招伟文潘巧英佛山市南海区气象局广东佛山528200 佛山市顺德区气象局广东佛山528300

利用佛山市南海区1961-2010年逐月降水量资料，采用趋势性分析、Morlet小波分析和Mann—Kendall法进行气候变化趋势和突变分析。结果表明：近50年南海区汛期（前、后汛期）降水总量呈上升趋势。20世纪90年代到2005年后汛期降水增加明显... 详细信息

利用佛山市南海区1961-2010年逐月降水量资料，采用趋势性分析、Morlet小波分析和Mann—Kendall法进行气候变化趋势和突变分析。结果表明：近50年南海区汛期（前、后汛期）降水总量呈上升趋势。20世纪90年代到2005年后汛期降水增加明显，而总汛期降水量在20世纪90年代以来偏多。20世纪80年代到90年代初期汛期降水量下降最为明显。汛期（前、后汛期）降水量偏少集中在20世纪80年代中期到90年代前期，而总汛期和后汛期在20世纪60年代前期和20世纪90年代中期到2005年降水偏多。汛期存在准2、准4和7—8年尺度的周期；前汛期存在3～4、准2和准4年时间尺度的周期振荡；后汛期存在3～4、准2和7—8年周期。突变检测确定1992年为汛期和后汛期降水量的突变年份。

关键词：气候学汛期降水小波分析周期振荡佛山南海

Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one

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World Journal of Diabetes 2025年第1期16卷 222-225页

作者： Zi-Yu zhao Pei-Li Luo Xia Guo Zheng-wei Huang State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative DrugsCollege of PharmacyJinan UniversityGuangzhou 511436Guangdong ProvinceChina

Ma et al recently reported in the World Journal of Diabetes that ferroptosis occurs in osteoblasts under high glucose conditions,reflecting diabetes *** condition could be protected by the upregulation of the gene encoding polycytosine RNA-binding protein 1(PCBP1).Additionally,Ma et al used a lentivirus infection system to express *** the authors’method of administration can be improved in terms of stability and cost,we propose delivering PCBP1 to treat type 2 diabetic osteoporosis by encapsulating it in protein ***,PCBP1 is small and ***,intravenous injection can help deliver PCBP1 across the mucosa while avoiding acid and enzyme-catalyzed ***,incorporating PCBP1 into nanoparticles prevents its interaction with water or oxygen and protects PCBP1’s structure and ***,the safety of the protein materials and the industrialization techniques for large-scale production of protein nanoparticles must be comprehensively investigated before clinical application.

关键词： Polycytosine RNA-binding protein 1 Protein nanoparticle Osteoblast Ferroptosis Diabetes

阻塞性睡眠呼吸暂停低通气综合征患者颞下颌关节间隙测量

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上海口腔医学 2017年第1期26卷 84-88页

作者：赵睿温伟生杨舸陶冶张安东贾芮解放军总医院口腔科北京100853 解放军总医院放射科北京100853

目的 :通过对阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者的颞下颌关节(temporomandibular joint,TMJ)行磁共振扫描分析,探讨OSAHS患者与正常人群颞下颌关节形态的差异。方法:选取2014年1月... 详细信息

