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Clock-Control Sequence Encryption Scheme and Simulation in the PCM/PPK Telemetry System

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China Communications 2010年第4期7卷 114-119页

作者： zhao Zemao LIU jianhao HE Fei School of Communication Engineering Hangzhou Dianzi University Hangzhou 310018 China

PCM/PPK telemetry system is a multi-nary pulse modulation *** is commonly used to transmit high-accuracy time information and some express *** the issue of security that telemetry data is transmitted in the open space,a data encryption scheme in the PCM/PPK telemetry system is *** this scheme,the PCM data of signal source are encrypted by stream cipher in which key streams are generated with clock control *** scheme can save system resource in the dual-modulation compound telemetry system.A backward key synchronization scheme is also proposed,which has the property of strong real-time and easy to implement.A simplified simulation model of PCM/PPK remote system is established based on the actual framework of telemetry system,and the model is simple and easy to *** error performance of the system is analyzed in theory and tested by computer *** the security of the system is *** simulation and analysis results show that the encryption scheme can ensure the security of the telemetry data and does not cause error-diffusion.

关键词： Telemetry PCM/PPK Stream Cipher Key Stream Generator

Microwave-assisted Immobilization of Heparin onto Polyurethane Surface for Improving Blood Compatibility

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Journal of Wuhan University of Technology(Materials Science) 2014年第5期29卷 1071-1077页

作者：邱炳崧 MAI Weizhong 曾戎 TU Mei zhao jianhao ZHA Zhengang Department of Materials Science and Engineering College of Science and Engineering Jinan University Guangzhou Overseas Chinese Hospital the First Affiliated Hospital of Jinan University

Heparin was covalently immobilized onto polyurethane surface via a PEG spacer by a microwave-assisted approach to improve blood compatibility. Firstly, amino-terminated poly（ethylene glycol）（APEG） was rapidly grafted onto PU surface within 20 rain by a two-step method involving microwave-assisted MDI-functionalization and subsequent microwave-assisted APEG coupling. Then, heparin was eovalently immobilized through an amide linkage by the direct coupling of the carboxylic acid of heparin with the amino group of APEG on PU surface using carbodiimide coupling reaction. The surface structure and properties were characterized by X-ray photoelectron spectroscopy （XPS）, atomic force microscopy （AFM） and water contact angle measurements. The results revealed that hepadn-immobilized PU surface had slightly increased roughness and significantly improved hydrophilicity in comparison to the original PU surface. The anticoagulant activity of films was evaluated by whole blood clotting time （CT） and prothrombin time （PT）. Complement activation was assessed by detecting complement fragment 3a concentrations of serum exposed to the films. The results revealed that the microwave-assisted heparin-immobilized PU films had excellent antithrombogenicity and suppressed complement activation, indicating improved blood compatibility.

关键词： surface modification microwave irradiation heparin polyurethane blood compatibility

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施工总承包模式下电梯工程的精益管理技术

城市建筑 2024年第2期21卷 187-191,220页

作者：赵健豪唐兵林江张峰夏志强覃江中建三局集团有限公司

施工总承包模式下的电梯工程作为专业性极强的分包工程,在项目管理过程中往往因为专业盲区、缺少直接管理经验,使得管理电梯工程的过程中存在知识壁垒,管理深度不够,导致电梯分包与其他分包工序穿插开展、精益建造等存在阻碍,甚至会造... 详细信息

施工总承包模式下的电梯工程作为专业性极强的分包工程,在项目管理过程中往往因为专业盲区、缺少直接管理经验,使得管理电梯工程的过程中存在知识壁垒,管理深度不够,导致电梯分包与其他分包工序穿插开展、精益建造等存在阻碍,甚至会造成返工。因此,探索施工总承包模式下的电梯工程在招采管理、深化设计、建造管理等方面的精细化管理,对丰富施工总承包管理以及项目创效等极具意义。

关键词：施工总承包模式电梯工程招采管理深化设计建造管理

Micro-interfaces modulation by UV-ozone substrate treatment for MPEA vapor fluorescence detection

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Nano Research 2023年第3期16卷 4055-4060页

作者： Bin Li Keke Li Wei Xu Mingzhu Yan jianhao zhao Wukun Zhang Mingshuai Yuan Yanyan Fu Qingguo He Jiangong Cheng State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Drug abuse directly endangers human health and social security,hence its sensitive and rapid detection is vitally *** recent years,organic film-based fluorescent sensing technology has attracted more and more attention in the detection of drugs and explosives due to its advantages of simple operation and rapid *** film-based fluorescent sensors,in addition to sensitive materials,the surface morphology of the film is also an important factor affecting the *** previous studies,the regulation of surface morphology mainly depends on concentration changes or complex ***,a novel fluorescent polymer probe was designed and synthesized,and a simple and efficient ultraviolet(UV)-ozone substrate treatment method is used to adjust their surface *** results show that film has an excellent fluorescence enhancement effect upon exposure to methylphenethylamine(MPEA,a simulant of methamphetamine)*** sensing effect of the film is significantly improved after UV-ozone substrate treatment,and the limit of detection was decreased by 10.4 times from 2.59 to 0.25 *** experiments show that the sensing performance of other fluorescent probe can also be improved by the UV-ozone substrate *** convenient and general method may become a very effective approach to improve the performance of film-based fluorescent sensors.

