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糖尿病视网膜病变患者自我感受负担的相关影响因素及护理措施分析

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现代医药卫生 2024年第4期40卷 614-618页

作者：徐文静贺攀赵福玉郑州市第二人民医院眼底二病区河南郑州450000 郑州市第二人民医院青光眼二病区河南郑州450000

目的分析糖尿病视网膜病变(DR)患者自我感受负担的相关影响因素及护理措施。方法选取2022年6月至2023年6月该院收治的110例DR患者作为研究对象,采用自我感受负担量表调查DR患者自我感受负担情况;收集患者年龄、性别等资料统计分析患... 详细信息

目的分析糖尿病视网膜病变(DR)患者自我感受负担的相关影响因素及护理措施。方法选取2022年6月至2023年6月该院收治的110例DR患者作为研究对象,采用自我感受负担量表调查DR患者自我感受负担情况;收集患者年龄、性别等资料统计分析患者自我感受负担的相关影响因素。结果 110例患者中有自我感受负担53例,占48.18%(53/110)。性别、年龄、体重指数、居住地、婚姻状况、工作情况与DR患者自我感受负担的发生无关,差异均无统计学意义(P>0.05);文化程度、家庭月收入、医疗费用支付方式、家庭关系、社会支持水平与DR患者的自我感受负担有关,差异均有统计学意义(P<0.05);初中及以下、家庭月收入低于5 000元、医疗费用自费、家庭关系不和睦、社会低支持水平为DR患者自我感受负担发生的独立危险因素,差异均有统计学意义(偏回归系数=2.096、1.085、0.812、1.438、2.461,优势比=8.131、2.960、2.253、4.213、11.717,95%可信区间:3.409~19.398、1.349~6.495、1.050~4.834、1.899~9.347、4.515~30.402,P<0.05)。结论大部分DR患者存在自我感受负担,初中及以下、家庭月收入低于5 000元、医疗费用自费、家庭关系不和睦、社会低支持水平等是造成患者自我感受负担发生的独立危险因素。故临床医护人员需对上述高危人群给予重点关注,积极施以有针对性的护理措施,以保证患者身心健康。

关键词：糖尿病视网膜病变自我感受负担影响因素分析护理措施

大临铁路区域活动断裂地热特征与地质选线研究

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云南水力发电 2024年第4期40卷 38-42页

作者：赵福玉张蕊刘伟杜宇本中铁二院工程集团有限责任公司四川成都610031 西南交通大学四川成都6117561

大理至临沧铁路跨过澜沧江后穿行于云县—临沧花岗岩体,地形地貌和地质条件复杂,铁路长大隧道设置不可避免,工程艰巨,深大活动断裂及高地温热害控制线路方案。结合白石头隧道地质勘察,分析了区域花岗岩体的多期次叠加侵入和形成机理,以... 详细信息

大理至临沧铁路跨过澜沧江后穿行于云县—临沧花岗岩体,地形地貌和地质条件复杂,铁路长大隧道设置不可避免,工程艰巨,深大活动断裂及高地温热害控制线路方案。结合白石头隧道地质勘察,分析了区域花岗岩体的多期次叠加侵入和形成机理,以及凤庆-云县—临沧水热活动带内活动断裂、地热分布特征和地热成因,开展高原艰险山区铁路综合地质选线研究,成功避开了区域地热异常带,推荐了常温带作为隧道线路方案,经过施工验证,推荐方案合理、可行。

关键词：大临铁路活动断裂高地温地质选线

PLAU plays a functional role in driving lung squamous cell carcinoma metastasis

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Genes & Diseases 2024年第2期11卷 554-557页

作者： Pengbo Ning fuyu Du Xiaocheng Gong Jingtong Yuan Caixia Ding Xilian zhao Wei Li School of Life Science and Technology Xidian UniversityXi'anShaanxi 710071China Engineering Research Center of Molecular & Neuroimaging Ministry of EducationXi'anShaanxi 710071China Department of Medical Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pathology Shaanxi Provincial Tumor HospitalXi'an Jiaotong UniversityXi'anShaanxi 710061China

