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A meta-analysis on the effects of probiotics on the performance of pre-weaning dairy calves

Journal of Animal Science and Biotechnology 2023年第3期14卷 1300-1314页

作者： liyun Wang Honghong Sun Haixu Gao Yaohui Xia Linsen Zan Chunping zhao College of Animal Science and Technology Northwest A&F UniversityNo.22 Xinong RoadYanglingShaanxi 712100P.R.China

Background:Probiotics have been used in livestock production for many years,but information on their benefits during the early life of calves is inconsistent.This study aimed to assess the effects of probiotics on the performance of pre-weaning dairy calves and identify the factors influencing their effect sizes.Results:Forty-nine studies were selected for meta-analysis based on the inclusion and exclusion criteria.The study qualities were evaluated using a predefined risk assessment tool following GRADE guidelines.Meta-analysis results showed that probiotics increased the growth performance(body weight by 1.988 kg and average daily gain by40.689 g/d),decreased digestibility and feed efficiency(feed conversion rate by 0.073),altered rumen parameter(decreased acetate by 2.815 mmol/L and increased butyrate by 0.788 mmol/L),altered blood parameter(decreased AST by 4.188 U/L,increased BHBA by 0.029 mmol/L and IgG by 0.698 g/L),increased faecal parameter(faecal bacteria counts by 0.680 log10CFU/g),based on the strict criteria(P_(SMD)50%).Regression and sub-group analyses showed that probiotic strains,supplementation dosage,and methods significantly affected the performance of calves.The probiotics supplied with more than 9.5 log10CFU/d significantly increased IgA and IgM contents(P_(SMD)<0.05).Additionally,the compound probiotics significantly increased TDMI,IgA,and IgM(P_(SMD)≤0.001).Furthermore,probiotics supplemented in liquid(whole milk or milk replacer)significantly increased TDMI and decreased faecal score(P_(SMD)<0.05),while in whole milk,they significantly increased body weight,IgA,and IgM(P_(SMD)<0.001).Con

关键词： Calves Growth Health Meta-analysis Probiotics

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Synthesis of an IMF zeolite membrane for the separation of xylene isomer

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中国化学工程学报:英文版 2023年第8期60卷 205-211页

作者： Wenwen Zhang Zhigang Xue liyun Cui Haoliang Gao Di zhao Rongfei Zhou Weihong Xing State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China Chambroad Chemical Industry Research Institute Co.Ltd. Binzhou 256500China

The synthesis of a continuous IMF zeolite membrane was fabricated on tubular substrates by seeded growth for the first time. The straight channels of IMF zeolite with diameters of 0.53–0.59 nm are distinguishable for p-xylene from o-xylene molecules. Pure IMF-phase high-silica IM-5 zeolite seeds with uniform and fine crystal size were fabricated by a new sonication-assisted aging process. The seeds were coated on the support by dipcoating and induced the formation of continuous membrane. Separation performance in p-/o-xylene mixture was investigated at various temperature and pressure. The typical IM-5zeolite membrane had p-/o-xylene separation factor of 3.7. Our results suggest that IM-5 zeolite is a potentially good membrane material for the separation of xylene mixtures.

关键词： Membranes Zeolites Separation Xylene Secondary growth

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Impact of vitamin D supplementation on the outcome of tuberculosis treatment： a systematic review and meta-analysis of randomized controlled trials

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Chinese Medical Journal 2014年第17期127卷 3127-3134页

作者： Xia Jingyan Shi liyun zhao Lifang Xu Feng Department of Radiation Oncology Second Affiliated HospitalZhejiang University School of Medicine Hangzhou Zhejiang310009 China Division of Immunology Hangzhou Normal University Hangzhou Zhejiang 310036 China Department ofInfectious Diseases Second Affiliated HospitalZhejiang University School of Medicine Hangzhou Zhejiang310009 China

Background Vitamin D supplementation is believed to be beneficial in the treatment of patients with tuberculosis （TB）,however,results from clinical trials have been inconclusive.Methods We performed a systematic literature search across MEDLINE,EMBASE,the Cochrane Central Register of Controlled Trials,Springer,EBSCO,ProQuest,HighWire Press,and Web of Science,published as of December 2013.We individually inspected citations and extracted data independently.We estimated pooled risk ratios （RR） and 95％ confidence intervals （CI） using random-effect models.We also assessed risk of bias using the Jadad scale and the quality of the evidence using GRADE.We included all randomized controlled trials comparing vitamin D with or without standard TB therapy or placebo.Results A total of five studies were analyzed in our meta analysis covering 841 newly-diagnosed TB cases.Patients receiving vitamin D supplementation had a 39％ reduced risk of sputum smear or culture positive after six weeks of antiTB treatment than those in the control group,although this is not statistically significant （pooled RR 0.61,95％ CI 0.24 to 1.56,P=0.30）.Apart from an increased serum vitamin D level in the supplement group after eight weeks of treatment there was no evidence of any additional adverse effects related to vitamin D.Conclusions The meta analysis results indicate that vitamin D supplementation does not seem to have any beneficial effect in the treatment of TB.Future rigorous randomized controlled trials are needed to explore whether the supplementation of vitamin D could shorten treatment duration and to confirm whether the polymorphisms of vitamin D receptor have any potentially beneficial effect.

