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Vitamin A regulates mitochondrial biogenesis and function through p38 MAPK‑PGC‑1α signaling pathway and alters the muscle fiber composition of sheep

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Journal of Animal Science and Biotechnology 2024年第2期15卷 898-910页

作者： Pengkang song Jiamin zhao Fanqinyu Li Xiaoyi zhao Jinxin Feng Yuan Su Bo Wang Junxing zhao College of Animal Science Shanxi Agricultural UniversityTaiguShanxi 030801People’s Republic of China State Key Laboratory of Animal Nutrition and Feeding Department of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193People’s Republic of China

Background Vitamin A(VA)and its metabolite,retinoic acid(RA),are of great interest for their wide range of physiological ***,the regulatory contribution of VA to mitochondrial and muscle fiber composition in sheep has not been *** Lambs were injected with 0(control)or 7,500 IU VA palmitate into the biceps femoris muscle on d 2 after *** the age of 3 and 32 weeks,longissimus dorsi(LD)muscle samples were obtained to explore the effect of VA on myofiber type *** vitro,we investigated the effects of RA on myofiber type composition and intrinsic *** The proportion of type I myofiber was greatly increased in VA-treated sheep in LD muscle at *** greatly promoted mitochondrial biogenesis and function in LD muscle of *** exploration revealed that VA elevated PGC-1αmRNA and protein contents,and enhanced the level of p38 MAPK phosphorylation in LD muscle of *** addition,the number of type I myofibers with RA treatment was significantly increased,and type IIx myofibers was significantly decreased in primary *** with in vivo experiment,RA significantly improved mitochondrial biogenesis and function in primary myoblasts of *** then used si-PGC-1αto inhibit PGC-1αexpression and found that si-PGC-1αsignificantly abrogated RA-induced the formation of type I myofibers,mitochondrial biogenesis,MitoTracker staining intensity,UQCRC1 and ATP5A1 expression,SDH activity,and enhanced the level of type IIx muscle *** data suggested that RA improved mitochondrial biogenesis and function by promoting PGC-1αexpression,and increased type I *** order to prove that the effect of RA on the level of PGC-1αis caused by p38 MAPK signaling,we inhibited the p38 MAPK signaling using a p38 MAPK inhibitor,which significantly reduced RA-induced PGC-1αand MyHC I *** VA promoted PGC-1αexpression through the p38 MAPK signaling pathway,improved mitochondrial biogenesis,and altered

关键词： Mitochondria Muscle fiber type PGC-1α p38 MAPK Retinoic acid Vitamin A

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Electronic control seed-metering system for precision seeding maize based on fuzzy PID

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 217-226页

作者： Xiaoshun zhao Hongpeng zhao Zehe Wang Jincai Li Huali Yu qing Yan State Key Laboratory of North China Crop Improvement and Regulation Hebei Agricultural UniversityBaoding 071001HebeiChina College of Mechanical and Electrical Engineering Hebei Agricultural UniversityBaoding 071001HebeiChina

Aiming at the problem of poor uniformity of maize sowing caused by ground wheel slip,an electronic control seed-metering system(ECSMS)for maize single seed precision sowing was designed and a mathematical model for motor control of the ECSMS was *** PID parameters were set by Z-N method and fuzzy *** fuzzy PID control design and Simulink simulation were completed by MATLAB,which reduced response time of the system by 0.23 s and improved the control *** on the JPS-12 test bench show that the qualification index(QI)of maize seed-metering device with the ECSMS increases by 4.47%,the multiples index(MI)decreases by 1.96%,the miss index(MIX)decreases by 2.81%,and the coefficient of variation(CV)of qualified seed spacing decreases by 5.06%,and the sowing uniformity has been greatly *** results of the soil-tank test bench show that the system has good sowing uniformity and *** the QI is 96.74%,the MI is 2.15%,the MIX is 1.10%,and the CV of qualified seed spacing is 16.24%.Under different setting seed spacing and different sowing operation speed,the change range of seeding quality index was within 10%.The results of field sowing test show that the QI was 84.21%,the MI was 2.63%,the MIX was 7.89%,and the CV of qualified seed spacing was 22.15%,which meet the requirements of JB/T 10293-2013‘Specification for single seed planters(precision planters)’and the agronomic requirements for maize precision *** system runs stably and reliably in practical operation and has good operation performance.