The high mortality of patients with lung squamous cell carcinoma(LUSC)results from metastasis rather than primary tumors,1 whereas the molecular pathogenesis of cancer metastasis remains poorly *** encodes urokinase-type plasminogen activator(uPA)which is closely related to tumor diagnosis,treatment target,and prognosis of patients.2.3 We previously predicted that PLAU is a key gene negatively associated with overall survival by integrated multidimensional analyses of The Cancer Genome Atlas(TCGA)datasets from 504 samples of LUSC tumor tissues and 46 samples of adjacent non-tumorous lung tissues.4 However,whether the role of PLAU contributes to the metastasis of LUC remains ***,we analyzed the association between uPA levels and LUSC and found that uPA levels were associated with pathological variations in LUSC patients.

关键词： metastasis lung squamous

Bid mediates lysosomal membrane permeabilization and the consequent mitochondrial outer membrane permeabilization in RH-35 hepatoma cells

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生物物理学报 2009年第S1期25卷 247-248页

作者： Xingyu zhao, Kai zhao, Taotao Wei, fuyu Yang Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China,

We reported previously that chymotrypsin B is cached in the lysosomes of rat hepatocytes and mediates apoptosis induced by TNF-alpha (1) and H2O2. However, the mechanism

关键词： Bid mediates lysosomal membrane permeabilization and the consequent mitochondrial outer membrane permeabilization in RH-35 hepat RH MOMP

A further study on the role of lysosomal chymotrypsin B in apoptosis

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生物物理学报 2009年第S1期25卷 233-234页

作者： Xingyu zhao, Kai zhao, Taotao Wei, fuyu Yang National Laboratory of Bio macromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China

We have reported that chymotrypsin B is not just a digestive enzyme secreted by the pancreas, but also cached in rat liver lysosomes and mediates extrinsic apoptotic pathway (1). Herein,

关键词： digestive pancreas cathepsin secreted extrinsic intestine cytosolic ovary hairpin stomach

Dual-Defect Engineering Strategy Enables High-Durability Rechargeable Magnesium-Metal Batteries

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Nano-Micro Letters 2024年第9期16卷 449-461页

作者： fuyu Chen Bai‑Qing zhao Kaifeng Huang Xiu‑Fen Ma Hong‑Yi Li Xie Zhang Jiang Diao Jili Yue Guangsheng Huang Jingfeng Wang Fusheng Pan National Innovation Center for Lndustry‑Education Integration of Energy Storage Technology School of Materials Science and EngineeringChongqing UniversityChongqing 400044People’s Republic of China National Magnesium Alloy Material Engineering Technology Research Center Chongqing UniversityChongqing 400044People’s Republic of China Materials and Energy Division Beijing Computational Science Research CenterBeijing 100193People’s Republic of China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China National Key Laboratory of Advanced Casting Technologies Chongqing UniversityChongqing 400044People’s Republic of China

Rechargeable magnesium-metal batteries(RMMBs)are promising next-generation secondary batteries;however,their development is inhibited by the low capacity and short cycle lifespan of *** various strategies have been devised to enhance the Mg^(2+)migration kinetics and structural stability of cathodes,they fail to improve electronic conductivity,rendering the cathodes incompatible with magnesium-metal ***,we propose a dual-defect engineering strategy,namely,the incorporation of Mg^(2+)pre-intercalation defect(P-Mgd)and oxygen defect(Od),to simultaneously improve the Mg^(2+)migration kinetics,structural stability,and electronic conductivity of the cathodes of *** lamellar V_(2)O_(5)·nH_(2)O as a demo cathode material,we prepare a cathode comprising Mg_(0.07)V_(2)O_(5)·1.4H_(2)O nanobelts composited with reduced graphene oxide(MVOH/rGO)with P-Mgd and *** Od enlarges interlayer spacing,accelerates Mg^(2+)migration kinetics,and prevents structural collapse,while the P-Mgd stabilizes the lamellar structure and increases electronic ***,the MVOH/rGO cathode exhibits a high capacity of 197 mAh g^(−1),and the developed Mg foil//MVOH/rGO full cell demonstrates an incredible lifespan of 850 cycles at 0.1 A g^(−1),capable of powering a light-emitting *** proposed dual-defect engineering strategy provides new insights into developing high-durability,high-capacity cathodes,advancing the practical application of RMMBs,and other new secondary batteries.

