检索结果-南通市图书馆

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

正常人与冠心病患者的第三心音分析

山东生物医学工程 2002年第2期21卷 11-13页

作者：刘毅邵庆余朱兴雷赵玲李桥张玉华山东大学计算机科学与技术学院济南250100 山东大学医学院济南250012 山东省立医院心内科济南250021

研究第三心音 (S3)在临床上的意义。在心前区采集心音数据 ,并采集一导心电信号来定位心音。采样频率为10 3 Hz。用小波变换时频分析方法 ,研究了 135例 (正常少儿 34例、正常成年人 31例、正常老年人 30例和冠心病老年人 40例 )心音图... 详细信息

研究第三心音 (S3)在临床上的意义。在心前区采集心音数据 ,并采集一导心电信号来定位心音。采样频率为10 3 Hz。用小波变换时频分析方法 ,研究了 135例 (正常少儿 34例、正常成年人 31例、正常老年人 30例和冠心病老年人 40例 )心音图中的S3。表明所有正常人均有S3;正常老年人与老年一般冠心病患者的S3存在明显差异 (p =0 .0 16 4) ,后者S3的频谱主峰频率明显上移。

关键词：正常人冠心病患者第三心音分析小波变换主峰频率

Porous Co_(2)VO_(4) Nanodisk as a High-Energy and Fast-Charging Anode for Lithium-Ion Batteries

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2022年第1期14卷 107-120页

作者： Jinghui Ren Zhenyu wang peng Xu Cong wang Fei Gao Decheng zhao Shupei liu Han Yang Di wang Chunming Niu Yusong Zhu Yutong Wu Xiang liu Zhoulu wang Yi zhang school of Energy science and Engineering Nanjing Tech UniversityNanjing 211816People’s Republic of China Center of Nanomaterials for Renewable Energy State Key Laboratory of Electrical Insulation and Power EquipmentSchool of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710054People’s Republic of China Department of Computational Materials Design Max-Planck-Insitut Für Eisenforschung GmbHMax-Planck-Straße 140237 DüsseldorfGermany

High-energy–density lithium-ion batteries(LIBs)that can be safely fast-charged are desirable for electric ***,sub-optimal lithiation potential and low capacity of commonly used LIBs anode cause safety issues and low energy *** we hypothesize that a cobalt vanadate oxide,Co_(2)VO_(4),can be attractive anode material for fast-charging LIBs due to its high capacity(~1000 mAh g^(−1))and safe lithiation potential(~0.65 V ***^(+)/Li).The Li+diffusion coefficient of Co2VO4 is evaluated by theoretical calculation to be as high as 3.15×10^(-10) cm^(2) s^(−1),proving Co_(2)VO_(4) a promising anode in fast-charging LIBs.A hexagonal porous Co2VO4 nanodisk(PCVO ND)structure is designed accordingly,featuring a high specific surface area of 74.57 m^(2) g^(−1) and numerous pores with a pore size of 14 *** unique structure succeeds in enhancing Li^(+) and electron transfer,leading to superior fast-charging performance than current commercial *** a result,the PCVO ND shows a high initial reversible capacity of 911.0 mAh g^(−1) at 0.4 C,excellent fast-charging capacity(344.3 mAh g^(−1) at 10 C for 1000 cycles),outstanding long-term cycling stability(only 0.024% capacity loss per cycle at 10 C for 1000 cycles),confirming the commercial feasibility of PCVO ND in fast-charging LIBs.

关键词： Lithium-ion batteries Anode Fast-charging High-energy Cobalt vanadate oxide

亲环素D介导的线粒体通透性转换孔开放对骨肉瘤MG63细胞生物学行为的影响

在线全文

学校读者我要写书评

暂无评论

郑州大学学报（医学版） 2024年第5期59卷 602-607页

作者：刘一夏德佳赵柔王旭彤赵岳马玉芳王文军张玲华北理工大学公共卫生学院儿少卫生与妇幼保健学教研室河北唐山063000 济宁医学院护理学院妇儿护理学教研室山东济宁272000 济南大家医学检验有限公司临床实验室济南250104 济宁医学院附属医院医学检验科山东济宁272000 滨州医学院公共卫生学院儿少卫生与妇幼保健学教研室山东烟台264003 潍坊护理职业学院党政办公室山东潍坊262500

