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Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury

Biomedical and Environmental Sciences 2024年第5期37卷 494-502页

作者： CAO Wei Hua JIANG Ting Ting SHEN Ge DENG Wen WANG Shi yu zhang zi yu LI Xin Xin LU Yao zhang Lu LIU Ru yu CHANG Min WU Shu Ling GAO yuan Jiao HAO Hong Xiao CHEN Xiao Xue HU Lei Ping XU Meng Jiao YI Wei XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DILI)caused by different drugs and their correlation with clinical *** The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with *** on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),antiinfective drugs,and other drugs,patients were divided into five *** were measured by Luminex *** characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were *** 73 patients were *** among five groups was statistically different(P=0.032).Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine ***-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:P<0.001;TNF-α:P<0.001)and cardiovascular medicine(IL-6:P=0.020;TNF-α:P=0.001)were lower than those in NSAIDs *** was a positive correlation between ALT(r=0.697,P=0.025),AST(r=0.721,P=0.019),and IL-6 in NSAIDs *** Older age may be more prone to *** with NSAIDs have more severe liver damage in early stages of DILI,TNF-αand IL-6 may partake the inflammatory process of DILI.

关键词： Drug-induced liver injury Cytokines Non-steroidal anti-inflammatory drugs Inflammation

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基于CMOS的高响应度太赫兹探测器线阵

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红外与毫米波学报 2024年第1期43卷 70-78页

作者：白雪张子宇徐雷钧赵心可范小龙江苏大学电气信息工程学院江苏镇江212013 中国电子科技集团公司第五十五研究所江苏南京210016

本文提出了一种基于CMOS 0.18μm工艺的改进型高响应度太赫兹探测器线阵,各探测像素单元由高增益片上天线、高耦合度差分自混频功率探测电路和集成电压放大器组成。其中,差分探测电路利用源极差分驱动场效应管的交叉耦合电容,将太赫兹... 详细信息

本文提出了一种基于CMOS 0.18μm工艺的改进型高响应度太赫兹探测器线阵,各探测像素单元由高增益片上天线、高耦合度差分自混频功率探测电路和集成电压放大器组成。其中,差分探测电路利用源极差分驱动场效应管的交叉耦合电容,将太赫兹差分信号耦合至场效应管的栅极与源极,增强场效应管沟道内自混频太赫兹信号的强度,实现高响应度。其次,该探测器配备高增益片上环形差分天线与集成电压放大器,可有效放大混频后的信号,进而提高系统信噪比,最终达到增强探测器响应度的目的。探测器1×3线阵系统充分利用CMOS工艺多层结构的特点,将电压放大器布置在天线地平面下方,提高了芯片面积的利用率,有效降低了制作成本,整个系统的面积为0.5 mm^(2)。测试结果表明,当场效应管的栅极偏置为0.42 V时,该探测系统对0.3 THz辐射信号的电压响应度(Rv)最大可达到43.8 kV/W,对应的最小噪声等效功率(NEP)为20.5 pW/Hz^(1/2)。动态测试结果显示该探测器可对不同材质的隔挡物进行区分。

关键词：互补金属氧化物半导体太赫兹探测器宽带天线高响应度

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怀中1号地黄中2-phenylethyl-beta-glucopyranoside通过调节PI3K/Akt/mTOR/HIF-1α通路对低氧性肺动脉高压的影响

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中国中药杂志 2024年第14期49卷 3857-3867页

作者：曾梦楠张宇涵郭彭莉张梓玉刘晏灵王茹铁玘美王媛媛常方卓冯卫生郑晓珂河南中医药大学药学院河南郑州450046 河南省中药开发工程技术研究中心河南郑州450046 河南中医药大学呼吸疾病中医药防治省部共建协同创新中心河南郑州450046

研究怀中1号地黄中2-phenylethyl-beta-glucopyranoside(Phe)对低氧诱导肺动脉高压小鼠的保护作用及其机制,为临床治疗肺动脉高压提供理论依据。首先将雄性C57BL/6N小鼠随机分为正常组,模型组,阳性药波生坦组(100 mg·kg^(-1)),Phe低、... 详细信息

