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Human vascular smooth muscle cells and endothelial cells cocultured on polyglycolic acid (70/30) scaffold in tissue engineered vascular graft

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Chinese Medical Journal 2007年第15期120卷 1331-1335页

作者： WEN Shao-jun zhao li-min WANG Shen-guo li Jing-xing CHEN Hua-ying liU Jie-lin liU Ya LUO Yi Roo Changizi Central Experiment Unit Beijing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing 100029 China State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China Shunyi Clinic Beijing United Family Hospital Beijing 101300

Background Current prosthetic, small diameter vascular grafts showing poor long term patency rates have led to the pursuit of other biological materials. Biomaterials that successfully integrate into surrounding tissue should match not only the mechanical properties of tissues, but also topography. Polyglycolic acid （70130） has been used as synthetic grafts to determine whether human vascular smooth muscle cells and endothelial cells attach, survive and secrete endothelin and 6-keto-prostaglandin F1α （6-keto-PGF1α）. Methods Endothelial cells and smooth muscle cells were isolated from adult human great saphenous vein. They were seeded on polyglycolic acid scaffold in vitro separately to grew vascular patch （Groups A and B respectively） and cocultured in vitro to grow into vascular patch （Group C）. Smooth muscle cells and endothelial cells were identified by immunohistochemical analysis and growth of cells on polyglycolic acid was investigated using scanning electron microscopy. The levels of endothelin and 6-keto-PGF1α in the culturing solutions were examined by radioimmunology to measure endothelial function. Results Seed smooth muscle cells adhered to polyglycolic acid scaffold and over 28 days grew in the interstices to form a uniform cell distribution throughout the scaffold. Then seed endothelial cells formed a complete endothelial layer on the smooth muscle cells. The levels of endothelin and 6-keto-prostaglandin F1 alpha in the culturing solution were （234±29） pg/ml and （428±98） pg/ml respectively in Group C and （196±30） pg/ml and （346±120） pg/ml in Group B; both significantly higher than in Groups A and D （blank control group, all P〈0.05 ）. Conclusions Cells could be grown successfully on polyglycolic acid and retain functions of secretion. Our next step is to use human saphenous vein smooth muscle cells and endothelial cells to grow tubular vascular grafts in vitro.

关键词： tissue engineering blood vessels endothelial cells smooth muscle cells saphenous vein

Study of steam heat transfer enhanced by CO_(2) and chemical agents: In heavy oil production

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Petroleum Science 2023年第2期20卷 1030-1043页

作者： Ya-li liu Chao Zhang Song-Yan li zhao-min li Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China

Steam flooding with the assistance of carbon dioxide (CO_(2)) and chemicals is an effective approach for enhancing super heavy oil recovery. However, the promotion and application of CO_(2) and chemical agent-assisted steam flooding technology have been restricted by the current lack of research on the synergistic effect of CO_(2) and chemical agents on enhanced steam flooding heat transfer. The novel experiments on CO_(2)–chemicals cooperate affected steam condensation and seepage were conducted by adding CO_(2) and two chemicals (sodium dodecyl sulfate (SDS) and the betaine temperature-salt resistant foaming agent ZK-05200).According to the experimental findings, a “film” formed on the heat-transfer medium surface following the co-injection of CO_(2) and the chemical to impede the steam heat transfer, reducing the heat transfer efficiency of steam, heat flux and condensation heat transfer coefficient. The steam seepage experiment revealed that the temperature at the back end of the sandpack model was dramatically raised by 3.5–12.8 °C by adding CO_(2) and chemical agents, achieving the goal of driving deep-formation heavy oil. The combined effect of CO_(2) and SDS was the most effective for improving steam heat transfer, the steam heat loss was reduced by 6.2%, the steam condensation cycle was prolonged by 1.3 times, the condensation heat transfer coefficient was decreased by 15.5%, and the heavy oil recovery was enhanced by 9.82%. Theoretical recommendations are offered in this study for improving the CO_(2)–chemical-assisted steam flooding technique.

