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用于微型生化分析的光探测系统

光谱学与光谱分析 2005年第4期25卷 633-636页

作者：李锋吴一辉赵华兵鞠挥中国科学院长春光学精密机械与物理研究所应用光学国家重点实验室吉林长春130033

针对微生化芯片样品剂量少和与微流体芯片集成等要求,设计了两种在芯片内用分光光度法对混合后液体的吸收光谱进行探测的方法。实验利用5 10～84 0nm的可见光光源,采用了直接探测法和消逝波探测法对样品进行探测。通过两种方法的比较证... 详细信息

针对微生化芯片样品剂量少和与微流体芯片集成等要求,设计了两种在芯片内用分光光度法对混合后液体的吸收光谱进行探测的方法。实验利用5 10～84 0nm的可见光光源,采用了直接探测法和消逝波探测法对样品进行探测。通过两种方法的比较证明:直接探测法具有原理简单、消耗样品量少和结构容易实现等优点;消逝波探测法具有需要样品量极少、灵敏度高和易于集成的优点。

关键词：探测系统生化分析消逝波探测法直接探测法微型分光光度法芯片集成吸收光谱样品量微流体可见光灵敏度

Zinc glycine chelate ameliorates DSS‑induced intestinal barrier dysfunction via attenuating TLR4/NF‑κB pathway in meat ducks

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Journal of Animal Science and Biotechnology 2024年第2期15卷 765-778页

作者： Yaqi Chang Ke Wang Guangmang Liu hua zhao Xiaoling Chen Jingyi Cai Gang Jia Institute of Animal Nutrition Key Laboratory for Animal Disease‑Resistance Nutrition of ChinaMinistry of EducationSichuan Agricultural UniversityChengdu 611130SichuanChina

Background Zinc glycine chelate(Zn-Gly)has anti-inflammation and growth-promoting properties;however,the mechanism of Zn-Gly contribution to gut barrier function in Cherry Valley ducks during intestinal inflammation is ***-hundred 1-day-old ducks were divided into 5 groups(6 replicates and 10 ducks per replicate)in a completely randomized design:the control and dextran sulfate sodium(DSS)groups were fed a corn-soybean meal basal diet,and experimental groups received supplements of 70,120 or 170 mg/kg Zn in form of *** DSS and treatment groups were given 2 mL of 0.45 g/mL DSS daily during d 15–21,and the control group received normal *** experiment lasted 21 *** Compared with DSS group,70,120 and 170 mg/kg Zn significantly increased body weight(BW),villus height and the ratio of villus to crypt,and significantly decreased the crypt depth of jejunum at 21 *** number of goblet cells in jejunal villi in the Zn-Gly group was significantly increased by periodic acid-Schiff *** with control,the content of intestinal permeability marker D-lactic acid(D-LA)and fluxes of fluorescein isothiocyanate(FITC-D)in plasma of DSS group significantly increased,and 170 mg/kg Zn supplementation significantly decreased the D-LA content and FITC-D *** with control,contents of plasma,jejunum endotoxin and jejunum pro-inflammatory factors IL-1β,IL-6 and TNF-αwere significantly increased in DSS group,and were significantly decreased by 170 mg/kg Zn *** Zn significantly increased the contents of anti-inflammatory factors IL-10,IL-22 and sIgA and IgG in ***-time PCR and Western blot results showed that 170 mg/kg Zn supplementation significantly increased mRNA expression levels of CLDN-1 and expression of OCLN protein in jejunum,and decreased gene and protein expression of CLDN-2 compared with DSS *** 120 mg/kg Zn significantly promoted the expressions of IL-22 and *** Zn-Gly supplementation sign

关键词： Cherry Valley ducks Growth performance Gut inflammation Intestinal barrier Zn-Gly

Effects of Maillard reaction and its product AGEs on aging and age-related diseases

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Food Science and Human Wellness 2024年第3期13卷 1118-1134页

作者： huan Peng Yuqi Gao Chenye Zeng Rui hua Yannan Guo Yida Wang zhao Wang Protein Science Key Laboratory of the Ministry of Education School of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China

Maillard reaction(MR)is a non-enzymatic browning reaction commonly seen in food processing,which occurs between reducing sugars and compounds with amino *** certain advantages based on Maillard reaction products(MRPs)found in some food for health and storage application have appeared,however,the MR occurring in human physiological environment can produce advanced glycation end products(AGEs)by non-enzymatic modification of macromolecules such as proteins,lipids and nucleic acid,which could change the structure and functional activity of the molecules *** this review,we take AGEs as our main object,on the one hand,discuss physiologic aging,that is,age-dependent covalent cross-linking and modification of proteins such as collagen that occur in eyes and skin containing connective *** the other hand,pathological aging associated with autoimmune and inflammatory diseases,neurodegenerative diseases,diabetes and diabetic nephropathy,cardiovascular diseases and bone degenerative diseases have been mainly *** on the series of adverse effects of accelerated aging and disease pathologies caused by MRPs,the possible harm caused by some MR can be slowed down or inhibited by artificial drug intervention,dietary pattern and lifestyle *** also stimulates people's curiosity to continue to explore the potential link between the MR and human aging and health,which should be paid more attention to for the development of life sciences.

