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Acta Pharmaceutica Sinica B 2019年第2期9卷 351-368页

作者： Peng Wei Bo Liu Ruifeng Wang Yinglei Gao Lanlan Li Yuchi Ma Zhiwei Qian Yuelei Chen Maosheng Cheng Meiyu Geng Jingkang Shen dongmei zhao Jing Ai Bing Xiong Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education Shenyang Pharmaceutical University Department of Medicinal Chemistry Shanghai Institute of Materia Medica Chinese Academy of Sciences Division of Anti-tumor Pharmacology State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences

Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors(FGFRs). Although there is no selective FGFR inhibitors in market, several promising inhibitors have been investigated in clinical trials, and showed encouraging efficacies in patients. By designing a hybrid between the FGFR-selectivity-enhancing motif dimethoxybenzene group and our previously identified novel scaffold, we discovered a new series of potent FGFR inhibitors, with the best one showing sub-nanomolar enzymatic activity. After several round of optimization and with the solved crystal structure, detailed structure–activity relationship was elaborated. Together with in vitro metabolic stability tests and in vivo pharmacokinetic profiling, a representative compound(35) was selected and tested in xenograft mouse model, and the result demonstrated that inhibitor 35 was effective against tumors with FGFR genetic alterations, exhibiting potential for further development.

关键词： Fibroblast growth factor Tyrosine kinase receptor Structure-based Crystallography Selectivity Hybrid 5-Hydrosulfonyl-5Hpyrrolo[2,3-b]pyrazine Inhibitor

Geometric structure of N_(2)O^(q+)(q=5,6)studied by Ne^(8+)ion-induced Coulomb explosion imaging

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Chinese Physics B 2021年第11期30卷 309-317页

作者： Xi zhao Xu Shan Xiaolong Zhu Lei Chen Zhenjie Shen Wentian Feng Dalong Guo dongmei zhao Ruitian Zhang Yong Gao Zhongkui Huang Shaofeng Zhang Xinwen Ma Xiangjun Chen Hefei National Laboratory for Physical Sciences at the Microscale and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

We report the study on the complete three-body Coulomb explosion(CE)of N_(2)O^(q+)(q=5,6)induced by 56-keV/u Ne8+ion collision with N2O gaseous *** CE channels for N_(2)O^(5+)and seven for N_(2)O^(6+)are identified by measuring three ionic fragments and the charge-changed projectile in quadruple *** the kinetic energy release(KER)and momentum correlation angle(MCA)distributions of three ionic fragments for each of the CE channels are also *** computation is presented to reconstruct the geometric structure of N_(2)O^(q+0prior to dissociation based on the measured KER and *** N–N and N–O bond lengths and the N–N–O bond angles of N_(2)O^(q+)for each of the channels are determined.

关键词： Coulomb explosion kinetic energy release molecular geometry ion collision nitrous oxide(N_(2)O)

Two New Electronic Transitions of Tungsten Monoxide Studied by Laser Spectroscopy

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IMP & HIRFL Annual Report 2018年第1期 68-69页

作者： Zhang Jicai zhao dongmei Ma Xinwen Yang Jie Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

Combing pulsed discharge supersonic beam and laser ablation techniques,we investigated the laser-induced fluorescence(LIF)excitation spectra of jet-cooled WO molecule in the range of 2100023200 cm−***.1(a)shows our experimental setup,the gas phase WO molecules were produced by the reaction to O2 molecules with the tungsten atoms ablated from a pure tungsten *** vibronic bands were observed for the first time and assigned to two electronic transition systems[21.2]0+–X0+and[22.2]0+–X0+.The rotational constants in these two excited electronic states have been derived by rotational analysis of the ***.1(b)shows the observation and calculation of the rotational spectra of[21.2]0+–X0+(0–)band,and the tungsten isotope splittings were clearly resolved in P-branch,which caused by four major tungsten isotopes,28.6%186W,30.7%184W,14.28%183W,and 26.3%*** on the vibrational frequencies in the ground electronic state X0+and upper[21.2]0+state,a blue isotopic shift0.03 cm−1/amu is expected in ***,a red isotopic shifts0.19 cm−1/amu is observed experimentally.

