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CircPMS1 promotes proliferation of pulmonary artery smooth muscle cells,pulmonary microvascular endothelial cells,and pericytes under hypoxia

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Animal Models and Experimental Medicine 2024年第3期7卷 310-323页

作者： Xiaoyi Hu Shang Wang Hui zhao Yaqin Wei Ruowang Duan Rong Jiang Wenhui Wu Qinhua zhao Sugang gong Lan Wang Jinming Liu Ping Yuan Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Institute of Bismuth Science University of Shanghai for Science and TechnologyShanghaiChina Department of Geriatrics Shanghai Institute of GeriatricsHuadong HospitalFudan UniversityShanghaiChina Department of Anesthesiology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina

Background:Circular RNAs(circRNAs)have been recognized as significant regulators of pulmonary hypertension(PH);however,the differential expression and function of circRNAs in different vascular cells under hypoxia remain ***,we identified co-differentially expressed circRNAs and determined their putative roles in the proliferation of pulmonary artery smooth muscle cells(PASMCs),pulmonary microvascular endothelial cells(PMECs),and pericytes(PCs)under ***:Whole transcriptome sequencing was performed to analyze the differential expression of circRNAs in three different vascular cell *** analysis was used to predict their putative biological *** real-time polymerase chain reaction,Cell Counting Kit-8,and EdU Cell Proliferation assays were carried out to determine the role of circular postmeiotic segregation 1(circPMS1)as well as its potential sponge mechanism in PASMCs,PMECs,and ***:PASMCs,PMECs,and PCs exhibited 16,99,and 31 differentially expressed circRNAs under hypoxia,***1 was upregulated in PASMCs,PMECs,and PCs under hypoxia and enhanced the proliferation of vascular ***1may upregulate DEP domain containing 1(DEPDC1)and RNA polymerase II subunit D expression by targeting microRNA-432-5p(miR-432-5p)in PASMCs,upregulate MAX interactor 1(MXI1)expression by targeting miR-433-3p in PMECs,and upregulate zinc finger AN1-type containing 5(ZFAND5)expression by targeting miR-3613-5p in ***:Our results suggest that circPMS1 promotes cell proliferation through the miR-432-5p/DEPDC1 or miR-432-5p/POL2D axis in PASMCs,through the miR-433-3p/MXI1 axis in PMECs,and through the miR-3613-5p/ZFAND5 axis in PCs,which provides putative targets for the early diagnosis and treatment of PH.

关键词： circular postmeiotic segregation 1 circular RNAs hypoxia pulmonary hypertension vascular cells

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基于坐标注意力的杂乱环境中机器人推抓协同学习

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北京工业大学学报 2024年第6期50卷 674-682页

作者：左国玉赵敏黄高龚道雄北京工业大学信息学部北京100124 计算智能与智能系统北京市重点实验室北京100124

为提升机器人在杂乱环境中推抓协同性能、增强网络感知物体位置和物体间的位置信息的能力,提出一种基于物体位置信息的推动与抓取协同网络来解决机器人在杂乱环境中的抓取问题。该网络使用2个全卷积网络分别从视觉观察中推断出抓取和推... 详细信息

为提升机器人在杂乱环境中推抓协同性能、增强网络感知物体位置和物体间的位置信息的能力,提出一种基于物体位置信息的推动与抓取协同网络来解决机器人在杂乱环境中的抓取问题。该网络使用2个全卷积网络分别从视觉观察中推断出抓取和推动操作的位置与方向。使用坐标注意力模块分别沿着二维空间的2个方向聚合特征,即在水平空间方向上捕获长距离依赖关系的同时在垂直空间方向上保持物体的位置信息。然后生成推动和抓取的位置特征的注意力图,以提升网络推断操作位置的准确性。提出物体分散度从全局角度衡量环境中物体间的分散程度,并设计基于物体分散度的推动奖励函数来提升推动动作的质量。在仿真实验中,该网络的抓取成功率和动作效率分别为75.1%和73.2%。在现实世界中,该网络的抓取成功率和动作效率分别为80.1%和76.2%。

关键词：机器人学习推抓协同杂乱环境物体位置信息坐标注意力物体分散度

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Lower extremity peripherally inserted central catheter placement ectopic to the ascending lumbar vein:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1430-1436页