目的:探讨干扰线粒体关键蛋白亲环素D(CypD)对骨肉瘤MG63细胞增殖、迁移、凋亡等生物学行为的影响。方法:构建3种转染不同siRNA的MG63细胞系,分别为CypD-siRNA1、CypD-siRNA2和CypD-siRNA3组,采用qRT-PCR和Western blot检测3组细胞中Cyp... 详细信息

目的:探讨干扰线粒体关键蛋白亲环素D(CypD)对骨肉瘤MG63细胞增殖、迁移、凋亡等生物学行为的影响。方法:构建3种转染不同siRNA的MG63细胞系,分别为CypD-siRNA1、CypD-siRNA2和CypD-siRNA3组,采用qRT-PCR和Western blot检测3组细胞中CypD的表达水平,筛选用于后续实验的CypD-siRNA。将MG63细胞分为阴性对照组(转染siRNA-NC)和敲减组(转染CypD-siRNA2)。采用CCK-8法和平板克隆实验检测细胞的增殖能力,Transwell小室实验检测细胞的迁移能力;采用MitoSOX Red检测线粒体活性氧(mROS)水平,钙黄绿素-钴评价线粒体通透性转换孔的开放状态;采用流式细胞术检测细胞凋亡情况,Western blot法检测细胞迁移和凋亡相关蛋白的表达。结果:与CypD-siRNA1组和CypD-siRNA3组相比,CypD-siRNA2组中CypD mRNA和蛋白表达水平下降(P2、Cleaved Caspase 3/Caspase 3以及E-cadherin和细胞色素C蛋白表达水平升高(P<0.05)。敲减组细胞mROS水平高于阴性对照组,而线粒体通透性转换孔开放程度低于阴性对照组(P<0.05)。结论:敲减CypD表达可上调MG63细胞氧化应激水平,抑制其增殖、迁移能力,并通过线粒体途径诱导其凋亡。

关键词：骨肉瘤亲环素D 线粒体通透性转换孔生物学行为 MG63细胞

Authentic compound-free strategy for simultaneous determination of primary coumarins in Peucedani Radix using offline high performance liquid chromatography–nuclear magnetic resonance spectroscopy–tandem mass spectrometry

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2018年第4期8卷 645-654页

作者： Yao liu Qingqing Song Wenjing liu peng Li Jun Li Yunfang zhao Liang zhang pengfei Tu Yitao wang Yuelin Song Modern Research Center for Traditional Chinese Medicine School of Chinese Materia MedicaBeijing University of Chinese Medicine State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macao State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural University

Herein, a strategy is proposed for the simultaneous determination of primary coumarins in Peucedani Radix(Chinese name: Qianhu). The methodology consists of three consecutive steps: 1) Semi-preparative LC in combination with a home-made automated fraction collection module to fragment the universal metabolome standard into ten fractions(Frs. I–X); 2) LC–accurate MS/MS and quantitative1 H NMR spectroscopy conducted in parallel to acquire the qualitative and quantitative data of each fraction; 3) Robust identification and quantification of components by use of LC coupled to multiple reaction monitoring. In this final step, the most significant fractions(Frs. III–X) were pooled to serve as the pseudo-mixed standard solution. Meticulous online parameter optimization was performed to obtain the optimal parameters, including ion transitions and collision energies. Concerns were particularly paid onto pursuing the parameters being capable of monitoring regiospecific isomers, notably praeruptorin E vs. 3′-isovaleryl-4′-angeloylkhellactone. The quantitative performance of the method was validated according to diverse assays. Eleven primary coumarins(1–11) were unambiguously identified and absolutely quantified, even though no external reference compound was used. Above all, the integrated strategy not only provides a feasible pipeline for the quality assessment of Peucedani Radix, but more importantly, shows the potential for authentic compound-free quantitative evaluation of traditional Chinese medicines.