关键词： fluorescence sensing ultraviolet(UV)-ozone substrate treatment organic sensing materials film-based gas sensors

Nontraditional energy-assisted mechanical machining of difficult-to-cut materials and components in aerospace community:a comparative analysis

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International Journal of Extreme Manufacturing 2024年第2期6卷 190-271页

作者： Guolong zhao Biao zhao Wenfeng Ding Lianjia Xin Zhiwen Nian jianhao Peng Ning He Jiuhua Xu College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

The aerospace community widely uses difficult-to-cut materials,such as titanium alloys,high-temperature alloys,metal/ceramic/polymer matrix composites,hard and brittle materials,and geometrically complex components,such as thin-walled structures,microchannels,and complex *** machining is the main material removal process for the vast majority of aerospace ***,many problems exist,including severe and rapid tool wear,low machining efficiency,and poor surface *** energy-assisted mechanical machining is a hybrid process that uses nontraditional energies(vibration,laser,electricity,etc)to improve the machinability of local materials and decrease the burden of mechanical *** provides a feasible and promising method to improve the material removal rate and surface quality,reduce process forces,and prolong tool ***,systematic reviews of this technology are lacking with respect to the current research status and development *** paper reviews the recent progress in the nontraditional energy-assisted mechanical machining of difficult-to-cut materials and components in the aerospace *** addition,this paper focuses on the processing principles,material responses under nontraditional energy,resultant forces and temperatures,material removal mechanisms,and applications of these processes,including vibration-,laser-,electric-,magnetic-,chemical-,advanced coolant-,and hybrid nontraditional energy-assisted mechanical ***,a comprehensive summary of the principles,advantages,and limitations of each hybrid process is provided,and future perspectives on forward design,device development,and sustainability of nontraditional energy-assisted mechanical machining processes are discussed.

关键词： difficult-to-cut materials geometrically complex components nontraditional energy mechanical machining aerospace community

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均衡发展的隐形壁垒:方言、制度与技术扩散

经济研究 2017年第9期52卷 182-197页

作者：林建浩赵子乐中山大学岭南学院中国转型与开放经济研究所暨南大学华侨华人研究院

技术差异是地区间贫富差距的核心表征,理解技术扩散的深层障碍是有效推行区域均衡发展政策的前提。本文利用方言数据测度文化差异,基于中国代表性城市样本进行实证研究,结果显示:以上海和广州作为技术前沿,各个城市与技术前沿的相对方... 详细信息

技术差异是地区间贫富差距的核心表征,理解技术扩散的深层障碍是有效推行区域均衡发展政策的前提。本文利用方言数据测度文化差异,基于中国代表性城市样本进行实证研究,结果显示:以上海和广州作为技术前沿,各个城市与技术前沿的相对方言距离对技术差距有显著影响,表明文化差异阻碍了技术从前沿地区向其他地区扩散,并且制度是这一过程的重要中介变量,即文化差异通过阻碍制度传播进而阻碍了技术扩散。进一步考察技术扩散壁垒的异质性,发现在同等条件下,更高的人力资本水平、更高的外来移民人口比例、更多的外国直接投资能削弱文化差异的阻碍效应;清末开埠通商、西方传教以及近代工业发展等早期对外开放和采用新技术的历史经验,同样有助于削弱文化差异这一技术扩散的隐形壁垒。

关键词：方言文化差异制度技术扩散

Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2936-2952页

作者： Liang zhao Yizhen Pang Yangfan Zhou jianhao Chen Hao Fu Wei Guo Weizhi Xu Xin Xue Guoqiang Su Long Sun Hua Wu Jingjing Zhang Zhanxiang Wang Qin Lin Xiaoyuan Chen Haojun Chen Department of Nuclear Medicine and Minnan PET Center Xiamen Key Laboratory of RadiopharmaceuticalsThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingaporeSingapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Radiation Oncology Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Colorectal Tumor Surgery Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Cardiothoracic Surgery Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Neurosurgery and Department of Neuroscience Fujian Key Laboratory of Brain Tumors Diagnosis and Precision TreatmentXiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamenChina

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor *** radionuclide therapy delivers radiation directly to tumor ***1004 is a fibroblast activation protein(FAP)-targeting radiopharmaceutical,conjugated with the albumin binder Evans Blue,which has demonstrated enhanced tumor uptake and retention in previous preclinical and clinical ***,we demonstrate that^(68)Ga/^(177)Lu-labeled LNC1004 exhibits increased uptake and prolonged retention in MC38/NIH3T3-FAP and CT26/NIH3T3-FAP tumor *** therapy with^(177)Lu-LNC1004 induced a transient upregulation of PD-L1 expression in tumor *** combination of^(177)Lu-LNC1004 and anti-PD-L1 immunotherapy led to complete eradication of all tumors in MC38/NIH3T3-FAP tumor-bearing mice,with mice showing 100%tumor rejection upon ***,single-cell RNA sequencing(scRNA-seq),and TCR sequencing revealed that combination therapy reprogrammed the tumor microenvironment in mice to foster antitumor immunity by suppressing malignant progression and increasing cell-to-cell communication,CD8^(+)T-cell activation and expansion,M1 macrophage counts,antitumor activity of neutrophils,and T-cell receptor diversity.A preliminary clinical study demonstrated that^(177)Lu-LNC1004 was well-tolerated and effective in patients with refractory ***,scRNA-seq of peripheral blood mononuclear cells underscored the importance of addressing immune evasion through immune checkpoint blockade *** was emphasized by the observed increase in antigen processing and presentation juxtaposed with T cell *** conclusion,our data supported the efficacy of immunotherapy combined with^(177)Lu-LNC1004 for cancer patients with FAP-positive tumors.

关键词： immunity retention holds

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方锥件渐进成形扭曲规律及影响因素

锻压技术 2017年第4期42卷 68-73页

作者：赵伟林剑豪陈丽福州大学至诚学院福建福州350002

渐进成形中,工具头在成形过程中不断推压板料,造成板料产生扭曲变形,影响零件的尺寸精度。为降低零件扭曲程度,提高零件成形精度,以方锥件为例,借助有限元数值模拟,研究渐进成形过程中板料扭曲变形规律,并采用单因素分析法,分析渐进成... 详细信息

渐进成形中,工具头在成形过程中不断推压板料,造成板料产生扭曲变形,影响零件的尺寸精度。为降低零件扭曲程度,提高零件成形精度,以方锥件为例,借助有限元数值模拟,研究渐进成形过程中板料扭曲变形规律,并采用单因素分析法,分析渐进成形各工艺参数对板料扭曲的影响。结果显示,零件底部和侧壁的板料产生了一定程度的扭曲,随着成形深度的增加,扭曲位移最大的位置逐渐向侧壁中部靠近,最终扭曲程度沿侧壁大致呈抛物线分布,且随着工具头半径的减小和层间距的增大,零件扭曲程度加剧。结果表明,通过改变工具头半径和层间距能降低零件扭曲程度,提高零件成形精度。

关键词：锥形件扭曲位移渐进成形层间距工具头半径

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关于对弱视定义的探讨

中国中医眼科杂志 2014年第5期24卷 353-359页

作者：赵建浩深圳希玛林顺潮眼科医院深圳518040

目的寻求较准确的弱视定义。方法笔者对国际现代主流弱视定义按照内涵与外延两方面进行归纳、探讨、补充及解读。结果发现此前所有对弱视的定义是没有注重运用以内涵和外延来表述。笔者在其内涵中将"光学性、物理性"修改为"物理光学性状... 详细信息

目的寻求较准确的弱视定义。方法笔者对国际现代主流弱视定义按照内涵与外延两方面进行归纳、探讨、补充及解读。结果发现此前所有对弱视的定义是没有注重运用以内涵和外延来表述。笔者在其内涵中将"光学性、物理性"修改为"物理光学性状况";提醒双眼交互作用异常尚属假说;补充上"注视中的微小视、形觉异常";在其外延上探讨发现我国高等学校教材供8年制及7年制第2版《眼科学》中,对"屈光不正性弱视"和"屈光参差性弱视",在新界定上的相互关系的处置却疏于周全,致使在其临床弱视诊断的理据上存在着缺陷,提议将其"屈光参差性弱视"的新界定修改为"双眼屈光力、等效球镜相差≥0.50D,或柱镜相差≥1.00D";指出弱视的类别应确立严谨的逻辑性包含关系。提出"高度屈光不正性弱视"、"单眼注视综合征性弱视"的概念和"弱视系列存在三种不同视觉功能性质"及其意义;强调LogMAR检测视力表和双眼最佳矫正视力相差2行以上在弱视诊断上的重要意义;在"临床检查无可见的器质性病变"句子之前添加"除弱视相关因素之外"以与内涵中的"视觉中枢缺陷"相关;对弱视治疗预期的评估采取结合统计数据的方法表述。结论由此方法归纳出新的弱视定义,以有利于弱视的临床和科研工作。

关键词：弱视定义归纳解读探讨明确