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Prognostic value of ultrasound in early arterial complications post liver transplant

World Journal of Gastrointestinal Surgery 2024年第1期16卷 13-20页

作者： ning-Bo zhao Yi Chen Rui Xia jian-Bo Tang Dong zhao Department of Ultrasound National Clinical Research Centre for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518112Guangdong ProvinceChina Department of Thyroid and Hernia Surgery The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 51800Guangdong ProvinceChina Department of Liver Surgery and Organ Transplantation Center Shenzhen Third People's HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518112Guangdong ProvinceChina

Liver transplantation is the primary therapeutic intervention for end-stage liver disease.However,vascular complications,particularly those involving the hepatic artery,pose significant risks to patients.The clinical manifestations associated with early arterial complications following liver transplantation are often non-specific.Without timely intervention,these complications can result in graft fai-lure or patient mortality.Therefore,early diagnosis and the formulation of an op-timal treatment plan are imperative.Ultrasound examination remains the pre-dominant imaging modality for detecting complications post liver transplan-tation.This article comprehensively reviews common causes and clinical present-ations of early hepatic artery complications in the post-transplantation period and delineates abnormal sonographic findings for accurate diagnosis of these con-ditions.Overall,ultrasound offers the advantages of convenience,safety,effect-iveness,and non-invasiveness.It enables real-time,dynamic,and precise evalua-tion,making it the preferred diagnostic method for post-liver transplantation assessments.INTRODUCTION Liver transplantation stands as the primary therapeutic approach for end-stage liver disease.Continuous advancements in surgical techniques and the application of novel immunosuppressive agents contribute to ongoing improvements in the success rate and overall survival in patients undergoing liver transplantation procedures.Despite these advan-cements,vascular complications,particularly those involving the hepatic artery,pose significant risks to patients.During the early stages following liver transplantation(within the first 30 d),proper hepatic artery function is crucial for hepatic arterial blood flow.During later stages,collateral circulation,including arteries such as the phrenic artery,right gastric artery,and gastroduodenal artery,becomes important for maintaining hepatic blood supply.It is now understood that the establishment of effective collateral circulation is pivotal for determining the

关键词： Liver transplantation Vascular complication Arterial complication Ultrasound

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A positive feedback inhibition of isocitrate dehydrogenase 3βon paired-box gene 6 promotes Alzheimer-like pathology

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2324-2340页

作者： Xin Wang Qian Liu Hai-tao Yu Jia-zhao Xie Jun-ning zhao Zhi-ting Fang Min Qu Yao Zhang Ying Yang jian-Zhi Wang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Fundamental Medicine Wuxi School of MedicineJiangnan UniversityWuxiJiangsu 214122China Hubei Provincial Key Laboratory for Applied Toxicology Hubei Provincial Center for Disease Control and PreventionHubei Provincial Academy of Preventive MedicineWuhan 430000China Endocrine Department of Liyuan Hospital Key Laboratory of Ministry of Education of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226000China

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease(AD);however,the fundamental mechanism is unknown.In this study,we found a substantial decline in isocitrate dehydrogenase 3β(IDH3β)levels,a critical tricarboxylic acid cycle enzyme,in AD patients and AD-transgenic mice’s brains.Further investigations demonstrated that the knockdown of IDH3βinduced oxidation-phosphorylation uncoupling,leading to reduced energy metabolism and lactate accumulation.The resulting increased lactate,a source of lactyl,was found to promote histone lactylation,thereby enhancing the expression of paired-box gene 6(PAX6).As an inhibitory transcription factor of IDH3β,the elevated PAX6 in turn inhibited the expression of IDH3β,leading to tau hyperphosphorylation,synapse impairment,and learning and memory deficits resembling those seen in AD.In AD-transgenic mice,upregulating IDH3βand downregulating PAX6 were found to improve cognitive functioning and reverse AD-like pathologies.Collectively,our data suggest that impaired oxidative phosphorylation accelerates AD progression via a positive feedback inhibition loop of IDH3β-lactate-PAX6-IDH3β.Breaking this loop by upregulating IDH3βor downregulating PAX6 attenuates AD neurodegeneration and cognitive impairments.