关键词： Rechargeable magnesium-metal batteries Dual-defect engineering Vanadium-based cathode High durability Lamellar structure

Chymotrypsin-dependent cleavage and activation of calcineurin

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生物物理学报 2009年第S1期25卷 246-247页

作者： Kai zhao, Taotao Wei, fuyu Yang National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China

We have reported that chymotrypsin B is not just a digestive enzyme secreted by the pancreas, but also cached in rat liver lysosomes and mediates extrinsic apoptotic pathway (1). Herein,

关键词： Chymotrypsin-dependent cleavage and activation of calcineurin

Pushing the high-k scalability limit with a superparaelectric gate layer

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Journal of Advanced Ceramics 2024年第4期13卷 539-547页

作者： Kun Wang Chao Liu Yuan Zhang fuyu Lv Jun Ouyang Houbing Huang Rui-Long Yang Yu-Yao zhao Hongbo Cheng Hanfei Zhu Xiaoming Shi Yun Tian Institute of Advanced Energy Materials and Chemistry Jinan Engineering Laboratory for Multi-scale Functional MaterialsSchool of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Key Laboratory for Liquid-Solid Structure Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China China Tobacco Shandong Industrial Co. Ltd.Jinan 250104China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Key Laboratory of Key Film Materials&Application for Equipments(Hunan Province) School of Material Sciences and EngineeringXiangtan UniversityXiangtan 411105China Advanced Research Institute of Multidisciplinary Science and School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education School of Chemistry and Materials ScienceShanxi Normal UniversityTaiyuan 030032China

To meet the expectation set by Moore’s law on transistors,the search for thickness-scalable high dielectric constant(k)gate layers has become an emergent research *** investigations have failed to solve the“polarizability–scalability–insulation robustness”*** this work,we show that this trilemma can be solved by using a gate layer of a high k ferroelectric oxide in its superparaelectric(SPE)*** the SPE,its polar order becomes local and is dispersed in an amorphous matrix with a crystalline size down to a few nanometers,leading to an excellent dimensional scalability and a good field-stability of the k *** an example,a stable high k value(37±3)is shown in ultrathin SPE films of(Ba_(0.95),Sr_(0.05))(Zr_(0.2),Ti_(0.8))O_(3)deposited on LaNiO_(3)-buffered Pt/Ti/SiO_(2)/(100)Si down to a 4 nm thickness,leading to a small equivalent oxide thickness of~0.46 *** aforementioned characteristic microstructure endows the SPE film a high breakdown strength(~10.5 MV·cm^(−1)for the 4 nm film),and hence ensures a low leakage current for the operation of the complementary metal oxide semiconductor(CMOS)***,a high electrical fatigue resistance is displayed by the SPE *** results reveal a great potential of superparaelectric materials as gate dielectrics in the next-generation microelectronics.

关键词： high-k transistors Moore's law superparaelectric insulation robustness

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石油测井仪器可靠性快速评价方法

仪器仪表学报 2006年第12期27卷 1729-1733页

作者：任晓荣赵福宇西安交通大学能源与动力工程学院西安710021

本文根据可靠性强化实验原理,提出了快速评价石油测井仪器可靠性的工作流程和实验方法。该方法先要确定石油测井仪器的可靠性控制点和极限工作条件,进而通过对可靠性控制点的局部评价,实现仪器整机可靠性的快速评价。在多种型号的自然... 详细信息

本文根据可靠性强化实验原理,提出了快速评价石油测井仪器可靠性的工作流程和实验方法。该方法先要确定石油测井仪器的可靠性控制点和极限工作条件,进而通过对可靠性控制点的局部评价,实现仪器整机可靠性的快速评价。在多种型号的自然伽玛测井仪设计和生产中应用了该方法,结果表明,设计阶段对关键部件的单一工作条件实验,能够实现仪器可靠性设计的快速评价;生产阶段对整机的综合工作条件实验,能够实现仪器整机可靠性的快速评价。该方法在实现石油测井仪器可靠性快速评价的同时,能够减少实验次数,缩短仪器设计和生产周期。

关键词：石油测井仪器可靠性强化实验可靠性快速评价方法可靠性控制点