研究怀中1号地黄中2-phenylethyl-beta-glucopyranoside(Phe)对低氧诱导肺动脉高压小鼠的保护作用及其机制,为临床治疗肺动脉高压提供理论依据。首先将雄性C57BL/6N小鼠随机分为正常组,模型组,阳性药波生坦组(100 mg·kg^(-1)),Phe低、高剂量(20、40 mg·kg^(-1))组。除正常组外,其余各组均在10%的低氧环境中连续造模5周,并在第3周开始灌胃给药14 d,探究各组小鼠心肺功能、右心室压力、咳喘指数、肺部损伤、细胞凋亡、氧化应激相关指标、免疫细胞及磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)/蛋白激酶B(protein kinase B,Akt)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)/缺氧诱导因子(hypoxic inducible facter,HIF)^(-1)α通路相关蛋白或mRNA水平。接着进一步采用缺氧诱导肺动脉平滑肌细胞(pulmonary arterial smooth muscle cell,PASMC)合并PI3K激动剂(740Y-P)对Phe干预肺动脉高压的机制进一步探究。结果显示Phe可显著提高肺动脉高压小鼠的心肺功能,降低右心室压力、咳喘指数及肺部损伤,减少细胞凋亡、氧化应激相关指标及磷酸化蛋白激酶B(phosphorylated protein kinase B,p-Akt)、磷酸化哺乳动物雷帕霉素靶蛋白(phosphorylated mammalian target of rapamycin,p-mTOR)入核水平,抑制HIF^(-1)α和PI3K mRNA与蛋白表达水平,并维持小鼠机体免疫细胞稳态。进一步的机制探究中发现,Phe显著降低缺氧诱导PASMC的细胞活力与迁移能力,减少HIF^(-1)α和PI3K蛋白表达及p-Akt、p-mTOR入核水平,且此作用可被740Y-P阻断。因此,推测Phe可通过减轻肺组织氧化应激失衡与凋亡,调节免疫水平来发挥抗肺动脉高压作用,其机制可能和调控PI3K/Akt/mTOR/HIF^(-1)α通路有关。该研究以期为肺动脉高压的治疗提供药物参考及研究思路。

关键词：肺动脉高压怀中1号地黄 2-phenylethyl-beta-glucopyranoside 缺氧 PI3K/Akt/mTOR/HIF-1α信号通路

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Modulation of d-orbital to realize enriched electronic cobalt sites in cobalt sulfide for enhanced hydrogen evolution in electrocatalytic water/seawater splitting

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Rare Metals 2024年第2期43卷 511-521页

作者： Jian-Peng Sun yu Zheng zi-Sheng zhang Xiang-Chao Meng zi-Zhen Li Key Laboratory of Marine Chemistry Theory and Technology(Ministry of Education) College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao266100China Shanxi Institute of Energy Taiyuan030600China Department of Chemical and Biological Engineering Faculty of EngineeringUniversity of OttawaOttawaONK1N6 N5Canada

Herein,a novel single-atomic Pt doping and interface-rich CoS/Co(OH)_(2)(Pt-CoS/Co(OH)_(2)/C)electrocatalyst has been successfully *** from precise regulation of d-orbital electronic structure modulation on Co site,Pt-CoS/Co(OH)_(2)/C exhibited remarkable HER activity and high stability for hydrogen evolution in splitting both water(73 mV@10 mA·cm^(−2)) and seawater(87 mV@10 mA·cm^(−2)).Notably,atomic Pt doping was introduced into CoS/Co(OH)_(2),which could produce local unbalanced Coulombic force and significantly increased the number of S vacancies,and then expose abundant Co ***,Co(OH)_(2) in Pt-CoS/Co(OH)_(2)/C could act as the adsorption sites for H_(2)O in hydrogen evolution reaction *** functional theory results also proved that atomic Pt doping,S vacancies and Co(OH)_(2) coupling could result in the formation of enriched electronic Co sites and optimize d_(z2) orbital electronic structure,and then realize the depth upward shift of d-band center and enhance the adsorption of H*on Co sites.

关键词： Electrocatalysts Hydrogen evolution reaction Pt-CoS/Co(OH)_(2) d-band center Electronic structure Water/seawater electrolysis

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Semi-supervised remote sensing image scene classification with prototype-based consistency

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Chinese Journal of Aeronautics 2024年第2期37卷 459-470页

作者： Yang LI zhang LI zi WANG Kun WANG Qifeng yu College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

Deep learning significantly improves the accuracy of remote sensing image scene classification,benefiting from the large-scale ***,annotating the remote sensing images is time-consuming and even tough for *** neural networks trained using a few labeled samples usually generalize less to new unseen *** this paper,we propose a semi-supervised approach for remote sensing image scene classification based on the prototype-based consistency,by exploring massive unlabeled *** this end,we,first,propose a feature enhancement module to extract discriminative *** is achieved by focusing the model on the foreground ***,the prototype-based classifier is introduced to the framework,which is used to acquire consistent feature *** conduct a series of experiments on NWPU-RESISC45 and Aerial Image Dataset(AID).Our method improves the State-Of-The-Art(SOTA)method on NWPU-RESISC45 from 92.03%to 93.08%and on AID from 94.25%to 95.24%in terms of accuracy.

关键词： Semi-supervised learning Remote sensing Scene classification Prototype network Deep learning

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深度学习在糖尿病视网膜病变分级中的应用

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计算机系统应用 2024年第1期33卷 231-244页

作者：张志强赵可辉牛惠芳张子宇周连田山东中医药大学智能与信息工程学院济南250355 山东中医药大学第二附属医院特检科济南250002 山东省药品不良反应监测中心济南250014 菏泽市中医医院碎石科菏泽274035

近年来,糖尿病视网膜病变(diabetic retinopathy,DR)成为全球失明人口增加的主要原因,早期的DR严重程度分级对防止DR患者视力丧失尤为重要.由于糖尿病患者数量的逐年上升,DR分级的需求量也不断增加,然而传统的人工分级不能满足日益增长... 详细信息

近年来,糖尿病视网膜病变(diabetic retinopathy,DR)成为全球失明人口增加的主要原因,早期的DR严重程度分级对防止DR患者视力丧失尤为重要.由于糖尿病患者数量的逐年上升,DR分级的需求量也不断增加,然而传统的人工分级不能满足日益增长的需求,且人工分级耗时费力.深度学习技术的发展,为DR检测和分级提供了高效率且更可靠的手段.虽然,目前的DR二元检测已经取得十分好的效果,然而由于糖尿病视网膜病变的复杂性和病变程度之间的差距细微,DR严重程度分级仍然是一个具有挑战性的问题.本文对近年来涌现的DR分级方法进行了研究和总结:介绍了基于VGG、InceptionNet、ResNet、EfficientNet、DenseNet、CapsNet模型的6种深度学习分级方法;并介绍了基于多网络融合的DR分级方法;最后对基于深度学习的DR分级方法的研究趋势进行总结和展望.

关键词：糖尿病视网膜病变深度学习卷积神经网络多网络融合多标签分类

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Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential

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World Journal of Stem Cells 2024年第5期16卷 512-524页

作者： Hang zhang Ling-zi Wu Zhen-yu Liu zi-Bing Jin Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND Human induced pluripotent stem cell(hiPSC)technology is a valuable tool for generating patient-specific stem cells,facilitating disease modeling,and invest-igating disease ***,iPSCs carrying specific mutations may limit their clinical applications due to certain inherent *** To investigate the impact of MERTK mutations on hiPSCs and determine whether hiPSC-derived extracellular vesicles(EVs)influence anomalous cell junction and differentiation *** We employed a non-integrating reprogramming technique to generate peripheral blood-derived hiPSCs with and hiPSCs without a MERTK ***-somal karyotype analysis,flow cytometry,and immunofluorescent staining were utilized for hiPSC *** and proteomics were employed to elucidate the expression patterns associated with cell junction abnormalities and cellular differentiation ***,EVs were isolated from the supernatant,and their RNA and protein cargos were examined to investigate the involvement of hiPSC-derived EVs in stem cell junction and *** The generated hiPSCs,both with and without a MERTK mutation,exhibited normal karyotype and expressed pluripotency markers;however,hiPSCs with a MERTK mutation demonstrated anomalous adhesion capability and differentiation potential,as confirmed by transcriptomic and proteomic ***,hiPSC-derived EVs were involved in various biological processes,including cell junction and *** HiPSCs with a MERTK mutation displayed altered junction characteristics and aberrant differentiation ***,hiPSC-derived EVs played a regulatory role in various biological processes,including cell junction and differentiation.