关键词： metabolism Alzheimer impaired

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Editable semiconductor photo-electrodes for sustainable ammonia synthesis

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Nano Research 2024年第4期17卷 3107-3112页

作者： ning Lan Kun Du Erling zhao Wei zhao Tao Ling Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education Institute of New-EnergySchool of Materials Science and EngineeringTianjin UniversityTianjin 300072China School of Materials Science and Engineering Tianjin Chengjian UniversityTianjin 300384China

Powered by an inexhaustible supply of solar energy,photoelectrochemical(PEC)nitrogen reduction reaction(NRR)provides an ideal solution for the synthesis of green ammonia(NH_(3)).Although great efforts have been made in the past decades,there are still significant challenges in increasing the NH_(3) yields of the PEC-NRR devices.In addition to the issues of low activity and selectivity similar to electrochemical NRR,the progress of PEC-NRR is also impeded by the limited increase in NH_(3) yields as the electrode is enlarged.Here,we propose an editable electrode design strategy that parallels unit photo-electrodes to achieve a linear increase in NH_(3) yields with electrode active area.We demonstrate that the editable electrode design strategy minimizes the electrode charge transfer resistance,allowing more photo-generated carriers to reach the electrode surface and promote the catalytic reaction.We believe that this editable electrode design strategy provides an avenue to achieve sustainable PEC NH_(3) production.

关键词： editable electrode photoelectrochemical nitrogen reduction reaction parallel electrode ZnSe

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Copper-Free Click Chemistry-Mediated Assembly of Single Quantum Dot Nanosensor for Accurately Monitoring Locus-Specific m^(6)A in Cancer Cells

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Chinese Journal of Chemistry 2024年第5期42卷 499-504页

作者： Yue-Ying Li ning-ning zhao Yi-Xuan Geng Qian Han jian-Ge Qiu Bing-Hua jiang Zi-Yue Wang Chun-Yang Zhang Translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityThe Academy of Medical SciencesHenan Institute of Medical and Pharmaceutical Sciences BGI CollegeZhengzhou UniversityZhengzhouHenan450052 China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinanShandong250014 China School of Chemistry and Chemical Engineering Southeast UniversityNanjingJiangsu211189 China

N6-methyladenosine(m^(6)A)plays an important role in embryogenesis,nuclear export,transcription splicing,and protein translation control.Herein,we demonstrate a copper-free click chemistry-mediated assembly of single quantum dot(QD)nanosensor for accurately monitoring locus-specific m^(6)A in cancer cells.The m^(6)A-sensitive endoribonuclease MazF can digest the unmethylated A-RNA,and the intact m^(6)A-RNA then hybridizes with DNA probes a and b to produce a sandwich hybrid,initiating the click chemistry to generate probe a–b ligation product via first tandem ligation detection reaction(LDR)cycle.Subsequently,DNA probes c and d can hybridize with the probe a–b ligation product to generate the probe c–d ligation product via second LDR cycle.Both LDR cycles can be repeated through denaturation and annealing reaction to generate abundant biotin-/fluorophore-modified probe c–d ligation products that can easily assemble on the QD surface to induce distinct fluorescence resonance energy transfer(FRET)between QD and Cy5.This assay can be homogenously performed without the involvement of copper catalyst,m^(6)A-specific antibody,radioactive labeling,ligase enzyme,enzymatic reverse transcription,and next-generation sequencing.Moreover,it can discriminate even 0.01% m^(6)A level in complex samples and accurately measure cellular m^(6)A-RNA expression,providing a promising avenue for clinical diagnostics and biomedical research.

关键词： RNA methylation Click chemistry Förster resonance energy transfer Biosensor Cancer

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Trajectory of COVID-19 response and management strategy in China:scientific rationale driven strategy adjustments

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Frontiers of Medicine 2024年第1期18卷 19-30页

作者： Zeyu Zhang Yue Yan Lina zhao Yizhou Bian ning zhao You Wu Dahai zhao Zongjiu Zhang Institute for Hospital Management Tsinghua UniversityBeijing100084China School of Medicine Tsinghua UniversityBeijing100084China School of International and Public Affairs Shanghai Jiao Tong UniversityShanghai200030China Yale University-Shanghai Jiao Tong University Joint Center for Health Policy Shanghai Jiao Tong UniversityShanghai200030China

The pneumonia caused by novel coronavirus SARS-CoV-2 infection in early December 2019,which was later named coronavirus disease 2019(COVID-19)by the World Health Organization(WHO),rapidly spread across the world.China has made extraordinary efforts to this unprecedented pandemic,put its response and control at a very high level of infectious disease management(Category B but with measures for Category A),given top priority to the people and their lives,and balanced the pandemic control and socio-economic development.After more than three years’fighting against this disease,China downgraded the management of COVID-19 to Category B infectious disease on January 8,2023 and the WHO declared the end of public health emergency on May 5,2023.However,the ending of pandemic does not mean that the disease is no longer a health threat.Experiences against COVID-19 from China and the whole world should be learned to prepare well for the future public health emergencies.This article gives a systematic review of the trajectory of COVID-19 development in China,summarizes the critical policy arrangements and provides evidence for the adjustment during policy making process,so as to share experiences with international community and contribute to the global health for all humanity.