关键词： tuberculosis vitamin D randomized controlled trials systematic review meta-analysis

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Strong exciton-photon interaction and lasing of two-dimensional transition metal dichalcogenide semiconductors

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Nano Research 2021年第6期14卷 1937-1954页

作者： liyun zhao Qiuyu Shang Meili Li Yin Liang Chun Li Qing Zhang Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China

Two-dimensional(2D)transition metal dichalcogenide(TMDC)semiconductors not only hold great promises for the development of ultra-thin optoelectronic devices with low-energy consumption,but also provide ideal platforms to explore and tailor light-matter interaction,e.g.,the exciton-photon interaction,at the atomic level,due to their atomic thickness,large exciton binding energy,and unique valley properties.In recent years,the exciton-photon interactions in TMDC semiconductor microcavities,including the strong exciton-photon coupling and lasing,have drawn increasing attention,which may open up new application prospects for transparent,on-chip coherent,and quantum light sources.Herein,we review the research progresses of strong exciton-photon interaction and lasing of TMDC semiconductors.First,we introduce the electronic structure,exciton,and emission properties of semiconducting TMDCs in the weak exciton-photon coupling regime.Next,the progresses on strong exciton-photon interaction and exciton-polaritons of these TMDCs are discussed from the aspects of photophysics,materials and fabrications,spectroscopies,and controls.Further,the progresses on TMDC lasers are introduced in the aspects of cavity types and materials,and finally,the challenges and prospects for these fields are discussed.

关键词： transition metal dichalcogenides light-matter interaction strong exciton-photon interaction lasing

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Advances of manganese-oxides-based catalysts for indoor formaldehyde removal

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Green Energy & Environment 2023年第3期8卷 626-653页

作者： Jiayu Zheng Wenkang zhao liyun Song Hao Wang Hui Yan Ge Chen Changbao Han Jiujun Zhang Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing100124China Key Laboratory of Beijing on Regional Air Pollution Control and Beijing Key Laboratory for Green Catalysis and Separation Beijing University of TechnologyBeijing100124China College of Sciences&Institute for Sustainable Energy Shanghai UniversityShanghai200444China

Formaldehyde(HCHO)has been identified as one of the most common indoor pollutions nowadays.Manganese oxides(MnO_(x))are considered to be a promising catalytic material used in indoor HCHO oxidation removal due to their high catalytic activity,low-cost,and environmentally friendly.In this paper,the progress in developing MnO_(x)-based catalysts for HCHO removal is comprehensively reviewed for exploring the mechanisms of catalytic oxidation and catalytic deactivation.The catalytic oxidation mechanisms based on three typical theory models(Mars-van-Krevelen,Eley-Rideal and Langmuir-Hinshelwood)are discussed and summarized.Furthermore,the research status of catalytic deactivation,catalysts’regeneration and integrated application of MnO_(x)-based catalysts for indoor HCHO removal are detailed in the review.Finally,the technical challenges in developing MnO_(x)-based catalysts for indoor HCHO removal are analyzed and the possible research direction is also proposed for overcoming the challenges toward practical application of such catalysts.

关键词： Manganese dioxide(MnOx) Formaldehyde(HCHO) Catalytic oxidation Room temperature Indoors

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Recent research and development of DYRK1A inhibitors

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Chinese Chemical Letters 2022年第4期33卷 1841-1849页

作者： liyun zhao Xuan Xiong Li Liu Qi Liang Rongsheng Tong Xuanlin Feng Lan Bai Jianyou Shi Personalized Drug Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Science&Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China College of Medicine Southwest Jiaotong UniversityChengdu 610031China Emergency Intensive Care Unit Personalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Academy of Medical Science&Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China

Dual specificity tyrosine phosphorylation regulated kinase 1 A(DYRK1 A) is an evolutionarily conserved protein kinase belonging to the CMGC kinase family, which is closely related to Down syndrome(DS)and Alzheimer’s disease(AD). In recent years, not only the treatment of diabetes, but also the treatment of cancer gradually focuses on targeting DYRK1 A. Therefore, a series of DYRK1 A inhibitors have been developed to treat relevant diseases and clarify their treatment mechanism furtherly. DYRK1 A inhibitors are mainly divided into natural products and synthetic compounds. Among them, harmine is an excellent DYRK1 A inhibitor. Therefore, the synthetic DYRK1 A inhibitors are mainly based on harmine, which greatly enriches the structure and quantity of DYRK1 A inhibitors. The interaction between the inhibitors and the DYRK1 A protein has a guiding significance in predicting the activity of the inhibitors, and plays an irreplaceable role in the design of the compounds. This paper mainly reviews DYRK1 A inhibitors found in recent years and their structure-activity relationship, looking forward to providing a theoretical basis for the development of DYRK1 A inhibitors.

