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房屋维修保险机制研究——以泰州为例

工程经济 2024年第3期34卷 56-61页

作者：赵安然王彬武钟庭军住房和城乡建设部政策研究中心

在当前住房养老金制度设计的关键时期,本文基于实地调研,对泰州市房屋维修保险机制的理念和“多方负担、应急使用”“、多参保多提取、少参保保基本”的原则进行了剖析,发现其实质是住宅专项维修资金的补充机制,并一定程度破解了住宅专... 详细信息

在当前住房养老金制度设计的关键时期,本文基于实地调研,对泰州市房屋维修保险机制的理念和“多方负担、应急使用”“、多参保多提取、少参保保基本”的原则进行了剖析,发现其实质是住宅专项维修资金的补充机制,并一定程度破解了住宅专项维修资金“使用难”的问题。同时,对该机制的普适性、居民参与和法律保障问题进行评析,强调要试点扩围,进一步加强上位法支撑、提高居民参与意愿。

关键词：专项维修资金房屋维修保险提取额度补充机制

SiC逆变器供电的牵引电机匝间绝缘性能评估

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绝缘材料 2024年第4期57卷 88-99页

作者：罗英露赵安然王鹏于超凡林沐泓黄文冬彭增中车株洲电力机车研究所有限公司湖南株洲410002 四川大学电气工程学院四川成都610065

采用碳化硅(SiC)逆变器供电,虽然可以减小牵引变频电机体积、质量、温升,提高电机效率,但逆变器输出电压的高频、短上升时间等特性给牵引变频电机绝缘带来了挑战,尤其是匝间绝缘将会承受更高的电压负荷,导致绝缘过早失效。本文首先通过... 详细信息

采用碳化硅(SiC)逆变器供电,虽然可以减小牵引变频电机体积、质量、温升,提高电机效率,但逆变器输出电压的高频、短上升时间等特性给牵引变频电机绝缘带来了挑战,尤其是匝间绝缘将会承受更高的电压负荷,导致绝缘过早失效。本文首先通过模拟SiC逆变器在最大开关频率及实际电缆线长度下高压变频牵引电机匝间绝缘所承受的电压波形,在不同电压参数(频率、电压峰峰值、上升时间)、不同温度、不同匝间绝缘层厚度(0.23 mm、0.30 mm)下对高压变频电机电磁线进行局部放电起始电压测试及耐电晕寿命测试,并根据牵引电机的实际运行工况和绝缘系统的电负荷失效机理,分析PDIV、局部放电特性及寿命的变化机理。PDIV测试结果表明:频率与上升时间的变化并不会对PDIV产生影响;温度升高,PDIV呈现下降趋势,但由于制作工艺问题,在部分温度下会出现上升趋势;厚度的增加对PDIV提升较大,在考虑成本及效率可控的前提下,提高厚度能有效提高变频电机匝间绝缘能力。耐电晕测试结果表明:温度与上升时间的变化会造成绝缘寿命发生较大改变;频率及电压峰峰值对绝缘寿命的影响呈非线性关系,可用反幂模型表达,并且在工业应用上针对频率对绝缘寿命的影响可直接通过比例关系进行折算。

关键词： SiC逆变器电压参数匝间绝缘层厚度 PDIV 耐电晕寿命

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Synthesis, In vitro Coagulation Activities and Molecular Docking Studies on Three L-Histidine Amide Derivatives

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Chemical Research in Chinese Universities 2018年第1期34卷 90-94页

作者： HE Wei zhao anran ZOU Jiajia LUO Xuan LIN Xiao WANG Lisheng LIN Cuiwu . School of Chemistry and Chemical Engineering Nanning & Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development Guangxi University Nanning 530004 P. R. China Department of Chemistry Cleveland State University Cleveland OH 44115 USA Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards Guangxi Institute of Traditional Medical and Pharmaceutical Sciences Nanning 530022 P. R. China

Three novel L-histidine amide derivatives were synthesized and the corresponding chemical structures were characterized by means of melting point analysis, IR, MS, ^1H NMR as well as ^13C NMR. The coagulation activities of the compounds were evaluated by an MOE（molecular operating environment） docking technique and coagulation test. The results obtained from molecular docking show that the interactions between the compounds and thrombin exhibit procoagulant activity in combination with an improved combinatory effect. Moreover, the results of in vitro coagulation tests show that the L-histidine amide derivatives feature coagulant activities in common coagulation pathways. Compared with the blank control group, the optimal shortening rates of compounds 1-3 were 39.08%（0.5 mmol/L）, 22.94%（1.0 mmol/L） and 15.38%（0.0625 mmol/L）, respectively.