关键词： maize seed-metering system electronic control precision sowing parameters tuning fuzzy PID control simulink simulation

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Research on a TOPSIS energy efficiency evaluation system for crude oil gathering and transportation systems based on a GA-BP neural network

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Petroleum Science 2024年第1期21卷 621-640页

作者： Xue-Qiang Zhang qing-Lin Cheng Wei Sun Yi zhao Zhi-Min Li Key Lab of Ministry of Education for Enhancing the Oil and Gas Recovery Ratio Northeast Petroleum UniversityDaqing163318HeilongjiangChina China Petroleum Pipeline Material and Equipment Co. LtdLangfang065000HebeiChina Research Institute of Petroleum Engineering and Technology Sinopec Northwest Oilfield CompanyUrumqi830011XinjiangChina

As the main link of ground engineering,crude oil gathering and transportation systems require huge energy consumption and complex *** is necessary to establish an energy efficiency evaluation system for crude oil gathering and transportation systems and identify the energy efficiency *** this paper,the energy efficiency evaluation system of the crude oil gathering and transportation system in an oilfield in western China is *** with the big data analysis method,the GA-BP neural network is used to establish the energy efficiency index prediction model for crude oil gathering and transportation *** comprehensive energy consumption,gas consumption,power consumption,energy utilization rate,heat utilization rate,and power utilization rate of crude oil gathering and transportation systems are *** the efficiency and unit consumption index of the crude oil gathering and transportation system,the energy efficiency evaluation system of the crude oil gathering and transportation system is established based on a game theory combined weighting method and TOPSIS evaluation method,and the subjective weight is determined by the triangular fuzzy analytic hierarchy *** entropy weight method determines the objective weight,and the combined weight of game theory combines subjectivity with objectivity to comprehensively evaluate the comprehensive energy efficiency of crude oil gathering and transportation systems and their ***,the weak links in energy utilization are identified,and energy conservation and consumption reduction are *** above research provides technical support for the green,efficient and intelligent development of crude oil gathering and transportation systems.

关键词： Crude oil gathering and transportation system GA-BP neural network Energy efficiency evaluation TOPSIS evaluation method Energy saving and consumption reduction

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Effect of ceramic work rolls on surface roughness of rolled SUS304 ultra-thin strips

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Journal of Iron and Steel Research International 2024年第7期31卷 1704-1718页

作者： Peng-cheng Li Tao Wang Chen-chen zhao Qi Liu qing-xue Huang College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024ShanxiChina Engineering Research Center of Advanced Metal Composites Forming Technology and Equipment of Ministry of Education Taiyuan University of TechnologyTaiyuan 030024ShanxiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment Taiyuan University of TechnologyTaiyuan 030024ShanxiChina

Surface morphology and roughness are important parameters of surface quality of cold-rolled ultra-thin strip *** order to study the effect of Si_(3)N_(4) ceramic work rolls on the surface roughness of SUS304 ultra-thin strip,ABAQUS finite element model calculation,3D laser profilometry,and other methods were adopted based on the physical characteristics of Si_(3)N_(4) ceramic roll and 9Cr2MoV steel roll,like anti-flattening performance and oil *** surface morphology and roughness of SUS304 ultra-thin strip rolled by different material work rolls under oil lubrication conditions were *** results showed that under the rolling force of 10 kN,the maximum flattening amount of Si_(3)N_(4) ceramic roll was reduced by 35.14%compared to that of 9Cr2MoV steel *** reduction rate of SUS304 ultra-thin strip rolled by ceramic roll was 34.19%,while that rolled by steel roll was only 22%;Si_(3)N_(4) ceramic roll can further increase the number of alternating convex peaks and concave valleys in the rolled thin strip,reduce the profile steepness,reduce surface roughness,and enhance the planarization effect of surface micro-convex bodies,with improving surface quality and surface ***,the mechanism of Si_(3)N_(4) ceramic roll significantly improving the surface roughness of rolled SUS304 ultra-thin strip was proposed.

