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DENND1A desensitizes granulosa cells to FSH by arresting intracellular FSHR transportation

Science China(Life Sciences) 2024年第8期67卷 1620-1634页

作者： Yunde Dou Rusong zhao Han Wu Zhiheng Yu Changjian Yin Jie Yang Chaoyan Yang Xiaohua Luan Yixiao Cheng Tao Huang Yuehong Bian Shan Han Yuqing Zhang Xin Xu zi-Jiang Chen Han zhao Shigang zhao Institute of Women Children and Reproductive HealthShandong UniversityJinan 250012China State Key Laboratory of Reproductive Medicine and Offspring Health Jinan 250012China Key laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinan 250012China Shandong Key Laboratory of Reproductive Medicine Shandong UniversityJinan 250012China Shandong Provincial Clinical Research Center for Reproductive Health Jinan 250012China National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinan 250012China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalNanjing Medical UniversitySuzhou 215008China Gusu School Nanjing Medical UniversitySuzhou 215000China Guangdong Provincial People’s Hospital Guangdong Academy of Medical SciencesGuangzhou 510080China Guangdong-Hong Kong Metabolism&Reproduction Joint Laboratory Guangdong Second Provincial General HospitalGuangzhou 510317China Reproductive Medicine Center Guangdong Second Provincial General HospitalGuangzhou 510317China Research Unit of Gametogenesis and Health of ART-Offspring Chinese Academy of Medical Sciences(No.2021RU001)Jinan 250012China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai 200127China Center for Reproductive Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Polycystic ovary syndrome(PCOS)is a complex ***-wide association studies(GWAS)have identified several genes associated with this condition,including ***1A encodes a clathrin-binding protein that functions as a guanine nucleotide exchange factor involved in vesicular ***,the specific role of DENND1A in reproductive hormone abnormalities and follicle development disorders in PCOS remain poorly *** this study,we investigated DENND1A expression in ovarian granulosa cells(GCs)from PCOS patients and its correlation with *** results revealed an upregulation of DENND1A expression in GCs from PCOS cases,which was positively correlated with testosterone *** further explore the functional implications of DENND1A,we generated a transgenic mouse model overexpressing Dennd1a(TG mice).These TG mice exhibited subfertility,irregular estrous cycles,and increased testosterone production following PMSG ***,the TG mice displayed diminished responsiveness to FSH,characterized by smaller ovary size,less well-developed follicles,and abnormal expressions of FSH-priming ***,we found that Dennd1a overexpression disrupted the intracellular trafficking of follicle stimulating hormone receptor(FSHR),promoting its internalization and inhibiting *** findings shed light on the reproductive role of DENND1A and uncover the underlying mechanisms,thereby contributing valuable insights into the pathogenesis of PCOS and providing potential avenues for drug design in PCOS treatment.

关键词： PCOS DENND1A FSHR ovarian granulosa cells

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Oscillation properties of eigenfunctions for Sturm-Liouville problems with interface conditions via Prufer transformation

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 191-200页

作者： LI Zhi-yu LI Kun CAI jin-ming QIN Jian-fang ZHENG zhao-wen School of Mathematical Sciences Qufu Normal UniversityQufu 273165China College of Mathematics and Systems Science Guangdong Polytechnic Normal UniversityGuangzhou 510665China

A class of Sturm-Liouville problems with discontinuity is studied in this *** oscillation properties of eigenfunctions for Sturm-Liouville problems with interface conditions are *** main method used in this paper is based on Prufer transformation,which is different from the classical ***,we give two examples to verify our main results.

关键词： Sturm-Liouville problem interface condition oscillatory solution

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Changes of nutrients and microbial communities in recovery process of abandoned rare earth tailings

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Pedosphere 2024年第4期34卷 826-836页

作者： Bing ZHANG Junli WU Mengyuan HUANG Yan ZHANG jin zhao Chuntao HE Zhongyi YANG School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China School of Agriculture State Key Laboratory for BiocontrolShenzhen Campus of Sun Yat-sen UniversitySun Yat-sen UniversityShenzhen 518107China

