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Bioactive chemical constituents from the marine-derived fungus Cladosporium ***-5

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Journal of Oceanology and Limnology 2024年第3期42卷 905-914页

作者： Luting DAI Qingyi XIE Jiaocen GUO Qingyun MA Li YANG Jingzhe YUAN Haofu DAI Zhifang YU youxing zhao College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences&Hainan Academy of Tropical Agricultural ResourceHaikou 571101China

A new isochromanone,cladosporinisochromanone(1),accompanied by 15 known compounds(2–16)were obtained from secondary metabolites produced by marine-derived fungus Cladosporium *** and HRESIMS spectra elucidation determined the planar structure of *** electronic circular dichroism(ECD)experiment assigned the absolute configuration of *** 1,2,4–6,and 10 displayed different degrees of neuroprotective activities on human neuroblastoma cells *** compounds(1,3–5,and 13)emerged resistance to protein tyrosine phosphatase 1B(PTP1B),further kinetic analysis and molecular docking study indicated that the most potent compound 13(IC50value of 10.74±0.61μmol/L)was found as a noncompetitive inhibitor for *** plasmon resonance(SPR)and molecular docking studies also demonstrated the interaction between compound 12 and Niemann-Pick C1 Like 1(NPC1L1),which has been identified as significant therapeutic target for *** addition,compounds 3,6,and 14 showed attractive inhibitory activity against the phytopathogenic fungi:Colletotrichum ***,library of Cladosporium metabolites is enriched and new active uses of known compounds are explored.

关键词： Cladosporium sp. marine-derived fungus neuroprotective effects protein tyrosine phosphatase 1B(PTP1B) Niemann-Pick C1 Like 1(NPC1L1) antifungal activity

Cytotoxic lanostanoids from the fruiting body of Ganoderma calidophilum

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Catechol-derived Inhibitors against Quorum Sensing from Retiboletus kauffmanii

中国菌物学会第七届全国会员代表大会暨2017年学术年会

作者： Shengzhuo Huang Qingyun Ma Fandong Kong Qingyi Xie Liman Zhou youxing zhao Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agriculture Sciences

Ganoderma calidophilum J.D zhao, L.W. Hsu ＆ X.Q. Zhang（Ganodermataceae） was one of the wild Ganoderma resources in Hainan Province and was recorded to be used for cancer prevention and treatment by the herbalist of Chinese Li minority. To search for anti-cancer active constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four new spiro-lactone lanostane triterpenoids（spiroganocalitones A-D, 1-4）, two new lanostanoids（ganodecalones A and B, 5, 6） together with twenty-three known ones（7-29）. The structures of the six previously undescribed compounds were elucidated based on 1D,2D-NMR, and HRMS analyses. Compounds 5 and 7-10 showed moderate cytotoxic activity. Ganoderone A（8）showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC50 values of 7.62,6.28, and 3.55?M, respectively.

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Medicinal Plant 2021年第1期12卷 68-70页

作者： Liman ZHOU Lin WANG Fandong KONG Qingyun MA Qingyi XIE Haofu DAI youxing zhao Haikou Key Laboratory for Research and Utilization of Tropical Natural Products Institute of Tropical Bioscience and BiotechnologyCATASHaikou 571101China Hainan Academy of Tropical Agricultural Resource CATASHaikou 571101China

[Objectives]This study aimed to screen anti-quorum sensing(QS)activity from the constituent of Retiboletus kauffmanii fruit body.[Methods]Chromatographic technology was used to isolate compounds,while well diffusion assay was applied to screen anti-quorum sensing activity.[Results]12 phenolic compounds were purified from extracts,three catechol-derived compounds at sub-inhibitory concentrations were found to inhibit the production of violacein in Chromobacterium violaceum for the first time.[Conclusions]Three catechol analogs isolated from *** fruit body extract were indicated as quorum sensing inhibitors against ***.

关键词： Chromobacterium violaceum Quorum sensing inhibitor Retiboletus kauffmanii Virulence factors

Chemical constituents from the cultures of fungus Xylaria polymorpha

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Chemical constituents from the cultures of fungus Xylaria po...

