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Targeting the adenosine A2A receptor for neuroprotection and cognitive improvement in traumatic brain injury and Parkinson's disease

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Chinese Journal of Traumatology 2024年第3期27卷 125-133页

作者： Yan zhao Yuan-Guo Zhou Jiang-Fan Chen Department of Army Occupational Disease State Key Laboratory of TraumaBurns and Combined InjuryResearch Institute of SurgeryDaping HospitalArmy Medical University.Chongqing400042China The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center The State Key Laboratory of OphthalmologyOptometry and Vision ScienceWenzhou Medical UniversityWenzhou325035Zhejiang ProvinceChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou325035Zhejiang ProvinceChina

Adenosine exerts its dual functions of homeostasis and neuromodulation in the brain by acting at mainly 2 G-protein coupled receptors,called A1 and A2A *** adenosine A2A receptor(A2AR)antagonists have been clinically pursued for the last 2 decades,leading to final approval of the istradefylline,an A2AR antagonist,for the treatment of OFF-Parkinson's disease(PD)*** approval paves the way to develop novel therapeutic methods for A2AR antagonists to address 2 major unmet medical needs in PD and traumatic brain injury(TBI),namely neuroprotection or improving *** this review,we first consider the evidence for aberrantly increased adenosine signaling in PD and TBI and the sufficiency of the increased A2AR signaling to trigger neurotoxicity and cognitive *** further discuss the increasing preclinical data on the reversal of cognitive deficits in PD and TBI by A2AR antagonists through control of degenerative proteins and synaptotoxicity,and on protection against TBI and PD pathologies by A2AR antagonists through control of ***,we provide the supporting evidence from multiple human prospective epidemiological studies which revealed an inverse relation between the consumption of caffeine and the risk of developing PD and cognitive decline in aging population and Alzheimer's disease ***,the convergence of clinical,epidemiological and experimental evidence supports the validity of A2AR as a new therapeutic target and facilitates the design of A2AR antagonists in clinical trials for disease-modifying and cognitive benefit in PD and TBI patients.

关键词： Receptor,Adenosine A2A Adenosine A2 receptor antagonists Parkinson's disease Brain injuries,traumatic

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Scalable fabrication of graphene-assembled multifunctional electrode with efficient electrochemical detection of dopamine and glucose

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Nano Research 2023年第5期16卷 6361-6368页

作者： Xiaodong Ji Xin zhao Zixin Zhang Yunfa Si Wei Qian Huaqiang Fu Zibo Chen Zhe Wang Huihui Jin Zhugen Yang daping He State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Information Engineering Wuhan University of TechnologyWuhan 430070China School of Water Energy and EnvironmentCranfield UniversityMilton KeynesMK430ALUK

Conventional glassy carbon electrodes(GCE)cannot meet the requirements of future electrodes for wider use due to low conductivity,high cost,non-portability,lack of ***,cost-effective and wearable electrode enabling rapid and versatile molecule detection is becoming important,especially with the ever-increasing demand for health monitoring and point-ofcare *** is considered as an ideal electrode due to its excellent physicochemical ***,we prepare graphene film with ultra-high conductivity and customize the 3-electrode system via a facile and highly controllable laser engraving *** from the ultra-high conductivity(5.65×10^(5)S·m^(−1)),the 3-electrode system can be used as multifunctional electrode for direct detection of dopamine(DA)and enzyme-based detection of glucose without further metal *** dynamic ranges from 1–200μM to 0.5–8.0 mM were observed for DA and glucose,respectively,with a limit of detection(LOD)of 0.6μM and 0.41 ***,the excellent target detection capability caused by the ultra-high conductivity and ease modification of graphene films,together with their superb mechanical properties and ease of mass-produced,provides clear potential not only for replacing GCE for various electrochemical studies but also for the development of portable and highperformance electrochemical wearable medical devices.

关键词： graphene film ultra-high conductivity multifunctional electrode point-of-care diagnosis wearable medical devices

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低频电磁综合疗法对马属动物大肠阻塞疗效试验

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甘肃农业大学学报 1989年第3期24卷 73-75页

作者：冯大刚黄虎祖魏开瑜马瑞有鲁希英耿大平赵生林甘肃农业大学兽医系

低频电磁综合疗法对人的消化性肠梗阻有较好的疗效。为了移植这一技术,作者应用低频电磁综合疗法试治了马属动物大肠阻塞78例,治愈47例.左下大结肠阻塞效果最好(治愈率达84.6%);胃状膨大部阻塞次之(沿愈率为68.4%);小结肠阻塞效果较差(... 详细信息

低频电磁综合疗法对人的消化性肠梗阻有较好的疗效。为了移植这一技术,作者应用低频电磁综合疗法试治了马属动物大肠阻塞78例,治愈47例.左下大结肠阻塞效果最好(治愈率达84.6%);胃状膨大部阻塞次之(沿愈率为68.4%);小结肠阻塞效果较差(治愈率仅40.6%)。该疗法可用于马属动物大肠阻塞的治疗,或者作为一种辅助治疗方法。