目的 :通过对阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者的颞下颌关节(temporomandibular joint,TMJ)行磁共振扫描分析,探讨OSAHS患者与正常人群颞下颌关节形态的差异。方法:选取2014年1月—2016年5月收治的18例OSAHS患者和18例健康成人,分别记为研究组和对照组;按照呼吸暂停及低通气指数(apnea and hypopnea index,AHI),将OSAHS患者分为轻、中、重3个亚组(n=6)。对所有纳入人群行TMJ的MRI扫描并测量关节间隙,采用SPSS 17.0软件包对测量数据进行统计学处理。结果:2组患者在年龄、性别构成、关节上间隙及髁突有无移位方面差异均无显著性(P>0.05)。OSAHS患者TMJ左侧前间隙[(2.61±0.19)mm∶(2.47±0.18)mm,P<0.05]、右侧前间隙[(2.63±0.18)mm∶(2.48±0.17)mm,P<0.05]大于正常人群。OSAHS患者TMJ左侧后间隙[(2.43±0.20)mm∶(2.51±0.19)mm,P<0.05]、右侧后间隙[(2.44±0.20)mm∶(2.60±0.13)mm,P<0.05]小于正常人群。轻度OSAHS组TMJ左侧前间隙[(2.53±0.26)mm∶(2.73±0.07)mm,P<0.05]、右侧前间隙[(2.54±0.11)mm∶(2.74±0.14)mm,P<0.05]均小于重度组;轻度OSAHS组TMJ左侧后间隙[(2.56±0.29)mm∶(2.29±0.09)mm,P<0.05]、右侧后间隙[(2.55±0.23)mm∶(2.31±0.09)mm,P<0.05]均大于重度组。结论 :OSAHS患者的髁突相比正常人群处于关节窝偏后位置。髁突位于关节窝偏后位置的趋势与OSAHS的严重程度相关。

关键词：阻塞性睡眠呼吸暂停低通气综合征颞下颌关节关节间隙

湖北地区9058例女性人乳头瘤病毒基因分型分析

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微循环学杂志 2017年第2期27卷 37-42页

作者：王京伟赵礼文吴薇陈振李艳武汉大学人民医院检验科武汉430060

目的:分析湖北地区人乳头瘤病毒(HPV)感染状况及基因型分布。方法:2012-03-2015-11在本院体检、门诊或住院9 058例女性宫颈脱落细胞,采用流式点阵仪/液态芯片分析系统检测其HPV基因分型,分析所有受检者HPV基因型分布及单一、多重感染分... 详细信息

目的:分析湖北地区人乳头瘤病毒(HPV)感染状况及基因型分布。方法:2012-03-2015-11在本院体检、门诊或住院9 058例女性宫颈脱落细胞,采用流式点阵仪/液态芯片分析系统检测其HPV基因分型,分析所有受检者HPV基因型分布及单一、多重感染分布,比较不同年龄、不同就诊途径及不同疾病组间HPV感染特点。结果:所有受检者中共检出HPV阳性2 524例,感染率27.86%。湖北地区最常见的四种HPV亚型为HPV16(7.37%)、52(5.05%)、58(4.03%)、18(2.27%)。单一基因型感染率最高(20.51%,1 858/9 058),二重-六重及以上感染逐渐减少。各年龄组HPV中低危型及高危型感染率差异有统计学意义(P0.05)。中低危型感染以≤20岁组最高,高危型感染率以41-60岁组最高,同一年龄组内均以高危型感染为主。不同就诊途径受检者HPV各型感染率组间差异有统计学意义(P0.01);高危型HPV感染率差异有统计学意义(P<0.01),恶性肿瘤组高危型感染率最高,其它组最低(P<0.01);各组高危型HPV感染率均明显高于中低危感染率(P<0.05)。结论:应加强湖北地区女性HPV的筛查力度,特别是HPV16、52、58、18四种最常见基因型的筛查,尤其针对41-60岁年龄组人群,可有效降低宫颈癌和由HPV引发的其它肿瘤或疾病发生率。

关键词：宫颈癌人乳头瘤病毒基因分型

Numerical simulations of multi-layer-liquid sloshing by multiphase MPS method

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Journal of Hydrodynamics 2021年第5期33卷 938-949页

作者： Xiao wen wei-wen zhao De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

In this paper,a multiphase moving particle semi-implicit(MPS)method is developed by introduction of various multiphase models into the original MPS method for single-phase flows,and is then applied to the numerical simulations of two-layer-liquid and three-layer-liquid sloshing in a 2-D rectangular tank under different external *** validate the accuracy of the present multiphase MPS method,the qualitative and quantitative results,including wave profiles,interface elevations and impact pressures,are compared with experimental data and other numerical results,which show a good *** particular,the evolutions of free surface and phase interfaces are compared and an obvious discrepancy is found,indicating that the phase interfaces may suffer from complex deformations while the free surface keeps relatively ***,the different modes of phase interface are observed under different excitation ***,the violent sloshing of a three-layer-liquid system is simulated and the phenomenon of internal wave breaking is well captured,which mainly benefitted from the Lagrangian basis of MPS method and its advantage in multiphase flows with complex ***,the three-layer-liquid sloshing with a vertical baffle are simulated to investigate the suppressing effect of baffle on multi-layer-liquid sloshing.