关键词： L-Histidine amide derivative Molecular docking Coagulation test

Synthesis of Caffeic Acid Sulphonamide Derivatives and Preliminary Exploration of Their Biological Applications

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Chemical Research in Chinese Universities 2020年第5期36卷 795-803页

作者： PENG Xiaoyu zhao anran HUANG Kelin HU Tingju LIU Burning HUANG Yan CHEN Hailan CHAI Ling LIN Cuiwu School of Chemistry and Chemical Engineeting Guangxi UniversityNanning 530004P.R.China School of Animal Science and Technology Guangxi UniversityNanning 530004P.R.China Laboratory Medicine Department First.Affiliated Hospital of Guangxi Medical UniversityNanning 530021P.R.China Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards Guangxi Institute of Traditional Medical and Pharmaceutical SciencesNanning 530022P.R.China China Academy of Science and Technology Development Guangxi Branch Nanning 530022P.R.China

Stnictural modification of native compounds is an effective way to develop new dmgs with increased pharmacological activities and improved material *** this study,cafteic acid sulphonamide derivatives(CSs)were synthesised by conjugating sulphonamides to the backbone of cafteic *** structures of these derivatives were elucidated by means of Fourier traiisfonn infrared spectroscopy(FTIR),1H NMR,13C NMR,and electrospray ionization mass spectroscopy(ESI-MS).A content determination method was established by ultraviolet *** lipophilicity,2,2-diphenyl-l-picrylhydrazy free radical(DPPH)scavenging capacity,anti-coagulant eitects,anti-bacterial activity,cytotoxicity,in vitro anti-proliterative activity against tumour cells,and the ability of the compounds to promote the proliferation of chondrocytes were *** results indicate that CSs exliibit strong DPPH scavenging activity,high lipophilicity,good anti-coagulant activities,wide anti-bacterial activity range,low cytotoxicity,and an excellent ability to promote chondrocyte proliferation.

关键词： Cafteic acid Sulphonamide Lipophilicity Anti-oxidant Cytotoxicity

Efficient optimization of electron transfer pathway by constructing phosphide/ceria interface boosts seawater hydrogen production

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Journal of Energy Chemistry 2024年第8期95卷 490-498,I0011页

作者： Yifan zhao Lingfeng Yang Youyu Long Min Xi anran Chen Hua Zhang School of Materials and Energy Yunnan UniversityKunming 650091YunnanChina Electron Microscopy Centre of Yunnan University Yunnan UniversityKunming 650091YunnanChina

Developing efficient and durable hydrogen evolution reaction(HER)electrocatalysts is one of the most important issues for the commercialization of seawater electrolysis,but it remains ***,we report a CeO_(2)-CoP nanoneedle array catalyst loaded on Ti mesh(CeO_(2)-CoP/TM)with workfunction-induced directional charge transport *** CeO_(2)-CoP/TM catalyst showed superior HER catalytic activity and stability,with over potentials of 41 and 60 mV to attain 10 mA cm^(-2),in 1 M KOH and 1 M KOH+seawater electrolyte,*** results and theoretical calculations reveal that the work function drives the charge transfer from CeO_(2)to CoP,which effectively balances the electronic density of CoP and CeO_(2),optimizes the d-band center,and accelerates the water activation kinetics,thus enhancing the HER *** solar-driven water electrolysis device displays a high and stable solar-to-hydrogen conversion efficiency of 19.6%.This study offers a work function-induced directional charge transport strategy to design efficient and durable catalysts for hydrogen production.

关键词： Work function Heterostructure Charge transport Seawater splitting Solar-to-hydrogen

Cofilin participates in regulating alpha-epithelial sodium channel by interaction with 14-3-3 isoforms

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The Journal of Biomedical Research 2020年第5期34卷 351-360页

作者： Ashfaq-Ahmad-Shah Bukhari Xue Zhang Min Li anran zhao Hao Dong Xiubin Liang Department of Pathophysiology Nanjing Medical UniversityNanjingJiangsu 211166China Department of Pathology Nanjing Medical UniversityNanjingJiangsu 211166China Department of Nephrology the Affiliated Sir Run Run Hospital of Nanjing Medical UniversityNanjingJiangsu 211166China

Renal epithelial sodium channel(ENaC) plays a crucial role in maintaining homeostasis and sodium *** insulin participates in controlling sodium transport across the renal epithelium,the underlying molecular mechanism remain *** this study,we found that insulin increased the expression and function of alphaepithelial sodium channel(α-ENaC) as well as phosphorylation of cofilin,a family of actin-binding proteins which disassembles actin filaments,in mouse cortical collecting duct(mpkCCDc14) *** wild-type(WT)cofilin and its constitutively phosphorylated form(S3 D),but not its constitutively non-phosphorylable form(S3 A),contributed to the elevated expression on α-*** of 14-3-3ε,β,or y increased the expression of α-ENaC and cofilin phosphorylation,which was blunted by knockdown of 14-3-3ε,β,or ***,it was found that insulin increased the interaction between cofilin and 14-3-3 isoforms,which indicated relevance of 14-3-3 isoforms with ***,LIMK1/SSH1 pathway was involved in regulation of cofilin and α-ENaC expression by *** results from this work indicate that cofilin participates in the regulation of α-ENaC by interaction with 14-3-3 isoforms.