关键词： COVID-19 public health response and control strategy science-based policy making

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To explore the mechanism of Yigong San anti-gastric cancer and immune regulation

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1965-1994页

作者： Dou-Dou Lu Ling Yuan zhao-zhao Wang jian-Jun zhao Yu-Hua Du Na ning Guo-Qing Chen Shi-Cong Huang Yi Yang Zhe Zhang Yi Nan School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Chinese Medical Gastrointestinal China-Japan Friendship HospitalBeijing 100029China Key Laboratory of ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Yigong San(YGS)is a representative prescription for the treatment of digestive disorders,which has been used in clinic for more than 1000 years.However,the mechanism of its anti-gastric cancer and regulate immunity are still remains unclear.AIM To explore the mechanism of YGS anti-gastric cancer and immune regulation.METHODS Firstly,collect the active ingredients and targets of YGS,and the differentially expressed genes of gastric cancer.Secondly,constructed a protein-protein interaction network between the targets of drugs and diseases,and screened hub genes.Then the clinical relevance,mutation and repair,tumor microenvironment and drug sensitivity of the hub gene were analyzed.Finally,molecular docking was used to verify the binding ability of YGS active ingredient and hub genes.RESULTS Firstly,obtained 55 common targets of gastric cancer and YGS.The Kyoto Encyclopedia of Genes and Genomes screened the microtubule-associated protein kinase signaling axis as the key pathway and IL6,EGFR,MMP2,MMP9 and TGFB1 as the hub genes.The 5 hub genes were involved in gastric carcinogenesis,staging,typing and prognosis,and their mutations promote gastric cancer progression.Finally,molecular docking results confirmed that the components of YGS can effectively bind to therapeutic targets.CONCLUSION YGS has the effect of anti-gastric cancer and immune regulation.

关键词： Gastric cancer Yigong San Mechanism Immune

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Current status of liver transplantation for human immunodeficiency virus-infected patients in China's Mainland

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World Journal of Gastroenterology 2024年第14期30卷 1958-1962页

作者： jian-Xin Tang Dong zhao Department of Liver Surgery and Organ Transplantation Center Shenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

According to the report from the Chinese Center for Disease Control and Prevention,the prevalence of human immunodeficiency virus(HIV)infection exceeded 1.2 million individuals by the year 2022,with an annual increase of about 80000 cases.The overall prevalence of hepatitis B surface antigen among individuals co-infected with HIV reached 13.7%,almost twice the rate of the general population in China.In addition to the well-documented susceptibility to opportunistic infections and new malignancies,HIV infected patients frequently experience liver-related organ damage,with the liver and kidneys being the most commonly affected.This often leads to the development of end-stage liver and kidney diseases.Therefore,organ transplantation has emerged as an important part of active treatment for HIV infected patients.However,the curative effect is not satisfactory.HIV infection has been considered a contraindication for organ transplantation.Until the emergence of highly active anti-retroviral therapy in 1996,the once intractable replication of retrovirus was effectively inhibited.With prolonged survival,the failure of important organs has become the main cause of death among HIV patients.Therefore,transplant centers worldwide have resu-med exploration of organ transplantation for HIV-infected individuals and reached a positive conclusion.This study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation(LT)in main-land China.To date,our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV,and all but one,who died two months postoperatively due to sepsis and progressive multi-organ failure,have survived.Comparative analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions,cytomegalovirus infection,bacteremia,pulmonary infections,acute kidney injury,new-onset cancers,or vascular and biliary complications.