关键词： Ceramic work roll-Steel roll SUS304 ultra-thin strip Reduction Surface roughness

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Cauchy matrix approach for H1a equation in the torqued Adler–Bobenko–Suris lattice list

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Communications in Theoretical Physics 2024年第10期76卷 3-8页

作者： Jing Wang song-lin zhao Shoufeng Shen School of Mathematical Sciences Zhejiang University of Technology

As a torqued version of the lattice potential Korteweg–de Vries equation, the H1ais an integrable nonsymmetric lattice equation with only one spacing parameter. In this paper, we present the Cauchy matrix scheme for this equation. Soliton solutions, Jordan-block solutions and soliton-Jordan-block mixed solutions are constructed by solving the determining equation set. All the obtained solutions have jumping property between constant values for fixed n and demonstrate periodic structure.

关键词： Cauchy matrix scheme exact solutions torqued H1 equation

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High-resolution neutronics model for ^(238)Pu production in high-flux reactors

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Nuclear Science and Techniques 2024年第5期35卷 226-236页

作者： qing-Quan Pan qing-Fei zhao Lian-Jie Wang Bang-Yang Xia Yun Cai Jin-Biao Xiong Xiao-Jing Liu School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610200China

We proposed and compared three methods(filter burnup,single energy burnup,and burnup extremum analysis)to build a high-resolution neutronics model for 238Pu production in high-flux *** filter burnup and single energy burnup methods have no theoretical approximation and can achieve a spectrum resolution of up to~1 eV,thereby constructing the importance curve and yield curve of the full energy *** burnup extreme analysis method combines the importance and yield curves to consider the influence of irradiation time on production efficiency,thereby constructing extreme *** three curves,which quantify the transmutation rate of the nuclei in each energy region,are of physical significance because they have similar distributions.A high-resolution neutronics model for ^(238)Pu production was established based on these three curves,and its universality and feasibility were *** neutronics model can guide the neutron spectrum optimization and improve the yield of ^(238)Pu by up to 18.81%.The neutronics model revealed the law of nuclei transmutation in all energy regions with high spectrum resolution,thus providing theoretical support for high-flux reactor design and irradiation production of ^(238)Pu.

关键词： ^(238)Pu Neutronics model High-flux reactor Spectrum resolution Spectrum optimization

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Resource Allocation in Multi-User Cellular Networks:A Transformer-Based Deep Reinforcement Learning Approach

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China Communications 2024年第5期21卷 77-96页

作者： zhao Di Zheng Zhong Qin Pengfei Qin Hao song Bin State Key Laboratory of Integrated Services Networks Xidian University710071China China Academy of Space Technology Beijing 100081China

To meet the communication services with diverse requirements,dynamic resource allocation has shown increasing *** this paper,we consider the multi-slot and multi-user resource allocation(MSMU-RA)in a downlink cellular scenario with the aim of maximizing system spectral efficiency while guaranteeing user *** first model the MSMURA problem as a dual-sequence decision-making process,and then solve it by a novel Transformerbased deep reinforcement learning(TDRL)***,the proposed TDRL approach can be achieved based on two aspects:1)To adapt to the dynamic wireless environment,the proximal policy optimization(PPO)algorithm is used to optimize the multi-slot RA strategy.2)To avoid co-channel interference,the Transformer-based PPO algorithm is presented to obtain the optimal multi-user RA scheme by exploring the mapping between user sequence and resource *** results show that:i)the proposed approach outperforms both the traditional and DRL methods in spectral efficiency and user fairness,ii)the proposed algorithm is superior to DRL approaches in terms of convergence speed and generalization performance.

