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Effects of Quantum Interference on the Profile of Excitation Spectra in the Atomic Sodium D1

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Chinese Journal of Lasers 2002年第1期11卷 15-19页

作者： li Yongfang 1,2 zhang xiangyang 2 sun Jianfeng 2 zhang Yanliang 3.{3. Yongmei 3.WANG Yongchang 1 DING liang’en 3.WANG Zugeng 3.( 1Institute of Modern Physics, department of Applied Physics, xi’an Jiaotong {3., xi’an 710049 Institute of Modern Physics Department of Applied Physics Xi'an Jiaotong University Xi'an 710049 College of Physical and Information Technology Shaanxi Normal University Xi'an 710062 Joint Lab. for Quantum Optics Shanghai Institute of Optics and Fine Mechanics and East China Normal University Lab. for Quantum Optics National Education Commission 上海 200062 Joint Lab. for Quantum Optics Shanghai Institute of Optics and Fine Mechanics and East China Normal University Lab. for Quantum Optics National Education Commission 上海 200062

In this paper, an experiment in a sodium vapor cell with cw laser pumping is reported. Two dips in the excitation spectrum profile of the sodium D 1.line are observed. Theoretically excitation spectra in the three-level system are calculated in detail and results are identical with experiments. It is demonstrated that the appearance of the two dips in the excitation spectrum is close connected with quantum interference effect.

关键词： atomic sodium excitation spectrum profile quantum interference effects

Genome assembly of autotetraploid Actinidia arguta highlights adaptive evolution and enables dissection of important economic traits

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Plant Communications 2024年第6期5卷 173-192页

作者： Xue-Mei Lu xiao-Fen Yu Guo-Qiang li Ming-Hao Qu Huan Wang Chuang liu Yu-Ping Man xiao-Han Jiang Mu-Zi li Jian Wang Qi-Qi Chen Rui Lei Cheng-Cheng zhao Yun-Qiu Zhou Zheng-Wang Jiang Zuo-Zhou li Shang Zheng Chang Dong Bai-lin Wang Yan-xiang sun Hui-Qin zhang Jie-Wei li Quan-Hui Mo Ying zhang xin Lou Hai-Xu Peng Ya-Ting Yi He-xin Wang xiu-Jun zhang Yi-Bo Wang Dan Wang li li Qiong zhang Wen-xia Wang Yongbo liu Lei Gao Jin-Hu Wu Yan-Chang Wang CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubeiChina Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhouGansuChina College of life Sciences University of Chinese Academy of SciencesBeijingChina Wuhan Frasergen Bioinformatics Co. LtdWuhanHubeiChina Institute of Soil and Fertilizer Anhui Academy of Agricultural SciencesHefeiChina College of Agricultural Sciences Xichang UniversityXichangSichuanChina department of Horticulture Heilongjiang Academy of Agricultural SciencesHarbinHeilongjiangChina College of life Sciences Langfang Normal UniversityLangfangHebeiChina Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiangChina Guangxi Institute of Botany Chinese Academy of SciencesGuilinGuangxiChina xi’an Botanical Garden of Shaanxi Province Institute of Botany of Shaanxi ProvinceXi’anShaanxiChina Institute of Modern Agricultural Research Dalian UniversityDalianLiaoningChina Bioinformatics Center College of Plant Science and TechnologyBeijing University of AgricultureBeijingChina College of Agriculture Eastern Liaoning UniversityDandongLiaoningChina Dalian Institute of Chemical Physics Chinese Academy of SciencesDalianLiaoningChina State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijingChina Hubei Hongshan Laboratory WuhanHubeiChina The New Zealand Institute for Plant and Food Research limited AucklandNew Zealand