Rare earth element(REE)mining has wrought severe ecosystem destruction,particularly in the loss of carbon(C),nitrogen(N),and phosphorus(P).Furthermore,its effects on nutrient recovery characteristics and associated microbial abundance are still poorly *** this study,an investigation was conducted to determine C,N,and P recovery patterns and microbial communities in abandoned REE mining tailings with different abandoned durations of 1.5(1.5-Y),7(7-Y),10(10-Y),and 14(14-Y)years and at an unmined site(the control group)in Jiangxi Province,*** tailing delamination at each site was investigated in 0–15(layer 1)and 15–30(layer 2)cm tailing *** the abandoned duration of REE tailings,C and P in layer 1 continued to recover from 1.62 to 8.51 g kg^(-1) and from 0.71 to 1.94 g kg^(-1),respectively;N losses of 0.60 and 0.22 g kg^(-1) occurred at the 1.5-Y and 10-Y sites,while N in layer 1 slightly increased at the 14-Y ***,Methylosinus,Bradyrhizobium,Pseudomonas,and Azospirillum were dominant bacteria at the 14-Y site and in the *** relative abundances of N-fixing bacteria Mesorhizobium(32.94%),Sinorhizobium(0.24%),Frankia(0.71%),and Burkholderia(2.38%)at the 14-Y site were 1.33–3.97 times those in the control(24.19%,0.18%,0.32%and 0.60%,respectively),which was helpful for tailing N *** the 14-Y site,Tylospora(50.24%),Luellia(11.02%),Tomentella(6.94%),and Chaetomium(4.34%)were the dominant fungal genera,while Tylospora(56.93%),Suillus(11.45%),and Penicillium(6.78%)predominated in the *** relative abundance of the P-dissolving fungus Aspergillus at the 14-Y site(0.42%)was 4.2 times that in the control(0.1%),which may lead to the improved tailing P *** the 14-Y site,woody plants such as Pinus massoniana and native pioneering herbs and ferns such as Dicranopteris dichotoma and Nephrolepis auriculata probably invaded from adjacent *** study unraveled the natural restoration of plant and micro

关键词： abandoned duration mining tailing N-fixing bacteria nutrient recovery P-solubilizing fungi rare earth element

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Modulating the alloying mode in the doping-induced synthesis of Au-Pd nanowires

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Nano Research 2024年第4期17卷 3334-3343页

作者： Hui jin Xiaoliang Wei Lecheng zhao Jialong Yu Qiao Pan Shumin Li Qian Wang zhaotong Yuan Dan Yang Donghui zhao Hongyu Chen Yawen Wang Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringJiangsu National Synergistic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 211816China School of Science Westlake UniversityHangzhou 310064China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310064China

Heterogeneous doping is one effective strategy for synthesizing metal alloy ***,the heterogeneous doping processes of Pd on the ultrathin Au nanowires were systematically modulated and ***-Pd alloy nanowires with various morphologies and lattice structures can be obtained by adjusting the morphology of the precursor Au nanowires and the kinetics of the heterogeneous doping *** effects of the rate of Pd reduction and the concentration of the ligand oleylamine(OAm)on the Pd deposition and alloying mode were ***,as the Pd deposition rate decreases,the Pd deposition and alloying mode switches from the island-forming Stransky–Krastanov(SK)mode to the epitaxial Frank-van der Merwe(FM)mode,and eventually to an unconventional twisting alloying mode,where the interdiffusion of Pd and Au causes drastic rearrangement of the lattice structure and formation of helical *** kinetics-related variation of alloying mode could also be observed in the Au-Ag nanowires,demonstrating a general design principle for the synthesis of alloy *** addition,the electrocatalytic performance of various Au-Pd nanowires was evaluated,and the alloy nanowire formed via the SK mode was found to be an excellent electrocatalyst for oxygen reduction and ethanol oxidation.

关键词： gold nanowires Au-Pd alloy oleylamine post-synthetic modification

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Lead-free(Ba,Sr)TiO_(3)-based ceramics with superior tunable properties by the semi-solution method

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Journal of Advanced Ceramics 2024年第6期13卷 746-756页

作者： Yi zhao Wenfeng Liu Dongsheng Ran Yihang jin Zhiyuan Li Chengzhi Zhong Fanyi Kong Shengtao Li State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China Jiaxing Electric Power Company State Grid Zhejiang Electric Power Co. Ltd.Jiaxing 314000China

High-performance dielectric tunable materials with both high dielectric tunability and low dielectric loss are urgently needed for new-generation electronic tunable *** the present study,a new system,(Ba_(0.675)Sr_(0.325))_(1−x)La_(x)Ti_(1−x)MnxO_(3)(x=0.25%,0.5%,0.75%,and 1.0%),was *** acceptor dopant Mn was added to lower dielectric loss,while the donor dopant La was introduced to enhance dielectric *** samples were prepared using the conventional solid-state(CS)reaction method and the semi-solution(SS)*** experimental results showed that the morphology of the ceramics was optimized by further improving the processing *** microstructures,homogeneous grains,and uniform dopant distributions could be achieved successfully by the semi-solution ***,a significant enhancement in the tunable properties was realized owing to the improved microstructure mentioned *** optimum tunable properties occurred in the samples prepared by the semi-solution method at x=0.75%,with a high dielectric tunability of 85.0%,a low dielectric loss of 0.0011,and an excellent figure of merit(FOM)of *** tunable properties of(Ba,Sr)TiO_(3)(BST)ceramics were even superior to those of lead-based materials,with an FOM of approximately *** the results suggested that the semi-solution method rendered BST ceramics more promising for applications in tunable devices.

