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TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response

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Current Medical Science 2024年第3期44卷 545-553页

作者： Shi-gui PANG xin ZHANG zhao-xin li li-fei HE Feng CHEN Ming-long liU Ying-ze HUANG Jian-mei MO Kong-lan LUO Juan-juan XIAO Feng ZHU Department of Oncology The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Cancer Research Institute The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Translational Medical Center Huaihe HospitalHenan UniversityKaifeng475000China Guangxi Key Laboratory of Molecular Medicine in liver Injury and Repair The Affiliated Hospital of Guilin Medical UniversityGuilin541001China

Objective Abnormal expression of T-lymphokine-activated killer cell-originated protein kinase(TOPK)was reported to be closely related to the resistance of prostate cancer to radiotherapy and to targeted drug resistance in lung ***,the role of TOPK inhibition in enhancing radiosensitivity of colorectal cancer(CRC)cells is *** study aimed to evaluate the radiosensitization of TOPK knockdown in CRC *** The expression of TOPK was detected in CRC tissues by immunohistochemistry,and the effect of TOPK knockdown was detected in CRC cells by Western ***-8 and clonogenic assays were used to detect the growth and clonogenic ability of CRC cells after TOPK knockdown combined with radiotherapy in CRC ***,proteomic analysis showed that the phosphorylation of TOPK downstream proteins changed after *** damage was detected by the comet *** in the DNA damage response signaling pathway were analyzed by Western blotting,and apoptosis was detected by flow *** The expression of TOPK was significantly greater in CRC tissues at grades 2–4 than in those at grade *** irradiation,CRC cells with genetically silenced TOPK had shorter comet tails and reduced expression levels of DNA damage response-associated proteins,including phospho-cyclin-dependent kinase 1(p-CDK1),phospho-ataxia telangiectasia-mutated(p-ATM),poly ADP-ribose polymerase(PARP),and meiotic recombination 11 homolog 1(MRE11).Conclusions TOPK was overexpressed in patients with moderately to poorly differentiated ***,TOPK knockdown significantly enhanced the radiosensitivity of CRC cells by reducing the DNA damage response.

关键词： T-lymphokine-activated killer cell-originated protein kinase colorectal cancer DNA damage response radiosensitivity

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任意特征域上sl(2)的Poisson结构

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东北师大学报（自然科学版） 2024年第2期56卷 7-10页

作者：李赵鑫王淑娟海南师范大学数学与统计学院海南海口571158 黑龙江大学数学科学学院黑龙江哈尔滨150080

利用李代数上Poisson代数的定义与双线性决定了任意特征域上李代数sl(2)的所有Poisson结构,得到结论:特征不为2的域上,sl(2)的Poisson结构由一个参数完全决定,都是非交换且非结合的;特征为2的域上,sl(2)的Poisson结构由8个参数完全决定... 详细信息

利用李代数上Poisson代数的定义与双线性决定了任意特征域上李代数sl(2)的所有Poisson结构,得到结论:特征不为2的域上,sl(2)的Poisson结构由一个参数完全决定,都是非交换且非结合的;特征为2的域上,sl(2)的Poisson结构由8个参数完全决定,而且既有结合的Poisson结构、交换的Poisson结构,也有非交换且非结合的Poisson结构.

关键词： sl(2) Poisson代数 Leibniz法则

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水热炭强化秸秆厌氧发酵产甲烷效能及作用机制

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中国环境科学 2024年第8期44卷 4415-4424页

作者：耿涛赵立欣姚宗路申瑞霞于佳动罗娟中国农业科学院农业环境与可持续发展研究所农业农村部华北平原农业绿色低碳重点实验室北京100081

以玉米秸秆和水稻秸秆为原料在不同温度下制备水热炭,观察原料种类与制备温度对水热炭理化特性的影响并进一步探究水热炭添加对秸秆厌氧发酵产甲烷的强化作用.研究发现,相同温度条件下,玉米秸秆的碳化程度较棉花秸秆更高;同一原料制备... 详细信息

以玉米秸秆和水稻秸秆为原料在不同温度下制备水热炭,观察原料种类与制备温度对水热炭理化特性的影响并进一步探究水热炭添加对秸秆厌氧发酵产甲烷的强化作用.研究发现,相同温度条件下,玉米秸秆的碳化程度较棉花秸秆更高;同一原料制备的水热炭,表面O-H、C-O含氧官能团丰度随温度升高而降低,但高温有利于材料碳化程度、表面孔隙复杂度的提高与表面碳微球构筑.将不同水热炭分别添加到秸秆厌氧消化系统中,发现水热炭对秸秆厌氧消化产甲烷具有明显强化效果.其中,Y1对秸秆厌氧发酵产甲烷强化效果最佳,累积甲烷产量与最大产甲烷速率较对照组分别提高13.74%与12.06%,发酵过程中VFA降解速度较对照组明显加快且体系应对pH值变化的稳定性增强.微生物群落结构研究发现水热炭添加使秸秆厌氧发酵体系中Firmicutes、Synergistota等产酸功能菌与Methanosarcina、Methanospirillum等氢营养型产甲烷菌得到富集,这可能与水热炭表面丰富的含氧官能团有关.

