检索结果-南通市图书馆

Acta Geologica Sinica(English Edition) 2006年第5期80卷 705-723页

作者： Marian MUNTEANU YAO Yong Allan H. WILSON Gordon CHUNNETT LUO Yaonan zhao qixue School of Geosciences University of the Witwatersrand Wits 2050 Private Bag 3 Johannesburg South Africa Anglo-Platinum 28 Harrison St. Johannesburg 2001 South Africa Sichuan Bureau of Geology and Mineral Resources No. 25 Section 1 Renminbeilu Chengdu Sichuan 610081 China

The Neoproterozoic Gaojiacun intrusive complex （GIC） is composed of one big intrusion （ca. 9 × 7.5 km） and numerous satellite intrusions, emplaced in the low-grade schists of the Neoproterozoic Yanbian Group. The main intrusion is concentrically zoned, with peridotite bodies ＋ leucogabbroids in its core （inner zone） and the sequence： olivine hornblende gabbronorite - porphyric pyroxene hornblende gabbronorite （transitional zone） - pyroxene hornblende gabbronorite ＋ hornblende gabbro ＋ diorite （outer zone）, towards the margins. The satellite intrusions are composed either of a single rock type （peridotite, gabbro, diorite or granite） or of different rock types （peridotite ＋ diorite ＋ granite）. Upper crustal contamination is evidenced by the occurrence of numerous metamorphic enclaves, migmatites and mixed rocks in the outer zone of the main intrusion and in the satellite intrusions. Hornblende （often oikocrystic） is present in all mafic and ultramafic rocks. Cu-Ni （-PGE） deposits occur in several satellite intrusions, hosted in peridotite. The geochemical and mineralogical features of GIC support the presence of a subduction zone at the western edge of the Yangtze Craton. A feederrelated genesis of the satellite intrusions is inferred.

关键词： China Neoproterozoic ultramafic-mafic rocks cumulate Cu-Ni deposits

容错与开拓“宽猛相济”:悖论式领导激发公务员创造力的双路径机制研究

在线全文

学校读者我要写书评

暂无评论

中国人力资源开发 2024年第4期41卷 43-61页

作者：张琳李启雪徐钊西北工业大学公共政策与管理学院西安710072 西安交通大学管理学院西安710049

公务员创新直接面对群众现实需求、能够有效提升政府运转效率和公共服务质量,对于建设人民满意的服务型政府至关重要。本研究基于社会信息加工理论,探讨了悖论式领导对公务员创造力的影响机制,揭示了公务员韧性和知识创造能力的中介作用... 详细信息

公务员创新直接面对群众现实需求、能够有效提升政府运转效率和公共服务质量,对于建设人民满意的服务型政府至关重要。本研究基于社会信息加工理论,探讨了悖论式领导对公务员创造力的影响机制,揭示了公务员韧性和知识创造能力的中介作用,以及公共服务动机的调节作用。通过分析223对领导与下属配对数据,研究发现:(1)悖论式领导正向影响公务员创造力;(2)公务员韧性、知识创造能力在悖论式领导与公务员创造力之间起中介作用;(3)公共服务动机调节悖论式领导通过公务员韧性、知识创造能力对公务员创造力的影响,当公共服务动机较强时,悖论式领导通过公务员韧性、知识创造能力对公务员创造力的正向影响较弱。研究结果有助于解释悖论式领导在政府部门的作用机制,为激发公务员创造力提供理论和实践借鉴。

关键词：悖论式领导公务员创造力公务员韧性知识创造能力公共服务动机

Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2023年第5期20卷 385-400页

作者： Junhu Zhou Fei Tong Jixing zhao Xiaoteng Cui Yunfei Wang Guangxiu Wang Chunsheng Kang Xiaomin Liu qixue Wang Tianjin Medical University General Hospital Tianjin 300052China Tianjin Neurological Institute Key Laboratory of NeurotraumaVariationand RegenerationMinistry of Education and Tianjin Municipal GovernmentTianjin 300052China Department of Oncology Gamma Knife CenterDepartment of Neurological SurgeryTianjin Huanhu HospitalNankai UniversityTianjin 300350China