中国菌物学会第七届全国会员代表大会暨2017年学术年会

作者： Ningning Yang Fandong Kong Qingyun Ma Qingyi Xie Duqiang Luo Liman Zhou Zhifang Yu youxing zhao Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences College of Food Science and Technology Nanjing Agricultural University College of Life Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of EducationHebei University

Xylaria polymorpha is a small black mushroom and widely distributed in the southeast of China’s mainland. In a search for new bioactive compounds from X. polymorpha, its deep chemical investigation led to the isolation of totally 25 compounds from the EtOAc extract of fermentation broth of this fungus, including five new drimane-type sesquiterpenoids named xylariaines A–C and polymorphines A and B, and one new phenyloxolane compound named 2-methyl-2-（4-hydroxymethyl phenyl） oxolane, together with 19 known compounds. The structures of these new compounds were elucidated by NMR and single-crystal X-ray diffraction analysis. Xylariaine A and polymorphine B exhibited definite anti-acetylcholinesterase activity with inhibition ratio of 34.3% and α-glucosidase inhibitory activity comparable to that of acarbose with IC50 value of543.8 μM. Moreover, 2-methyl-2-（4-hydroxymethyl phenyl） oxolane showed moderate inhibitory activity against the nematode Panagrellus redivivus with mortality ratio of 59.6%.

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适合致密油藏的低伤害可回收清洁压裂液体系

油田化学 2022年第4期39卷 595-601页

作者：邓长生赵有兴苏明健蔡永吉西安石油大学地球科学与工程学院陕西西安710065 陕西省油气成藏地质学重点实验室陕西西安710065 长庆油田分公司页岩油产能建设项目组甘肃庆阳745400 中国石油长庆油田分公司第十二采油厂甘肃庆阳745400 中国石油长庆油田分公司第二采油厂甘肃庆城745100

为了降低致密砂岩油藏压裂施工的成本和环境污染风险,提高压裂液的利用效率,以脂肪酸、二甲氨基丙二胺、二氯异丙醇、非离子表面活性剂、多组分有机溶剂等为原料,制得新型复合表面活性剂(GEMR-2),将其与有机酸盐调节剂复配制得适合致密... 详细信息

为了降低致密砂岩油藏压裂施工的成本和环境污染风险,提高压裂液的利用效率,以脂肪酸、二甲氨基丙二胺、二氯异丙醇、非离子表面活性剂、多组分有机溶剂等为原料,制得新型复合表面活性剂(GEMR-2),将其与有机酸盐调节剂复配制得适合致密油藏的低伤害可回收清洁压裂液体系。室内对压裂液的携砂性、破胶性、对岩心的伤害性、可回收等综合性能进行了评价,并成功进行了现场应用。结果表明,该压裂液体系的耐温抗剪切性能良好,在80℃、170 s^(-1)的条件下剪切120 min后的黏度仍能达到50 mPa·s以上。压裂液的携砂能力较强,并且可以迅速破胶,破胶液的残渣含量低于1.5 mg/L,界面张力较低。该压裂液破胶后对储层天然岩心渗透率的伤害率低于5%,具有低伤害的特点。使用破胶液重复配制的压裂液仍然具备较强的耐温抗剪切性能,具有良好的可回收重复利用性能。在ZM-12井使用低伤害可回收清洁压裂液体系的施工过程顺利,压裂增产效果显著,现场返排液重复配液性能较好,节约了大量的水资源。

关键词：致密油藏低伤害可回收清洁压裂液复合表面活性剂

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Chemical constituents and their antitumor activities from Ganoderma tropicum(Jungh.) Bres.

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Chemical constituents and their antitumor activities from Ga...

中国化学会第9届天然有机化学学术会议

作者： HU Lili,MA Qingyun,HUANG Shengzhuo,DAI Haofu,zhao youxing~* Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China

The family Ganodermataceae comprising more than 200 fungi species is mainly distributed in the tropical and subtropical areas of Asia,Australia,Africa and America,among which more than 100 species grow in China and 78 wild species were found in Hainan *** chemical investigation on the fruiting bodies of Ganoderma tropicum(Jungh.) Bres.,wild "Lingzhi"genus in Hainan Province,led to the isolation of thirty two compounds (1-32) including four new compounds by column chromatography on silica gel and sephadex *** structures mainly including triterpenes,steroids and xanthones were elucidated by NMR analysis as well as comparison with those reported in the literatures,and were reported for the first time from Ganoderma *** was found for the first time from Ganoderma species,which maybe one of the important natural pigment contributed to the yellow color of the fruiting bodies of *** bioassay of cytotoxic activities of nine compounds was evaluated against five human tumor cell lines HL-60,SMMC-7721, A-549,MCF-7,and ***(1) displayed obvious cytotoxic activities on HL-60, SMMC-7721,A-549,MCF-7 and SW-480 with IC50 values of 7.49,9.04,4.44,21.61 and 14.02μmol.L,respectively.22E-7α-methoxy -5α,6α-epoxyergosta-8(14),22-dien-3β-ol(10) also exhibited definite cytotoxic activities on HL-60,MCF-7,and SW-480.