关键词： Authentic compoundindependent quantitation Offline LC–NMR–MS/MS Automated fraction collection module Quantitative1H NMR Peucedani Radix Regio-specific monitoring

High-capacity potassium ion storage mechanisms in a soft carbon revealed by solid-state NMR spectroscopy

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2022年第11期41卷 3752-3761页

作者： Jing-Heng Han Jia He Qi-Yao Zou Jie zhang Zhi Yang Zhi-Wei zhao Hui-Xin Chen Hong-Jun Yue Da-Wei wang Hai-Chen Lin Hao-Dong liu Gui-Ming zhong zhang-Quan peng College of Chemistry and Material science Fujian Normal UniversityFuzhou350000China CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare-Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen361021China Laboratory of Advanced Spectro-Electrochemistry and Li-Ion Batteries Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Key Laboratory of Automobile Materials of Ministry of Education&school of Materials science and Engineering Jilin UniversityChangchun130025China Chemical Engineering University of California San DiegoLa JollaSan DiegoCA92093USA

Carbon materials are crucially important for the realization of potassium-ion ***,the potassium storage mechanisms in various carbon materials are incompletely ***,solid-state ^(13)C nuclear magnetic resonance(NMR) spectroscopy coupled with Raman and X-ray diffraction(XRD) techniques are employed to study the reaction mechanism in a soft carbon *** is revealed that the insertion of potassium ions into the soft carbon firstly induces a transformation of the disordered region to short-range ordered stacking,involving both the pristine local unorganized and organized carbon ***,potassium ions intercalate into the rearranged carbon structure,finally producing the nano-sized KC_(8).Moreover,a remarkable c apacity of 322 mAh·g^(-1) with a low mid potassiation voltage of <0.3 V is present for the prepared soft carbon,which is on account of the underlying potassium storage sites,including the disordered stacking carbon as a main component of the soft *** results suggest that regulating the disordered stacking region in the turbostratic structure of soft carbon is a critical issue for further improving the potassium storage performance.

关键词： Reaction mechanism Soft carbon Solid-state nuclear magnetic resonance(NMR) Anode Potassium-ion batteries(PIBs)

在线全文

学校读者我要写书评

暂无评论

分布式光纤传感技术研究和应用的现状及未来

光学学报 2024年第1期44卷 3-65页

作者：张旭苹张益昕王亮余贶琭刘波尹国路刘琨李璇李世念丁传奇汤玉泉尚盈王奕首王晨王峰樊昕昱孙琪真谢尚然吴慧娟吴昊王花平赵志勇南京大学智能光感知与调控技术教育部重点实验室江苏南京210023 华中科技大学光学与电子信息学院湖北武汉430074 北京交通大学信息科学研究所北京100044 之江实验室光纤传感研究中心浙江杭州311100 重庆大学光电技术及系统教育部重点实验室重庆400044 天津大学精密仪器与光电子工程学院天津300072 中国电力科学研究院有限公司北京100192 中国煤炭地质总局勘查研究总院北京100039 中油奥博(成都)科技有限公司四川成都611731 中国科学院合肥物质科学研究院安徽光学精密机械研究所光子器件与材料安徽省重点实验室安徽合肥230031 齐鲁工业大学(山东省科学院) 山东省科学院激光研究所山东济南250104 厦门大学航空航天学院福建厦门361005 上海交通大学电子信息与电气工程学院区域光纤通信网与新型光通信系统国家重点实验室上海200240 北京理工大学光电学院信息光子技术工信部重点实验室北京100081 电子科技大学光纤传感与通信教育部重点实验室四川成都611731 兰州大学土木工程与力学学院甘肃兰州730000

我国大型基础设施的建设规模已多年位居世界之首,分布式光纤传感技术(DOFS)作为大型基础设施健康状态实时监测最有潜力的技术,近年来得到了迅速发展。针对DOFS在技术和应用的突破上面临的挑战,在介绍DOFS各技术基本工作原理、发展历史... 详细信息

我国大型基础设施的建设规模已多年位居世界之首,分布式光纤传感技术(DOFS)作为大型基础设施健康状态实时监测最有潜力的技术,近年来得到了迅速发展。针对DOFS在技术和应用的突破上面临的挑战,在介绍DOFS各技术基本工作原理、发展历史、现状以及典型应用原理和方案等的基础上,对其工作新机理、系统设计方案、研究发展方向等进行了阐述和讨论。

关键词：光纤光学分布式光纤传感技术光时域反射仪光频域反射仪干涉型分布式光纤传感

A new multi-source remote sensing image sample dataset with high resolution for flood area extraction:GF-FloodNet