关键词： Maillard reaction Advanced glycation end products Physiologic aging Pathological aging Drug intervention

Diabetic retinopathy identification based on multi-sourcefree domain adaptation

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1193-1204页

作者： Guang-hua Zhang Guang-Ping Zhuo zhao-Xia Zhang Bin Sun Wei-hua Yang Shao-Chong Zhang School of Big Data Intelligent Diagnosis&Treatment Industry Taiyuan UniversityTaiyuan 030032Shanxi ProvinceChina Shanxi Key Laboratory of Intelligent Optimization Computing and Blockchain Technology Taiyuan Normal UniversityTaiyuan 030619Shanxi ProvinceChina Shanxi Eye Hospital Taiyuan 030002Shanxi ProvinceChina College of Computer Science and Technology Taiyuan Normal UniversityTaiyuan 030619Shanxi ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina

AIM:To address the challenges of data labeling difficulties,data privacy,and necessary large amount of labeled data for deep learning methods in diabetic retinopathy(DR)identification,the aim of this study is to develop a source-free domain adaptation(SFDA)method for efficient and effective DR identification from unlabeled ***:A multi-SFDA method was proposed for DR *** method integrates multiple source models,which are trained from the same source domain,to generate synthetic pseudo labels for the unlabeled target ***,a softmax-consistence minimization term is utilized to minimize the intra-class distances between the source and target domains and maximize the inter-class *** is performed using three color fundus photograph datasets(APTOS2019,DDR,and EyePACS).RESULTS:The proposed model was evaluated and provided promising results with respectively 0.8917 and 0.9795 F1-scores on referable and normal/abnormal DR identification *** demonstrated effective DR identification through minimizing intra-class distances and maximizing inter-class distances between source and target ***:The multi-SFDA method provides an effective approach to overcome the challenges in DR *** method not only addresses difficulties in data labeling and privacy issues,but also reduces the need for large amounts of labeled data required by deep learning methods,making it a practical tool for early detection and preservation of vision in diabetic patients.

关键词： diabetic retinopathy multisource-free domain adaptation pseudo-label generation softmaxconsistence minimization

In-situ U-Pb Dating of Quartz:A Preliminary Study

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Journal of Earth Science 2024年第2期35卷 726-728页

作者： Entao Liu Jian-Xin zhao Songqi Pan Detian Yan hua Wang Hubei Key Laboratory of Marine Geological Resources China University of GeosciencesWuhan 430074China Radiogenic Isotope Facility School of Earth and Environmental SciencesThe University of QueenslandBrisbane Qld 4072Australia PetroChina Research Institute of Petroleum Exploration&Development Beijing 100083China Key Laboratory of Tectonics and Petroleum Resources Ministry of EducationChina University of GeosciencesWuhan 430074China

CHALLENGES AND RESEARCH PROGRESS Recent advancements in analytical capabilities and the precision of measuring instruments in in-situ laser ablation mass spectrometry(LA-MC-ICPMS)have markedly broad ened the utility of the U-Pb isotopic *** progress has paved the way for accurately determining the ab solute ages of minerals with low uranium *** re cent years,in-situ U-Pb dating has witnessed rapid advance ments across diverse mineral types,encompassing calcite,dolo mite,fluorite,nacrite,anatase,and wolframite(Roberts et al.,2020).

关键词： dating minerals isotopic

基于多Agent的智能空间决策支持系统模型

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弹箭与制导学报 2005年第S7期25卷 454-456页

作者：赵冰化魏鑫王勇空军工程大学西安710038 空军驻甘肃地区军事代表室兰州730070

将 Agent 技术和智能空间决策支持相结合,提出了基于多 Agent 的智能空间决策支持系统,给出了体系结构模型和系统通讯模型,并研究了其智能空间决策过程。

关键词： Agent 智能空间决策支持模型

Effects of maternal methyl donor intake during pregnancy on ileum methylation and function in an intrauterine growth restriction pig model

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1173-1189页

作者： Yan Lin Jiangnan Wu Yong Zhuo Bin Feng Zhengfeng Fang Shengyu Xu Jian Li hua zhao De Wu Lun hua Lianqiang Che Key Laboratory of Animal Disease‑Resistance Nutrition Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina

Background Intrauterine growth retardation(IUGR)affects intestinal growth,morphology,and function,which leads to poor growth performance and high *** present study explored whether maternal dietary methyl donor(MET)supplementation alleviates IUGR and enhances offspring’s growth performance by improving intestinal growth,function,and DNA methylation of the ileum in a porcine IUGR *** Forty multiparous sows were allocated to the control or MET diet groups from mating until *** farrowing,8 pairs of IUGR and normal birth weight piglets from 8 litters were selected for sampling before suckling *** The results showed that maternal MET supplementation tended to decrease the IUGR incidence and increased the average weaning weight of ***,maternal MET supplementation significantly reduced the plasma concentrations of isoleucine,cysteine,urea,and total amino acids in sows and newborn *** also increased lactase and sucrase activity in the jejunum of newborn *** addition resulted in lower ileal methionine synthase activity and increased betaine homocysteine S-methyltransferase activity in the ileum of newborn *** methylation analysis of the ileum showed that MET supplementation increased the methyla-tion level of DNA CpG sites in the ileum of newborn ***-regulated differentially methylated genes were enriched in folic acid binding,insulin receptor signaling pathway,and endothelial cell *** contrast,up-regulated methylated genes were enriched in growth hormone receptor signaling pathway and nitric oxide biosyn-thetic *** Maternal MET supplementation can reduce the incidence of IUGR and increase the weaning litter weight of piglets,which may be associated with better intestinal function and methylation status.

关键词： Ileum Intrauterine growth restriction Methyl donor Methylation Sows

Increased retinal venule diameter as a prognostic indicator for recurrent cerebrovascular events:a prospective observational study

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Neural Regeneration Research 2024年第5期19卷 1156-1160页

作者： Ying zhao Dawei Dong Ding Yan bing Yang Weirong Gui Man Ke Anding Xu Zefeng Tan Department of Neurology and Stroke Center the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Clinical Neuroscience Institute the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Neurology the First People’s Hospital of FoshanFoshanGuangdong ProvinceChina

Microvasculature of the retina is considered an alternative marker of cerebral vascular risk in healthy ***,the ability of retinal vasculature changes,specifically focusing on retinal vessel diameter,to predict the recurrence of cerebrovascular events in patients with ischemic stroke has not been determined *** previous studies have shown a link between retinal vessel diameter and recurrent cerebrovascular events,they have not incorporated this information into a predictive ***,this study aimed to investigate the relationship between retinal vessel diameter and subsequent cerebrovascular events in patients with acute ischemic ***,we sought to establish a predictive model by combining retinal veessel diameter with traditional risk *** performed a prospective observational study of 141 patients with acute ischemic stroke who were admitted to the First Affiliated Hospital of Jinan *** of these patients underwent digital retinal imaging within 72 hours of admission and were followed up for 3 *** found that,after adjusting for related risk factors,patients with acute ischemic stroke with mean arteriolar diameter within 0.5-1.0 disc diameters of the disc margin(MAD_(0.5-1.0DD))of≥74.14μm and mean venular diameter within 0.5-1.0 disc diameters of the disc margin(MVD_(0.5-1.0DD))of≥83.91μm tended to experience recurrent cerebrovascular *** established three multivariate Cox proportional hazard regression models:model 1 included traditional risk factors,model 2 added MAD_(0.5-1.0DD)to model 1,and model 3 added MVD0.5-1.0DD to model *** 3 had the greatest potential to predict subsequent cerebrovascular events,followed by model 2,and finally model *** findings indicate that combining retinal venular or arteriolar diameter with traditional risk factors could improve the prediction of recurrent cerebrovascular events in patients with acute ischemic stroke,and that retinal imaging c

关键词： acute ischemic stroke arteriolar cerebrovascular events diameter digital retinal imaging microvasculature prediction recurrent retina venular

In-situ defect passivation assisted three-step printing of efficient and stable formamidine-lead bromide solar cells

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Journal of Energy Chemistry 2024年第9期96卷 396-405页

作者： Hang Yang Tao Zhou Haoyu Cai Wenjian Shen Hao Chen Yongjun Liu Juan zhao Yi-bing Cheng Jie Zhong State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan 528216GuangdongChina School of Automobile Engineering Wuhan University of TechnologyWuhan 430070HubeiChina

Perovskite solar cells(PSCs)emerge as the most promising photovoltaics(PV)for their high performance and potential convenient cost-effective production routes comparing to the sophomore PV *** printed PSCs with simplified device architecture and fabrication procedures could further enhance the competitive strength of PSC *** this work,we present an in-situ defect passivation(ISDP)assisted full-printing of high performance formamidine-lead bromide(FAPbBr_(3))*** three rapid printing steps are involved for electron transporting layer(ETL),perovskite and carbon to form a complete solar cell on the low-cost fluorine-doped tin oxide(FTO)***-chain polymer monomethyl ether polyethylene glycol is particularly utilized as the ISDP passivator,leading to conformal coating on the rough FTO and defect passivation for both ETL and perovskite during printing.A high efficiency of 10.85%(certified 10.14%)and a high V_(oc)up to 1.57 V are achieved for the printed *** unencapsulated PSCs maintain above 90%of the initial efficiency after continuously heating at 85℃for 1000 h and over 80%of the efficiency after the maximum power point tracking for 3500 *** fully printed semitransparent PSCs with carbon grids(CGs)show average visible light transmittance over 33%and an efficiency of 8.81%.

关键词： Formamidinium lead bromide Fully printed Lowcosts Carbon electrode Semitransparent