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不同保鲜处理对即食菠萝质量变化的影响

南京农业大学学报 2000年第4期23卷 97-99页

作者：郁志芳陈崇顺赵友兴徐英南京农业大学食品科技学院南京农业大学园艺系南京210095

新鲜菠萝经机械削皮、去果眼、切分和清洗后用 4种保鲜方法处理 ,分别在 4～ 5℃和 14～ 15℃下贮存 ,并测定菠萝的呼吸强度、可溶性固形物和可滴定酸含量 ,菌落总数、大肠菌群、霉菌和酵母及致病菌 ,同时进行色、香、味和质地等的感官... 详细信息

新鲜菠萝经机械削皮、去果眼、切分和清洗后用 4种保鲜方法处理 ,分别在 4～ 5℃和 14～ 15℃下贮存 ,并测定菠萝的呼吸强度、可溶性固形物和可滴定酸含量 ,菌落总数、大肠菌群、霉菌和酵母及致病菌 ,同时进行色、香、味和质地等的感官评定。试验结果表明 ,含 0 2～ 0 4g/ 10 0mL食盐、 8～ 12g/ 10 0mL蔗糖和 0 3～ 0 5g/ 10 0mL柠檬酸的溶液于 6 6～ 75℃处理 3～ 6min能使菠萝的生命活动维持在较低水平 ,保持菠萝原有的新鲜状况 ,且产品的各项微生物指标均符合即食产品的卫生要求。产品贮存在 14～ 15℃下 7d或 4～ 5℃下 14d均无明显的质量变化。据此提出了即食菠萝产品的质量指标和要求。

关键词：菠萝即食保鲜处理质量变化

Impact of Startup Strategy and Buffer Tank Volume on the Compressor Inlet State for a 3-MW sCO2 Brayton Cycle

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Journal of Thermal Science 2025年第1期34卷 159-175页

作者： zhao Decai WANG Bo Key Laboratory of Advanced Energy and Power Institute of Engineering Thermophysics(IET)Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences

The supercritical carbon dioxide（sCO2） Brayton cycle system has become an emerging and highly promising method of thermal power conversion due to its efficiency advantage,system compactness,and excellent adaptability of the heat *** the low carbon sCO2Brayton cycle testbed with cycle output power approaching 3 MW,a relatively detailed dynamic simulation model of the entire system is constructed to explore the dynamic response characteristics of the system with different startup strategies and different buffer tank volumes during the startup *** simulation results indicate that the smaller the volume of the buffer tank,the more rapid and obvious the parameter fluctuation in the buffer tank during the *** the allowable relative deviation limit of density is 5%,then the ratio of the buffer tank volume to the volume of the entire closed loop should not be lower than 36.80%.The strategy of simultaneous temperature and speed increase during turbine bypass start can effectively reduce the fluctuation of compressor inlet parameters and reach the steady-state more *** paper provides the recommended matching table for the opening of the turbine bypass valve（TBV） and the main regulating valve（MGV） to reduce the parameter fluctuation during the bypass *** effectiveness of the proposed turbine bypass and bypass switching startup strategy is verified by simulation,which may be used as a reference for test bench's future debugging and operation.

关键词： buffer tank dynamic characteristic dynamic model sCO2 Brayton cycle startup strategy

海洋管理的风险防范——基于博弈论的一种分析框架

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中国海洋大学学报（社会科学版） 2011年第4期 11-14页

作者：徐敬俊赵有星中国海洋大学管理学院山东青岛266100 中国海洋大学网络中心山东青岛266100

对海洋的有效管理是保证海洋经济可持续发展的前提。大量事实表明,长期以来海洋管理未如人意。海洋产业间和海洋产业内的海洋经济利益相关者的跨界影响是海洋管理过程中面对的直接和首要问题。以自身利益最大化为目标的海洋利益相关者... 详细信息

对海洋的有效管理是保证海洋经济可持续发展的前提。大量事实表明,长期以来海洋管理未如人意。海洋产业间和海洋产业内的海洋经济利益相关者的跨界影响是海洋管理过程中面对的直接和首要问题。以自身利益最大化为目标的海洋利益相关者之间的博弈必然会致使各博弈主体行为偏差程度较大,进而很可能会给海洋管理带来一定的风险,加强对这种风险的防范意识,是保证海洋经济的可持续发展的前提和基础。

关键词：海洋管理博弈风险防范