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A combined evaluation of the characteristics and antibiotic resistance induction potential of antibiotic wastewater during the treatment process

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Journal of Environmental Sciences 2024年第4期138卷 626-636页

作者： Sun Miao yanyan zhang Cong Men Yiou Mao Jiane Zuo State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China School of Energy and Environmental Engineering Beijing Key Laboratory of Resource-Oriented Treatment of Industrial PollutantsUniversity of Science and Technology BeijingBeijing 100083China High School Affiliated to Renmin University of China Beijing 100080China Tsinghua Shenzhen International Graduate School Shenzhen 518055China

Antibiotic wastewater contains a variety of pollutant stressors that can induce and promote antibiotic resistance(AR)when released into the *** these substances are mostly in concentrations lower than those known to induce AR individually,it is possible that antibiotic wastewater discharge might still promote the AR transmission risk via additive or synergistic ***,the comprehensive effect of antibiotic wastewater on AR development has rarely been evaluated,and its treatment efficiency remains ***,samples were collected from different stages of a cephalosporin production wastewater treatment plant,and the potential AR induction effect of their chemical mixtures was explored through the exposure of the antibiotic-sensitive Escherichia coli K12 *** with raw cephalosporin production wastewater significantly promoted mutation rates(3.6×10^(3)-9.3×10^(3)-fold)and minimum inhibition concentrations(6.0-6.7-fold)of *** against ampicillin and *** may be attributed to the inhibition effect and oxidative stress of cephalosporin wastewater on *** AR induction effect of cephalosporin wastewater decreased after the coagulation sedimentation treatment and was completely removed after the full treatment process.A Pearson correlation analysis revealed that the reduction in the AR induction effect had a strong positive correlation with the removal of organics and biological *** indicates that the antibiotic wastewater treatment had a collaborative processing effect of conventional pollutants,toxicity,and the AR induction *** study illustrates the potential AR transmission risk of antibiotic wastewater and highlights the need for its adequate treatment.

关键词： Antibiotic wastewater treatment plant Antibiotic resistance Antibiotic resistance induction effect Correlation analysis Biological toxicity

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Flurbiprofen microneedle patches for the management of acute postoperative pain

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Nano Research 2024年第8期17卷 7493-7503页

作者： Huaqing Chu yanyan zhang Yuan Yang Jiangtao Xue Cong Li Wei zhang Zhou Li Hui Zheng National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases School of Integrated Chinese and Western MedicineHunan University of Chinese MedicineChangsha 410208China School of Life Science Institute of Engineering MedicineBeijing Institute of TechnologyBeijing 100081China Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China

Acute postoperative pain is commonly treated with flurbiprofen(FBP),but conventional delivery methods are *** study prepared a new non-burst release microneedles(MNs)using genipin cross-linked gelatin(cGel).By adding varying amounts of genipin to modulate the crosslinking degree of cGel,the drug release behavior of the drug-loaded MNs in the skin can be *** crosslinking parameters that meet therapeutic requirements are selected,thus providing rapid and longlasting analgesic *** solutions were successfully cross-linked,altering matrix material microstructure,confirmed by scanning electron microscope imaging and fourier transform infrared *** demonstrated increasing mechanical strength with higher *** release rates were rapid initially,then slowed,exhibiting a characteristic of decreased release rates with increasing degrees of *** vivo,FBP/cGel MNs significantly reduced allodynia and hyperalgesia post-surgery,with the greatest effect observed at 2–3 h post-surgery,and can maintain analgesia for up to 6 *** tests confirmed good ***/cGel MNs effectively penetrate the stratum corneum,safely delivering drugs with significant analgesic effects,excellent mechanical properties,and good biocompatibility,representing a promising strategy for managing acute postoperative pain.

关键词： microneedle postoperative pain flurbiprofen non-steroid anti-inflammatory drug cross-linked gelatin

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Nullification of GFTs fortifies bioactive folates in foxtail millet

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Journal of Integrative Plant Biology 2024年第8期66卷 1540-1543页

作者： Jianzhou Pang Wei zhang yanyan zhang Shihui zhang Yannan Wang Hui Zhi Chunyi zhang Qiuju Liang Xianmin Diao College of Life Science Hebei Normal UniversityShijiazhuang 050024China Dry Land Farming Institute of Hebei Academy of Agricultural and Forestry Sciences Key Laboratory of Crop Drought Tolerance Research of Hebei ProvinceHengshui 053000China Institute of Crop Sciences Chinese Academy of Agricultural SciencesState Key Laboratory of Crop Gene Resources and BreedingBeijing 100081China Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China

Folates—tetrahydrofolate(THF)and its derivatives(also known collectively as vitamin B9)—are essential micronutrients for almost all living *** as carriers of one-carbon(C1)units,folates participate in the biosynthesis of numerous biomolecules and play central roles in cellular methylation reactions(Strobbe and Van Der Straeten,2017).