关键词： calculation. rotational Transition

A Lightweight IoT Malware Detection and Family Classification Method

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Journal of Computer and Communications 2024年第4期12卷 201-227页

作者： Changguang Wang Ziqi Ma Qingru Li dongmei zhao Fangwei Wang College of Computer and Cyber Security Hebei Normal University Shijiazhuang China Key Laboratory of Network and Information Security of Hebei Province Hebei Normal University Shijiazhuang China

A lightweight malware detection and family classification system for the Internet of Things (IoT) was designed to solve the difficulty of deploying defense models caused by the limited computing and storage resources of IoT devices. By training complex models with IoT software gray-scale images and utilizing the gradient-weighted class-activated mapping technique, the system can identify key codes that influence model decisions. This allows for the reconstruction of gray-scale images to train a lightweight model called LMDNet for malware detection. Additionally, the multi-teacher knowledge distillation method is employed to train KD-LMDNet, which focuses on classifying malware families. The results indicate that the model’s identification speed surpasses that of traditional methods by 23.68%. Moreover, the accuracy achieved on the Malimg dataset for family classification is an impressive 99.07%. Furthermore, with a model size of only 0.45M, it appears to be well-suited for the IoT environment. By training complex models using IoT software gray-scale images and utilizing the gradient-weighted class-activated mapping technique, the system can identify key codes that influence model decisions. This allows for the reconstruction of gray-scale images to train a lightweight model called LMDNet for malware detection. Thus, the presented approach can address the challenges associated with malware detection and family classification in IoT devices.

关键词： IoT Security Visual Explanations Multi-Teacher Knowledge Distillation Lightweight CNN

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职业英语听力实训平台的探究

中国劳动关系学院学报 2016年第3期30卷 96-99页

作者：康春杰赵冬梅中国劳动关系学院高职学院北京100048 呼和浩特职业学院外国语学院内蒙古呼和浩特010050

培养一线专业技能人才是高等职业教育目的所在。实现高等职业英语教育目的的必要环节就是实训教学。职业英语实训教学要帮助学生获得实用的专业技能或职业技能,使之成为高素质的职业技能型人才。

关键词：职业英语听力实训平台

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社会文化变迁与当代台湾的小城叙事

中国文化研究 2009年第1期 184-192页

作者：赵冬梅北京语言大学比较文学研究所 100083

论文以当代台湾文学中那些以小城为故事发生背景的小说为研究对象,由其中部分作品的回忆视角,推衍出这些小说的叙事结构中所共有的基本要素,即今与昔、现代与传统、都市与乡土对比的二元模式,分析了这组二元模式同当代台湾社会文化变迁... 详细信息

论文以当代台湾文学中那些以小城为故事发生背景的小说为研究对象,由其中部分作品的回忆视角,推衍出这些小说的叙事结构中所共有的基本要素,即今与昔、现代与传统、都市与乡土对比的二元模式,分析了这组二元模式同当代台湾社会文化变迁之间的关系,"小城"既存在于叙事之中、又独立于叙事之外的象征功能、时间功能、审美功能,以及小城所具有的诸种功能同叙事结构中那组二元模式的关系,并由小城不同于都市和农村的社会、生活场景和文化特性,突显小城叙事之不同于都市小说、农村题材的乡土小说的独特性。

关键词：社会文化变迁小城叙事叙事结构叙事功能

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和解的破灭:司马光最后18个月的宋朝政治

文史哲 2019年第5期 24-40,165,166页

作者：赵冬梅北京大学历史学系

在推翻新法的政策诉求之外,司马光在政治上追求协调新旧关系,实现政治和解,重返多元政治。然而,他以做谏官的姿态做宰相,追求个人道德的完美,既乏手段,又乏资源。相对年轻的台谏官群体主张清算,反对和解。新晋宰执推动太皇太后发布“务... 详细信息

在推翻新法的政策诉求之外,司马光在政治上追求协调新旧关系,实现政治和解,重返多元政治。然而,他以做谏官的姿态做宰相,追求个人道德的完美,既乏手段,又乏资源。相对年轻的台谏官群体主张清算,反对和解。新晋宰执推动太皇太后发布“务全大体诏”,对熙丰官僚实行政治赦免,力求和解。在台谏官强烈反对下,诏虽出而和解之义亡。元祐之政因而失去了大部分普通官僚的支持,进一步陷入“人才实难”的境地,而司马光对于变神宗法度的核心理论解释“干父之蛊说”被“以母改子说”掩盖,既不能达到统一思想的目的,又为未来的分裂、恶斗埋下了引子。和解的破灭,司马光难辞其咎,然亦无法独任其责。