作者： Xiao-Ju Zhu Ling zhao Na Peng Jia-min Luo Shui-Xia Liu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Peripherally inserted central catheters(PICCs)are an essential infusion route for oncology patients receiving intravenous treatments,but lower extremity veni-puncture is the preferred technique for patients with superior vena cava syndrome(SVCS).We report the case of a patient with a lower extremity PICC ectopic to the ascending lumbar vein,to indicate and verify PICC catheterisation in the lower extremity is safe and *** hope to provide different per-spectives for clinical PICC venipuncture to get the attention of *** SUMMARY On 24 August 2022,a 58-year-old male was admitted to our department due to an intermittent cough persisting for over a month,which worsened 10 d *** and laboratory investigations suggested the patient with pulmonary malignancy and *** was not an absolute contraindication in this *** extremity venipuncture is the preferred technique because administering upper extremity venous transfusion to patients with SVCS can exacerbate oedema in the head,neck,and upper *** patient and his family were informed about the procedure,and informed consent was *** successful puncture and prompt treatment,the patient was discharged,experiencing some relief from *** Inferior vena cava catheterisation is rare and important for cancer patients with SVCS,particularly in complex situations involving ectopic placement.

关键词： Superior vena cava syndrome Peripherally inserted central catheter Ascending lumbar vein Complications Case report

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Multiple Uplift and Exhumation of the Southeastern Tibetan Plateau:Evidence from Low-Temperature Thermochronology

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 569-584页

作者： WU Limin PENG Touping FAN Weiming zhao Guochun GAO Jianfeng DONG Xiaohan PENG Shili min Kang Tin Aung MYINT State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Chinese Academy of Sciences Center for Excellence in Deep Earth Science Guangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China Department of Earth Sciences The University of Hong KongHong Kong 999077China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiGuangdong 519085China Department of Geology University of MandalayMandalay 05011Myanmar

Since the Cenozoic,the Tibetan Plateau has experienced large-scale uplift and outgrowth due to the India-Asia ***,the mechanism and timing of these tectonic processes still remain ***,using apatite fission track dating and inverse thermal modeling,we explore the mechanism of different phases of rapid cooling for different batholiths and intrusions in the southeastern Tibetan *** contrast to previous views,we find that the coeval granitic batholith exposed in the same tectonic zone experienced differential fast uplift in different sites,indicating that the present Tibetan Plateau was the result of differential uplift rather than the entire lithosphere uplift related to lithospheric collapse during Cenozoic *** addition,we also suggest that the 5-2 Ma mantle-related magmatism should be regarded as the critical trigger for the widely coeval cooling event in the southeastern Tibetan Plateau,because it led to the increase in atmospheric CO_(2)level and a hotter upper crust than before,which are efficient for suddenly fast rock weathering and ***,we propose that the current landform of the southeastern Tibetan Plateau was the combined influences of tectonic and climate.

关键词： apatite fission track rapid cooling differential uplift magmatism southeastern Tibetan Plateau

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Insight into vertical piezoelectric characteristics regulated thermal transport in van der Waals two-dimensional materials

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Rare Metals 2024年第2期43卷 770-779页

作者： Dong-Hai Wei E Zhou Jin-Yuan Xu Hui-min Wang Chen Shen Hong-Bin Zhang Zhen-Zhen Qin Guang-zhao Qin State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha410082China Hunan Key Laboratory for Micro-Nano Energy Materials and Device and School of Physics and Optoelectronics Xiangtan UniversityXiangtan411105China Institute of Materials Science Technical University of DarmstadtAlarich-Weiss-Str.264287DarmstadtGermany School of Physics and Microelectronics Zhengzhou UniversityZhengzhou450001China

The urgent demand of extreme(ultra-high/low)thermal conductivity materials is triggered by the high-power device,where exploring the theories and mechanisms of regulating thermal transport properties plays a key ***,we elaborately investigate the effect of vertical(out-of-plane)piezoelectric characteristics on thermal transport,which is historically *** different stacking-order(AA and AB)bilayer boron nitride(Bi-BN)in two-dimensional(2D)materials are selected as study *** performing state-of-the-art first-principles calculations,it is found that the polarization charge along the out-of-plane orientation ascends significantly with the increasing piezoelectric response in AB stacked Bi-BN(Bi-BN-AB)followed by the enhanced interlayer B–N atomic ***,the amplitude of phonon anharmonicity in Bi-BN-AB increases larger than that in the AA stacked Bi-BN(Bi-BN-AA),resulting in the dramatic weakening of the thermal conductivity by 20.34%under 18%*** research reveals the significant role of the vertical(out-of-plane)piezoelectric characteristic in regulating thermal transport and provides new insight into accurately exploring the thermal transport performance of 2D van der Waals materials.

关键词： Thermal conductivity Piezoelectric effect 2D materials Bilayer BN Strain engineering

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Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

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Chinese Chemical Letters 2024年第9期35卷 223-226页

作者： gongcheng Ma Qihang Ding Yuding Zhang Yue Wang Jingjing Xiang mingle Li Qi zhao Saipeng Huang Ping gong Jong Seung Kim Guangdong Key Laboratory of Nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Korea UniversitySeoul 02841South Korea School of Chemical Engineering Northwest UniversityXi’an 710069China Cancer Center Institute of Translational MedicineFaculty of Health SciencesUniversity of MacaoMacao 999078China State Key Laboratory of Fine Chemicals College of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China

Carbon monoxide(CO)is a vital intracellular gas messenger known for its cytoprotective and homeostatic *** plays a pivotal role in a myriad of biological ***,the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease *** herein introduce NFCOP,a state-of-the-art near-infrared(NIR)turn-on fluorescence(FL)probe that has been meticulously designed for highly sensitive,swift and selective imaging of *** NFCOP response occurred rapidly with CO,within just 10 s,and the calculated detection limit for CO was determined to be 0.32μmol/*** investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.

关键词： Palladium-free Chemoselective probe Fluorescence imaging Carbon monoxide Near-infrared

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Numerical Prediction of Ride Comfort of Tracked Vehicle Equipped with Novel Flexible Road Wheels

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Chinese Journal of Mechanical Engineering 2024年第4期 290-302页

作者： Yaoji Deng Zhiyue Wang Youqun zhao Junjie gong Hui Shen Fen Lin College of Mechanical Engineering Yangzhou University College of Energy and Power Engineering Nanjing University of Aeronautics and Astronautics

Enhancing ride comfort has always constituted a crucial focus in the design and research of modern tracked vehicles, heavily reliant on the driving system's performance. While the road wheel is a key component of the driving system, traditional road wheels predominantly adopt a solid structure, exhibiting subpar adhesion performance and damping effects, thereby falling short of meeting the demands for high-speed, stable, and long-distance driving in tracked vehicles. Addressing this issue, this paper proposes a novel type of flexible road wheel(FRW) characterized by a catenary construction. The study investigates the ride comfort of tracked vehicles equipped with flexible road wheels by integrating finite element and vehicle dynamic. First, three-dimensional(3D) finite element(FE) models of both flexible and rigid road wheels are established, considering material and contact nonlinearities. These models are validated through a wheel radial loading test. Based on the validated FE model, the paper uncovers the relationship between load and radial deformation of the road wheel, forming the basis for a nonlinear mathematical ***, a half-car model of a tracked vehicle with seven degrees of freedom is established using Newton's second law. A random road model, considering the track effect and employing white noise, is constructed. The study concludes by examining the ride comfort of tracked vehicles equipped with flexible and rigid road wheels under various speeds and road grades. The results demonstrate that, in comparison to the rigid road wheel(RRW), the flexible road wheel enhances the ride comfort of tracked vehicles on randomly uneven roads. This research provides a theoretical foundation for the implementation of flexible road wheels in tracked vehicles.

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Publication trends of Leber congenital amaurosis researches:a bibliometric study during 2002-2022

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1501-1509页

作者： Xiao-Xu Huang Yi-min Wang min-Yue Xie Yi-Qing Sun Xiao-Huan zhao Yu-Hong Chen Jie-Qiong Chen Si-Yang Han min-Wen Zhou Xiao-Dong Sun Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China National Clinical Research Center for Eye Disease Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080China Department of Ophthalmology Zhongshan HospitalFudan UniversityShanghai 200030China Beijing Tongren Hospital Capital Medical UniversityBeijing 100054China Eberly College of Science Penn State UniversityUniversity Park 16802-1503United States

AIM:To analyze the changes in scientific output relating to Leber congenital amaurosis(LCA)and forecast the study trends in this ***:All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Science(WOS)*** analyzed the quantity(number of publications),quality(citation and H-index)and development trends(relative research interest,RRI)of published LCA research over the last two ***,VOSviewer software was applied to define the co-occurrence network of keywords in this ***:A total of 2158 publications were ultimately *** found that the focus on LCA kept rising and peaked in 2015 and 2018,which is consistent with the development trend of gene *** USA has contributed most to this field with 1162 publications,56674 citations and the highest H-index value(116).The keywords analysis was divided into five clusters to show the hotspots in the field of LCA,namely mechanism-related,genotype-related,local phenotype-related,system phenotype-related,and *** also identified gene therapy and antiretinal degeneration therapy as a major focus in recent ***:Our study illustrates historical research process and future development trends in LCA *** may help to guide the orientation for further clinical diagnosis,treatment and scientific research.

