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Semiparametric Bayesian Inference for Mean-Covariance Regression Models

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Acta Mathematica Sinica,English Series 2017年第6期33卷 748-760页

作者： Han Jun YU Jun Shan SHEN zhao nan li Xiang Zhong FANG School of Mathematical Sciences Peking University School of Statistics Capital University of Economics and Business

In this paper, we propose a Bayesian semiparametric mean-covariance regression model with known covariance structures. A mixture model is used to describe the potential non-normal distribution of the regression errors. Moreover, an empirical likelihood adjusted mixture of Dirichlet process model is constructed to produce distributions with given mean and variance constraints. We illustrate through simulation studies that the proposed method provides better estimations in some non-normal cases. We also demonstrate the implementation of our method by analyzing the data set from a sleep deprivation study.

关键词： Clustered data Dirichlet process empirical likelihood moment constraints nonparamet-ric Bayes

Expression of aquaporin-1 and aquaporin-3 in lung tissue of rat model with ischemia-reperfusion injury

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Chinese Medical Journal 2010年第24期123卷 3711-3713页

作者： zhao Song li Xiang-nan Department of Thoracic Surgery First Affiliated Hospital Zhengzhou University Zhengzhou Henan 450052 China

End-stage lung diseases are common and frequentlyoccurring diseases which are difficult for clinical treatment. In recent years, lung transplantation has become a widely accepted and effective therapeutic option for patients with the end-stage pulmonary diseases. Early pulmonary edema resulting from ischemia-reperfusion injury accounts for the major part of mortality and morbidity after lung transplantation. The water channel proteins in lung injury have been little studied, and their impact on the formation of pulmonary edema remains unclear. In this study, we established a rat lung ischemia-reperfusion model to study its impact on the expressions of water channel proteins in lung tissue and explore a new approach to lung transplantation in pulmonary edema pathogenesis.

关键词： ischemia-reperfusion injury aquaporin lung tissue

New tumor-associated antigen SC6 in pancreatic cancer

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World Journal of Gastroenterology 2005年第48期11卷 7671-7675页

作者： Min-Pei liu Xiao-Zhong Guo Jian-Hua Xu Di Wang Hong-Yu li Zhong-Min Cui Jia-Jun zhao li-nan Ren Department of Experimental Medicine Northern Hospital Shenyang Liaoning Province China

AIM: To examine the concentration of a new antigen SC6 (SC6-Ag) recognized by monoclonal antibody (MAb)in patients with pancreatic cancer and other malignant or benign diseases and to understand whether SC6-Ag has any clinical significance in distinguishing pancreatic cancer from other gastrointestinal ***: Six hundred and ninety-five serum specimens obtained from 115 patients with pancreatic cancer, 154 patients with digestive cancer and 95patients with non-digestive cancer were used and classified in this study. Serum specimens obtained from 140 patients with benign digestive disease and 89 patients with non-benign digestive disease served as controls. Ascites was tapped from 16 pancreatic cancer patients, 19 hepatic cancer patients, 16 colonic cancer patients, 10 gastric cancer and 6 severe necrotic pancreatitis patients. The samples were quantitated by solid-phase radioimmunoassay. The cut-off values (CV)of 41, 80, and 118 U/mL were ***: The average intra- and interassay CV detected by immunoradiometric assay of SC6-Ag was 5.4% and 8.7%, respectively. The sensitivity and specificity were 73.0% and 90.9% respectively. The levels in most malignant and benign cases were within the normal upper limit. Among the 16 pancreatic cancer cases, the concentration of SC6-Ag in ascites was over the normal range in 93.8% patients. There was no significant difference in the concentration of *** expression of SC6-Ag in sera was significantly related to tumor differentiation. The concentration of SC6-Ag was higher in patients before surgery than after surgery. The specificity of SC6-Ag and CA19-9 was significantly higher than that of ultrasound and computer tomography (CT) in pancreatic cancer patients. Higher positive predictive values were indicated in 92.3% SC6-Ag and 88.5% CA19-9, but lower in 73.8% ultrasound and 76.2% ***: The combined test of SC6-Ag and CA19-9 may improve the diagnostic rate of primary cancer. The detection of