关键词：农业废弃物秸秆水热炭厌氧发酵产甲烷

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磁场强化非均相分离技术的工业应用进展

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化工机械 2024年第1期51卷 1-12页

作者：冯丽丽赵立新蒋明虎东北石油大学机械科学与工程学院、黑龙江省石油石化多相介质处理及污染防治重点实验室

概述了磁场分离技术在分离多相混合介质中的研究和应用进展,对磁场分离技术的应用原理和分离优势进行了分析。根据混合相内的介质类别,分别针对固、液、气不同应用领域,介绍了磁场分离工艺在矿物精选、污水处理、气体除杂中的典型应用,... 详细信息

概述了磁场分离技术在分离多相混合介质中的研究和应用进展,对磁场分离技术的应用原理和分离优势进行了分析。根据混合相内的介质类别,分别针对固、液、气不同应用领域,介绍了磁场分离工艺在矿物精选、污水处理、气体除杂中的典型应用,并分析了相应运行工况下的磁场排布规律和介质分离特性。从组合工艺的研究视角出发,总结了磁场分离技术与气浮分离技术、膜分离技术、旋流分离技术的耦合应用现状,并分析了上述组合工艺的技术特点、运行成效。为拓宽磁场分离技术的适用范围,讨论了磁种在磁场分离工艺中的辅助应用,以强化该技术对无磁性介质的分离。

关键词：磁场分离技术多相混合介质组合工艺耦合应用磁种工业应用

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Topological Structure of Knotted Vortex lines in liquid Crystals

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Communications in Theoretical Physics 2007年第6期47卷 1129-1134页

作者： DUAN Yi-Shi zhao li ZHANG xin-Hui Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China

In this paper, a novel decomposition expression for the U（1） gauge field in liquid crystals （LCs） is derived. Using this decomposition expression and the b-mapping topological current theory, we investigate the topological structure of the vortex lines in LCs in detail. A topological invariant, i.e., the Chern-Simons （CS） action for the knotted vortex lines is presented, and the CS action is shown to be the total sum of all the self-linking and linking numbers of the knot family. Moreover, it is pointed out that the CS action is preserved in the branch processes of the knotted vortex lines.

关键词： knotted vortex lines liquid crystals Chern-Simons action branch processes

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Two cases of exudative retina detachment and uveitis following H1N1 influenza vaccination

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Chinese Medical Journal 2011年第22期124卷 3838-3840页

作者： TAO Yong CHANG li-bing zhao Min li Xiao-xin Department of Ophthalmology Peking University People＇s Hospital Key Laboratory of Vision Loss and Restoration Ministry of Education Beijing 100044 China

Uveitis was a rare adverse event of vaccination. We met two cases of acute uveitis with exudative retinal detachment following vaccination of H1 N1 influenza. Case 1 was a 10-year-old boy who was admitted for bilateral blurred vision at 10 days after vaccination of H1N1 influenza. Vitreous opacity was obvious in both eyes. Broad exudative retinal detachment was observed in the right eye. Case 2 was a 47-year-old female who suffered from an acute high fever at 2 days after the vaccination of H1 N1 influenza. Later, she encountered bilateral headache and decreasing vision. In both eyes, mutton fat keratic precipitates, positive Tyndall phenomenon, congestion of optic disc and exudative retinal detachment were observed.

关键词： retinal detachment uveitis vaccine H1N1 influenza

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Entanglement of Non-symmetric Two Charge Qubits Induced by a Damped Cavity

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Communications in Theoretical Physics 2007年第4期47卷 643-646页

作者： li zhao-xin li Jun-Gang li Juan-Juan CUI Hui-Ping Department of Applied Physics School of Science Shandong University of Science and Technology Qingdao 266510 China Department of Physics School of Science Beijing Institute of Technology Beijing 100081 China

Two charge qubits being coupled to a damped cavity with different couplings are considered. The dynamical evolution of the entanglement between the two qubits is demonstrated analytically or numerically. It is found that with the cavity dissipation, the steady entanglement between the two qubits can be achieved. The two qubits being initially in the separable and most mixed state can be easily induced to a steady entangled state, and the relative difference of the couplings can be used to enhance the steady entanglement between the two charge qubits.

