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Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 765-780页

作者： Siqin He Lulu Wang Dongxu Wu Fan Tong Huan zhao Hanmei Li Tao gong Huile Gao Yang Zhou Key Laboratory of Tropical Biological Resources of ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China Key Laboratory of Drug-Targeting and Drug Delivery System West China School of PharmacySichuan UniversityChengdu 610041China Revvity Inc. WalthamMA 02451USA School of Food and Biological Engineering Chengdu UniversityChengdu 610106China

A major challenge facing photodynamic therapy(PDT) is that the activity of the immuneinduced infiltrating CD8^(+)T cells is subject to the regulatory T lymphocytes(Tregs), leaving the tumor at risk of recurrence and metastasis after the initial ablation. To augment the antitumor response and reprogram the immunosuppressive tumor microenvironment(TME), a supramolecular photodynamic nanoparticle(DACss) is constructed by the host-guest interaction between demethylcantharidin-conjugated β-cyclodextrin(DMC-CD) and amantadine-terminated disulfide-conjugated FFVLGGGC peptide with chlorin e6 decoration(Ad-ss-pep-Ce6) to achieve intelligent delivery of photosensitizer and immunomodulator for breast cancer treatment. The acid-labile β-carboxamide bond of DMC-CD is hydrolyzed in response to the acidic TME, resulting in the localized release of DMC and subsequent inhibition of *** guest molecule Ad-ss-pep-Ce6 can be cleaved by a high level of intracellular GSH, reducing photosensitizer toxicity and increasing photosensitizer retention in the tumor. With a significant increase in the CTL/Treg ratio, the combination of Ce6-based PDT and DMC-mediated immunomodulation adequately achieved spatiotemporal regulation and remodeling of the TME, as well as improved primary tumor and in situ lung metastasis suppression with the aid of PD-1 antibody.

关键词： Photodynamic therapy Immunosuppressive microenvironment Immunomodulator Dual-responsive Supramolecularassembly Checkpointblockade

Stackelberg Game-Based Optimal Dispatch for PEDF Park and Power Grid Interaction under Multiple Incentive Mechanisms

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Energy Engineering 2024年第10期121卷 3075-3093页

作者： Weidong Chen Yun zhao Xiaorui Wu Ziwen Cai min Guo Yuxin Lu Integrated Energy Research Institute Electric Power Research Institute of Guangxi Power Grid Co.Ltd.Nanning530023China Guangxi Key Laboratory of Intelligent Control and Maintenance of Power Equipment Nanning530023China Institute of Electricity Consumption and Measurement Technology CSG Electric Power Research InstituteGuangzhou510663China

The integration of photovoltaic,energy storage,direct current,and flexible load(PEDF)technologies in building power systems is an importantmeans to address the energy crisis and promote the development of green *** friendly interaction between the PEDF systems and the power grid can promote the utilization of renewable energy and enhance the stability of the power *** this purpose,this work introduces a framework of multiple incentive mechanisms for a PEDF park,a building energy system that implements PEDF *** incentive mechanisms proposed in this paper include both economic and noneconomic aspects,which is the most significant innovation of this *** modeling the relationship between a PEDF park and the power grid into a Stackelberg game,we demonstrate the effectiveness of these incentive measures in promoting the friendly interaction between the two *** this game model,the power grid determines on the prices of electricity trading and incentive subsidy,aiming to maximize its revenue while reducing the peak load of the PEDF *** the other hand,the PEDF park make its dispatch plan according to the prices established by the grid,in order to reduce electricity consumption expense,improve electricity utility,and enhance the penetration rate of renewable *** results show that the proposed incentive mechanisms for the PEDF park can help to optimize energy consumption and promote sustainable energy practices.

关键词： Demand response(DR) incentives photovoltaic energy storage direct current and flexible load(PEDF) reputation Stackelberg game

Disease Burden and Costs Associated with Multiple Sclerosis in China:A Cross-sectional Analysis of Nationwide Survey Data

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Neuroscience Bulletin 2024年第4期40卷 533-538页

作者： Yusheng Jia Xuanqi Qiao Jin zhao Hainan Li Shanlian Hu min Hu Department of Health Economics School of Public HealthFudan UniversityShanghai200032China National Health Commission Key Laboratory of Health Technology Assessment Fudan UniversityShanghai200032China

DearEditors,Multiple sclerosis(MS)is a chronic,autoimmune neurological disorder characterized by inflammatory demyelination of the central nervous system;it is associated with reduced mobility,cognitive impairment,and numerous comorbidities[1].Global MS incidence(2.1 per 100,000 person-years)and prevalence(30.1 per 100,000)have increased in recent years,and its prevalence is notably higher in Western countries,ranging from~30 to 200 cases per 100,000[2].In China,recent epidemiological research has shown that the crude prevalence was 2.44 per 100,000 in 2016[3],and the age-and sex-adjusted incidence was 0.235 per 100,000 person-years[4].Despite the relatively low prevalence compared with the global average,China has extensively addressed the well-being of over 30,000 MS patients,enrolling MS in China's First National List of Rare Diseases in 2018.

关键词： prevalence impairment autoimmune

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创新数量、创新质量与高技术产业出口

中国管理科学 2021年第2期29卷 61-68页

作者：赵公民俞立平戴化勇中北大学经济与管理学院山西太原030051 浙江工商大学统计与数学学院浙江杭州310018 湖北经济学院工商管理学院湖北武汉430205

中国已经成为创新大国,拥有较大规模的创新数量,但还不是创新强国,创新质量水平较低。在贸易保护主义日趋严重的今天,研究创新数量、创新质量与外贸出口的互动机制具有重要意义。本文基于高技术产业面板数据,采用面板数据模型、贝叶斯... 详细信息

中国已经成为创新大国,拥有较大规模的创新数量,但还不是创新强国,创新质量水平较低。在贸易保护主义日趋严重的今天,研究创新数量、创新质量与外贸出口的互动机制具有重要意义。本文基于高技术产业面板数据,采用面板数据模型、贝叶斯向量自回归模型分析了创新数量、创新质量与出口的互动关系。研究结果表明:创新数量与外贸出口之间呈现良性互动;创新质量与外贸出口互动作用较低;企业研发经费投入能有效地促进创新数量与创新质量的提升;政府研发经费投入不能有效地促进创新数量与创新质量的提升;创新数量、创新质量之间具有一定的良性互动关系。

关键词：创新数量创新质量外贸出口面板数据模型贝叶斯向量自回归

Event-triggered distributed cross-dimensional formation control for heterogeneous multi-agent systems

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Frontiers of Information Technology & Electronic Engineering 2024年第8期25卷 1123-1133页

作者： Huimin WEI Chen PENG min zhao School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444China School of Mathematics and Statistics Nantong UniversityNantong 226019China

This paper concerns the event-triggered distributed cross-dimensional formation control problem of heterogeneous multi-agent systems(HMASs)subject to limited network *** central aim is to design an effective distributed formation control scheme that will achieve the desired formation control objectives even in the presence of restricted ***,a multi-dimensional HMAS is first developed,where a group of agents are assigned to several subgroups based on their ***,to mitigate the excessive consumption of communication resources,a cross-dimensional event-triggered communication mechanism is designed to reduce the information interaction among agents with different *** the proposed event-based communication mechanism,the problem of HMAS cross-dimensional formation control is transformed into the asymptotic stability problem of a closed-loop error ***,several stability criteria for designing a cross-dimensional formation control protocol and communication schedule are presented in an environment where there is no information interaction among follower ***,a simulation case study is provided to validate the effectiveness of the proposed formation control protocol.

关键词： Heterogeneous multi-agent systems Formation control Cross-dimensional event-triggered mechanism

Superhydrophilic nickel hydroxide ultrathin nanosheets enable high-performance asymmetric supercapacitors

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Rare Metals 2024年第1期43卷 138-147页

作者： Yi-Ran Wang Fei Zhang Jian-min Gu Xiao-Yu zhao Ran zhao Xing Wang Tian-Hui Wu Jing Wang Ji-Dong Wang De-Song Wang State Key Laboratory of Metastable Materials Science and Technology(MMST) Hebei Key Laboratory of Applied ChemistryYanshan UniversityQinhuangdao 066004China Department of Food and Pharmaceutical Engineering Suihua UniversitySuihua 152000China School of Chemical Science and Engineering Tongji UniversityShanghai 200092China School of Sciences Hebei University of Science and TechnologyShijiazhuang 050018China

Superhydrophilic surfaces have been applied for supercapacitor;however,during energy storage reaction,how the wettability affects the process of electrochemical reaction specifically is still ***,we demonstrate superhydrophilic surface for promotion of electrochemical reactions by liquid affinity and further explain the mechanism,where the transition of the wettability state caused by the change in surface free energy is the main reason for the obvious increase in specific *** citric acid assistance strategy,an intrinsically hydrophobic Ni(OH)_(2)thick nanosheets(HNHTNs,16 nm)can be transitioned into superhydrophilic Ni(OH)_(2)ultrathin nanosheets(SNHUNs,6.8 nm),where the water contact angle was 0°and the surface free energy increased from 8.6to 65.8 mN·m^(-1),implying *** with HNHTNs,the specific capacitance of SNHUNs is doubled:from 1230 F·g^(-1)(HNHTNs)to 2350 F·g^(-1)(2A·g^(-1))and,even at 20 A·g^(-1),from 833 F·g^(-1)(HNHTNs)to 1670 F·g^(-1).The asymmetric capacitors assembled by SNHUNs and activated carbon show 52.44 Wh·kg^(-1)at 160W·kg^(-1)and excellent stability with~90%retention after5000 cycles(~80%retention after 9500 cycles).The promotion of electrochemical performances is ascribed to the change of surface wettability caused by surface free energy,which greatly increase affinity of electrode to the surrounding liquid environment to reduce the interface resistance and optimize the electron transport path.

关键词： Asymmetric supercapacitor Superhydrophilic interface Transition metal hydroxides Ultrathin nanosheets High specific capacitance

Solid-state lithium-ion batteries for grid energy storage:opportunities and challenges

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Science China Chemistry 2024年第1期67卷 43-66页

作者： Xin Chang Yu-ming zhao Boheng Yuan min Fan Qinghai Meng Yu-Guo Guo Li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The energy crisis and environmental pollution drive more attention to the development and utilization of renewable *** the capricious nature of renewable energy resource,it has difficulty supplying electricity directly to consumers stably and efficiently,which calls for energy storage systems to collect energy and release electricity at peak *** to their flexible power and energy,quick response,and high energy conversion efficiency,lithium-ion batteries stand out among multiple energy storage technologies and are rapidly deployed in the *** superior performance and ensuring the safety of energy storage systems,intrinsically safe solid-state electrolytes are expected as an ideal alternative to liquid *** this review,we systematically evaluate the priorities and issues of traditional lithium-ion batteries in grid energy *** lithium-ion batteries containing liquid electrolytes,solid-state lithium-ion batteries have the potential to play a more significant role in grid energy *** challenges of developing solid-state lithium-ion batteries,such as low ionic conductivity of the electrolyte,unstable electrode/electrolyte interface,and complicated fabrication process,are discussed in ***,the safety of solid-state lithium-ion batteries is *** the obtained insights,inspiring prospects for solid-state lithium-ion batteries in grid energy storage are depicted.

关键词： lithium-ion batteries grid energy storage solid-state electrolytes interface stability

B-cell-specific signatures reveal novel immunophenotyping and therapeutic targets for hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第34期30卷 3894-3925页

作者： Ke-Quan Xu Zheng gong Jia-Ling Yang Chu-Qi Xia Jian-Yi zhao Xi Chen Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina School of Basic Medical Sciences Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina Department of General Surgery Second People’s Hospital of Jiaozuo CityJiaozuo 454001Henan ProvinceChina

BACKGROUND Immunotherapy presents both promises and challenges in treating hepatocellular carcinoma(HCC)due to its complex immunological *** role of B cells,a key part of the immune system,remains uncertain in *** To identify B-cell-specific signatures and reveal novel immunophenotyping and therapeutic targets for *** Using the Tumor Immune Single-cell Hub 2 database,we identified B-cell-related genes(BRGs)in *** enrichment analysis was performed to explore the possible collaboration between B cells and T cells in *** conducted univariate Cox regression analysis using The Cancer Genome Atlas liver HCC collection dataset to find BRGs linked to HCC ***,least absolute shrinkage and selection operator regression was utilized to develop a prognostic model with 11 *** model was validated using the International Cancer Genome Consortium dataset and *** The risk score derived from the prognostic model emerged as an independent prognostic factor for *** of the immune microenvironment and cell infiltration revealed the immune status of various risk groups,supporting the cooperation of B and T cells in suppressing *** BRGs model identified new molecular subtypes of HCC,each with distinct immune *** sensitivity analysis identified targeted drugs effective for each HCC subtype,enabling precision therapy and guiding clinical *** We clarified the role of B cells in HCC and propose that the BRGs model offers promising targets for personalized immunotherapy.

关键词： B cell Hepatocellular carcinoma Immune microenvironment Immunotherapy Molecular subtype

Adsorption behavior of CO2/H2S mixtures in calcite slit nanopores for CO2 storage:An insight from molecular perspective

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Petroleum Science 2024年第4期21卷 2444-2456页

作者： Cheng Qian Zhen-Hua Rui Yue-Liang Liu Kai Du Chen Liu Yang zhao Xiao-min Ma State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum College of Petroleum Engineering China University of Petroleum College of Carbon Neutrality Future Technology China University of Petroleum College of Petroleum China University of Petroleum-Beijing at Karamay College of mining Engineering Taiyuan University of Technology

It is acknowledged that injecting CO2into oil reservoirs and saline aquifers for storage is a practical and affordable method for *** CO2produced from industrial exhaust contains impurity gases such as H2S that might impact CO2sequestration due to competitive *** study makes a commendable effort to explore the adsorption behavior of CO2/H2S mixtures in calcite slit *** Canonical Monte Carlo（GCMC） simulation is employed to reveal the adsorption of CO2,H2S as well as their binary mixtures in calcite *** show that the increase in pressure and temperature can promote and inhibit the adsorption capacity of CO2and H2S in calcite nanopores,***2exhibits stronger adsorption on calcite surface than *** energy plays the dominating role in the adsorption *** energy accounts for 97.11% of the CO2-calcite interaction energy and 56.33% of the H2S-calcite interaction energy at 10 MPa and 323.15 *** presence of H2S inhibits the CO2adsorption in calcite nanopores due to competitive adsorption,and a higher mole fraction of H2S leads to less *** quantity of CO2adsorbed is lessened by approximately 33% when the mole fraction of H2S reaches ***2molecules preferentially occupy the regions near the po re wall and H2S molecules tend to reside at the center of nanopore even when the molar ratio of CO2is low,indicating that CO2has an adsorption priority on the calcite surface over *** addition,moisture can weaken the adsorption of both CO2and H2S,while CO2is more *** interestingly,we find that pure CO2is more suitable to be sequestrated in the shallower formations,i.e.,500-1500 m,whereas CO2with H2S impurity should be settled in the deeper reservoirs.

关键词： Adsorption behavior CO 2 /H 2 S binary mixtures Molecular perspective Calcite slit nanopores CO 2 sequestration