关键词： Tumor antigen SC6 Pancreatic neoplasm Immunoradiometric assay

Discovery of 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine as Novel Cyclin-dependent Kinases 4 and 6 Dual Inhibitors via 3D-QSAR and Molecular Simulation

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Chinese Journal of Structural Chemistry 2022年第3期41卷 108-124,I0010页

作者： FU Le zhao li-nan GUO Hong-Mei YU Na QUAN Wen-Xuan CHEN Yi SHU Mao WANG Rui liN Zhi-Hua School of Pharmacy and Bioengineering Chongqing University of TechnologyChongqing 400054China Qianjiang Central Hospital of Chongqing Chongqing 409099China

Cyclin D dependent kinases 4/6 regulate the entry of cells into S phase and are effective target for the discovery of anticancer *** this article,3D-QSAR modeling including comparative molecular field analy-sis(CoMFA)and comparative molecular similarity indices analysis fields(CoMSIA)was implemented on 52 dual CDK4/6 *** a result,we obtained a pretty good 3D-QSAR model,which is CoMFACDK4 with q2 to be 0.543 and r^(2) to be 0.967;CoMSIACDK4 with q2 being 0.518 and r^(2) being 0.937;CoMFACDK6 with q2 to be 0.624 and r^(2) to be 0.984;CoMSIACDK6 with q2 being 0.584 and r^(2) being *** docking confirmed the important residues for *** dynamics simulation further confirmed binding affinity with key residues of protein,such as Lys22,Lys35,Val96 for CDK4 and Lys43,His100,Val101 for CDK6 at the active *** these results offered new directions to explore new inhibitors of CDK4/***,we designed 10 novel compounds with promising expected activity and ADME/T properties,and provided referable synthetic routes.

关键词： cyclin-dependent kinases 4 and 6 dual inhibitors 3D-QSAR drug design molecular simulation

真空发电机断路器用铝支架的设计和发热仿真计算的试验验证

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高压电器 2012年第9期48卷 63-66页

作者：赵力楠赵力鹏西安高压电器研究院有限责任公司西安710077 中机国际(西安)技术发展有限公司西安710054

通过对真空发电机断路器铝支架三维模型的建立,运用有限元仿真法计算得到了模型在工频额定电流6 300 A下的发热数据。在此基础上加工了样机,并在西高院完成了样机工频额定电流6 300 A的温升试验。通过对计算数据和试验数据的对比,验证... 详细信息

通过对真空发电机断路器铝支架三维模型的建立,运用有限元仿真法计算得到了模型在工频额定电流6 300 A下的发热数据。在此基础上加工了样机,并在西高院完成了样机工频额定电流6 300 A的温升试验。通过对计算数据和试验数据的对比,验证了该设计方案的可行性。

关键词：大容量真空断路器散热

The antidepressant effect of the total flavonoids extracted from cottonseed （CTN -T） on the learned helplessness model and chronic variable stress model of depression in rats

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中国药理通讯 2005年第4期22卷 16-17页

作者： zhao nan li Yun - Feng Zhang You - Zhi Yang Ming zhao Yi - Min Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Beijing 100850 China

基于RNA-seq技术的活血化瘀法治疗乳腺癌关键基因的筛选和验证

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中国实验方剂学杂志 2019年第4期25卷 101-108页