关键词： microstructure tunable properties (Ba,Sr)TiO_(3)(BST)ceramics semi-solution(SS)method

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Recent advances in quantifying the inactive lithium and failure mechanism of Li anodes in rechargeable lithium metal batteries

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Journal of Energy Chemistry 2024年第9期96卷 226-248页

作者： Mingming Tao Junning Chen Hongxin Lin Yingao Zhou Danhui zhao Peizhao Shan Yanting jin Yong Yang State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Department of ChemistryCollege of Chemistry and Chemical EngineeringTan Kah Kee Innovation Laboratory(IKKEM)Xiamen UniversityXiamen 361005FujianChina School of Engineering Westlake UniversityHangzhou 310024ZhejiangChina School of Energy Research Xiamen UniversityXiamen 361005FujianChina

Lithium metal is considered as the ultimate anode material for the next generation of high-energy density ***,non-uniform lithium dendrite growth,serious electrolyte consumption,and significant volume changes during lithium deposition/stripping processes lead to sustained accumulation of inactive lithium and poor cycling *** the formation and evolution of inactive lithium under different conditions and fully evaluating the complex failure modes are the key issues in this challenging *** article comprehensively reviews recent research progress on the quantification of formation and evolution of inactive lithium detected by different quantitative techniques in rechargeable lithium metal *** key research challenges such as failure mechanism,modification strategies and operando characterization of lithium metal anodes are systematically summarized and *** review provides a new angle of view to understand failure mechanism of lithium metal anodes and inspiration and guidance for the future development of rechargeable lithium metal batteries.

关键词： Lithium metal anodes Inactive lithium Quantitative technique Failure mechanism

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Framework and Key Technologies of Human-machine Hybrid-augmented Intelligence System for Large-scale Power Grid Dispatching and Control

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 1-12页

作者： Shixiong Fan Jianbo Guo Shicong Ma Lixin Li Guozheng Wang Haotian Xu jin Yang Zening zhao China Electric Power Research Institute Beijing 100192China the Beijing Huairou Laboratory Beijing 101400China School of Engineering the University of GlasgowGlasgow G128QQUK

With integration of large-scale renewable energy,new controllable devices,and required reinforcement of power grids,modern power systems have typical characteristics such as uncertainty,vulnerability and openness,which makes operation and control of power grids face severe security *** of artificial intelligence(AI)technologies represented by machine learning in power grid regulation is limited by reliability,interpretability and generalization ability of complex *** of hybrid-augmented intelligence(HAI)based on human-machine collaboration(HMC)is a pivotal direction for future development of AI technology in this *** on characteristics of applications in power grid regulation,this paper discusses system architecture and key technologies of human-machine hybrid-augmented intelligence(HHI)system for large-scale power grid dispatching and control(PGDC).First,theory and application scenarios of HHI are introduced and analyzed;then physical and functional architectures of HHI system and human-machine collaborative regulation process are *** technologies are discussed to achieve a thorough integration of human/machine ***,state-of-theart and future development of HHI in power grid regulation are summarized,aiming to efficiently improve the intelligent level of power grid regulation in a human-machine interactive and collaborative way.

关键词： Artificial intelligence human-machine collaborative control human-machine hy brid intelligence optimization and evolution power grid dispatching and control

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The chemical environment and structural ordering in liquid Mg-Y-Zn system:An ab-initio molecular dynamics investigation of melt for the formation mechanism of LPSO structure

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Journal of Magnesium and Alloys 2024年第2期12卷 815-824页

作者： Tangpeng Ma jin Wang Kaiming Cheng Chengwei Zhan Jixue Zhou jingyu Qin Guochen zhao Xinfang Zhang Shandong Provincial Key Laboratory of High Strength Lightweight Metallic Materials Advanced Materials InstituteQilu University of Technology(Shandong Academy of Sciences)Jinan 250014China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