关键词： DYRK1A inhibitor Natural product Synthetic compound Alzheimer’s disease Down syndrome

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Dipyrrin-based Complexes for Solution-processed Organic Solar Cells

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Chemical Research in Chinese Universities 2015年第5期31卷 801-808页

作者： ZOU liyun GUAN Shuang LI Leijiao zhao Li School of Life Sciences Jilin University Changchun 130012 P. R. China College of Chemistry and Life Sciences Changchun University of Techology Changchun 130012 P. R. China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China

Three dipyrrin-containing metal complexes and a boron dipyrromethene（BODIPY）-containing complex were designed and synthesized. The photophysical properties, electrochemical behaviours and photovoltaic performance were extensively investigated. Density functional theory calculations were also performed on those complexes These complexes, together with electron-acceptor [6,6]-phenyl-C71-butyric acid methyl ester, were utilized for the fabrication of solution-processed bulk heterojunction solar cells as the electron-donor materials. The more efficient electron acceptor BODIPY segment renders a lower energy gap and a relatively better photovoltaic conversion efficiency of 0.58%. These results prove that BODIPY segment has a great potential for constructing efficient organic solar cell materials.

关键词： Dipyrrin-metal Boron dipyrromethene（BODIPY） Solution-processed Bulk-heterojunction Organic solar cell

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Tribological properties of TiAlN-coated cermets

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Rare Metals 2009年第1期28卷 57-62页

作者： ZHENG liyun zhao Lixin XIONG Weihao Key Laboratory of Resource Explore Research of Hebei Province Hebei University of Engineering Handan 056038 China College of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

Ti（C,N）-based cermets were coated with TiAlN using multi-arc ion plating technology. Sliding wear tests were performed on the coated cermets. The microstructure and morphologies of the coated cermets before and after friction and wear tests were characterized. The results show that the TiAlN coating surface was smooth and its root mean square roughness was 16.6 nm. The hardness （HK） of TiAlN coating layers reached approximately 3200 and the critical load （Lc） under which the coating failure occurred was 59 N. The sliding wear test results show that the friction coefficients of the TiAlN-coated cermets were lower than that of the cermets without any coating. Under the same load, the adhesion phenomenon of the counterpart materials on the specimens was improved and the mean friction coefficient increased with increasing sliding velocity. When the sliding velocity was 0.26 m·s^-1, the mass of the coated cermets reduced. At the same sliding velocity, the average friction coefficient of the TiAlN-coated cerrnets was lower under a higher load. The wear mechanisms of the TiAlN-coated cermets were mainly adhesive and abrasive wear.

关键词： cermets tribological properties wear TiAIN coating

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Serum Vitamin A Nutritional Status of Children and Adolescents Aged 6−17 Years—China,2016−2017

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China CDC weekly 2021年第9期3卷 189-192页

作者： Rui Wang Huidi Zhang Yi-chun Hu Jing Chen Zhenyu Yang liyun zhao Lichen Yang National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina.

Summary What is already known on this topic?Vitamin A deficiency(VAD)in children is still a global public health problem,which needs continuous monitoring and timely intervention.What is added by this report?Using surveillance data from China Nutrition and Health Surveillance of Children and Lactating Mothers in 2016−2017,the prevalence of VAD and marginal deficiency was 0.96%and 14.71%,respectively.

关键词： Serum prevalence Vitamin

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Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration

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Protein & Cell 2023年第6期14卷 398-415页

作者： Qian zhao Yandong Zheng Dongxin zhao liyun zhao Lingling Geng Shuai Ma Yusheng Cai Chengyu Liu Yupeng Yan Juan Carlos Izpisua Belmonte Si Wang Weiqi Zhang Guang-Hui Liu Jing Qu Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuan Wu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciencesand China National Center for BioinformationBeijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China The Fifth People's Hospital of Chongqing Chongqing 400062China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China Altos Labs Inc.San DiegoCA 94022USA

Hair loss affects millions of people at some time in their life,and safe and efficient treatments for hair loss are a significant unmet medical need.We report that topical delivery of quercetin(Que)stimulates resting hair follicles to grow with rapid follicular keratinocyte proliferation and replenishes perifollicular microvasculature in mice.We construct dynamic single-cell transcriptome landscape over the course of hair regrowth and find that Que treatment stimulates the differentiation trajectory in the hair follicles and induces an angiogenic signature in dermal endothelial cells by activating HIF-1αin endothelial cells.Skin administration of a HIF-1αagonist partially recapitulates the pro-angiogenesis and hair-growing effects of Que.Together,these findings provide a molecular understanding for the efficacy of Que in hair regrowth,which underscores the translational potential of targeting the hair follicle niche as a strategy for regenerative medicine,and suggest a route of pharmacological intervention that may promote hair regrowth.

关键词： single-cell RNA-sequencing Que hair follicle regeneration endothelial cells HIF-1α

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