关键词：低频电磁大肠阻塞

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Dual-crosslinked regenerative hydrogel for sutureless long-term repair of corneal defect

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Bioactive Materials 2023年第2期20卷 434-448页

作者： Xuanren Shen Saiqun Li Xuan zhao Jiandong Han Jiaxin Chen Zilong Rao Kexin Zhang daping Quan Jin Yuan Ying Bai Guangdong Engineering Technology Research Centre for Functional Biomaterials School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou510006China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou510623China

Corneal transplantation is the most effective clinical treatment for corneal defects,but it requires precise size of donor corneas,surgical sutures,and overcoming other technical *** patients may suffer graft rejection and complications caused by *** glues that can long-term integrate with the corneal tissue and effectively repair the focal corneal damage are highly ***,a hybrid hydrogel consisting of porcine decellularized corneal stroma matrix(pDCSM)and methacrylated hyaluronic acid(HAMA)was developed through a non-competitive dual-crosslinking *** can be directly filled into corneal defects with various *** importantly,through formation of interpenetrating network and stable amide bonds between the hydrogel and adjacent tissue,the hydrogel manifested excellent adhesion properties to achieve suture-free ***,the hybrid hydrogel not only preserved bioactive components from pDCSM,but also exhibited cornea-matching transparency,low swelling ratio,slow degradation,and enhanced mechanical properties,which was capable of withstanding superhigh intraocular *** combinatorial hydrogel greatly improved the poor cell adhesion performance of HAMA,supported the viability,proliferation of corneal cells,and preservation of keratocyte *** a rabbit corneal stromal defect model,the experimental eyes treated with the hybrid hydrogel remained transparent and adhered intimately to the stroma bed with long-term retention,accelerated corneal re-epithelialization and wound *** the advantages of high bioactivity,low-cost,and good practicality,the dual-crosslinked hybrid hydrogel served effectively for long-term suture-free treatment and tissue regeneration after corneal defect.

关键词： Corneal defect Decellularized extracellular matrix Hydrogel Sutureless repair Cornea regeneration

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Spin-Modulated Oxygen Electrocatalysis

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Precision Chemistry 2023年第7期1卷 395-417页

作者： Zhi Fang Wanting zhao Tong Shen daping Qiu Yucheng Lv Xinmei Hou Yanglong Hou Beijing Key Laboratory for Magnetoelectric Materials and Devices(BKL-MMD) Beijing Innovation Centre for Engineering Science and Advanced Technology(BIC-ESAT)School of Materials Science and EngineeringPeking UniversityBeijing 100871China Innovation Research Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The electrocatalysis reactions involving oxygen,such as oxygen evolution reaction(OER)and oxygen reduction reaction(ORR),play a critical role in energy storage/conversion applications,e.g.,fuel cells,metal-air batteries,and electrochemical water *** high kinetic energy barrier of the OER/ORR is highly associated with the spin state interconversion between singlet OH^(−)/H_(2)O and triplet O_(2),which is influenced by the spin state and magnetism of *** Review summarizes recent progress and advances in understanding spin/magnetism-related effects in oxygen electrocatalysis to develop spin *** is demonstrated that the spin states(low,intermediate,and high spin)of magnetic transition metal catalysts(TMCs)can directly affect the reaction barriers of OER/ORR by tailoring the bonding of oxygen intermediates with ***,the spin states of TMCs can build a spin-selective channel to filter the electron spins required for the single/triplet interconversion of O species during OER/*** this Review,we introduced many approaches to modulating spin state,for instance,altering the crystal field,oxidation state of active-site ions,and the morphology of ***’s more,a magnetic field can drive the spin flip of magnetic ions to achieve the spin alignment(↑↑)(i.e.,facilitating spin polarization),which will strengthen the spin selectivity for accelerating the filtration and transfer of the spins with the same direction for the generation and conversion of triplet ↑O=O↑.Importantly,the origin of magnetic field enhancement on OER/ORR are deeply discussed,which provides a great vision for the magnetism-assisted ***,the challenges and perspectives for future development of spin/magnetism catalysis are *** Review is expected to highlight the significance of spin/magnetism theory in breaking the bottleneck of electrocatalysis field and promote the development of high-efficientcy electrocatalysts for practical applications.

