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Diagnostic Classification of normal Persons andCancer Patients by Using Neural NetworkBased on Trace Metal Contents in Serum Samples

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Chemical Research in Chinese Universities 2001年第2期17卷 153-158页

作者： ZHANG Zhuo-yong, HONG Zhe, ZHOU Hua-lan and LIU Si-dong (Faculty of chemistry, northeast normal university, changchun 130024, P. R. China Chemical Engineering department, Dandong College, Dandong 118003, P. R. China) NE normal Univ Fac Chem Changchun 130024 Peoples R China Dandong Coll Dept Chem Engn Dandong 118003 Peoples R China

Artificial neural network with the back-propagation (BP-ANN) approach was applied to the classification of normal persons and various cancer patients based on the elemental contents in serum samples. This method was verified by the cross-validation method. The effects of the net- work parameters were investigated and the related problems were discussed. The samples of 72, 42, and 52 for lung, liver, and stomach cancer patients and normal persons, respectively, were used for the classification study. About 95% of the samples can be classified correctly. There- fore, the method can be used as an auxiliary means of the diagnosis of cancer.

关键词： Artificial neural network Classification Trace element Cancer

Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis

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World Journal of Gastroenterology 2024年第15期30卷 2143-2154页

作者： Sen Li Qian-Jun Ren Can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang Su Li Xing-Qiu liang Bin Wen Ming-Kun liang Xiao-Fang zhao department of Basic Science Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Traditional Chinese Medicine Specialty Office Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina

BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury,and finally leads to liver cirrhosis or even hepatocellular *** pathogenesis of hepatic fibrosis is associated with the progressive accumulation of activated hepatic stellate cells(HSCs),which can transdiffer-entiate into myofibroblasts to produce an excess of the extracellular matrix(ECM).Myofibroblasts are the main source of the excessive ECM responsible for hepatic ***,activated hepatic stellate cells(aHSCs),the principal ECM producing cells in the injured liver,are a promising therapeutic target for the treatment of hepatic *** To explore the effect of taurine on aHSC proliferation and the mechanisms *** Human HSCs(LX-2)were randomly divided into five groups:normal control group,platelet-derived growth factor-BB(PDGF-BB)(20 ng/mL)treated group,mmol/L,respectively)with PDGF-BB(20 ng/mL)treated *** Counting Kit-8 method was performed to evaluate the effect of taurine on the viability of ***-linked immunosorbent assay was used to estimate the effect of taurine on the levels of reactive oxygen species(ROS),malondialdehyde,glutathione,and iron *** electron microscopy was applied to observe the effect of taurine on the autophagosomes and ferroptosis features in *** real-time polymerase chain reaction and Western blot analysis were performed to detect the effect of taurine on the expression ofα-SMA,Collagen I,Fibronectin 1,LC3B,ATG5,Beclin 1,PTGS2,SLC7A11,and *** Taurine promoted the death of aHSCs and reduced the deposition of the *** with taurine could alleviate autophagy in HSCs to inhibit their activation,by decreasing autophagosome formation,downregulating LC3B and Beclin 1 protein expression,and upregulating p62 protein ***,treatment with taurine triggered ferroptosis and ferritinophagy to eliminate aHSCs characterized b

关键词： Hepatic stellate cells Autophagy Ferroptosis Molecular docking Taurine

Catalytic Acylation of Ethylidenecyclohexane over Zeolite Catalysts

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应用化学 2002年第4期19卷 310-312页

作者： zhao Zhen Hua (department of chemistry,Hunan normal university,Changsha 410081) department of chemistry Hunan Normal University Changsha 410081

Some environmentally friendly catalysts such as HY and H β zeolites, various cation exchanged β zeolites, and some other solids have been used in the acylation reaction of ethylidenecyclohexane with acetic anhydride at room temperature to synthesize 3 (1 cyclohexenyl) 2 butanone instead of conventional catalysts. The effect of the amount of HY zeolite used on the acylation reaction was investigated. The yield of the acylated product was 72% in the case of n (ethylidenecyclohexane)∶ n (acetic anhydride)∶ m (HY zeolite)=1 mmol∶10 mmol∶0 100 g, reaction temperature: 25 ℃, and reaction time:2 h. The regenerated HY zeolite showed almost the same catalytic activity as the fresh zeolite.