关键词： VOSviewer bibliometrics Leber congenital amaurosis gene therapy hotpots

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Clinical characteristics of peripapillary hyperreflective ovoid mass-like structures in myopic children

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1292-1299页

作者： Lu Zhang Zuo-Hui-Zi Yi Xuan Jiang gong-Peng Sun Fang zhao Li Zhang Yi Xiang Chang-Zheng Chen Department of Ophthalmology the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina Eye Center Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

AIM:To describe the characteristics of peripapillary hyperreflective ovoid mass-like structure(PHOMS)in myopic children and to investigate factors associated with ***:This retrospective observational study included 101 eyes of 101 children(age≤17y)with *** included patients underwent comprehensive clinical *** nerve canal parameters,including disc diameter,optic nerve head(ONH)tilt angle,and border tissue angle were measured using serial enhanced-depth imaging spectral-domain optical coherence tomography(EDI-OCT).Based on the optic disc drusen consortium’s definition of PHOMS,eyes were classified as PHOMS group and non-PHOMS *** was categorized according to ***:Sixty-seven(66.3%)eyes were found with *** PHOMS could only be detected by optical coherence tomography(OCT).Medium PHOMS could be seen with blurred optic disc borders corresponding to *** most frequent location of PHOMS was at the nasosuperior(91%,61 of 67 eyes)to ONH *** axial length and spherical equivalent were more myopic in the PHOMS group than in the non-PHOMS group(both P<0.001).ONH tilt angle was also significantly greater in PHOMS group than in non-PHOMS group[8.90(7.16-10.54)vs 3.93(3.09-5.25),P<0.001].Border tissue angle was significantly smaller in PHOMS group than in non-PHOMS group[29.70(20.90-43.81)vs 45.62(35.18-60.45),P<0.001].In the multivariable analysis,spherical equivalent(OR=3.246,95%CI=1.209-8.718,P=0.019)and ONH tilt angle(OR=3.275,95%CI=1.422-7.542,P=0.005)were significantly correlated with *** was no disc diameter associated with *** the linear regression analysis,border tissue angle was negatively associated with PHOMS height(β=-2.227,P<0.001).CONCLUSION:PHOMS is associated with optic disc tilt and optic disc nasal shift in *** diameter is not a risk factor for *** changes in ONH caused by axial elongation facilitated an understanding of the mechanism of PHOMS.

关键词： peripapillary hyperreflective ovoid masslike structure myopia optic disc edema enhanced-depth imaging spectral-domain optical coherence tomography

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Photoredox catalytic alkylarylation of alkynes with arylsulfonylacetate as bifunctional reagent

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Science China Chemistry 2024年第6期67卷 2022-2028页

作者： Chonglong He min Wang Yulong Wang Lirong zhao Youkang Zhou Keyuan Zhang Shenyu Shen Yaqiong Su Xin-Hua Duan Le Liu School of Chemistry Engineering Research Center of Energy Storage Materials and DevicesMinistry of EducationXi’an Key Laboratory of Sustainable Energy Material ChemistryXi’an Jiaotong UniversityXi’an710049China

Difunctionalization of alkynes represents a powerful and straightforward approach to the synthesis of complex ***,the radical difunctionalization of alkynes mediated by bifunctional reagents remains challenging and underexplored,despite significant progress having been made in alkene ***,we report a novel arylsulfonylacetate skeleton in which aryl rings are attached to acetates through SO_(2),serving as a powerful bifunctional reagent for the alkylarylation of alkynes via vinyl-radical intermediate under photoredox *** modular bifunctional reagent enables the simultaneous incorporation of a wide range of functional groups,including(hetero)aryl ring and alkyl carboxylate into alkynes,resulting in synthetically valuable all-carbon tetrasubstituted alkene *** transformation is distinguished by its redox-neutral nature,readily accessible starting materials,compatibility with diverse functional groups and its capacity to facilitate convergent *** utility of this approach was further demonstrated by the late-stage functionalization of complex molecules and the preparation of fluorescent molecules and anti-cancer drugs.

关键词： bifunctional reagent photoredox catalysis Smiles rearrangement alkylarylation tetrasubstituted acyclic all-carbon olefins

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