关键词： Liver transplantation Human immunodeficiency virus Infection Hepatitis B virus End-stage liver disease China'Mainland

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Machine Learning-Based Research on Tensile Strength of SiC-Reinforced Magnesium Matrix Composites via Stir Casting

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 453-466页

作者： Zhihong Zhu Wenhang ning Xuanyang Niu Yuhong zhao Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Collaborative Innovation Center of Ministry of Education and Shanxi Province for High-Performance Al/Mg Alloy MaterialsNorth University of ChinaTaiyuan 030051China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

SiC is the most common reinforcement in magnesium matrix composites,and the tensile strength of SiC-reinforced magnesium matrix composites is closely related to the distribution of SiC.Achieving a uniform distribution of SiC requires fine control over the parameters of SiC and the processing and preparation process.However,due to the numerous adjustable parameters,using traditional experimental methods requires a considerable amount of experimentation to obtain a uniformly distributed composite material.Therefore,this study adopts a machine learning approach to explore the tensile strength of SiC-reinforced magnesium matrix composites in the mechanical stirring casting process.By analyzing the influence of SiC parameters and processing parameters on composite material performance,we have established an effective predictive model.Furthermore,six different machine learning regression models have been developed to predict the tensile strength of SiC-reinforced magnesium matrix composites.Through validation and comparison,our models demonstrate good accuracy and reliability in predicting the tensile strength of the composite material.The research findings indicate that hot extrusion treatment,SiC content,and stirring time have a significant impact on the tensile strength.

关键词： Machine learning Stirring casting Magnesium matrix composite Tensile strength

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Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 30-50页

作者： Yu-Hua Du jian-Jun zhao Xia Li Shi-Cong Huang Na ning Guo-Qing Chen Yi Yang Yi Nan Ling Yuan College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina ningxia Chinese Medicine Research Center Manufacturing LaboratoryYinchuan 750004Ningxia Hui Autonomous RegionChina College of Foundation Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Pachymic acid(PA)is derived from Poria cocos.PA has a variety of pharmacological and inhibitory effects on various tumors.However,the mechanism of action of PA in gastric cancer(GC)remains unclear.AIM To investigate the mechanism of PA in treating GC via the combination of network pharmacology and experimental verification.METHODS The GeneCards and OMIM databases were used to derive the GC targets,while the Pharm Mapper database provided the PA targets.Utilizing the STRING database,a protein-protein interaction network was constructed and core targets were screened.The analyses of Gene Ontology,Kyoto Encyclopedia of Genes and Genomes(KEGG),and gene set enrichment analysis were conducted,and molecular docking and clinical correlation analyses were performed on the core targets.Ultimately,the network pharmacology findings were validated through in vitro cell assays,encompassing assessments of cell viability,apoptosis,cell cycle,cloning,and western blot analysis.RESULTS According to network pharmacology analysis,the core targets were screened,and the PI3K/AKT signaling pathway is likely to be the mechanism by which PA effectively treats GC,according to KEGG enrichment analysis.The experimental findings showed that PA could control PI3K/AKT signaling to prevent GC cell proliferation,induce apoptosis,and pause the cell cycle.CONCLUSION Network pharmacology demonstrated that PA could treat GC by controlling a variety of signaling pathways and acting on a variety of targets.This has also been supported by in vitro cell studies,which serve as benchmarks for further research.

关键词： Pachymic acid Gastric cancer Network pharmacology Enrichment analysis Cell proliferation

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Sustainable production of high-energy-density jet fuel via cycloaddition reactions

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Journal of Energy Chemistry 2024年第8期95卷 712-722页

作者： Yan-Cheng Hu Yingying zhao ning Li Jing-Pei Cao School of Chemical Engineering and Technology China University of Mining and Technology School of Education Science Jiangsu Normal University CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Developing an energy supply-chain based on renewable biomass holds great potential to build a low carbon society. High-energy-density(HED) jet fuel, featuring unique fused/strained cycloalkanes, is of great significance for volume-limited military aircrafts, as their high density and combustion heat can extend flight duration and increase the payload. Therefore, the exploration of biomass-based routes towards HED fuel has drawn much attention over the past decade. Cycloaddition reaction features rapid construction of various carbocycles in an atom-and step-economical fashion. This elegant strategy has been widely applied in the manufacture of sustainable HED fuel. Here we carefully summarize the progress achieved in this fascinating area and the review is categorized by the cycloaddition patterns including [4+2], [2+2],[4+4], and [2+1] cycloadditions. Besides, the energy densities of the as-prepared biofuels and petroleumbased fuels(conventional Jet-A and advanced JP-10) are also compared. This review will provide important insights into rational design of new HED fuel with different ring-types/sizes and inspire the chemists to turn those literature studies into practical applications in military field.

关键词： Biomass-based chemicals Catalysis Cycloaddition Cycloalkanes High-energy-density fuel

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