In an effort to clarify the formation mechanism of LPSO structure in Mg-Y-Zn alloy,the chemical environment and structural ordering in liquid Mg-rich Mg-Y-Zn system are investigated with the aid of ab-initio molecular dynamics *** liquid Mg-rich Mg-Y alloys,the strong Mg-Y interaction is determined,which promotes the formation of fivefold symmetric local *** Mg-Zn alloys,the weak Mg-Zn interaction results in the fivefold symmetry weakening in the liquid *** to the coexistence of Y and Zn,the strong attractive interaction is introduced in liquid Mg-Y-Zn ternary alloy,and contributes to the clustering of Mg,Y,Zn launched from *** is more,the distribution of local structures becomes closer to that in pure Mg compared with that in binary Mg-Y and Mg-Zn *** results should relate to the origins of the Y/Zn segregation zone and close-packed stacking mode in LPSO structure,which provides a new insight into the formation mechanism of LPSO structure at atomic level.

关键词： Mg-Y-Zn Chemical environment Structural ordering ab-initio molecular dynamics

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Recent developments in three-dimensional Zn metal anodes for battery applications

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InfoMat 2024年第1期6卷 1-30页

作者： Jianyu Chen Yizhou Wang Zhengnan Tian jin zhao Yanwen Ma Husam N.Alshareef State Key Laboratory of Organic Electronics and Information Displays(KLOEID)and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts&Telecommunications(NUPT)Nanjingthe People's Republic of China Materials Science and Engineering King Abdullah University of Science and Technology(KAUST)ThuwalSaudi Arabia Suzhou Vocational Institute of Industrial Technology Suzhouthe People's Republic of China

Aqueous zinc(Zn)ion batteries(AziBs)are regarded as one of the promising candidates for next-generation electrochemical energy storage systems due to their low cost,high safety,and environmental ***,the commercialization of AziBs has been severely restricted by the growth of dendrite at the Zn metal *** the planar-structured Zn anodes into threedimensional(3D)structures has proven to be an effective way to modulate the plating/stripping behavior of Zn anodes,resulting in the suppression of dendrite *** review provides an up-to-date review of 3D structured Zn metal anodes,including working principles,design,current status,and future *** aim to give the readers a comprehensive understanding of 3D-structured Zn anodes and their effective usage to enhance AziB performance.

关键词： 3D metal anodes aqueous Zn ion batteries dendrite suppression Zn dendrite Zn metal anodes

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UPLC-Q-TOF/MS-Based Serum Metabolomics Reveals Potential Anti-tumor Mechanism of Banxia Xiexin Decoction in Colorectal Cancer Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 623-632页

作者： YUE Yin-zi LI Ming-xuan WANG Xiao-hui QIN Yuan-yuan WANG Ya-hui TAN jin-hua SU Lian-lin YAN Shuai Department of General Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China School of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of General Surgery Bayinguoleng Mongolian Autonomous Prefecture People’s HospitalXinjiang Uygur Autonomous RegionKorla841000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China Department of Anorectal Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China

Objective To clarify the potential mechanism of Banxia Xiexin Decoction(BXD)on colorectal cancer(CRC)from the perspective of *** Forty male C57BL/6 mice were randomly divided into normal control(NC),azoxymethane/dextran sulfate sodium(AOM/DSS)model,low-dose BXD(L-BXD),high-dose BXD(H-BXD)and mesalamine(MS)groups according to a random number table,8 mice in each *** cancer model was induced by AOM/*** was administered daily at doses of 3.915(L-BXD)and 15.66 g/kg(H-BXD)by gavage for consecutive 21 days,and 100 mg/kg MS was used as positive *** the entire modeling cycle,colon length of mice was measured and quantity of colorectal tumors were *** spleen and thymus index were determined by calculating the spleen/thymus weight to body *** cytokine and changes of serum metabolites were analyzed by enzyme-linked immunosorbent assay kits and ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry(UPLC-Q/TOF-MS),*** Notably,BXD supplementation protected against weight loss,mitigated tumor formation,and diminished histologic damage in mice treated with AOM/DSS(P<0.05 or P<0.01).Moreover,BXD suppressed expression of serum inflammatory enzymes,and improved the spleen and thymus index(P<0.05).Compared with the normal group,102 kinds of differential metabolites were screened in the AOM/DSS group,including 48 potential biomarkers,involving 18 main metabolic *** 18 potential biomarkers related to CRC were identified,and the anti-CRC mechanism of BXD was closely related to D-glutamine and D-glutamate metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,arginine biosynthesis,nitrogen metabolism and so *** BXD exerts partial protective effects on AOM/DSS-induced CRC by reducing inflammation,protecting organism immunity ability,and regulating amino acid metabolism.

关键词： colorectal cancer metabolomics ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry azoxymethane dextran sulfate sodium Banxia Xiexin Decoction Chinese medicine

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