关键词： Steam flooding Heavy oil Carbon dioxide Chemical agent Enhanced oil recovery(EOR) Heat transfer

抗纤缓急方治疗特发性肺纤维化急性加重患者多中心随机对照研究

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中国中西医结合杂志 2024年第2期44卷 163-168页

作者：张海龙王露郭雯张东赵丽敏周淼河南中医药大学第一附属医院呼吸科郑州450003 河南中医药大学呼吸疾病中医药防治省部共建协同创新中心/河南省中医药防治呼吸病重点实验室郑州450003 河南省人民医院呼吸与危重症医学科郑州463599 河南中医药大学第三附属医院肺病科郑州450008

目的观察抗纤缓急方治疗特发性肺纤维化急性加重(AE-IPF)患者的临床疗效及其对C反应蛋白(CRP)、单核细胞趋化蛋白-1(MCP-1)、转化生长因子-β_(1)(TGF-β_(1))水平的影响。方法将80例AE-IPF患者随机分为试验组和对照组,每组40例。在健... 详细信息

目的观察抗纤缓急方治疗特发性肺纤维化急性加重(AE-IPF)患者的临床疗效及其对C反应蛋白(CRP)、单核细胞趋化蛋白-1(MCP-1)、转化生长因子-β_(1)(TGF-β_(1))水平的影响。方法将80例AE-IPF患者随机分为试验组和对照组,每组40例。在健康教育和西医常规治疗基础上,试验组给予抗纤缓急方,对照组给予抗纤缓急方安慰剂,治疗4周,随访12周。计算治疗失败率并记录住院时间,采用酶联免疫吸附法检测两组治疗前后CRP、MCP-1、TGF-β_(1)水平。结果试验组3例脱落,对照组4例脱落,采用全分析数据集。与对照组比较,试验组治疗失败率(5.0%vs.22.5%)、平均住院时间[(14.13±5.98)天vs.(17.43±7.42)天]、治疗后CRP及MCP-1水平降低(P0.05)。结论抗纤缓急方可降低AE-IPF患者治疗失败率并缩短住院时间,其机制可能与降低患者CRP、MCP-1水平从而减轻炎症反应有关。

关键词：中药复方抗纤缓急方特发性肺纤维化急性加重临床疗效 C反应蛋白单核细胞趋化蛋白-1 转化生长因子-β1 随机对照试验

A sponge-based iron-tannic-acid hydrogel interface evaporator designed for clean water production

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Science China(Technological Sciences) 2024年第5期67卷 1579-1591页

作者： ZHANG ZeKun li ChengLong TAO HuaYu GE Bo ZHANG YongLe zhao limin liU JunChang REN GuiNa ZHANG zhaoZhu School of Materials Science and Engineering Liaocheng UniversityLiaocheng252059China School of Environmental and Material Engineering Yantai UniversityYantai264405China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China

Due to the rapid advancement of technologies,there has been a significant increase in the discharge of industrial wastewater,and freshwater is becoming a scarce resource.Currently,research on solar evaporators is mainly focused on the efficient production of clean water,with less emphasis on the removal of residual pollutants remaining in the original solutions.Through this study,problems,including the difficult recovery of catalyst powder and the difficult removal of floating organic matter are solved by co-depositing low-surface-tension zirconia particles and bismuth tungstate onto the floating layer.Hydrogels and melamine sponges were combined to solve the problem that traditional hydrogels lack mechanical strength.An excellent water-repellent effect can be seen from the contact angle between the liquid globule and canvas/felt,which is greater than 155°.The steam generation rate of the assembled evaporation system is 1.78 kg m^(-2)h^(-1),and its purification efficiency for methyl orange and rhodamine B exceeds 99%.This study presents a novel strategy for treating wastewater contaminated with organic dyes,aiming to solve problems including environmental damage,water pollution,and water scarcity.

