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Status of aquatic organisms resources and their environments in Yangtze River system(2.1.-2.2.)⋆

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Aquaculture and Fisheries 2024年第5期9卷 833-850页

作者： Haile Yang li Shen Yongfeng He Huiwu Tian Lei Gao Jinming Wu Zhigang Mei Nian Wei lin Wang Tingbing Zhu Feifei Hu Jinling Gong Hongchun Du Xinbin Duan Huatang Deng Daoqun Wang Fengyue Zhu Yunfeng li Fan Wu Huijun Ru Yan Zhang Junyi li Junlin Yang Yuntao Zhou Dongdong Fang Yinping Wang Danqing lin Yanping Yang Peijie li Silei liu Jian Yang Ping Zhuang Sikai Wang Tao Zhang Gang Yang Wenbo Yang lilai Yuan kun Cao Shuo Xu Huiyuan liu Zhiqiang liang Chongrui Wang Hong li Xiping Yuan Xin Yang Yilong Fu Yanping Zhang Haixin Zhang Zhiying Tao Sheng Wang Xiaoping Gao Binsong Jin Kemao li Guojie Wang Shenglong Jian Yingqin li Chenjiang Xue Chunyun Lei Shaowei Xue Yi sun Bin Zhu Ke Shao Xingkun Hu Meihua Xiong Jun Du Bin He Tao Yan Yingying Huang Yuanchao Zou Biwen Xie Yongming Wang Bin li Fei liu Yaoyao Zhang Fei Fan Zhijian Wang Jing Huang Haoran Gu Hailong Ge Yan Dan Yan li Shuqiao Wang Chuang Zhang Lu Zhou Xue Wang Sheng Zeng Yan Xiang Xugang He Jianhui Qin Chengxing Xia Jie Hou Yifu Shi lifang Gao Zhiqiang Zhu Hongbao Shen Yun Du Xuejun Duan Jiawu Xiong Deguo Yang Shaoping liu zhaohui Ni Hui Zhang Kai liu Feng zhao Yingren li Jianwei Wang Qiwei Wei Yangtze River Fisheries Research Institute Chinese Academy of Fishery SciencesWuhan430223China Institute of Hydrobiology Chinese Academy of SciencesWuhan430072China Fishery Resource and Environment Research Center Chinese Academy of Fishery SciencesBeijing100141China Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization Ministry of Agriculture and Rural AffairsFreshwater Fisheries Research CenterChinese Academy of Fishery SciencesWuxi214081China East china Sea Fisheries Research Institute Chinese Academy of Fishery SciencesShanghai200090China Institute of Fisheries Engineering Chinese Academy of Fishery SciencesBeijing100141China Hunan Fisheries Science Institute Changsha410153China Jiangxi Fisheries Research Institute Nanchang330039China Jiujiang Academy of Fishery Sciences Jiujiang332000China School of life Sciences Nanchang UniversityNanchang330031China Qinghai Provincial Fishery Technology Extension Center Xining810012China Yunnan Academy of Fishery Sciences Kunming650111China Institute of Hydroecology Ministry of Water Resources and Chinese Academy of SciencesWuhan430079China Fisheries Institute Sichuan Academy of Agricultural SciencesChengdu611731China School of life Sciences Neijiang Normal UniversityNeijiang641100China School of life Sciences Southwest UniversityChongqing400715China Chongqing Fishery Sciences Research Institute Chongqing401120China Guizhou Fisheries Research Institute Guiyang550025China College of Fisheries Huazhong Agricultural UniversityWuhan430072China Hubei Fisheries Science Research Institute Wuhan430070China Shaanxi Fisheries Research Institute Xi’an710086China Innovation Academy for Precision Measurement Science and Technology Chinese Academy of SciencesWuhan430077China Nanjing Institute of Geography and limnology Chinese Academy of SciencesNanjing210008China Central South Inventory and Planning Institute of State Forestry and Grassland Administration Changsha410014China