Objective:Epidermal growth factor receptor variant III(EGFRvIII)is a constitutively-activated mutation of EGFR that contributes to the malignant progression of glioblastoma multiforme(GBM).Temozolomide(TMZ)is a standard chemotherapeutic for GBM,but TMZ treatment benefits are compromised by *** study aimed to elucidate the crucial mechanisms leading to EGFRvIII and TMZ ***:CRISPR-Cas13a single-cell RNA-seq was performed to thoroughly mine EGFRvIII function in *** blot,realtime PCR,flow cytometry,and immunofluorescence were used to determine the chemoresistance role of E2F1 and RAD51-associated protein 1(RAD51AP1).Results:Bioinformatic analysis identified E2F1 as the key transcription factor in EGFRvIII-positive living *** RNA-seq analysis revealed that E2F1 is a crucial transcription factor under TMZ *** blot suggested enhanced expression of E2F1 in EGFRvIII-positive and TMZ-treated glioma *** of E2F1 increased sensitivity to *** diagram profiling showed that RAD51AP1 is positively correlated with E2F1,mediates TMZ resistance,and has a potential E2F1 binding site on the *** of RAD51AP1 enhanced the sensitivity of TMZ;however,overexpression of RAD51AP1 was not sufficient to cause chemotherapy resistance in glioma ***,RAD51AP1 did not impact TMZ sensitivity in GBM cells with high O6-methylguanine-DNA methyltransferase(MGMT)*** level of RAD51AP1 expression correlated with the survival rate in MGMT-methylated,but not MGMT-unmethylated TMZ-treated GBM ***:Our results suggest that E2F1 is a key transcription factor in EGFRvIII-positive glioma cells and quickly responds to TMZ ***51AP1 was shown to be upregulated by E2F1 for DNA double strand break *** RAD51AP1 could facilitate achieving an ideal therapeutic effect in MGMT-methylated GBM cells.

关键词： TMZ EGFRvIII E2F1 RAD51AP1 MGMT

Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2023年第12期43卷 1326-1353页

作者： Xiaoteng Cui Jixing zhao Guanzhang Li Chao Yang Shixue Yang Qi Zhan Junhu Zhou Yunfei Wang Menglin Xiao Biao Hong Kaikai Yi Fei Tong Yanli Tan Hu Wang qixue Wang Tao Jiang Chuan Fang Chunsheng Kang Laboratory of Neuro-oncology Tianjin Neurological Institute Tianjin Medical University General Hospital Tianjin P. R. China Key Laboratory of Post-Neuro Injury Neuro-repair and Regeneration in Central Nervous System Ministry of Education and Tianjin City Tianjin P. R. China Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing P. R. China Chinese Glioma Genome Atlas Network (CGGA) and Asian Glioma Genome Atlas Network (AGGA) Beijing P. R. China Department of Neurosurgery The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan P. R. China Tianjin Key Laboratory of Composite and Functional Materials School of Material Science and Engineering Tianjin University Tianjin P. R. China Department of Neurosurgery Affiliated Hospital of Hebei University Baoding Hebei P. R. China Hebei Key Laboratory of Precise Diagnosis and Treatment of Glioma Baoding Hebei P. R. China Department of Neuro-Oncology and Neurosurgery Tianjin Medical University Cancer Institute and Hospital Tianjin P. R. China Department of Pathology Affiliated Hospital of Hebei University Baoding Hebei P. R. China Department of Pathology Hebei University School of Basic Medical Sciences Baoding Hebei P. R. China Department of Neurosurgery Tianjin Huanhu Hospital Tianjin P. R. China Department of Molecular Neuropathology Beijing Neurosurgical Institute Capital Medical University Beijing P. R. China Research Unit of Accurate Diagnosis Treatment and Translational Medicine of Brain Tumors Chinese Academy of Medical Sciences Beijing P. R. China

Background Metabolism reprogramming plays a vital role in glioblastoma(GBM)progression and recurrence by producing enough energy for highly proliferating tumor *** addition,metabolic reprogramming is crucial for tumor growth and immune-escape *** growth factor receptor(EGFR)amplification and EGFR-vIII mutation are often detected in GBM cells,contributing to the malignant *** study aimed to investigate the functional role of the EGFR pathway on fatty acid metabolism remodeling and energy *** Clinical GBM specimens were selected for single-cell RNA sequencing and untargeted metabolomics analysis.A metabolism-associated RTK-fatty acid-gene signature was constructed and ***-2206 and MK-803 were utilized to block the RTK pathway and mevalonate pathway induced abnormal *** metabolism in GBM with activated EGFR pathway was *** antitumor effect of Osimertinib and Atorvastatin assisted by temozolomide(TMZ)was analyzed by an intracranial tumor model in *** GBM with high EGFR expression had characteristics of lipid remodeling and maintaining high cholesterol levels,supported by the single-cell RNA sequencing and metabolomics of clinical GBM *** of the EGFR/AKT and mevalonate pathways could remodel energy metabolism by repressing the tricarboxylic acid cycle and modulating ATP ***,the EGFR/AKT pathway upregulated the expressions of acyl-CoA synthetase short-chain family member 3(ACSS3),acyl-CoA synthetase long-chain family member 3(ACSL3),and long-chain fatty acid elongation-related gene ELOVL fatty acid elongase 2(ELOVL2)in an NF-κB-dependent ***,inhibition of the mevalonate pathway reduced the EGFR level on the cell membranes,thereby affecting the signal transduction of the EGFR/AKT ***,targeting the EGFR/AKT and mevalonate pathways enhanced the antitumor effect of TMZ in GBM cells and animal *** Our findings no

