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Evaluation of ERA5 reanalysis temperature data over the Qilian Mountains of China

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Journal of Mountain Science 2025年第1期22卷 198-209页

作者： zhao Peng HE Zhibin School of Computer Science Huainan Normal UniversityHuainan 232038China Linze Inland River Basin Research Station Key Laboratory of Inland River Basin ScienceNorthwest Institute of Eco-Environment and ResourceChinese Academy of SciencesLanzhou 730000China

Air temperature is an important indicator to analyze climate change in mountainous ***5 reanalysis air temperature data are important products that were widely used to analyze temperature change in mountainous ***,the reliability of ERA5 reanalysis air temperature over the Qilian Mountains(QLM)is *** this study,we evaluated the reliability of ERA5 monthly averaged reanalysis 2 m air temperature data using the observations at 17 meteorological stations in the QLM from 1979 to *** results showed that:ERA5 reanalysis monthly averaged air temperature data have a good applicability in the QLM in general(R2=0.99).ERA5 reanalysis temperature data overestimated the observed temperature in the QLM in *** mean square error(RMSE)increases with the increasing of elevation range,showing that the reliability of ERA5 reanalysis temperature data is worse in higher elevation than that in lower ***5 reanalysis temperature can capture observational warming rates *** the smallest warming rates of observational temperature and ERA5 reanalysis temperature are found in winter,with the warming rates of 0.393°C/10a and 0.360°C/10a,*** study will provide a reference for the application of ERA5 reanalysis monthly averaged air temperature data at different elevation ranges in the Qilian Mountains.

关键词： ERA5 Reanalysis data Air temperature Qilian Mountains Climate change

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慢性缺氧、缺氧诱导因子与肝癌研究进展

世界华人消化杂志 2025年第1期33卷 11-20页

作者：池肇春青岛市市立医院消化内科山东省青岛市266011

当前对缺氧与肝癌的相关性研究取得了一些新的认识与进展,近年在应用缺氧诱导因子抑制剂和抗癌药物联用治疗肝癌取得了可喜的疗效,降低了肝癌的进展和转移,延长了患者的生存期限.肝脏损伤会破坏肝脏血管系统,扰乱正常的血液流动和氧气供... 详细信息

当前对缺氧与肝癌的相关性研究取得了一些新的认识与进展,近年在应用缺氧诱导因子抑制剂和抗癌药物联用治疗肝癌取得了可喜的疗效,降低了肝癌的进展和转移,延长了患者的生存期限.肝脏损伤会破坏肝脏血管系统,扰乱正常的血液流动和氧气供应,造成缺氧微环境.缺氧时肝细胞沉积于胶原蛋白,导致纤维化和肝硬化,从而进一步加剧缺氧.研究结果表明缺氧、线粒体异常、氧化应激、肝脏炎症和肝癌密切相关.本文就慢性缺氧、缺氧诱导因子与肝癌的研究进展和最新治疗进行综述.

关键词：缺氧缺氧诱导因子肝细胞癌缺氧诱导因子抑制剂

腹主动脉瘤患者腔内治疗与开腹修复术的围手术期比较

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中华医学杂志 2012年第47期92卷 3324-3328页

作者：赵纪春马玉奎黄斌卢武胜杨轶袁丁四川大学华西医院血管中心成都610041

目的评估腹主动脉瘤腔内和开腹修复术在治疗腹主动脉瘤患者的安全性和有效性。方法回顾性分析华西医院血管外科2006年1月至2011年1月期间收治的371例行择期手术的腹主动脉瘤患者，比较腔内修复术治疗患者（EVAR组，n=174）与开腹手术治... 详细信息