关键词：司马光政治和解台谏官务全大体诏干父之蛊说

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计及风电不确定性优化调度研究综述

中国电机工程学报 2023年第7期43卷 2608-2626页

作者：杜刚赵冬梅刘鑫华北电力大学电气与电子工程学院北京市昌平区102206 国网吉林省电力有限公司长春供电公司吉林省长春市130000

大规模风电并网后为系统带来不确定性因素,对系统优化调度造成极大的挑战。该文立足于国内外电力系统适应高比例风电并网消纳的实际进展,首先,从机组组合计划、经济调度、市场机制等多角度对国内外研究现状进行梳理;其次,依据时间尺度... 详细信息

大规模风电并网后为系统带来不确定性因素,对系统优化调度造成极大的挑战。该文立足于国内外电力系统适应高比例风电并网消纳的实际进展,首先,从机组组合计划、经济调度、市场机制等多角度对国内外研究现状进行梳理;其次,依据时间尺度、调控目标、建模机理及不确定模型等多种准则对计及风电不确定性优化调度模型进行归类分析,归纳并总结各类优化模型的优缺点及应用情况;然后,分别从模糊隶属度函数、场景集、鲁棒不确定集及分布鲁棒不确定集等四个方面,详尽地阐述各类处理风电不确定性模型的架构、应用现状、优势及不足;最后,对相关领域未来研究方向进行展望,以期为计及风电不确定性优化调度的研究提供参考和建议。

关键词：风电不确定性优化调度模糊优化随机优化鲁棒优化分布鲁棒优化

基于全概率风险度量的电力系统备用风险评估方法

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电力自动化设备 2020年第1期40卷 156-162页

作者：殷加玞赵冬梅华北电力大学电气与电子工程学院

为了量化分析源荷双侧预测误差引起的电力系统备用缺额风险,提出了一种基于全概率公式和条件风险价值的风险度量,作为表征随机误差潜在风险的评估指标。为了明确不同的风险等级,以风险价值为临界点,将常规机组的备用缺额风险划分为缓冲... 详细信息

为了量化分析源荷双侧预测误差引起的电力系统备用缺额风险,提出了一种基于全概率公式和条件风险价值的风险度量,作为表征随机误差潜在风险的评估指标。为了明确不同的风险等级,以风险价值为临界点,将常规机组的备用缺额风险划分为缓冲区和极端区,并计算不同风险区域的条件期望损失。针对风电、负荷预测和可中断负荷的预测误差,引入机会约束目标规划构建常规机组的可调备用约束,依据不同的风险等级将备用缺额风险转化为不同类型的风险成本,引入模型目标函数中以确保电网运行的安全性。为了提高模型的求解效率,采用分段线性化方法将非线性模型转化为混合整数线性规划。

关键词：电力系统不确定性风险评估全概率条件风险价值机会约束目标规划

中西音乐“基因”的邂逅——融会中西的“曲式”教科书

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中国音乐 2023年第1期 66-70,148页

作者：赵冬梅中国音乐学院作曲系中国乐派“8+1、思政+X”课程体系曲式与作品分析课程团队

中国乐派“8+1、思政+X”课程体系《曲式》教材是以中国音乐学院办学理念为指导思想编写而成。该教材最突出的特色是,在本科的曲式基础课教学中加大了中国音乐作品的比重,除了以往中外作曲家应用西方作曲技术创作的作品,还特别增加了根... 详细信息

中国乐派“8+1、思政+X”课程体系《曲式》教材是以中国音乐学院办学理念为指导思想编写而成。该教材最突出的特色是,在本科的曲式基础课教学中加大了中国音乐作品的比重,除了以往中外作曲家应用西方作曲技术创作的作品,还特别增加了根植中国文化土壤、应用中国音乐思维的传统音乐作品。对分析谱例的选择,除了本专业必须掌握的知识点,还特别注重与其他七门专业基础课和各专业主课之间的互通性、共融性。本文主要介绍了中国乐派“8+1、思政+X”课程体系曲式课程的培养目标、教学理念、课程改革的必要性、《曲式》教材的内容与创新点,并对新版教材的教学与应用进行了相关说明。

关键词：中国乐派“8+1、思政+X”课程体系《曲式》教材中国音乐作品教学与应用