关键词：催化酰化亚乙基环己烷沸石催化剂

HYDROXYLATION OF BENZENE BY HETEROPOLY ACIDS(SALTS)CONTAINING VANADIUM

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Chinese Chemical Letters 1993年第4期4卷 319-320页

作者： Ru Dan HUANG Xin Hong LU Bao Jian ZHANG En Bo WANG department of chemistry,northeast normal Univeristy,changchun 130024Jin Chang LI Jing shi Centre of Test,northeast normal university,changchun 130024

Direct hydroxylation of benzene catalyzed by vanadium-con- taining heteropoly compounds with Keggin or Dawson structure has been *** effects of several factors upon the hydroxylation reaction have also been *** is ind... 详细信息

关键词： Ph SALTS)CONTAINING VANADIUM HYDROXYLATION OF BENZENE BY HETEROPOLY ACIDS

Variable　Structure　Control　of　Distributed　Parameter　Systems　and　Application　to　the　System　of　Heat　Process

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Systems Science and Systems Engineering 1994年第3期4卷 257-262页

作者： zhao Wenrong department of Mathematics,Ningxia Education College,Yinchuan,750002 HOU Xuezhang department of Mathematics,northeast normal university,changchun,130024

The variable structure control problems of distributed parameter system are in vestrigated in this *** the conditions more general than in[1],[2],the equivalent, control theorem is ***,as an application to system of heat process,we give some conditons for sliding model such that the solution of system of heat process is exonentially stable unde the variable structure control.

关键词： distributed parameter system sliding mode variable structure control heat process

Jianpi Decoction Combined with Medroxyprogesterone Acetate Alleviates Cancer Cachexia and Prevents Muscle Atrophy by Directly Inhibiting E3 Ubiquitin Ligase

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Chinese Journal of Integrative Medicine 2024年第6期30卷 499-506页

作者： LI Qi KONG zhao-di WANG Huan GU Hong-hui CHEN Zhong Li shi-guang CHEN Yi-qi CAI Yu YANG Zhen-jiang department of Oncology and Hematology Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong Province518033China College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou510632China Guangdong Key Lab of Traditional Chinese Medicine Information Technology Jinan UniversityGuangzhou510632China

ObjectiveTo provide comprehensive evidence for the anti-cancer cachexia effect of Jianpi Decoction(JP)and to explore its mechanism of anti-cancer *** mouse model of colon cancer(CT26)-induced cancer cachexia(CC)was used to investigate the anti-CC effect of JP combined with medroxyprogesterone acetate(MPA).Thirty-six mice were equally divided into 6 groups:normal control,CC,MPA(100 mg·kg^(−1)·d^(−1)),MPA+low-dose(20 mg·kg^(−1)·d^(−1))JP(L-JP),MPA+medium-dose(30 mg·kg^(−1)·d^(−1))JP(M-JP),and MPA+high-dose(40 mg·kg^(−1)·d^(−1))JP(H-JP)*** successful modeling,the mice were administered by gavage for 11 *** body weight and tumor volume were measured and recorded every 2 d starting on the 8th day after *** liver,heart,spleen,lung,kidney,tumor and gastrocnemius muscle of mice were collected and *** pathological changes of the tumor was observed,and the cross-sectional area of the gastrocnemius muscle was *** protein expressions of STAT3 and E3 ubiquitinase in the gastrocnemius muscle were measured by Western *** addition,an in vitro C2C12 myotube formation model was established to investigate the role of JP in hindering dexamethasone-induced muscle *** vitro experiments were divided into control,model,and JP serum *** 2-d administration,microscopic photographs were taken and myotube diameters were *** blot was performed to measure the protein expressions of STAT3 and E3 *** combined with MPA restored tumor-induced weight loss(P<0.05,***)and muscle fiber size(P<0.01,***).Mechanistically,JP reduced the expression of atrophy-related proteins MuRF1 and MAFbx in tumor-induced muscle atrophy in vivo(P<0.05,***).In addition,JP reduced the expression of atrophy-related proteins MuRF1 and MAFbx and p-STAT3 phosphorylation(P<0.05 or P<0.01 *** group)in C2C12 myotubes treated with dexamethasone in *** of JP combined with MPA restores t