关键词： oil removal non-wetting interface

Observation of ^(186m)Ta

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Nuclear Science and Techniques 2006年第1期17卷 16-20页

作者： XU Yan-Bing DING Hua-Jie ZHANG Sheng-Dong YUAN Shuang-Gui YANG Wei-Fan LU Xi-Ting WANG Xian-Yi zhao li-min WANG Ping-Zhi li Heng-Yuan Institute of Modern Physics the Chinese Academy of Sciences Lanzhou 730000 China China Institute of Atomic Energy Beifing 102413 China School of Physics Peking University Beijing 100871 China

Unreported tantalum isomer 186mTa has been produced through the reaction 186W(n,p) by irradiation of natW with 14 MeV neutrons. The activity of 186mTa and 186Ta was measured using HPGe detectors and several X-γ as well as γ-γ coincidence arrangements. The 186mTa has been identified by means of measuring known γ rays from 186Ta β-decay. The half-life of 186mTa has been determined to be (1.5±0.1) min.

关键词： ^186mTa 中子反应 β衰变钽同分异构体

Flow characteristics and regime transition of aqueous foams in porous media over a wide range of quality,velocity,and surfactant concentration

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Petroleum Science 2023年第2期20卷 1044-1052页

作者： Bin-Fei li Meng-Yuan Zhang zhao-min li Anthony Kovscek Yan Xin Bo-liang li Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China Department of Energy Resources Engineering Stanford UniversityStanfordCA94305USA

Aqueous foam is broadly applicable to enhanced oil recovery(EOR).The rheology of foam as a function of foam quality,gas and liquid velocities,and surfactant concentration constitute the foundation of its application.The great variations of the above factors can affect the effectiveness of N2 foam in EOR continuously in complex formations,which is rarely involved in previous relevant studies.This paper presents an experimental study of foam flow in porous media by injecting pre-generated N2 foam into a sand pack under the conditions of considering a wide range of gas and liquid velocities and surfactant concentrations.The results show that in a wide range of gas and liquid velocities,the pressure gradient contours are L-shaped near the coordinate axes,but V-shaped in other regions.And the surfactant concentration is a strong factor influencing the trend of pressure gradient contours.Foam flow resistance is very sensitive to the surfactant concentration in both the high-and low-foam quality regime,especially when the surfactant concentration is less than CMC.The foam quality is an important variable to the flow resistance obtained.There exists a transition point from low-to high-quality regime in a particular flow system,where has the maximum flow resistance,the corresponding foam quality is called transition foam quality,which increases as the surfactant concentration increases.The results can add to our knowledge base of foam rheology in porous media,and can provide a strong basis for the field application of foams.

关键词： Foam flow regime and transition Porous media Pressure gradient Flow velocity Surfactant concentration Foam quality

An Environment‑Tolerant Ion‑Conducting Double‑Network Composite Hydrogel for High‑Performance Flexible Electronic Devices

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Nano-Micro Letters 2024年第5期16卷 352-369页

作者： Wenchao zhao Haifeng Zhou Wenkang li Manlin Chen min Zhou Long zhao State Key Laboratory of Advanced Electromagnetic Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China

High-performance ion-conducting hydrogels(ICHs)are vital for developing flexible electronic devices.However,the robustness and ion-conducting behavior of ICHs deteriorate at extreme tempera-tures,hampering their use in soft electronics.To resolve these issues,a method involving freeze–thawing and ionizing radiation technology is reported herein for synthesizing a novel double-network(DN)ICH based on a poly(ionic liquid)/MXene/poly(vinyl alcohol)(PMP DN ICH)system.The well-designed ICH exhibits outstanding ionic conductivity(63.89 mS cm^(-1) at 25℃),excellent temperature resistance(-60–80℃),prolonged stability(30 d at ambient temperature),high oxidation resist-ance,remarkable antibacterial activity,decent mechanical performance,and adhesion.Additionally,the ICH performs effectively in a flexible wireless strain sensor,thermal sensor,all-solid-state supercapacitor,and single-electrode triboelectric nanogenerator,thereby highlighting its viability in constructing soft electronic devices.The highly integrated gel structure endows these flexible electronic devices with stable,reliable signal output performance.In particular,the all-solid-state supercapacitor containing the PMP DN ICH electrolyte exhibits a high areal specific capacitance of 253.38 mF cm^(-2)(current density,1 mA cm^(-2))and excellent environmental adaptability.This study paves the way for the design and fabrication of high-performance mul-tifunctional/flexible ICHs for wearable sensing,energy-storage,and energy-harvesting applications.