关键词： Moving particle semi-implicit(MPS) multiphase flows multi-layer-liquid liquid sloshing

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多媒体教学环境下交互式CAI系统的设计

广西大学学报（自然科学版） 2000年第4期25卷 310-312页

作者：韦兆文苏一丹广西大学计算机与信息工程学院广西南宁530004

在分析了 CAI系统特性的基础上 ,针对当前 CAI系统设计中存在的问题 ,提出了一种新型的 CAI系统 ( WSCAI)构架 ,并阐述了 WSCAI系统的设计原则以及如何使用 WSCAI系统进行教学的方式和方法 .

关键词： CAI 交互式计算机教学 WSCAI系统多媒体教学

Ubiquitination in diabetes and its complications:A perspective from bibliometrics

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World Journal of Diabetes 2025年第1期16卷 187-203页

作者： Li-Yuan Xiong wei zhao Fa-Quan Hu Xue-Mei Zhou Yu-Jiao Zheng College of Traditional Chinese Medicine Anhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

BACKGROUND Diabetes has a substantial impact on public health,highlighting the need for novel ***,an intracellular protein modification process,is emerging as a promising strategy for regulating pathological *** hypothesize that ubiquitination plays a critical role in the development and progression of diabetes and its complications,and that understanding these mechanisms can lead to new therapeutic *** To uncover the research trends and advances in diabetes ubiquitination and its complications,we conducted a bibliometric *** Studies on ubiquitination in diabetes mellitus and its complications were retrieved from the Web of Science Core *** mapping analysis was conducted using the CiteSpace *** We gathered 791 articles published over the past 23 years,focusing on ubiquitination in diabetes and its associated *** articles originated from 54 countries and 386 institutions,with China as the leading *** Jiao Tong University has the highest number of publications in this *** most prominent authors contributing to this research area include wei-Hua Zhang,with Zhang Y being the most frequently cited ***,The Journal of Biological Chemistry is noted as the most cited in this *** predominant keywords included expression,activation,oxidative stress,phosphorylation,ubiquitination,degradation,and insulin *** The role of ubiquitination in diabetes and its complications,such as diabetic nephropathy and cardiomyopathy,is a key research ***,these areas require further investigations.

关键词： Diabetes mellitus Ubiquitination Bibliometric analysis CiteSpace Research trends

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浅谈天然气场站防雷电

天然气技术 2009年第6期3卷 56-58页

作者：邓军孝高京卫赵杨文陕西省天然气股份有限公司延安分公司陕西延安716000

防雷电是确保天然气场站安全的一项重要措施。介绍了雷电对天然气场站和输气管道的危害及主要表现,指出应构建一个完善的防雷工程:利用外部防雷装置(接闪器、引下线和接地装置)承接50%以上的雷电流并将其泄入大地;采用等电位连结、屏蔽... 详细信息

防雷电是确保天然气场站安全的一项重要措施。介绍了雷电对天然气场站和输气管道的危害及主要表现,指出应构建一个完善的防雷工程:利用外部防雷装置(接闪器、引下线和接地装置)承接50%以上的雷电流并将其泄入大地;采用等电位连结、屏蔽、防闪络技术和装置,阻塞雷电波沿金属导线和空间电磁场入侵的途径;利用某些元件的非线性特性,组成电涌保护器(SPD)并将其连结在配电和信号线路中,将累计产生的过电压和过电流通过SPD泄入大地。以仪表控制系统为例,指出治理侵入仪表控制系统雷电危害的主要措施包括接闪、分流、均压、接地和屏蔽等。

关键词：天然气场站雷电危害防护措施

RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-Yao Wang Bang Liu Yang-Pu Jia zhao-Xiong Zhang Xin Liu Dao-Han Wang Yong-Jia Yan wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition