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Establishment of a blunt impact-induced brain injury model in rabbits

Chinese Journal of Traumatology 2012年第2期

作者： li Kui CAO Yun-xing YANG Yong-qiang YIN Zhi-yong~* zhao hui and wang li-jun chongqing municipal public security bureau chongqing 400054 China Department of Neurosurgery First Affiliated Hospital of liaoning Medical University Jinzhou 121001 China chongqing Key Laboratory of Vehicle Crash/Bio-impact and Traffic Safety Department 4th Daping Hospital and Institute of Surgery Research Third Military Medical University chongqing 400042 China chongqing municipal public security bureau Chongqing 400054 China Department of Neurosurgery First Affiliated Hospital of Liaoning Medical University Jinzhou 121001 China chongqing Key Laboratory of Vehicle Crash Bio-impact and Traffic Safety Department 4th Daping Hospital and Institute of Surgery Research Third Military Medical University Chongqing 400042 China

Objective:To establish an animal model to replicate the blunt impact brain injury in forensic medicine. Methods:Twenty-four New Zealand white rabbits were randomly divided into control group(n=4),minor injury group(n=10) and severe injury group(n=10).Based on the BIM-ⅡHorizontal Bio-impact Machine,self-designed iron bar was used to produce blunt brain *** rabbits from each injury group were randomly selected to monitor the change of intracranial pressure(ICP) during the impacting process by pressure *** hours after injury, all the rabbits were dissected to observe the injury morphology and underwent routine pathological examination. Results:Varying degrees of nervous system positive signs were observed in all the injured *** 6 hours, the mortality rate was 1/10 in the minor injury group and 6/10 in the severe injury *** changes con- sisted of different levels of scalp hematoma,skull fracture, epidural hematoma,subdural hematoma,subarachnoid hemorrhage and brain *** the moment of hitting,the ICP was greater in severe injury group than in mild injury group; and within the same group,the impact side showed positive pressure while the opposite side showed negative pressure. Conclusions:Under the rigidly-controlled experimental condition,this animal model has a good reproducibility and stable ***,it is able to simulate the morphology of iron strike-induced injury,thus can be used to study the mechanism of blunt head injury in forensic medicine.

关键词： Brain injuries Forensic medicine Wounds,nonpenetrating Models,animal Rabbits

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Establishment of a blunt impact-induced brain injury model in rabbits

引用

Chinese Journal of Traumatology 2012年第2期15卷 100-104页

作者： li Kui CAO Yun-xing YANG Yong-qiang YIN Zhi-yong zhao hui wang li-jun chongqing municipal public security bureau Chongqing 400054China

Objective： To establish an animal model to replicate the blunt impact brain injury in forensic medicine. Methods： Twenty-four New Zealand white rabbits were randomly divided into control group （n=4）, minor injury group （n：10） and severe injury group （n=10）. Based on the BIM- II Horizontal Bio-impact Machine, self-designed iron bar was used to produce blunt brain injury. Two rabbits from each injury group were randomly selected to monitor the change ofintracranial pressure （ICP） during the impact- ing process by pressure microsensors. Six hours after injury, all the rabbits were dissected to observe the injury mor- phology and underwent routine pathological examination. Results： Varying degrees of nervous system positive signs were observed in all the injured rabbits. Within 6 hours, the mortality rate was 1/10 in the minor injury group and 6/10 in the severe injury group. Morphological changes con-sisted of different levels of scalp hematoma, skull fracture, epidural hematoma, subdural hematoma, subarachnoid hemo- rrhage and brain injury. At the moment of hitting, the ICP was greater in severe injury group than in mild injury group; and within the same group, the impact side showed positive pressure while the opposite side showed negative pressure. Conclusions： Under the rigidly-controlled experimental condition, this animal model has a good reproducibility and stable results. Meanwhile, it is able to simulate the morphology of iron strike-induced injury, thus can be used to study the mechanism of blunt head injury in forensic medicine.

关键词： Brain injuries Forensic medicine Wounds, nonpenetrating Models, animal Rabbits

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