关键词： Oxygen electrocatalysis Magnetic transition metal catalyst Spin modulation Magnetic field Spin polarization Spin selectivity

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基于经筋骨一体观探讨脊柱调衡点穴手法治疗非特异性腰痛的机制研究进展

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实用中医内科杂志 2024年第6期38卷 89-92页

作者：李锦锋张晓刚赵希云王志鹏权桢赵雅文秦大平甘肃中医药大学甘肃兰州730000 甘肃中医药大学附属医院甘肃兰州730020

非特异性腰痛(NSLBP)的病机较为复杂,与“经-筋-骨”三者彼此失和密切相关。脊柱调衡点穴手法以经、筋、骨为治疗节点,是治疗NSLBP的有效方法,但其作用机制尚未明确。文章以经筋骨三位一体观为理论基础,从经络不畅、筋骨失衡的角度出发... 详细信息

非特异性腰痛(NSLBP)的病机较为复杂,与“经-筋-骨”三者彼此失和密切相关。脊柱调衡点穴手法以经、筋、骨为治疗节点,是治疗NSLBP的有效方法,但其作用机制尚未明确。文章以经筋骨三位一体观为理论基础,从经络不畅、筋骨失衡的角度出发,对脊柱调衡点穴手法治疗NSLBP的作用机制展开论述。

关键词：经筋骨一体观脊柱手法非特异性腰痛研究进展

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从筋骨失衡力学源性分析探讨骨质疏松症的防治策略

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辽宁中医杂志 2024年第6期51卷 35-38页

作者：秦大平高国栋赵雅文李锦锋郑礼李磊权祯徐斌王志鹏徐世伟张晓刚甘肃中医药大学中医临床学院甘肃兰州730000 甘肃中医药大学附属医院甘肃兰州730020

骨质疏松症(osteoporosis,OP)的诊断率逐年上升,其高发病风险、发病率以及并发脆性骨折,致残、致死率增加给家庭、社会带来极大的危害和负担,也成为世界范围内所面临的老年性、慢性疾病防治的热点和重点问题。从生物力学角度分析其发病... 详细信息

骨质疏松症(osteoporosis,OP)的诊断率逐年上升,其高发病风险、发病率以及并发脆性骨折,致残、致死率增加给家庭、社会带来极大的危害和负担,也成为世界范围内所面临的老年性、慢性疾病防治的热点和重点问题。从生物力学角度分析其发病过程,明确力学退变性筋骨病原因与其力学平衡和稳定有关的脊柱关节静力系统、肌肉、筋膜、韧带、关节囊等动力系统之间的相互作用,其发生与持续静态负荷和动态负荷、额外负荷、增龄性因素均相关。OP筋-骨系统力学生物学特性失衡,这与现代医学所讲的力学源性平衡因素改变如出一辙。通过对人体力学平衡特点和骨质疏松症患者筋骨失衡的力学源性分析,揭示筋骨系统力学失衡的功能性与结构性代偿临床病理变化分型,针对骨质疏松症患者筋骨力学失衡不同病理分型,为临床防治策略的建立和制定提供参考依据。

关键词：骨质疏松症筋骨失衡脊柱生物力学防治策略

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Risk factors and predictive model of cerebral edema after road traffic accidents-related traumatic brain injury

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Chinese Journal of Traumatology 2024年第3期27卷 153-162页

作者： Di-You Chen Peng-Fei Wu Xi-Yan Zhu Wen-Bing zhao Shi-Feng Shao Jing-Ru Xie Dan-Feng Yuan Liang Zhang Kui Li Shu-Nan Wang Hui zhao Institute for Traffic Medicine Daping HospitalArmy Medical UniversityChongqing400042China Department of Radiology Daping HospitalArmy Medical UniversityChongqing400042China Chongqing Key Laboratory of Traffic Injury and Vehicle Ergonomics Chongqing400042China Wound Trauma Medical Center State Key Laboratory of TraumaBurns and Combined InjuryInstitute of Surgery ResearchDaping HospitalArmy Medical UniversityChongqing.400042China

Purpose:Cerebral edema(CE)is the main secondary injury following traumatic brain injury(TBI)caused by road traffic accidents(RTAs).It is challenging to be predicted *** this study,we aimed to develop a prediction model for CE by identifying its risk factors and comparing the timing of edema occurrence in TBI patients with varying levels of ***:This case-control study included 218 patients with TBI caused by *** cohort was divided into CE and non-CE groups,according to CT results within 7 *** data,imaging data,and clinical data were collected and *** variables that follow normal distribution were presented as mean±standard deviation,those that do not follow normal distribution were presented as median(Q1,Q3).Categorical variables were expressed as *** Chi-square test and logistic regression analysis were used to identify risk factors for *** curve fitting was performed to predict the time to secondary CE in TBI patients with different levels of *** efficacy of the model was evaluated using the receiver operator characteristic ***:According to the study,almost half(47.3%)of the patients were found to have *** risk factors associated with CE were bilateral frontal lobe contusion,unilateral frontal lobe contusion,cerebral contusion,subarachnoid hemorrhage,and abbreviated injury scale(AIS).The odds ratio values for these factors were 7.27(95%confidence interval(CI):2.08-25.42,p=0.002),2.85(95%CI:1.11-7.31,p=0.030),2.62(95%CI:1.12-6.13,p=0.027),2.44(95%CI:1.25-4.76,p=0.009),and 1.5(95%CI:1.10-2.04,p=0.009),*** also observed that patients with mild/moderate TBI(AIS≤3)had a 50%probability of developing CE 19.7 h after injury(χ^(2)=13.82,adjusted R2=0.51),while patients with severe TBI(AIS>3)developed CE after 12.5 h(χ^(2)=18.48,adjusted R2=0.54).Finally,we conducted a receiver operator characteristic curve analysis of CE time,which showed an area under the curve of 0