关键词： cofilin ENaC insulin 14-3-3 LIMK1 SSH1

基于CRISPR/Cas9技术构建SLC19A2基因敲除小鼠及其表型验证

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中国医药导报 2024年第22期21卷 1-5,21页

作者：钱晨向利群覃媛媛闫婕赵安然叶玉萍林发全广西医科大学第一附属医院检验科、广西高校临床检验诊断学重点实验室广西南宁530021

目的利用CRISPR/Cas9技术构建SLC19A2基因敲除的纯合子小鼠模型,并验证其表型。方法设计gRNA载体,将构建好的gRNA载体和Cas9载体进行体外转录后共注射到受精卵,经胚胎移植后获得6只(雌性3只、雄性3只)阳性F0代小鼠。通过繁育获得12只(雄... 详细信息

目的利用CRISPR/Cas9技术构建SLC19A2基因敲除的纯合子小鼠模型,并验证其表型。方法设计gRNA载体,将构建好的gRNA载体和Cas9载体进行体外转录后共注射到受精卵,经胚胎移植后获得6只(雌性3只、雄性3只)阳性F0代小鼠。通过繁育获得12只(雄性6只、雌性6只)SLC19A2基因敲除纯合子小鼠[SLC19A2-/-小鼠(C57BL/6)]。8周龄野生型C57BL/6小鼠和SLC19A2-/-小鼠各12只(雄性6只、雌性6只),分别设为野生型组与基因敲除纯合子组。采用PCR扩增凝胶电泳法鉴定小鼠基因型;采用实时荧光定量PCR检测胰腺组织和肝脏组织中SLC19A2 mRNA表达,采用蛋白质印迹法检测胰腺组织和肝脏组织中THTR-1蛋白表达。结果PCR扩增凝胶电泳法成功鉴定出SLC19A2-/-小鼠。基因敲除纯合子组胰腺组织和肝脏组织中SLC19A2 mRNA及THTR-1蛋白表达水平低于野生型组,差异有统计学意义(P<0.05)。结论基于CRISPR/Cas9技术成功构建了SLC19A2基因敲除小鼠。

关键词： SLC19A2 基因敲除 CRISPR/Cas9

Heterogeneous bimetallic oxides/phosphides nanorod with upshifted d band center for efficient overall water splitting

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Chinese Chemical Letters 2024年第9期35卷 414-420页

作者： Ji Chen Yifan zhao Shuwen zhao Hua Zhang Youyu Long Lingfeng Yang Min Xi Zitao Ni Yao Zhou anran Chen School of Materials and Energy Yunnan UniversityKunming 650091China School of Engineering The University of EdinburghSouth BridgeEdinburgh EH89YLUnited Kingdom Electron Microscopy Center Yunnan UniversityKunming 650091China School of Internet of Things Engineering Jiangnan UniversityWuxi 214122China

Electrocatalytic water splitting is the most directly available route to generate renewable and sustainable ***,we report the design of a composite material in which arrays of square pillar-like NiMoO4nanorods coated with N,P-doped carbon layers are uniformly contained in numerous nested nanoparticle *** catalysts have superior catalytic activity,requiring only 59 mV and 187 mV for HER and OER to attain a current density of 10 mA/cm^(2),*** assembled two-electrode electrolytic cell required a voltage of 1.48 V to reach 10 mA/cm^(2),along with excellent long-term *** calculations reveal that electrons aggregate and redistribute at the heterogeneous interface,with the d-band centers of the Ni and Fe atoms being positively shifted compared to the Fermi level,effectively optimizing the adsorption of intermediates and reducing the Gibbs free energy,thus accelerating the catalytic ***,an integrated solar-driven water-splitting system demonstrated a high and stable solar-to-hydrogen efficiency of 18.20%.This work provides new possibilities for developing non-precious metal-based bifunctional electrocatalysts for large-scale water splitting applications.

关键词： Hydrogen evolution reaction Bimetallic oxides Bimetallic phosphides Overall water splitting Solar-to-hydrogen efficiency

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高中地理课堂深度学习的设计与实践

地理教学 2019年第7期 34-37页

作者：赵安冉仲小敏天津师范大学教师教育学院天津300387

本文从深度学习的特质出发,结合具体课例,从自我导向、内容的理解、学习过程的建构反思、思维的创新批判、成果的迁移运用探讨基于深度学习的中学地理课堂实践,以期为核心素养下的中学地理课堂教学评价提供参考。

关键词：深度学习课堂观察地理核心素养