The Yangtze River is the mother river of *** promote the aquatic ecosystem protection of the great river,the Project of Yangtze Fisheries Resources and Environment Investigation(2.1.-2.2.)supported by the Ministry of Agriculture and Rural Affairs,*** carried out by 2. institutes and universities that located in the Yangtze River basin surveys the status of(1.fish species composition and spatial distribution,(2.current fish abundance,(3)endangered fishes,(4)Yangtze finless porpoise,(5)aquatic eco-environments,(6)water-level fluctuation areas,(7)capture fisheries and recreational fisheries of the Yangtze River mainstream and 1. of its main tributaries,including Yalong River,Heng River,Min River(including Dadu River),Chishui River,Tuo River,Jialing River,Wu River,Han River,Dongting Lake and Poyang *** results showed that there were 443 fish species(belonging to 1.3 genus,37 families,and 1. orders)before 2.1.,but only 32. fish species(including 1. new recorded exotic species)were recorded in the project of *** them,Cyprinus carpio,Carassius auratus,Hypophthalmichthys molitrix,Pelteobagrus fulvidraco,Coilia brachygnathus,Silurus asotus,Saurogobio dabryi,Ctenopharyngodon idellus,Pelteobagrus nitidus,Hemiculter leucisculus,Siniperca chuatsi,Coreius heterodon,Culter alburnus,Parabramis pekinensis,and Aristichthys nobilis were the dominant species across the whole Yangtze River *** is estimated that there were 886 million individuals weighing 1.0}.8 million kg,merely equivalent to 2..3%of the resources in 1.50s,30.9%of the resources in 1.60s,or 58.7%of the resources in *** the new list of protected fishes that recorded in the Yangtze River system,only 1. of 2. were collected in this project of *** gladius has been affirmed to be Extinct by International Union for Conservation of Nature(IUCN).The wild individuals of Tenualosa reevesii and Luciobrama macrocephalus have disappeared for many years and maybe have been extinct

关键词： Fishes Yangtze finless porpoise Resources Aquatic ecosystem Fisheries Background investigation Yangtze river system

气相中Fe^(2.)和H_2._2.用生成OH自由基的理论研究

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化学学报 2003年第12期61卷 1934-1938页

作者：赵红梅孙成科刘鲲李宗和北京师范大学化学系

利用B3LYP方法 ,在 6 3 1.G 基组下研究了气相中Fe2.+与H2.O2.作用生成OH自由基的反应途径 ,探讨了铁离子对生成羟基自由基所起的作用 .结果表明反应的途径为 :Fe2.+与H2.O2.首先形成中间体 (FeO2.H2.) 2.+,然后通过O—O键的断裂生成... 详细信息

利用B3LYP方法 ,在 6 3 1.G 基组下研究了气相中Fe2.+与H2.O2.作用生成OH自由基的反应途径 ,探讨了铁离子对生成羟基自由基所起的作用 .结果表明反应的途径为 :Fe2.+与H2.O2.首先形成中间体 (FeO2.H2.) 2.+,然后通过O—O键的断裂生成中间体 (HOFeOH) 2.+,再断Fe—OH键生成羟基自由基 .Fe2.+和H2.O2.的电荷强烈相互作用以及Fe2.+的d轨道上的电子促进H2.O2.中的O—O键断裂。

关键词：过氧化氢 Fe^2. OH自由基气相自由基反应铁离子羟基自由基

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植物耐盐机制研究进展及展望

华北农学报 2024年第5期39卷 80-92页

作者：王大江刘昭路翔高源孙思邈郭含欣田雯王霖李子琛李连文王昆刘继红中国农业科学院果树研究所农业农村部园艺作物种质资源利用重点实验室辽宁兴城125100 石河子大学农学院特色果树栽培生理与种质资源利用兵团重点实验室新疆石河子832000 华中农业大学园林学院果蔬园艺作物种质创新与利用全国重点实验室湖北武汉430070 国家盐碱地综合利用技术创新中心山东东营257000

植物的生长和生产面临各种生物和非生物胁迫,其中盐胁迫严重影响植物的正常生长发育、品质和产量形成。植物在长期的演化过程中,进化出了适应盐胁迫的形态结构、生理生化反应和遗传基础。在形态结构上,耐盐植物的叶片具有蜡质层、气孔... 详细信息