目的评估腹主动脉瘤腔内和开腹修复术在治疗腹主动脉瘤患者的安全性和有效性。方法回顾性分析华西医院血管外科2006年1月至2011年1月期间收治的371例行择期手术的腹主动脉瘤患者，比较腔内修复术治疗患者（EVAR组，n=174）与开腹手术治疗患者（OR组，n=197）的围手术期资料、并发症和死亡率情况。结果腔内组的平均年龄为（72±8）岁；手术组的平均年龄为（60±14）岁，两组差异有统计学意义（P〈0．05）。腔内组患者合并COPD的比例为31．0％高于OR组的比例为21．8％（P〈0．05）。腔内组患者术中失血量为（125±43）ml少于手术组为（858±602）ml（P〈0．05）。腔内组患者术中无输血，手术组术中有140例患者输血。腔内组术后ICU时间和禁食时间分别为（15±5）h和（7±4）h均低于手术组分别为（31±11）h和（90±32）h（P〈0．05）。腔内组手术时间为（146±39）min短于手术组为（210±24）rain，（P〈0．05）。腔内组术后带呼吸机时间的中位数为（90±23）min短于手术组（220±132）min，（P〈0．05）。腔内组88例（50．6％）全身麻醉、52例（30．0％）硬膜外阻滞麻醉、34例（19．4％）局麻，手术组全部选择全麻。腔内组术后平均住院时间为（9．1±2．7）d与手术组（9．2±2．6）d相似（P=0．798）。围手术期并发症发生率EVAR组为12．6％低于手术组27．0％（P〈0．05）。EVAR组30d围手术期死亡率1．15％，手术组30d围手术期死亡率2．0％。结论腹主动脉瘤腔内修复术比开腹手术具有创伤小、术中失血少、术后恢复快，围手术期死亡率低等优点，使部分高危不能耐受开腹手术患者能够获得有效治疗，长期生存率有待进一步随访观察。

关键词：主动脉瘤腹腔内修复术外科手术

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： jia zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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腹主动脉瘤的发病机理及治疗进展

中国普外基础与临床杂志 2008年第6期15卷 422-425页

作者：刘仁贵赵纪春大理学院附属医院普外科大理671000 四川大学华西医院普外科成都610041

目的探讨腹主动脉瘤的发病机理及治疗进展。方法复习近几年有关腹主动脉瘤的发病机理及治疗的文献,进行综述。结果腹主动脉瘤的形成是遗传、解剖、环境、生物化学等多因素相互影响和共同作用的结果。腹主动脉中层细胞外基质的代谢失衡... 详细信息

目的探讨腹主动脉瘤的发病机理及治疗进展。方法复习近几年有关腹主动脉瘤的发病机理及治疗的文献,进行综述。结果腹主动脉瘤的形成是遗传、解剖、环境、生物化学等多因素相互影响和共同作用的结果。腹主动脉中层细胞外基质的代谢失衡在腹主动脉瘤的形成中起主要作用,而基质金属蛋白酶的活性增加和弹性蛋白与胶原蛋白的基因表达失衡可能是主要原因。腹主动脉瘤的治疗包括外科和内科治疗,内科治疗还处于探索和研究阶段。结论腹主动脉瘤的形成是多因素共同作用的结果,内科治疗是外科治疗的重要补充。

关键词：腹主动脉瘤细胞外基质基质金属蛋白酶治疗

糖尿病并发下肢血管病变的发病机理及治疗进展

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中国普外基础与临床杂志 2006年第6期13卷 676-679页

作者：刘仁贵赵纪春四川大学华西医院普外二科成都610041

目的介绍糖尿病合并下肢血管病变的发病机理及治疗进展。方法复习近几年的相关文献,进行综述。结果糖尿病为周围动脉病变的主要危险因素之一,糖尿病血管病变包括大血管病变和微血管病变两种,动脉硬化和微循环的血流减少是下肢缺血的重... 详细信息

目的介绍糖尿病合并下肢血管病变的发病机理及治疗进展。方法复习近几年的相关文献,进行综述。结果糖尿病为周围动脉病变的主要危险因素之一,糖尿病血管病变包括大血管病变和微血管病变两种,动脉硬化和微循环的血流减少是下肢缺血的重要因素。下肢的缺血性病变是糖尿病的常见并发症,内科治疗及外科治疗均可改善其症状。结论外科治疗是治疗糖尿病合并下肢血管病变的有效方法。

关键词：糖尿病血管病变治疗

Graph reinforcement learning with relational priors for predictive power allocation

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Science China(Information Sciences) 2025年第2期68卷 230-247页

作者： jianyu zhao Chenyang YANG School of Electronics and Information Engineering Beihang University

Deep reinforcement learning for resource allocation has been investigated extensively owing to its ability of handling model-free and end-to-end problems. However, its slow convergence and high time complexity during online training hinder its practical use in dynamic wireless systems. To reduce the training complexity, we resort to graph reinforcement learning for leveraging two kinds of relational priors inherent in many wireless communication problems: topology information and permutation properties. To harness the two priors, we first conceive a method to convert the state matrix into a state graph,and then propose a graph deep deterministic policy gradient(DDPG) algorithm with the desired permutation property. To demonstrate how to apply the proposed methods, we consider a representative problem of using reinforcement learning, predictive power allocation, which minimizes the energy consumption while ensuring the quality-of-service of each user requesting video streaming. We derive the time complexity required by training the proposed graph DDPG algorithm and fully-connected neural network-based DDPG algorithm in each time step. Simulations show that the graph DDPG algorithm converges much faster and needs much lower time and space complexity than existing DDPG algorithms to achieve the same learning performance.

关键词： reinforcement learning graph neural network relational priors resource allocation

Dual-Mode Colorimetric and Fluorescent Detection of Tumor Cells Based on Gold Nanoparticles-Loaded Phosphine Covalent Organic Frameworks

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Journal of Analysis and Testing 2025年第01期 21-31页

作者： Bilian Li Min Zhou chun zhao Lin Xiao Tianle Qi Hanbin Xu Linjiang Guo Guobao Ning Xiaokang Lu Keming Zhu Hui zhao Can-Peng Li School of Chemical Science and Technology Yunnan University Affiliated Hospital of Yunnan University School of Life Science Yunnan University Laboratory for Conservation and Utilization of Bioresource Yunnan University

Circulating tumor cells(CTCs) are important markers for cancer. The part of tumor cells that are detached from the primary tumor or metastatic tumor and enter the blood circulation is called CTCs. It is crucial to develop a rapid, accurate, and easy-to-implement diagnostic system for CTCs for early tumor diagnosis and for monitoring progression of the disease. In this work, we reported a colorimetric and fluorescent dual-mode assay for the detection of CTCs. Our assay used magnetic nanoparticles and aptamer for CTCs capture and gold nanoparticles-loaded covalent organic frameworks(Au@COFs) for signal amplification, respectively. The magnetic nanoparticles were modified with folic acid to capture CTCs by interaction between folic acid and the folate receptor overexpressed on the surface of tumor cells. The covalent organic frameworks were engineered to have both nitro-reductase-like and glucose–oxidase-like activities. The nitro-reductase-like activity converted the substrate p-nitrophenol to p-nitroaniline for colorimetric detection, and the glucose-oxidase-like activity enabled fluorescence detection. Specifically, Au@COFs catalyzed glucose oxidation and generated hydrogen peroxide to oxidize Fe 2+to Fe 3+, which converted MIL(Al)-MOF to MIL(Fe)-MOF through ion exchange, resulting in the fluorescence quenching of MIL(Al)-MOF. Our assay showed high sensitivity with a detection limit of 17 cells/mL using MCF-7 cells as model cancer cells. This work provided an e fficient and ultrasensitive strategy for CTCs detection and has potential applications in cancer identification and diagnosis. Dual-mode detection system, combining colorimetric and fluorescent signals, integration of magnetic nanoparticles and aptamers for CTC capture, and utilization of covalent organic frameworks loaded with gold nanoparticles for signal amplification can improve sensitivity and accuracy.

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CCUS:A Panacea or a Placebo in the fight against climate change?

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Green Energy & Environment 2025年第2期10卷 239-243页

作者： Yuxin zhao CNPC Tubular Goods Research Institute(TGRI) Xi'an710077China School of Mechanical Engineering Hebei University of TechnologyTianjin300401China

Carbon Capture,Utilization,and Storage(CCUS)is a crucial technology for achieving carbon neutrality,but it faces significant *** substantial investments and policy support,CCUS projects have underperformed due to technical difficulties,high costs,and controversies surrounding the fossil fuel industry's *** effectiveness and feasibility of CCUS in reducing carbon emissions remain *** viewpoint provides a comprehensive analysis of the current state of CCUS technology,examining its potential to reduce carbon emissions,the challenges hindering its deployment,and the strategies needed to overcome these *** discuss the need for a combinatorial approach to unlock CCUS's full potential,and also emphasize the importance of selecting optimal CO_(2)utilization pathways to maximize economic benefits and CO_(2)*** CCUS faces technical,economic,and social barriers,it can still play a valuable role in mitigating emissions from hard-to-abate sectors when supported by comprehensive strategies and collaborative efforts among governments,industries,and research *** addressing these challenges and investing in innovation,CCUS can contribute to achieving carbon neutrality and building a sustainable,low-carbon future.

关键词： CCUS Carbon neutrality Net-zero emissions Fossil fuel industry Sustainable development