在线全文

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2023年第1期16卷 2522-2554页

作者： Yuwei zhang peng liu Lajiao Chen Mengzhen Xu Xingyan Guo Lingjun zhao Aerospace Information Research Institute Chinese Academy of SciencesBeijingPeople’s Republic of China school of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijingPeople’s Republic of China State Key Laboratory of Hydroscience and Engineering Department of Hydraulic EngineeringTsinghua UniversityBeijingPeople’s Republic of China

Deep learning algorithms show good prospects for remote sensingflood *** mostly rely on huge amounts of labeled ***,there is a lack of available labeled data in actual *** this paper,we propose a high-resolution multi-source remote sensing dataset forflood area extraction:***-FloodNet contains 13388 samples from Gaofen-3(GF-3)and Gaofen-2(GF-2)*** use a multi-level sample selection and interactive annotation strategy based on active learning to construct *** with otherflood-related datasets,GF-FloodNet not only has a spatial resolution of up to 1.5 m and provides pixel-level labels,but also consists of multi-source remote sensing *** thoroughly validate and evaluate the dataset using several deep learning models,including quantitative analysis,qualitative analysis,and validation on large-scale remote sensing data in real *** results reveal that GF-FloodNet has significant advantages by multi-source *** can support different deep learning models for training to extractflood *** should be a potential optimal boundary for model training in any deep learning *** boundary seems close to 4824 samples in *** provide GF-FloodNet at https://***/datasets/pengliuair/gf-floodnet and https://***/s/1vdUCGNAfFwG5UjZ9RLLFMQ?pwd=8v6o.

关键词： Flood area extraction dataset construction multi-source remote sensing data deep learning

Human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第11期8卷 5325-5337页

作者： Ying Fang Mu-Chen zhang Yang He Chen Li Hai Fang peng-peng Xu Shu Cheng Yan zhao Yan Feng Qian liu Li wang Wei-Li zhao Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Network and Information Center Shanghai Jiao Tong UniversityShanghaiChina State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina

TP53 mutation(TP53^(mut))occurs in 10–20%of diffuse large B-cell lymphoma(DLBCL)cases and serves as an unfavorable biomarker of DLBCL *** confers resistance to immunochemotherapy,high-dose chemotherapy,autologous stem cell transplantation,and anti-CD19 chimeric antigen receptor T-cell *** targeting of TP53^(mut) remains a significant challenge in DLBCL *** we assessed TP53^(mut) in 667 patients with newly diagnosed DLBCL,including 576 patients treated with immunochemotherapy rituximab,cyclophosphamide,doxorubicin,vincristine,and prednisone(R-CHOP)and 91 patients with decitabine plus R-CHOP(DR-CHOP,NCT02951728 and NCT04025593).TP53^(mut) independently predicted an inferior prognosis in R-CHOP-treated DLBCL,although this could be mitigated by DR-CHOP *** TP53^(mut) patients,multiple viral regulation pathways were repressed,resulting in the inhibition of immune modulation,as revealed by gene set enrichment ***53^(mut) DLBCL exhibited increased methyltransferase SUV39H1 expression and H3K9 trimethylation(H3K9me3),contributing to repression of endogenous retroviruses(ERVs)and immunosuppressive tumor *** TP53^(mut) DLBCL cell lines,decitabine down-regulated SUV39H1,inhibited H3K9me3 occupancy on ERVs,and triggered ERV expression,thereby unleashing interferons program and CD4^(+)T/CD8^(+)T cell *** silencing of SUV39H1 significantly abrogated decitabine-induced H3K9me3 inhibition and ERV *** TP53^(mut) patient-derived xenograft models and TP53^(mut) patients,the anti-tumor effect was improved upon the use of combined treatment of decitabine and doxorubicin via SUV39H1-H3K9me3-ERVs ***,our findings highlight an ERV regulatory circuitry in TP53^(mut) DLBCL and the crucial roles ERVs for epigenetically reprogramming tumor microenvironment for treating TP53^(mut)-driven cancers.