植物的生长和生产面临各种生物和非生物胁迫,其中盐胁迫严重影响植物的正常生长发育、品质和产量形成。植物在长期的演化过程中,进化出了适应盐胁迫的形态结构、生理生化反应和遗传基础。在形态结构上,耐盐植物的叶片具有蜡质层、气孔密度低于盐敏感植物,另外具有泌盐或者阻断功能的盐腺、毛状体、盐囊泡、凯氏带等结构;在生理活动调节方面,一方面耐盐植物具有高的酶促和非酶促抗氧化物质,如SOD、CAT、酚类物质等,另一方面耐盐植物具有较高的渗透调节物质含量,或者在盐胁迫下可以合成渗透调节物质,包括有机物质可溶性蛋白和糖以及无机盐离子等;在分子机理方面,SOS途径是研究得最为清晰的离子调控途径,通过SOS1.SOS2.SOS3协同作用维持细胞内Na^(+)/K^(+)平衡;此外,植物激素及碳代谢途径在植物耐盐过程中亦具有重要作用。本研究通过综述植物耐盐研究进展,探讨耐盐植物在形态结构、生理基础、遗传分子基础和转基因手段在响应盐胁迫的潜在研究重点和方向,有助于研究人员快速找到切入点,逐步完善植物的耐盐机理体系,加快耐盐植物的高效利用。

关键词：植物耐盐抗氧化渗透调控离子毒害

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing beijing Computational Science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research Institute Co. LtdBeijing beijing Institute of Technology Beijing beijing {1. {2. Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china {1. {2. WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Ji{1.ang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china {1. of Geosciences Beijing china {1. of Geosciences WuhanHubei china {1. of Mining and Technology XuzhouJiangsu china West {1. {2. NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu {1. DalianLiaoning Dalian {1. of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china {1. Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by{1.,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1.GeV Damping Ring,a Booster capable of achieving energies up to 1.0 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 1.0 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×1.^(34)cm^(-2.s^(-1.per interaction point(IP),resulting in an integrated luminosity of 1. ab^(-1.for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.1.)and the Conceptual Design Report(CDR,2.1.),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

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异氰酸光解的动态学研究

化学学报 2002年第4期60卷 600-605页

作者：赵丽刘鲲戴年珍李宗和北京师范大学化学系北京100875

在异氰酸光解势能面研究的基础上 ,计算了不同电子态势能面交叉点S1.T1.S1.T1.态 -态积累跃迁速率kS1.→T1.,S1.S0 处S1.S0 的跃迁速率kS1.→S0 ,结果表明 ,在交叉点处态 -态跃迁速率非常大 ,可以认为高能态在交叉点可以直接跃迁到... 详细信息

在异氰酸光解势能面研究的基础上 ,计算了不同电子态势能面交叉点S1.T1.S1.T1.态 -态积累跃迁速率kS1.→T1.,S1.S0 处S1.S0 的跃迁速率kS1.→S0 ,结果表明 ,在交叉点处态 -态跃迁速率非常大 ,可以认为高能态在交叉点可以直接跃迁到低能态 .据此我们又根据单分子微正则过渡态理论计算了不同光解波长下S1.和T1.的光解反应速率k反S1.(E)和kT1.(E)和S1.反 -顺异构化的反应速率 .在光解波长为 2.30nm时 ,kT1./kS1.=9 4 8,与实验值为 5相接近 ;在低能时kT1.>k反S1.,获得了和实验相一致的结果 .

关键词：异氰酸光解动态学研究态-态积累跃迁几率光解反应速率异氰酸

Azvudine is a thymus-homing anti-SARS-CoV-2.drug effective in treating COVID-1. patients

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Signal Transduction and Targeted Therapy 2022年第1期7卷 228-242页

作者： Jin-Lan Zhang Yu-Huan li Lu-Lu Wang Hong-Qi liu Shuai-Yao Lu Yong liu Ke li Bin liu Su-Yun li Feng-Min Shao kun Wang Ning Sheng Rui li Jin-Jin Cui Pei-Chun sun Chun-Xia Ma Bo Zhu Zhe Wang Yuan-Hao Wan Shi-Shan Yu Yongsheng Che Chao-Yang Wang Chen Wang Qiangqian Zhang li-Min zhao Xiao-Zhong Peng Zhenshun Cheng Jun-Biao Chang Jian-Dong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Institute of Medical Biology Chinese Academy of Medical Science and Peking Union Medical CollegeKunming 650031 YunnanChina Genuine Biotech.Inc. Pingdingshan 467000 HenanChina Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan Research Center for Infectious Diseases and CancerWuhan 430071 HubeiChina The First Affiliated Hospital of Henan {1. of Chinese Medicine Zhengzhou 450000 HenanChina Department of Internal Medicine Henan Provincial Peoples HospitalZhengzhou 450003 HenanChina Henan Key Laboratory of Organic Functional Molecule and Drug Innovation School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007 HenanChina National Clinical Research Center for Respiratory Diseases Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100005China School of chemistry Zhengzhou UniversityZhengzhou 450001 HenanChina