关键词： dynamic resource allocation multi-user cellular network spectrum efficiency user fairness

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Review of the research on the development and utilization of clay-type lithium resources

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Particuology 2024年第4期87卷 46-53页

作者： Ruiqi Xie Zhihui zhao Xiong Tong Xian Xie Qiang song Peiqiang Fan Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming650093China Yunnan Engineering Research Center for Metal Tailings Resource Utilization Kunming650093China

Since the demands for lithium have been in explosive growth recently and several great clay lithium resources were founded in China,the development and utilization of clay-type lithium resources become a hot *** order to provide a guidance for the concentration and extracting lithium of clay-type lithium resources,this review systematically summarized the main types and characteristics of clay-type lithium resources and the research status of lithium extraction from clay lithium ***,the flotation research status of the main mineral of clay lithium ore was also ***,we discussed the difficulties in the development and utilization of clay-type lithium ore and put forward the subsequent research *** paper can provide a guidance for the con-centration and extracting lithium of clay-type lithium resources in the future.

关键词： Clay lithium Clay mineral flotation Lithium extraction Leaching

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Effect of Incoming Vortex on Secondary Flows in Turbine Cascades with Planar and Non-Axisymmetric Endwall

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Journal of Thermal Science 2024年第1期33卷 138-157页

作者： CAO Zhiyuan WANG Chuxuan song Zhigao GAO Xi zhao Wei LIU Bo School of Power and Energy Northwestern Polytechnical UniversityXi'an 710072China National Key Laboratory of Science and Technology on Aerodynamic Design and Research Northwestern Polytechnical UniversityXi'an 710072China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100080China School of Aeronautics and Astronautics University of Chinese Academy of SciencesBeijing 100080China

Non-Axisymmetric Endwall Profiling(NAEP) is commonly utilized in turbines to eliminate secondary ***,most of the NAEP methods consider a single-blade row environment without incorporating the effect of the stage *** paper aims to investigate the influence mechanism of the incoming vortex on the endwall secondary flow structures of NAEP in a highly loaded turbine *** model the incoming vortex in a stage environment,this study considers a half-delta wing as the vortex generator at the upstream of the turbine *** NAEP is then carried out for a highly loaded turbine cascade with an in-house numerical optimization design platform subject to no incoming *** simulation is also carried out under the influence of the incoming vortex for the turbine cascades with both planar and non-axisymmetric *** paper furthers investigated the pitchwise effect of the incoming vortex on the near endwall secondary *** results indicate that the NAEP effectively improves the endwall secondary flow of the turbine cascade,where the total pressure loss coefficient and the secondary kinetic energy(SKE) are reduced by 7.3%,and 45.7%,*** is further seen that with the incoming vortex,the NAEP achieves a considerable control effect on the endwall secondary flow of the turbine *** incoming vortex,the NAEP can still achieve considerable control effect on the endwall secondary flow of the turbine cascade;the averaged reductions of loss coefficient and SKE are 7.8% and 14.2%,*** some pitchwise locations,incoming vortex can suppress the convection of cross-passage flow toward the suction corner greatly and reduce the loss coefficient of the baseline *** incoming vortex at 4/7 pitch impinged right at the blade leading edge,leading to the generation of low-momentum fluid,which increased the size and the strength of the horseshoe *** all the pitchwise locations,NAEP can suppress the seco

关键词： non-axisymmetric endwall secondary flow incoming vortex passage vortex stage environment

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Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions

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World Journal of Gastroenterology 2024年第14期30卷 1968-1981页

作者： Hong-Ju Sun Bo Jiao Yan Wang Yue-Hua Zhang Ge Chen Zi-Xuan Wang Hong zhao qing Xie Xiao-Hua song Department of General Medicine Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Gastroenterology Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Medical Administration Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina qingdao Medical College Qingdao UniversityQingdao 266042Shandong ProvinceChina Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver ***,the disease is underappreciated as a remarkable chronic disorder as there are rare managing *** studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic ***,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular *** the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the *** study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic ***,further studies are necessary.

关键词： Nonalcoholic fatty liver disease Apoptosis Necroptosis Cell death Diagnosis Treatment

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