关键词： combinatorial therapeutic strategy EGFR energy metabolism glioblastoma

Nitromethane-Enabled Fluorination of Styrenes and Arenes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2020年第6期2卷 566-575页

作者： Weijin Wang Tongyu Huo Xinyi zhao qixue Qin Yujie Liang Song Song Guosheng Liu Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191 State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023Jiangsu State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032

The electrophilic fluorination of unsaturated compounds provides a reliable approach to the generation of organofluorides,which are used widely in agrochemicals,pharmaceuticals,and other *** active electrophilic fluorine reagents,such as the fluorine molecule(F_(2))or xenon difluoride(XeF_(2)),have been applied in ***,these reagents suffer from their hazardous,toxic,corrosive,and poor selective properties,and the relatively weak electrophilicity of Selectfluor or N-fluorobenzenesulfonimide(NFSI)usually limits their broad ***,we disclose nitromethane(MeNO_(2))as an efficient activator of Selectfluor and NFSI,as well as a stabilizer of ***,the fluoro-azidation,fluoroamination,fluoroesterification of styrenes,and C–H fluorination of(hetero)arenes were well realized just by the facilitation of MeNO_(2).The mild reaction conditions and practicability made our current method a versatile protocol for accessing organofluorides.

关键词： fluoroazidation fluoroamination fluoroesterification electrophilic fluorination nitromethane

胶质母细胞瘤中的分子标记物和靶向治疗的研究进展

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华神经医学杂志 2019年第6期18卷 629-633页

作者：王琦雪赵凯康春生天津医科大学总医院神经病学研究所天津300052

多形性胶质母细胞瘤是最常见的中枢神经系统侵袭性恶性肿瘤。胶质母细胞瘤的分子标志物是建立在庞大数据库的基础上,通过大量的研究和算法得到的特异性存在于胶质母细胞瘤中,并且能够反映胶质母细胞瘤发生、发展或者监测其对治疗反应的... 详细信息

多形性胶质母细胞瘤是最常见的中枢神经系统侵袭性恶性肿瘤。胶质母细胞瘤的分子标志物是建立在庞大数据库的基础上,通过大量的研究和算法得到的特异性存在于胶质母细胞瘤中,并且能够反映胶质母细胞瘤发生、发展或者监测其对治疗反应的一类物质。对胶质母细胞瘤分子标志物的筛选和鉴定能够有效区分肿瘤亚型、恶性程度和放化疗的响应性。本文归纳总结胶质母细胞瘤的分子标记物,并且探讨针对它们的靶向治疗的前景。

关键词：胶质母细胞瘤分子标志物靶向治疗

大型发电机及其机端外接元件单相接地故障定位

在线全文

学校读者我要写书评

暂无评论

中国电力 2020年第3期53卷 119-125页

作者：赵思腾桂林张琦雪王祥珩电力系统及发电设备控制和仿真国家重点实验室(清华大学电机系) 北京100084 南京南瑞继保电气有限公司江苏南京211102

为了区分大型发电机及其机端外接元件的单相接地故障,提出了一种基于零序方向判别原理的定位方案,将发电机及其机端外接元件划分为发电机本体、励磁变高压绕组、高厂变高压绕组和剩余外接元件4个区域,采用排除法依次排查并确定故障位置... 详细信息

为了区分大型发电机及其机端外接元件的单相接地故障,提出了一种基于零序方向判别原理的定位方案,将发电机及其机端外接元件划分为发电机本体、励磁变高压绕组、高厂变高压绕组和剩余外接元件4个区域,采用排除法依次排查并确定故障位置。该定位方案的关键在于机端零序电流和励磁变/高厂变高压侧零序电流的测量,需要结合故障区域选择不同的电流互感器。采用现场故障案例对所提定位方案进行了验证,表明该方案能够实现发电机及其外接元件接地故障的准确定位,缩短了故障检修时间,保证了发电机及时恢复供电。该故障定位方法具有推广应用价值。

关键词：发电机机端外接元件接地故障定位零序方向判别原理排除法

在线全文

学校读者我要写书评

暂无评论

EC细网格对黔南州温度预报的订正研究

中低纬山地气象 2022年第1期46卷 79-85页

作者：赵杰陈波莫乙冬潘启学顾欣贵州省黔南布依族苗族自治州气象局贵州都匀558000

该文采用EC细网格2 m温度预报场及国家站实况资料,通过滑动平均法、双权重滑动平均法、多项式拟合法以及最佳系数法对EC细网格2 m温度在黔南州的预报进行订正分析,结果显示:4种方法订正后最高气温7 d平均准确率分别提升了12.70%~17.84%... 详细信息