Azvudine(FNC)is a nucleoside analog that inhibits HIV-1.RNA-dependent RNA polymerase(RdRp).Recently,we discovered FNC an agent against SARS-CoV-2.and have taken it into Phase III trial for COVID-1. *** monophosphate analog inhibited SARS-CoV-2.and HCoV-OC43 coronavirus with an EC_(50) between 1.2.and 4.3 μM,depending on viruses or cells,and selective index(SI)in 1.-83 *** administration of FNC in rats revealed a substantial thymus-homing feature,with FNC triphosphate(the active form)concentrated in the thymus and peripheral blood mononuclear cells(PBMC).Treating SARS-CoV-2.infected rhesus macaques with FNC(0.07 mg/kg, qd,orally)reduced viral load,recuperated the thymus,improved lymphocyte profiles,alleviated in flammation and orga n damage,and lessened grou nd・glass opacities in chest *** gle-cell seque ncing suggested the promotion of thymus function by FNC.A randomized,single-arm clinical trial of FNC on compassionate use(n=31.showed that oral FNC(5 mg,qd)cured all COVID-1. patients,with 1.0%viral ribonucleic acid negative conversion in 3.2.±2.2. days(range:1.9 days)and 1.0%hospital discharge rate in 9.00±4.93 days(range:2.2. days).The side-effect of FNC is minor and transient dizziness and nausea in 1..1.0}(5/31.***,FNC might cure COVID-1. through its anti-SARS-CoV-2.activity concentrated in the thymus,followed by promoted immunity.

关键词： patients inhibited concentrated

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心绞痛牵涉痛与穴位敏化的关系

针刺研究 2018年第5期43卷 277-284页

作者：施静王健王渊刘坤付勇孙建华赵吉平邵晓梅冯斯峰杨有为李杰曹乾安何勋刘梅芳陈璐崔翔吴江昀吴媛媛高昕妍朱兵云南省中医医院针灸科昆明650000 山东中医药大学针灸推拿学院济南250355 陕西中医药大学针药结合创新研究中心陕西咸阳712046 中国中医科学院针灸研究所北京100700 江西中医药大学附属医院针灸一科南昌330006 江苏省中医院针灸康复科南京210029 北京中医药大学东直门医院针灸科北京100700 浙江中医药大学第三医院杭州310053

目的:观察冠心病稳定型心绞痛牵涉痛分布区域与穴位的关系,并结合动物实验探讨局部敏化出现的规律。方法:临床研究部分,观察1.046例冠心病稳定型心绞痛患者外周压痛敏感部位、局部皮肤形态异常改变,并测量了77位患者疼痛阈值的变化。动... 详细信息

目的:观察冠心病稳定型心绞痛牵涉痛分布区域与穴位的关系,并结合动物实验探讨局部敏化出现的规律。方法:临床研究部分,观察1.046例冠心病稳定型心绞痛患者外周压痛敏感部位、局部皮肤形态异常改变,并测量了77位患者疼痛阈值的变化。动物实验部分,以SD大鼠冠状动脉左前降支结扎4h为心肌缺血模型组(n=1.),以假手术为对照组(n=4),分别用在自然光下拍摄观察和活体荧光成像的方法,记录大鼠尾静脉注射Evans Blue后体表出现蓝染的部位,并检测痛阈变化。结果:心绞痛患者压痛部位以及皮肤局部组织结构的改变多分布在左侧胸前区、背部、肩部、上肢尺侧部;右侧也有一定数量的分布。压痛点出现在穴位上、穴位附近和穴位以外。心肌缺血的大鼠模型出现类似的变化。结论:心脏发生缺血性病变时,其相应节段(T 1.T 5)神经支配皮节区域发生规律性的牵涉性的"敏化"反应,这些敏感度改变的部位与"穴位"形成有关。

关键词：心绞痛牵涉痛穴位敏化机械痛阈

The short-term efficacy of icotinib on the treatment of advanced non-small-cell lung cancer

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The Chinese-German Journal of Clinical Oncology 2014年第1期13卷 1-5页

作者： Jianing Jiang Cong liu {1. Deng Jinbo {2. Man li Jinghua sun li li liying Ban Xiuhua sun Oncology Department of The Second Hospital of Dalian Medical {1. Oncology Department of Lvshunkouqu People's Hospital of Dalian Oncology Department of The First Hospital of Dalian Medical {1.