关键词： Road traffic accident Traumatic brain injury Cerebral edema Risk factors Time window

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宫颈浸润性复层产黏液性癌18例HER2扩增与PD-L1表达

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中华病理学杂志 2024年第10期53卷 1018-1023页

作者：唐丹付萍赵连花陆军军医大学陆军特色医学中心(大坪医院)病理科重庆400042 西南医科大学附属中医医院病理科泸州646000

目的探讨宫颈浸润性复层产黏液性癌(invasive stratified mucin-producing carcinoma,ISMC)的临床病理特征、预后及HER2、PD-L1的表达情况。方法收集陆军军医大学陆军特色医学中心(大坪医院)2018年1月至2023年12月诊治的18例根治性宫颈I... 详细信息

目的探讨宫颈浸润性复层产黏液性癌(invasive stratified mucin-producing carcinoma,ISMC)的临床病理特征、预后及HER2、PD-L1的表达情况。方法收集陆军军医大学陆军特色医学中心(大坪医院)2018年1月至2023年12月诊治的18例根治性宫颈ISMC患者的临床病理资料并对其进行分析,同时进行了PD-L1、HER2免疫组织化学染色及荧光原位杂交(FISH)HER2检测。结果患者年龄31~72岁,平均45岁;约占我院同期宫颈腺癌的8%;11例为纯ISMC,7例为混合型,混合成分为鳞状细胞癌及普通型腺癌;1例合并小细胞神经内分泌癌;活检明确诊断3例(3/18);浸润模式Silva B型5例,C型13例;3例出现区域淋巴结转移;13例患者无病生存,1例合并小细胞神经内分泌癌的患者发生远处转移;15例(15/18)PD-L1综合阳性评分≥1,7例(7/18)PD-L1肿瘤细胞阳性比例分数≥1%;1例HER23+和1例HER22+,均为FISH扩增阳性;2例HER21+,14例HER20。结论宫颈ISMC罕见,形态学谱系广泛,可与其他类型的宫颈癌混合存在,活检诊断准确率极低;PD-L1在大部分ISMC病例中呈阳性表达,HER2在少数病例中过表达及低表达,有望尝试针对PD-L1的免疫治疗及HER2的靶向治疗。

关键词：宫颈肿瘤基因,erbB-2 浸润性复层产黏液性癌

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内源性CO和NO与小儿哮喘关系的研究

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实用儿科临床杂志 1997年第6期12卷 361-362页

作者：蒋东波李华强史源潘捷沈际皋姚忠凯覃世文潘凤赵锦宁第三军医大学附属大坪医院野战外科研究所重庆630042

目的:探讨小儿哮喘时血浆一氧化碳（CO）和一氧化氮（NO）的含量变化及意义。方法哮喘患儿21例，20名健康儿童为对照，分别在急性发作期和缓解期采静脉血测定血浆CO和NO水平。对测定结果进行统计学分析。结果发作期哮喘患儿血浆CO明显... 详细信息

目的:探讨小儿哮喘时血浆一氧化碳（CO）和一氧化氮（NO）的含量变化及意义。方法哮喘患儿21例，20名健康儿童为对照，分别在急性发作期和缓解期采静脉血测定血浆CO和NO水平。对测定结果进行统计学分析。结果发作期哮喘患儿血浆CO明显高于正常儿童（分别为1．66±035、1．06±0.12mg／L，t=7．26，P＜0.001），缓解期CO降至正常水平（1．13±0．14mg／L，t=1．56，P＞0．05）；发作期哮喘息地血浆NO2／NO3水平亦明显高于正常儿童（分别为32．8±3．9、29．3±0．28μmol／L，t=3．28，P＜0．01），缓解期NO2／NO3水平亦降至正常水平（29．7±3．0μmol／L，t=0．39，P＞0．05）。且哮喘患儿血浆CO和NO水平呈显著正相关（r=0.485，P＜0．05）。结论小儿哮喘发作期血浆CO和NO水平明显高于缓解期患儿及正常儿童。内源性CO和NO在哮喘发病机制中占有重要地位。

关键词：一氧化碳一氧化氮哮喘儿童

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