该文采用EC细网格2 m温度预报场及国家站实况资料,通过滑动平均法、双权重滑动平均法、多项式拟合法以及最佳系数法对EC细网格2 m温度在黔南州的预报进行订正分析,结果显示:4种方法订正后最高气温7 d平均准确率分别提升了12.70%~17.84%,最低气温7 d平均准确率分别提升了1.14%~2.86%。对于高温预报,最佳系数法订正效果最优,其次是多项式拟合法,对于最低气温,前3 d采用滑动平均法订正效果最明显,第4 d开始则采用最佳系数法订正,订正效果更明显。4种订正方法均在7-9月效果最明显。黔南州西部及中部地区多项式拟合法订正效果更好,州东南部地区最佳系数法与滑动平均法订正效果更好,但在120 h时效后滑动平均法的订正效果明显下降,州北部地区最佳系数法订正效果更为明显。

关键词：黔南滑动平均双权重滑动平均多项式拟合最佳系数

武汉市青山地区637例变应性鼻炎患者变应原种类分析

在线全文

学校读者我要写书评

暂无评论

临床耳鼻咽喉头颈外科杂志 2008年第14期22卷 634-636页

作者：王鹏李伟赵平娄佑云高起学武钢职工总医院耳鼻咽喉科武汉430080 华中科技大学同济医学院附属同济医院耳鼻咽喉科

目的:调查武汉市青山地区引起变应性鼻炎的主要吸入和食物性变应原种类。方法:采用酶联免疫法对青山地区637例变应性鼻炎患者(变应性鼻炎组)和63例下呼吸道疾病患者(下呼吸道疾病组)进行7种特异性IgE抗体的检测,并比较2组患者中致敏原... 详细信息

目的:调查武汉市青山地区引起变应性鼻炎的主要吸入和食物性变应原种类。方法:采用酶联免疫法对青山地区637例变应性鼻炎患者(变应性鼻炎组)和63例下呼吸道疾病患者(下呼吸道疾病组)进行7种特异性IgE抗体的检测,并比较2组患者中致敏原阳性率分布上的差异。结果:变应性鼻炎组阳性率排在前7位的吸入性变应原分别为尘螨(47%)、杂草(19.7%)、树(18%)、动物毛屑(8.5%)、屋尘(6.5%)、真菌(4.9%)及蒿草(3%),2种主要致敏原的检出率在变应性鼻炎组和下呼吸道疾病组间差异无统计学意义(P>0.05)。结论:尘螨、杂草花粉及木本植物花粉是青山地区最主要的变应原。

关键词：鼻炎变应性变应原酶联免疫法流行病学

在线全文

学校读者我要写书评

暂无评论

独活寄生汤治疗痹症研究进展

陕西中医 2024年第3期45卷 420-423页

作者：孙瑞杨宇赵彦宇宁子锋李建男徐杰广西中医药大学研究生院广西南宁530001 广西中医药大学第一附属医院广西南宁530022 广西中医药大学附属瑞康医院广西南宁530011

独活寄生汤是唐代著名医家孙思邈《备急千金要方》中治疗风寒湿痹的经典名方,其临床应用广泛且疗效较好。药理学研究已证实独活寄生汤不仅可以抗炎镇痛、调节免疫、干预氧化应激、促进骨代谢,在抗阿尔茨海默病、抗肿瘤、扩张血管,改善... 详细信息

独活寄生汤是唐代著名医家孙思邈《备急千金要方》中治疗风寒湿痹的经典名方,其临床应用广泛且疗效较好。药理学研究已证实独活寄生汤不仅可以抗炎镇痛、调节免疫、干预氧化应激、促进骨代谢,在抗阿尔茨海默病、抗肿瘤、扩张血管,改善循环等方面也具有明显疗效。古代医家多用该方治疗痹证日久,肝肾两虚,气血不足,正虚邪实者。现代医家已将该方广泛用于治疗类风湿性关节炎、膝骨关节炎、腰椎间盘突出症、骨质疏松、骨折、腰背痛、神经根型颈椎病等骨伤科疾病。同时有研究表明,独活寄生汤联合针灸、手法、艾灸、中药熏洗等,疗效更为显著。随着现代医学技术和中西医结合的发展,后世医家的不断探究,独活寄生汤治疗痹症的地位和发展进程不断受到认可和推进。多项实验研究已证实,独活寄生汤的药理作用和治疗痹症的临床效果。现从药理作用及该方在痹症中的临床应用对近十年独活寄生汤相关37篇文献进行梳理,研究探讨独活寄生汤的应用,为临床应用提供更为科学的参考。

关键词：独活寄生汤骨伤科疾病药理作用临床应用中医疗法痹证