作者：赵利南赵益孙有智濮阳市中医院河南濮阳457001 江西中医药大学南昌330004

目的:研究活血化瘀治法(the medicine group of promoting blood circulation and removing stasis,PBCRS)对7,12-二甲基苯蒽[7,12-dimethylbenz(a) anthracene,DMBA]诱发性大鼠乳腺癌的抑制作用,及运用转录组测序技术(RNA sequencing,RNA-seq)和信号网络分析(ingenuity pathway analysis,IPA)软件筛选关键基因和验证。方法:将96只SD大鼠随机分为空白组,DMBA模型组,枸橼酸他莫昔芬(Tamoxifen,TAM)组(1.9 mg·kg^(-1)·d-1),PBCRS高、中、低剂量组(12.96,6.48,3.24 g·kg^(-1)·d-1)。药物干预1周后,除空白组外,采用DMBA诱导大鼠乳腺癌模型(灌服2次,间隔1周,剂量100 mg·kg^(-1))。给药10周后,观察大鼠荷瘤重、荷瘤体积变化,用总RNA提取试剂盒提取总RNA,从DMBA模型组和PBCRS中剂量组各取3个RNA样品进行基因检测,筛选出关键差异基因,用实时荧光定量PCR(Real-time PCR)验证关键基因。结果:与DMBA模型组比较,PBCRS中剂量组荷瘤重和荷瘤体积均明显降低(P<0.05),PBCRS高、低剂量组荷瘤重和荷瘤体积虽有降低,但与DMBA模型组比较差异均无统计学意义;基于RNA-seq技术及IPA分析软件筛选出果糖1,6二磷酸酶1 (fructose-1,6-bisphosphatase1,FBP1),浦肯野细胞蛋白4(purkinje cell protein 4,PCP4),肌红蛋白(myoglobin,MB) 3个关键基因;与DMBA模型组比较,PBCRS高、中剂量组FBP1 mRNA表达均明显升高(P<0.05),PBCRS低剂量组FBP1 mRNA表达升高,但差异无统计学意义,PBCRS高、中、低剂量组PCP4 mRNA的表达增高,但无统计学差异,PBCRS低剂量组MB mRNA的表达虽降低,差异无统计学意义。结论:PBCRS可能通过干预乳腺癌组织中FBP1的表达,抑制乳腺癌的发生。

关键词：乳腺癌 RNA-seq 活血化瘀法果糖1,6二磷酸酶1(FBP1) 浦肯野细胞蛋白4(PCP4) 肌红蛋白(MB)

农业合作社视角下生态脆弱区粮食产量影响因素及其优势度测算——以甘肃省为例

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北方民族大学学报（哲学社会科学版） 2018年第6期 137-142页

作者：李昭楠北方民族大学经济学院宁夏银川750021

粮食问题是关系国计民生根本的战略问题,也是实施乡村振兴战略的关键。西部生态脆弱区粮食产量受诸多因素制约,使得其粮食生产面临的不确定性风险进一步加剧。耕地资源禀赋、自然灾害、农业水利设施、水资源短缺等因素都对该区域粮食生... 详细信息

粮食问题是关系国计民生根本的战略问题,也是实施乡村振兴战略的关键。西部生态脆弱区粮食产量受诸多因素制约,使得其粮食生产面临的不确定性风险进一步加剧。耕地资源禀赋、自然灾害、农业水利设施、水资源短缺等因素都对该区域粮食生产产生不同程度的影响,而且资源优势度高的地区,其粮食安全保障度也越高。同时,农业合作社在生态脆弱地区农业增产增收中具有明显效应。

关键词：农业合作社生态脆弱区粮食产量甘肃

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单细胞测序技术在肝癌研究中的应用

中国生物化学与分子生物学报 2020年第5期36卷 488-493页

作者：王娜赵利楠韩泽广上海交通大学系统生物医学研究院上海200240

传统的细胞遗传信息研究方法是对大量混合细胞进行高通量测序,得到一群细胞基因表达的平均值,忽视了细胞间存在的异质性。肝癌作为一种人类常见的恶性致命肿瘤,其内部肿瘤细胞存在高度异质性,群体水平分析无法精确揭示其恶性细胞克隆结... 详细信息

传统的细胞遗传信息研究方法是对大量混合细胞进行高通量测序,得到一群细胞基因表达的平均值,忽视了细胞间存在的异质性。肝癌作为一种人类常见的恶性致命肿瘤,其内部肿瘤细胞存在高度异质性,群体水平分析无法精确揭示其恶性细胞克隆结构和免疫微环境的细胞种类、状态和亚群分布,因此迫切需要进行单细胞水平的分析,这将有助于深入了解肝癌发病机制,进行精准肝癌分型指导临床治疗。同时发现,新型治疗靶点及有效生物标记物,为肝癌患者今后进行精准诊疗提供参考。本文综述了单细胞基因组和转录物组测序技术在肝癌免疫微环境、肝癌细胞异质性、肝癌细胞演化与诊疗和肝癌转移机制及生物标志物研究中的应用。本文还总结了在肝癌研究中,单细胞多组学测序技术在发现新肿瘤亚群、精确识别肿瘤细胞间的异质性和了解肿瘤微环境构成等方面的优势。

关键词：单细胞测序肝癌免疫微环境异质性精准诊疗