Actinidia arguta,the most widely distributed Actinidia species and the second cultivated species in the genus,can be distinguished from the currently cultivated Actinidia chinensis on the basis of its small and smooth fruit,rapid softening,and excellent cold *** evolution of tetraploid Actinidia species and the genetic basis of their important agronomic traits are still ***,we generated a chromosome-scale genome assembly of an autotetraploid male *** *** genome assembly was 2.77 Gb in length with a contig N50 of 9.97 Mb and was anchored onto 1.6 *** and clustering of 1.1.geographically representative accessions showed that they could be divided into two geographic groups,Southern and Northern,which first diverged 1..9 million years *** underwent two prominent expansions and one demographic bottleneck from the midPleistocene climate transition to the late *** genomics studies using paleoclimate data enabled us to discern the evolution of the species’adaptation to different historical *** genes(AaCEL1.AaPME1.and AaDOF1.related to flesh softening were identified by multi-omics analysis,and their ability to accelerate flesh softening was verified through transient expression assays.A set of genes that characteristically regulate sexual dimorphism located on the sex chromosome(Chr3.or autosomal chromosomes showed biased expression during stamen or carpel *** chromosome-level assembly of the autotetraploid *** genome and the genes related to important agronomic traits will facilitate future functional genomics research and improvement of ***.

关键词： kiwiberry dioecism adaptive evolution paleoclimate GEA rapid softening

Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1. experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao zhang Jun-Zheng Wang {1.-Tao Yang Qian Yue Ke-Jun Kang Yuan-Jing {1. Hai-Peng An C.Greeshma Jian-Ping Chang Yun-Huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-Yuan Guo {1. He Sheng-Ming He Jin-Wei Hu Han-xiong Huang Tu-Chen Huang Hai-Tao Jia xi Jiang S.Karmakar Hao-Bin {1. Jian-Min {1. Jin {1. Qian-Yun {1. Ren-Ming-Jie {1. Xue-Qian {1. Yu-Lan {1. Yi-Fan {1.ang Bin {1.ao Fong-Kay {1.n Shin-Ted {1.n Jia-Xuan {1.u Shu-Kui {1.u Yan-Dong {1.u Yu {1.u Yuan-Yuan {1.u Zhong-Zhi {1.u Hao Ma Yu-Cai Mao Qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren xi-Chao Ruan Ze She Manoj Kumar Singh Tian-xi sun Chang-Jian Tang Wei-You Tang Yang Tian Guang-Fu Wang {1. Wang Qing Wang Yu-Feng Wang Yun-xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu Hao-Yang xing Rui Xu Yin Xu Tao Xue Yu-Lu Yan Nan Yi Chun-Xu Yu Hai-Jun Yu Jian-Feng Yue Ming Zeng Zhi Zeng Feng-Shou zhang Lei zhang Zhen-Hua zhang Zhen-Yu zhang Kang-Kang zhao Ming-Gang zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and department of Engineering Physics Tsinghua UniversityBeijing 100084 department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 department of Physics Banaras Hindu UniversityVaranasi 221005 department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1.,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3.days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3.kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1.89–2089 keV for this work)with a factor of 23.A background level of 0.3. counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1.2)^(0ν)>1.0×1.^(23.yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Phi{1.p Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Big{1.etti Shalva Bilanishvi{1. Deng Bing{1.n Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapag{1.a Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Ca{1.bbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Ma{1. Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen xiang Chen xiaoyu Chen xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Ze{1.n Chen Zi{1.n Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Zi{1.ang Chu Gug{1.elmo Coloretti Andreas Crivel{1.n Hanhua Cui xiaohao Cui {21.yuan Cui Brunella D'Anzi {1.ng-Yun Dai xinchen Dai Xuwen Dai Antonio De Maria Nicola De Fi{1.ppis Christophe De La Taille Francesca De Mori Chiara De Sio E{1.sa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics {1. Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing beijing Computational Science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research Institute Co. LtdBeijing beijing Institute of Technology Beijing beijing {1. university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China normal {1. WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang {1. HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China university of Geosciences Beijing China university of Geosciences WuhanHubei China university of Mining and Technology XuzhouJiangsu China West normal {1. NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu {1. DalianLiaoning Dalian {1. of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a {1. GeV linac,a 1.1.GeV Damping Ring,a Booster capable of achieving energies up to 1.0 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 1.0 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of {1. MW per beam,it can achieve a luminosity of 5×1.^({1.)cm^(-2)s^(-1.per interaction point(IP),resulting in an integrated luminosity of 1.1.ab^(-1.for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.{1.million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,201.)and the Conceptual Design Report(CDR,201.),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-20{1.s.

关键词： initiated exceeding precise

PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1.mediated cell metabolism

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Acta Pharmaceutica Sinica B 2023年第1期13卷 157-173页

作者： Mingming sun Leilei {1. Yujia Niu Yingzhi Wang Qi Yan Fei xie Yaya Qiao Jiaqi Song Huanran sun Zhen {1. Sizhen Lai Hongkai Chang Han zhang Jiyan Wang Chenxin Yang Huifang {3. Junzhen Tan Yanping {1. Shuangping {1.u Bin Lu Min {1.u Guangyao Kong Yujun {3. Chunze zhang Shu-Hai {1.n Cheng Luo Shuai zhang Chang{1.ang Shan State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300350China Biomedical Translational Research Institute Jinan UniversityGuangzhou 510632China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen 361102China School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China department of Pathology and Institute of Precision Medicine Jining Medical UniversityJining 272067China department of Pathology Medical SchoolDalian UniversityDalian 116622China department of Bio{1. and Molecular Biology School of Basic Medical SciencesHengyang Medical SchoolUniversity of South ChinaHengyang 421001China School of Laboratory Medicine and life Sciences Wenzhou Medical UniversityWenzhou 325035China Institute of Biomedical Sciences Shandong Provincial Key Laboratory of Animal Resistance BiologyCollaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy the Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China department of Colorectal Surgery Tianjin Union Medical Center Nankai UniversityTianjin 300121China

Metabolic reprogramming is a hallmark of cancer,including lung ***,the exact underlying mechanism and therapeutic potential are largely *** we report that protein arginine methyltransferase 6(PRMT6)is highly expressed in lung cancer and is required for cell metabolism,tumorigenicity,and cisplatin response of lung ***6 regulated the oxidative pentose phosphate pathway(PPP)flux and glycolysis pathway in human lung cancer by increasing the activity of 6-phosphogluconate dehydrogenase(6PGD)and a-enolase(ENO1..Furthermore,PRMT6 methylated R3.4 of 6PGD to enhancing its activity;while methylation at R9 and R3.2 of ENO1.promotes formation of active ENO1.dimers and 2-phosphoglycerate(2-PG)binding to ENO1.***,targeting PRMT6 blocked the oxidative PPP flux,glycolysis pathway,and tumor growth,as well as enhanced the antitumor effects of cisplatin in lung ***,this study demonstrates that PRMT6 acts as a posttranslational modification(PTM)regulator of glucose metabolism,which leads to the pathogenesis of lung *** was proven that the PRMT6-6PGD/ENO1.regulatory axis is an important determinant of carcinogenesis and may become a promising cancer therapeutic strategy.

关键词： Lung cancer Metabolic reprogramming Post-translational modification PRMT6 Pentose phosphate pathway flux Glycolysis 6-Phospho-gluconate dehydrogenase a-enolase ENO1

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生物钟在口腔医学研究中合理应用专家共识

实用口腔医学杂志 2024年第4期40卷 455-460页

作者：杨凯孙沫逸李龙江唐瞻贵任国欣郭伟祝颂松郑家伟张杰孙志军任杰郑佳雯吕晓强唐洪陈丹席庆黄欣武和明马洪尚伟孟箭李吉辰李春洁李一赵宁波谭雪梅杨轶昕吴亚东尹仕琳张志伟重庆医科大学附属第一医院口腔颌面外科 400016 口颌系统重建与再生全国重点实验室国家口腔疾病临床医学研究中心陕西省口腔疾病临床医学研究中心空军军医大学第三附属医院口腔颌面头颈肿瘤科四川大学华西口腔医学院头颈肿瘤外科中南大学湘雅口腔医学院口腔颌面外科上海交通大学医学院附属第九人民医院口腔医学院口腔颌面-头颈肿瘤科四川大学华西口腔医院正颌及关节外科北京大学口腔医学院口腔颌面外科武汉大学口腔医学院口腔颌面头颈肿瘤外科重庆医科大学附属第一医院口腔科中国人民解放军总医院第一医学中心口腔科首都医科大学附属北京口腔医院口腔颌面头颈肿瘤科南京医科大学附属口腔医院口腔颌面外科贵州医科大学附属口腔医院口腔颌面外科青岛大学附属医院口腔颌面外科徐州市中心医院口腔颌面外科哈尔滨医科大学附属第一医院口腔颌面外科西安交通大学口腔医院种植科德阳市人民医院口腔科昆明医科大学附属口腔医院云南省口腔医学重点实验室