关键词： Ionic liquids Double-network hydrogels Temperature tolerance Multifunctionality Flexible electronic devices

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不同气象条件对高油酸花生产量的影响

中国油料作物学报 2024年第1期46卷 129-134页

作者：胡延岭杨海棠李盼于沐石彦召刘软枝朱桢桢韩艳红郑晓川赵利民无郑州市农林科学研究所河南郑州450005 荥阳市扶贫开发服务中心河南荥阳450100 河南省植物保护检疫站河南郑州450005

以河南、山东等5个花生主要产区培育的19个高油酸花生新品种为材料,于2019年~2021年连续3年在郑州种植,采集3年间花生关键生育期(6月~9月)的旬平均气温、旬降水量和旬日照时数等气象数据,结合各个品种的产量数据进行综合分析。研究结果... 详细信息

以河南、山东等5个花生主要产区培育的19个高油酸花生新品种为材料,于2019年~2021年连续3年在郑州种植,采集3年间花生关键生育期(6月~9月)的旬平均气温、旬降水量和旬日照时数等气象数据,结合各个品种的产量数据进行综合分析。研究结果表明,不同的品种对于气温、降水量和日照时数的敏感程度不同,冀花16、冀花11对开花下针期的温度和日照时数比较敏感,该时期的异常高温会致使其产量明显下降。中花413、中花412和花育917的产量与旬降水量成显著负相关,耐涝程度较差。对品种的稳定性分析表明,开农1768、南充1704、冀农16、开选016、花育961、郑农花25、郑农花23、冀农11、花育633和1508G等10个高油酸品种为年际间稳定性较好的品种,研究结论为高油酸品种的培育及深入利用提供了指导。

关键词：花生高油酸气象条件产量

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乳糜胸—淋巴瘤的病例报道并文献复习

医药论坛杂志 2024年第1期45卷 49-53页

作者：郭亚丽张晓菊张杰赵丽敏河南省人民医院呼吸与危重症医学科郑州大学人民医院河南大学人民医院郑州450003

目的探讨乳糜胸的诊断、病因及临床管理,加强对其认识,指导临床,减少误诊。方法检测2例患者胸腔积液甘油三酯及乳糜微粒、血清白蛋白及球蛋白含量、血清免疫固定电泳、骨髓穿刺流式细胞学。结果患者乳糜胸常呈牛奶样外观,甘油三酯含量大... 详细信息

目的探讨乳糜胸的诊断、病因及临床管理,加强对其认识,指导临床,减少误诊。方法检测2例患者胸腔积液甘油三酯及乳糜微粒、血清白蛋白及球蛋白含量、血清免疫固定电泳、骨髓穿刺流式细胞学。结果患者乳糜胸常呈牛奶样外观,甘油三酯含量大于110 mg/dL或可见乳糜微粒,血清白蛋白降低而球蛋白升高;华氏巨球蛋白血症免疫固定电泳示IgM及κ区出现对应阳性条带,骨髓穿刺流式细胞学示B细胞表达;边缘区B细胞淋巴瘤免疫固定电泳示IgA及κ区出现对应单克隆免疫球蛋白淡然条带,骨髓穿刺流式细胞学示:0.10%细胞(占有核细胞)为κ轻链限制性表达的异常浆细胞,BCMA阳性细胞占总浆细胞的67.67%;6.77%细胞(占有核细胞)为异常κ单克隆成熟小B淋巴细胞。结论乳糜胸临床少见,病因诊断困难,淋巴瘤是非创伤性乳糜胸的常见原因,诊断依靠血清生化、免疫固定电泳、骨髓穿刺、淋巴结活检等综合手段,治疗上除治疗原发病外,胸腔积液管理非常重要。

关键词：乳糜胸淋巴瘤诊断病因