Objective： The aim of the study was, （1. to observe the short-term efficacy and adverse reactions of icotinib hydrochloride on the treatment of advanced non-small cell lung cancer （NSCLC）; （2. to explore whether there is difference in the efficacy of icotinib hydrochloride among the subgroups of sex, age, smoking history, classification of CEA, histological type, multi-{1.ne treatment and PS score. Methods： The study was conducted to collect 1.8 patients taking icotinib hydrochloride with advanced non-small cell lung cancer in hospitals of Da{1.an （china） from September 1.t 2.1. to June 1.th 2.1.0} All patients had taken icotinib hydrochloride （1.0} mg three times a day） until the disease was progressed or the adverse reactions could not be tolerated. During the period of taking it, other anti-tumor treatments were forbidden. We observed the symptoms, such as cough, short breath, hemoptysis, pain. The objective efficacy was evaluated by RECIST criteria, and the adverse reactions related to the treatment was assessed on the basis of NCl-CTC 3.0. Results： Of all patients, CR was 1.（0.7%）, PR was 59 （42.8%）, SD was 37 （2..8%）, PD was 41.（2..7%）. And ORR was 43.5% （60/1.8）, DCR 70.3% （97/1.8）. The DCR of females was 83.5% （71.85） versus 49.1. （2./53） of males. The difference of ORR and DCR between the two subgroups had statistical significance （X2.= 8.065, P = 0.05; X2.= 1..577, P = 0.000）. The difference of ORR and DCR between the subgroups of patients after or before 70 years old had no statistical significance. The difference of ORR and DCR between the subgroups of smoking and non-smoking had statistical significance （X2.= 8.492. X2.= 1..602.. The difference of ORR and DCR between the CEA subgroups had statistical significance （X2.= 1..1.1. X2.= 1..1.0）, showed 81.patients with abnormal CEA before the treatment with ORR 56.8.0% （46/81., DCR 81.5% （66/81.; 57 patients of normal CEA before the treatment with ORR 2..6% （1./57）, DCR 52.6% （30/57）. The 36 patients （2..1.） usi

关键词： non-small-cell lung cancer (NSCLC) icotinib hydrochloride efficacy

Electron-ion collider in{1.

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Frontiers of physics 2021年第6期16卷 1-78页

作者： Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin li Hengne li Minxiang li Xueqian li Yutie liang Zuotang liang Chen liu Chuan liu Guoming liu Jie liu liuming liu Xiang liu Tianbo liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei zhao Kuang-Ta Chao Qiang zhao Yuxiang zhao Zhengguo zhao liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou liping Zou Guangdong Provincial Key Laboratory of Nuclear Science Institute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China IRFU CEAUniversitéParis-SaclayF-91191 Gif-sur-YvetteFrance Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China university of Chinese Academy of Sciences Beijing 100049China Nankai university Tianjin 300071China Xinyang normal {1. Xinyang 464000China School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China Hunan university Changsha 410082China Nanjing university Nanjing 210093China Huazhong university of Science and Technology Wuhan 430074China European Centre for Theoretical Studies in Nuclear Physics and Related Areas(ECT*)and Fondazione Bruno Kessler Villa TambosiStrada delle Tabarelle 286I-38123 Villazzano(TN)Italy School of Physics Peking UniversityBeijing 100871China Hunan normal {1. Changsha 410081China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Nanjing normal {1. Nanjing 210023China Department of Physics College of SciencesNortheastern UniversityShenyang 110819China Southwest Jiaotong university Chengdu 610000China Department of Physics Faculty of ScienceUniversity of ZagrebBijenička c.3210000 ZagrebCroatia Bogoliubov Laboratory of Theoretical Physics Joint Institute for Nuclear ResearchDubna 141980Russia School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Lanzhou university Lanzhou 730000China Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityQingdao 266237China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China School of Physics Southeast UniversityNanjing 211189China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Depa

Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as *** a future high energy nuclear physics project,an Electron-ion collider in china(EicC)has been *** will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron *** proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 1. to 2. GeV and the luminosity of(2.3)×1.33 cm^(−2.·s^(−1..Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the *** main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark *** addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the *** order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge *** document is the result of collective contributions and valuable inputs from experts across the *** EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United *** success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in china.

关键词： electron ion collider nucleon structure nucleon mass exotic hadronic states quantum chromodynamics 3D-tomography helicity transverse momentum dependent parton distribution generalized parton distribution energy recovery linac polarization spin rotator