机体生物钟(也称昼夜节律)是地球上所有生物体能适者生存在地球自转环境中的基础。昼夜节律是生命活动最基本的调控机制,在维持人体正常生理生化稳态、疾病发生及治疗中均扮演关键角色。研究表明,生物钟在口腔组织发育生长、口腔疾病发... 详细信息

机体生物钟(也称昼夜节律)是地球上所有生物体能适者生存在地球自转环境中的基础。昼夜节律是生命活动最基本的调控机制,在维持人体正常生理生化稳态、疾病发生及治疗中均扮演关键角色。研究表明,生物钟在口腔组织发育生长、口腔疾病发生及治疗中具有重要作用。由于目前还没有包括口腔医学在内的生物钟研究方法的指导性文献,研究者主要基于已发表的参考文献进行探讨,致使口腔医学中有关生物钟的研究方法存在争议,如何合理应用昼夜节律的研究方法还存在诸多困惑。该共识在总结生物钟的作用特点以及分析目前生物钟在口腔医学研究中不足的基础上,组织相关专家归纳推荐了生物钟在口腔医学研究中合理实施的1.条原则,为生物钟在口腔医学研究中的合理应用提供参考。

关键词：生物钟昼夜节律口腔医学医学专家共识

Evaluation of triage strategies for high-risk human papillomavirus-positive women in cervical cancer screening:A multicenter randomized controlled trial in different resource settings in China

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Chinese Journal of Cancer Research 2022年第5期34卷 496-509页

作者： Le Dang linghua Kong Yuqian {1. Yi Dai li Ma lihui Wei Shulan zhang Jihong liu Mingrong xi Long Chen xianzhi Duan Qing xiao Guzhalinuer Abulizi Guonan zhang Ying Hong Qi Zhou xing xie li li Mayinuer Niyazi Zhifen zhang Jiyu Tuo Yiling Ding Youlin Qiao Jinghe Lang department of Gynecology and Obstetrics Peking Union Medical College HospitalChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100730China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Center for Cancer Prevention Research Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041China department of Epidemiology Dalian Medical UniversityDalian 116044China department Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China department of Obstetrics and Gynecology Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China department of Gynecology and Obstetrics Sun Yat-sen University Cancer CenterGuangzhou 510060China department of Gynecology and Obstetrics West China Second University HospitalSichuan UniversityChengdu 610041China department of Gynecology and Obstetrics Zhejiang Xiaoshan Hospital Affiliated to Hangzhou Normal UniversityChinese Academy of Medical Sciences/Zhejiang Xiaoshan Hospital Affiliated to Hangzhou Normal UniversityHangzhou 310000China department of Obstetrics and Gynecology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China department of Gynecology and Obstetrics the Eight Affiliated Hospital Sun Yat-sen UniversityShenzhen 518000China 5th department of Gynecology the Affiliated Cancer Hospital of Xinjiang Medical UniversityUrumqi 830011China department of Gynecologic Oncology Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041China department of Gynecology and Obstetrics Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjing 210008China department of Gynecological Oncology Chongqing University Cancer Hospital/Chongqing Cancer HospitalCho