关键词： cancer cachexia muscle atrophy Jianpi Decoction Chinese medicine E3 ubiquitin ligases

Asymmetric Photocatalyzed Addition of Cyclic Ammes to the Chiral 5-(l)-Menthyloxy-2(5H)-furanone

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Chinese Chemical Letters 1999年第11期10卷 889-892页

作者： zhao Yang WANG Tian Ying JIAN Qing Hua CHEN(department of chemistry,Beijing normal university, Beijing 100875) department of chemistry Beijing Normal University Beijing 100875 China

The benzophenone-initiated photoaddition of N-methyl ammes 2 to the chiral synthon1 proceeds in a regiospecitlc and highlyr stereocontrolled thshion to give the C-C photoadductscontaining a ne\viy stereogenic center 3a-3c. The enantiomerically pure N-C photoadducts, aminobutenolides 5a-5c have been obtained from the enantioselective photoaddition of secondary cyclicammes 4 with the chiral synthon 1 under the same conditions.

关键词： Asymmetric photocatalysed conjugate addition enantiomerically pure C-Cphotoadducts. secondary cyclic amine enantiomerically pure N-C photoaducts.

Sporophytic control of tapetal development and pollen fertility by a mitogen-activated protein kinase cascade in rice

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Journal of Integrative Plant Biology 2024年第7期66卷 1500-1516页

作者： Jianguo Zeng Manman Duan Yiqing Wang Guangtao Li Yujing You Jie shi Changhao Liu Jinyang Zhang Juan Xu Shuqun Zhang Jing zhao department of Plant Pathology Nanjing Agricultural UniversityNanjing 210095China State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China Division of Biochemistry University of MissouriColumbia65211MOUSA

Tapetum,the innermost layer of the anther wall,provides essential nutrients and materials for pollen *** degradation of anther tapetal cells is a prerequisite for normal pollen development in flowering *** cells facilitate male gametogenesis by providing cellular contents after highly coordinated programmed cell death(PCD).Tapetal development is regulated by a transcriptional ***,the signaling pathway(s)involved in this process are poorly *** this study,we report that a mitogen-activated protein kinase(MAPK)cascade composed of OsYDA1/OsYDA2-OsMKK4-OsMPK6 plays an important role in tapetal development and male gametophyte *** of function of this MAPK cascade leads to anther indehiscence,enlarged tapetum,and aborted pollen *** cells in osmkk4 and osmpk6 mutants exhibit an increased presence of lipid body-like structures within the cytoplasm,which is accompanied by a delayed occurrence of *** of a constitutively active version of OsMPK6(CA-OsMPK6)can rescue the pollen defects in osmkk4 mutants,confirming that OsMPK6 functions downstream of OsMKK4 in this *** crosses also demonstrated that the MAPK cascade sporophyticly regulates pollen *** study reveals a novel function of rice MAPK cascade in plant male reproductive biology.

关键词： degradation MAPK cascade pollen fertility rice tapetum

The Controllability of Cartesian Flexible Robot System

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Systems Science and Systems Engineering 1996年第2期6卷 240-245页

作者： WANG Zheng LIN Xianning HOU Xuezhang(department of Mathematics, northeast normal university, changchun, 130024)

The control system of X-Y Catesian flexible robot is considered in present *** have established the evolution equation model in an appropriate Hilbert space for the system of one-link flexible arm with payload, and us... 详细信息

关键词： flexible robot control system controllability