关键词： collective organisms vitamin

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Revitalizing sodium-ion batteries via controllable microstructures and advanced electrolytes for hard carbon

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eScience 2024年第3期4卷 65-103页

作者： Feng Wang Zhenming Jiang yanyan zhang Yanlei zhang Jidao Li Huibo Wang Yinzhu Jiang Guichuan Xing Hongchao Liu Yuxin Tang College of Chemical Engineering Fuzhou UniversityFuzhou 350116PR China Institute of Applied Physics and Materials Engineering University of MacaoMacao999078PR China School of Materials Science and Engineering ZJU-Hangzhou Global Scientific and Technological Innovation CentreZhejiang UniversityHangzhou 310027China Qingyuan Innovation Laboratory 1 Xueyuan RoadQuanzhou 362801PR China

Sodium-ion batteries(SIBs)with low cost and high safety are considered as an electrochemical energy storage technology suitable for large-scale energy *** carbon,which is inexpensive and has both high capacity and low sodium storage potential,is regarded as the most promising anode for commercial ***,the commercialization of hard carbon still faces technical issues of low initial Coulombic efficiency,poor rate performance,and insufficient cycling stability,due to the intrinsically irregular microstructure of hard *** address these challenges,the rational design of the hard carbon microstructure is crucial for achieving high-performance SIBs,via gaining an in-depth understanding of its structure-performance *** this context,our review firstly describes the sodium storage mechanism from the perspective of the hard carbon microstructure's *** then summarize the state-of-art development of hard carbon,providing a critical overview of emergence of hard carbon in terms of precursor selection,microstructure design,and electrolyte regulation to optimize strategies for addressing practical ***,we highlight directions for the future development of hard carbon to achieve the commercialization of high-performance *** believe this review will serve as basic guidance for the rational design of hard carbon and stimulate more exciting research into other types of energy storage devices.

关键词： Hard carbon Coulombic efficiency Controllable microstructure Electrolyte regulation Sodium storage mechanism Sodium-ion batteries

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Taohong Siwu decoction(桃红四物汤)ameliorates atherosclerosis in rats possibly through toll-like receptor 4/myeloid differentiation primary response protein 88/nuclear factor-κB signal pathway

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Journal of Traditional Chinese Medicine 2024年第1期44卷 103-112页

作者： CHANG Fengjin ZHOU Peng LI Guoying zhang Weizhi zhang yanyan PENG Daiyin CHEN Guangliang Department of Pharmacy the First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031China School of Integrated Traditional and Western Medicine Anhui University of Chinese MedicineHefei 230012China Anhui Province Key Laboratory of Chinese Medicinal Formula Hefei 230012China School of Pharmacy Anhui University of Chinese MedicineHefei 230012China

OBJECTIVE:To investigate the effect of Taohong Siwu decoction(桃红四物汤,TSD)on atherosclerosis in rats as well as investigate the underlying mechanism based on molecular ***:Sixty healthy male Sprague-Dawley rats were randomly divided into 6 groups with 10 rats in each group:control group,model group,atorvastatin group(AT,2.0 mg/kg),and TSD groups(20,10,5 g/kg)after 7 d of *** model of atherosclerosis was successfully established except the control group by high fat diet(HFD)and vitamin *** analyzers were used to detect the levels of triglyceride(TG),total cholestero(TC),low density lipoprotein-cholesterol(LDLC)and high density lipid-cholesterol(HDL-C)in blood *** levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-1β(IL-1β)were determined by enzyme-linked immunosorbent *** IV staining and Hematoxylin and eosin staining(HE staining)were performed to observe the pathological changes in aortic *** docking technology was used to predict the best matching between the main components of TSD and the target *** expression of target proteins was further detected by quantitative real time polymerase chain reaction(q RTPCR)and Western blot ***:The results showed that TSD restricted atherosclerosis development and decreased the inflammatory cytokines in *** docking results predicted that the main components of TSD showed a strong binding ability with toll-like receptor(TLR4),myeloid differentiation primary response protein 88(My D88),and nuclear factor kappa-B(NF-κB).The results of q RT-PCR and Western blot analysis showed that the m RNA and protein expressions of TLR4,My D88 and NF-κB p65 in the aorta were reduced in atorvastatin group and TSD ***:TSD can ameliorate atherosclerosis in rats,and the underlying mechanism is supposed be related to the suppression of inflammatory response by regulating TLR4/My D88/NF-κB signal pathway.