Objective:We aimed to evaluate the effectiveness of different triage strategies for high-risk human papillomavirus(hrHPV)-positive women in primary healthcare settings in ***:This study was undertaken in 1. rural and 9 urban *** aged 3.-64 years old were ***-positive women were randomly allocated to {1.quid-based cytology(LBC),visual inspection with acetic acid and Lugol’s iodine(VIA/VI{1.)(rural only)triage,or directly referred to colposcopy(direct COLP).At 24 months,hrHPV testing,LBC and VIA/VI{1. were conducted for combined ***:In rural sites,1.949 hrHPV-positive women were analyzed.A total of 852,21. and 480 women were randomly assigned to direct COLP,LBC and VIA/*** base{1.ne,colposcopy referral rates of LBC or VIA/VI{1. triage could be reduced by 70%-80%.LBC(n=3.and n=7)or VIA/VI{1.(n=8 and n=26)could significantly decrease the number of colposcopies needed to detect one cervical intraepithe{1.al neoplasia(CIN)2 or worse and CIN3.compared with direct COLP(n=1. and n=23..For the 24-month cumulative detection rate of CIN2+,VIA/VI{1. triage was 0.50-fold compared with LBC triage and 0.46-fold with the direct *** stratified by age,base{1.ne LBC triage+performed best(P1.,peaking among women aged 3.-44 years(Ptrend=0.002).In urban sites,1.728 women were hrHPV genotyping test positive.A total of 408,571.and 568women were randomly assigned to direct COLP for HPV1./1.+,direct COLP for other hrHPV subtypes+,and LBC triage for other hrHPV subtypes+.LBC(n=1. and n=3.)significantly decreased the number of colposcopies needed to detect one CIN2+and CIN3.compared with direct COLP(n=1. and n=44).HPV1./1.+increased the 24-month cumulative detection rate of CIN2+(1..89%,P1..Conclusions:LBC triage for hrHPV-positive women in rural settings and direct COLP for HPV1./1.+women and LBC triage for other hrHPV subtype+women in urban settings might be feasible strategies.

关键词： Cervical cancer screening hrHPV-positive LBC triage strategy VIA/VIli

陕产七叶一枝花对小鼠溃疡性结肠炎的治疗作用及机制实验研究

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陕西医学杂志 2024年第9期53卷 1161-1165页

作者：付静刘小婷孙婷赵景峰杨冰冰邱鹏程李捷张永强空军军医大学唐都医院药剂科陕西西安710038 西北大学生命科学与医学部陕西西安710127 空军军医大学化学制药学教研室陕西西安710032 空军军医大学中药与天然药物学教研室陕西西安710032

目的:探讨陕产七叶一枝花对小鼠溃疡性结肠炎的治疗作用,分析可能的机制。方法:利用葡聚糖硫酸钠(DSS)建立溃疡性结肠炎小鼠模型。将50只小鼠分为Con组、DSS组、陕产七叶一枝花低剂量组(L-RPTS+DSS组,干浸膏5 mg/kg)与高剂量组(H-RPTS+... 详细信息

目的:探讨陕产七叶一枝花对小鼠溃疡性结肠炎的治疗作用,分析可能的机制。方法:利用葡聚糖硫酸钠(DSS)建立溃疡性结肠炎小鼠模型。将50只小鼠分为Con组、DSS组、陕产七叶一枝花低剂量组(L-RPTS+DSS组,干浸膏5 mg/kg)与高剂量组(H-RPTS+DSS组,干浸膏1. mg/kg)、阳性对照5-氨基水杨酸组(5-ASA组,50 mg/kg),每组1.只。Con组自由饮用蒸馏水,其余各组小鼠自由饮用每日新鲜配制的3.DSS溶液,持续7 d;陕产七叶一枝花低、高剂量组及5-ASA组除自由饮用DSS溶液外,第1.开始通过灌胃给予不同剂量药物,持续1. d。每日观察小鼠生活状态并记录相应的疾病活动指数(DAI)评分。1. d后进行相关表型测定,酶联免疫吸附法(E{1.SA)检测小鼠结肠组织炎症因子肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-1.的水平变化;HE染色和透射电镜评估结肠组织病理学变化。最后采用Western blot检测TNF-α、IL-6、紧密连接闭合蛋白(Occludin)、Claudin-7蛋白表达水平。结果:与Con组比较,DSS组小鼠结肠组织出现严重溃疡反应,炎症细胞浸润,肠上皮细胞严重坏死,结肠组织炎症因子含量及TNF-α、IL-6蛋白表达升高,而Occludin、Claudin-7蛋白表达降低(均P<0.05)。与DSS组比较,L-RPTS+DSS与H-RPTS+DSS组及5-ASA组能够明显改善小鼠溃疡症状,其DAI评分降低(均P<0.05),炎症浸润现象减轻,炎症因子水平减少,肠道黏膜屏障损伤减轻。同时,陕产七叶一枝花给药组结肠组织TNF-α、IL-6蛋白表达降低,而Occludin、Claudin-7蛋白表达增加(均P<0.05)。H-RPTS+DSS组溃疡指标的改善优于L-RPTS+DSS(均P<0.05)。结论:陕产七叶一枝花能够改善DSS诱导的小鼠溃疡性结肠炎症状,其可能机制与调节炎症因子释放及调控肠道紧密连接蛋白、改善肠黏膜屏障损伤有关。