关键词： Cell junction Cellular differentiation Extracellular vesicle Human induced pluripotent stem cells Transcriptomics Proteomics

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Relation Between the Eventual Continuity and the E-property for Markov-Feller Semigroups

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 1-16页

作者： Yong Liu zi-yu Liu LMAM School of Mathematical SciencePeking UniversityBeijing100871China

We investigate some relations between two kinds of semigroup regularities, namely the e-property and the eventual continuity, both of which contribute to the ergodicity for Markov processes on Polish *** precisely, we prove that for Markov-Feller semigroup in discrete time and stochastically continuous MarkovFeller semigroup in continuous time, if there exists an ergodic measure whose support has a nonempty interior,then the e-property is satisfied on the interior of the support. In particular, it implies that, restricted on the support of each ergodic measure, the e-property and the eventual continuity are equivalent for the discrete-time and the stochastically continuous continuous-time Markov-Feller semigroups.

关键词： Markov-Feller semigroup ergodicity e-property eventual continuity

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Analysis of mechanical strengths of extreme line casing joint considering geometric, material, and contact nonlinearities

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Petroleum Science 2024年第3期21卷 1992-2004页

作者： Ji-yun zhang Chi Peng Jian-Hong Fu Quan Cao yu Su Jian-yun Pang zi-Qiang yu Petroleum Engineering School Southwest Petroleum UniversityChengdu610500SichuanChina Engineering Technology Research Institute of CNPC Southwest Oil and Gas Field Company Chengdu610017SichuanChina

To address the challenges associated with difficult casing running,limited annular space,and poor cementing quality in the completion of ultra-deep wells,the extreme line casing offers an effective solution over conventional ***,due to its smaller size,the joint strength of extreme line casing is reduced,which may cause failure when running in the *** address this issue,this study focuses on the CST-ZTΦ139.7 mm×7.72 mm extreme line casing and employs the elastic-plastic mechanics to establish a comprehensive analysis of the casing joint,taking into account the influence of geometric and material nonlinearities.A finite element model is developed to analyze the forces and deformations of the extreme line casing joint under axial tension and external collapse *** model investigates the stress distribution of each thread tooth subjected to various tensile forces and external ***,the tensile strength and crushing strength of the extreme line casing joint are determined through both analytical and experimental *** findings reveal that,under axial tensile load,the bearing surface of each thread tooth experiences uneven stress,with relatively high equivalent stress at the root of each thread *** end thread teeth are valuable spots for *** is observed that the critical fracture axial load of thread decreases linearly with the increase of thread tooth *** external pressure,the circumferential stress is highest at the small end of the external thread,leading to yield *** tensile strength of the joint obtained from the finite element model exhibits a relative error of less than 7%compared to the analytical and experimental values,proving the reliability of the finite element *** tensile strength of the joint is 3091.9 k ***,in terms of anti-collapse capability,the joints demonstrate higher resistance to collapse compared to the casing body,which is consistent with the test resul

关键词： Extreme line casing Elastic-plastic mechanics Finite element analysis Tensile strength Collapse strength

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小麦生长监测大数据平台系统开发和应用

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安徽农业科学 2024年第12期52卷 215-221页

作者：李振星张子玉欧阳薇高洁李昊珉查沛郝娟娟宁津县农业农村局山东宁津253400 安徽科技学院管理学院安徽蚌埠233030 安徽科技学院机械工程学院安徽凤阳233100 安徽易刚信息技术有限公司安徽安庆246000

为实现农业现代化,推进农业供给侧结构性改革,保障小麦生产高质高效,通过对小麦种植过程中的土壤墒情、苗情长势、光合作用、虫情、气象等数据的收集和分析整理,为农技人员和生产经营者提供决策所需数据和种植方案。以宁津县小麦生产为... 详细信息

为实现农业现代化,推进农业供给侧结构性改革,保障小麦生产高质高效,通过对小麦种植过程中的土壤墒情、苗情长势、光合作用、虫情、气象等数据的收集和分析整理,为农技人员和生产经营者提供决策所需数据和种植方案。以宁津县小麦生产为例,运用物联网、无人机遥感、大数据平台处理等技术,设计开发了小麦生长监测大数据平台系统。该系统分为3个模块,包括1个大数据平台和5个现场监测点,系统每隔30 min采集1次虫情、墒情和气象数据,并24 h不间断地提供现场小麦长势的监控画面,数据通过互联网的形势传输到大数据平台的数据库中,平台对数据的汇总形成图像和报表,为农业专家和农业生产经营者提供更合适的种植方案。

关键词：小麦大数据平台生长监测物联网

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