关键词： charge qubit entanglement dissipation

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Early Outcomes of Primary Total Hip Arthroplasty for Osteonecrosis of the Femoral Head in Patients with Human Immunodeficiency Virus in China

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Chinese Medical Journal 2015年第15期128卷 2059-2064页

作者： Chang-Song zhao xin li Qiang Zhang Sheng Sun Ru-Gang zhao Juan Cai Department of Orthopedics Beijing Ditan Hospital Capital Medical University Beijing 100015 China

Background：Studies have reported that patients with human immunodeficiency virus （HIV） have a high incidence of osteonecrosis of the femoral head （ONFH）.Total hip arthroplasty （THA） is an effective management of ***,little data exist regarding the use of THA for the HIV patients with ONFH in *** study reviewed the outcomes of HIV-positive patients who underwent THA for ONFH,compared with HIV-negative ***：The patients who underwent THA for ONFH from September 2012 to September 2014 in Beijing Ditan Hospital,Capital Medical University were retrospectively ***-eight HIV-positive patients and 35 HIV-negative patients underwent 48 THAs and 45 THAs with cementless components,*** records and follow-up data were *** Hip Score （HHS） was applied to evaluate the pain and function of the hips before and after *** such as wound healing,surgical site infection,deep venous thrombosis,pulmonary embolism,sepsis,mortality,and complications from the prosthesis were *** operation time,blood loss,and hospital stay were compared between the two ***：The mean follow-up period was 19.5 ± 5.8 months （ranging from 6 to 30 months）.The mean age of the HIV-positive patients with osteonecrosis at the time of surgery was 35 years old,which was significantly lower than that of the HIV-negative group （42 years old）（P 〈 0.05）.The HIV-positive patients underwent surgery a mean of 2.5 years after their original symptoms,which was significantly shorter than the HIV-negatives＇（mean 4 years）（P 〈 0.05）.Among HIV-positive patients,the prevalence of being male and rate of bilateral procedures were significantly higher than those in the HIV-negative group （P 〈 0.05）.The operation time in HIV-positive patients was significantly longer than that in HIV-negative patients （P 〈 0.05）.There were no significant differences in blood loss or hospital stay between the two groups （P 〉 0.05）.The HHSs of two groups

关键词： Arthroplasty Harris Hip Score Hip Human Immunodeficiency Virus Infections Osteonecrosis of the Femoral Head Outcomes

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Recent Progress in Two-dimensional Nanomaterials Following Graphene for Improving Fire Safety of Polymer(Nano)composites

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Chinese Journal of Polymer Science 2021年第8期39卷 935-956,I0004页

作者： Wei Cai Bi-Bo Wang xin Wang Yu-Lu Zhu zhao-xin li Zhou-Mei Xu Lei Song Wei-zhao Hua Yuan Hua State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230000China Suzhou Advanced Research Institute University of Science and Technology of ChinaSuzhou 215000China

The high fire safety of polymer nanocomposites is being pursued by research institutions around the *** addition to intrinsic flame retardancy strategy,the additive-type flame retardants have attracted increasing attention due to low commercial cost and easy fabrication ***,traditional additive-type flame retardants usually need high addition amount to achieve a desirable effect which causes many side-effects on the overall performance of polymer materials,such as deteriorated mechanical property and *** present two-dimensional(2D)nanomaterials have also been applied to reduce the fire hazards of polymer(nano)composites with the coupling of barrier function and catalysis as well as carbonization *** though most research work mainly focus on graphene-based flame retardants,more emerging two-dimensional nanomaterials are taking away research attention,due to their complementary and unique properties,mainly including hexagonal boron nitride(h-BN),molybdenum disulfide(MoS2),metal organic frameworks(MOF),carbon nitride(CN),titanium carbide(MXene)and black phosphorene(BP).In this review,except for graphene,the flame retardant mechanism involving different layered nanomaterials are also ***,the functionalization method and flame retardancy effect of different layered nanomaterials are emphatically discussed for offering an effective reference to solve the fire hazards of polymer ***,this work objectively evaluates the practical significance of polymer/layered nanomaterials composites for industrial application.

关键词： Polymer(nano)composites Layered nanomaterials Fire safety Flame retardant mechanism

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Improvement to Maize Growth Caused by Biochars Derived From Six Feedstocks Prepared at Three Different Temperatures

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Journal of Integrative Agriculture 2014年第3期13卷 533-540页

作者： LUO Yu JIAO Yu-jie zhao Xiao-rong li Gui-tong zhao li-xin MENG Hai-bo Institute of Energy and Environmental Protection Chinese Academy of Agricultural Engineering Key Laboratory of Energy Resource Utilization from Agriculture Residue Ministry of Agriculture/Chinese Academy of Agricultural Engineering College of Resources and Environmental Sciences China Agricultural University

Biochar is increasingly proposed as a soil amendment, with reports of benefits to soil physical, chemical and biological properties. In this study, different biochars were produced from 6 feedstocks, including straw and poultry manure, at 3 pyrolysis temperatures （200, 300 and 500℃） and then added separately to a calcareous soil. Their effects on soil properties and maize growth were evaluated in a pot experiment. The biochars derived from crop straw had much higher C but smaller N concentrations than those derived from poultry manure. Carbon concentrations, pH and EC values increased with increasing pyrolysis temperature. Biochar addition resulted in increases in mean maize dry matter of 12.73% and NPK concentrations of 30, 33 and 283%, respectively. Mean soil pH values were increased by 0.45 units. The biochar-amended soils had 44, 55, 254 and 537% more organic C, total N, Olsen-P and available K, respectively, than the control on average. Both feedstocks and pyrolysis temperature determined the characteristics of the biochar. Biochars with high mineral concentrations may act as mineral nutrient supplements.

关键词： biochar feedstock temperature maize soil

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