关键词： TP53 endogenous chemotherapy

一种高效稳定的高熵合金电催化剂用于析氢反应

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 2024年第7期62卷 156-165页

作者：赵贵路宽李玉楠卢发贵高朋南兵李丽娜张熠霄徐鹏涛刘晰陈立桅上海交通大学化学化工学院物质科学原位中心上海200240 上海交通大学变革性分子前沿科学中心上海200240 上海交通大学上海电化学能源器件工程技术研究中心上海200240 中国科学院山西煤炭化学研究所煤转化国家重点实验室山西太原030001 上海高等研究院上海同步辐射光源上海201204

水分解是一种利用可再生能源驱动的绿色制氢方法,零碳排放特性使其成为解决氢能源生产的重要途径.在电化学水分解中,制备高活性和稳定性的催化剂至关重要.高熵合金(HEAs)由于独特的结构和性能使其成为理想的催化剂材料,其多元成分和可... 详细信息

水分解是一种利用可再生能源驱动的绿色制氢方法,零碳排放特性使其成为解决氢能源生产的重要途径.在电化学水分解中,制备高活性和稳定性的催化剂至关重要.高熵合金(HEAs)由于独特的结构和性能使其成为理想的催化剂材料,其多元成分和可调组成提供了丰富的表面活性位点和灵活的催化特性,有望提高水分解的效率并降低成本.然而,简易高效地制备HEAs仍面临挑战,且目前对HEA催化剂的结构-活性关系的了解存在不足.因此,探索一种简便有效的方法用以制备高性能HEAs催化剂,并深入理解其在水分解反应中的作用机制和结构演变,能够为未来绿色制氢技术的发展提供重要的科学基础和技术支持.本文采用了电化学测量、CuK-边和PtL3-边的原位同步辐射X射线吸收光谱(XAS)测试以及密度泛函理论(DFT)计算相结合的方法,系统地研究了高熵合金电催化剂PtPdRhRuCu/C的析氢反应(HER)活性、反应机制以及结构演变规律.PtPdRhRuCu HEAs纳米颗粒由简便的一步溶剂热法制备,直径约为6.7±0.6 nm,其合金结构和元素分布通过多种表征手段(扫描透射电子显微镜、X射线衍射和能量色散X射线光谱等)得到确认.XAS对Cu K-边和PtL3-边的分析结果显示,HEAs纳米颗粒表面的少量铜氧化物在HER过程中被还原至金属态.扩展X射线吸收精细结构的拟合结果表明,HEAs在工况HER中保持了金属态和无序的原子排列,没有新的分离相形成.电化学测试结果表明,得益于多金属活性位点,PtPdRhRuCu/C催化剂在酸性和碱性条件下均表现出较好的HER活性和耐久性.在10 m Acm^(-2)的电流密度下,该催化剂在1molL^(-1)KOH中具有23.3 m V的极低过电位,优于商业Pt/C催化剂(50.3 m V),其质量活性是Pt/C的7.9倍,达到3.0 Amg^(-1)***的高熵效应显著提升了催化剂在HER中的长期稳定性,在稳定性测试中,PtPdRhRuCu/C催化剂在10000次循环伏安测试后几乎无性能衰减,而Pt/C的过电位增加了约24 m V.在-55 m V过电位下的30 h的HER测试中,PtPdRhRuCu/C保持95.7%的初始电流密度,而Pt/C衰减了53.6%.在酸性条件下,PtPdRhRuCu/C的循环稳定性和耐久性也优于Pt/***计算结果表明,PtPdRhRuCu/C较好的HER性能和稳定性归因于高熵合金的协同效应,多金属成分提供了多样的活性位点,优化了HER反应路径,特别是在Volmer步骤中降低了水裂解的反应能垒.PtPdRhRuCu/C上的HER过程遵循Volmer-Tafel机理,水分子优先吸附在Ru位点,促进HO-H键的解离,解离出的质子迁移到Pt上,而OH通过Ru和Rh的桥接作用而稳定,最终在Cu上释放H2.综上,本文展示了高熵合金在HER中较好的性能,并通过详细的表征深入理解了其构-效关系.研究成果为高熵合金催化剂的合理设计和应用提供理论支持,为未来高效、耐久和低成本的绿色制氢技术提供重要的科学依据和技术支持.

关键词：析氢反应高熵合金原位X射线吸收光谱一步溶剂热法低过电位