关键词：溃疡性结肠炎陕产七叶一枝花葡聚糖硫酸钠炎症因子肠黏膜屏障紧密连接蛋白

A Bayesian Stepwise Discriminant Model for Predicting Risk Factors of Preterm Premature Rupture of Membranes： A Case-control Study

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Chinese Medical Journal 2017年第20期130卷 2416-2422页

作者： li-{1.a zhang Yang sun Hai zhao Na Zhu {1.ng-De sun {1.ng Jin Ai-Min Zou Yang Mi Ji-Ru Xu department of Microbiology and Immunology Health Science Center Xi'an Jiaotong University Xi'an Shaanxi 710061 China Deparment of Clinical Laboratory Shaanxi Provincial People's Hospital Xi'an Shaanxi 710068 China department of Medical Statistics Shaanxi Provincial People's Hospital Xi'an Shaanxi 710068 China Deparment of Clinical Laboratory Xi'an Fourth Hospital Xi'an Shaanxi 710004 China Deparment of Clinical Laboratory Xi'an Gaoxin Hospital Xi'an Shaanxi 710075 China Deparment of Clinical Laboratory Chang'an Hospital Xi'an Shaanxi 710018 China department of Obstetrics and Gynecology The Northwest Women and Children Hospital Xi'an Shaanxi 710061 China

Background： Preterm premature rapture of membrane （PPROM） can lead to serious consequences such as intrauterine infection, prolapse of the umbilical cord, and neonatal respiratory distress syndrome. Genital infection is a very important risk which closely related with PPROM. The preliminary study only made qualitative research on genital infection, but there was no deep and clear judgment about the effects of pathogenic bacteria. This study was to analyze the association of in fections with PPROM in pregnant women in Shaanxi, China, and to establish Bayesian stepwise discriminant analysis to predict the incidence of PPROM. Methods： In training group, the 1.2 pregnant women with PPROM were enrolled in the case subgroup, and 1.8 normal pregnant women in the control subgroup using an unmatched case-control method. The sociodemographic characteristics of these participants were collected by face-to-face interviews. Vaginal excretions fiom each participant were sampled at 28 3.-6 weeks of pregnancy using a sterile swab. DNA corresponding to Chlamrdia trachomalix （CT）, Ureaplasma urealyticwn （UU）, Candida albicans, group B streptococci （GBS）, herpes simplex virus- 1.（HSV-1., and HSV-2 were detected in each participant by real-time polymerase chain reaction. A model of Bayesian discriminant analysis was established and then verified by a mull）center validation group that included 500 participants in the case subgroup and 5（1. participants in the control subgroup from five different hospitals in the Shaanxi province, respectively. Results： The sociological characteristics were not significantly different between the case and control subgroups in both training and validation groups （all P 〉 0.05）. In training group, the infection rates of UU （1..6% vs. 3.7%）, CT （1..0% vs. 5.6%）, and GBS （22.3. vs. 6.5%） showed statistically different between the case and control subgroups （all P 〈 0.05）, Iog-transfomacd quantification of UU, CE GBS, and HSV-2 showed statistically different

关键词： Bayesian Stepwise Discfiminant Analysis EtiologicalFactors Infection Preterm Premature Rupture of Membranes