关键词： atherosclerosis molecular docking simulation tolllike receptor 4 myeloid differentiation factor 88 NF-kappa B signal transduction Taohong Siwu decoction

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醒面对面团水分状态、微观形态和物性的影响研究

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食品工业科技 2024年第6期45卷 42-48页

作者：张艳艳张捷张菁张普刘兴丽张华郑州轻工业大学食品与生物工程学院中原食品实验室冷链食品加工与安全控制教育部重点实验室河南郑州450002

为研究醒面对冷冻面团品质的影响,本文研究了醒面过程中(0、30、60、90、120 min),面团水分分布的变化规律以及面团冷冻后冰晶分布、微观结构和蠕变恢复特性的变化。结果表明:随着醒面时间的延长,面团中可冻结水含量降低了0.96%;微观结... 详细信息

为研究醒面对冷冻面团品质的影响,本文研究了醒面过程中(0、30、60、90、120 min),面团水分分布的变化规律以及面团冷冻后冰晶分布、微观结构和蠕变恢复特性的变化。结果表明:随着醒面时间的延长,面团中可冻结水含量降低了0.96%;微观结构的结果表明,面团在冻结过程中形成的冰晶空隙和数量逐渐减小,冰晶分布越来越均匀;随着醒面时间从0 min延长至120 min,冷冻面团的平均空隙面积从22.65减小到11.80,空隙数目从10627.00减少到3346.00;随着醒面时间的延长,在蠕变阶段,冷冻面团的最大蠕变柔量Jmax显著增加(P<0.05),零剪切粘度η0显著降低(P<0.05);面团醒发120 min后,冷冻面团最大蠕变柔量Jmax降低了0.50×10^(-4)Pa^(-1),零剪切粘度η0降低了0.43×10^(5)Pa^(-1),这说明冷冻面团的硬度降低,面团的形状更容易保持;在恢复阶段,瞬时柔量J_(0)与黏弹性柔量J_(m)分别增加了1.26×10^(-4)和2.88×10^(-4)Pa^(-1),冷冻面团的恢复力增加。综上,醒面降低了面团中可冻结水的含量,提高了面团的持水力,减小了冷冻过程中冰晶对面团网络结构的破坏,从而提高了冷冻面团的品质。

关键词：醒面水分状态微观结构冷冻面团

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基于刚度矩阵分析法的变刚度橡胶支座力学性能研究

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振动与冲击 2024年第20期43卷 106-118页

作者：杨静潘文张岩岩蔡正昆明理工大学建筑工程学院昆明650500 云南省抗震工程技术研究中心昆明650500 云南省设计院集团有限公司科技研发中心昆明650500

在橡胶支座力学行为基础上提出了一种适合隔离三维地震或竖向振动的新型变刚度橡胶支座,并阐述了能解决变刚度支座非均质体力学问题的刚度矩阵分析法。首先,基于常用橡胶支座解析解和压剪试验的非线性响应分析,采用刚度矩阵分析法对该... 详细信息

在橡胶支座力学行为基础上提出了一种适合隔离三维地震或竖向振动的新型变刚度橡胶支座,并阐述了能解决变刚度支座非均质体力学问题的刚度矩阵分析法。首先,基于常用橡胶支座解析解和压剪试验的非线性响应分析,采用刚度矩阵分析法对该支座进行计算,其结果和试验值高度一致验证了该方法计算精度较高。接着,对比三种支座结果:在相同外部荷载和材料参数下,厚层支座力和变形最大,变刚度支座和普通支座力和变形显著低于厚层支座;不同轴压下,P-Δ效应表现为厚层支座力和变形及水平刚度受轴压影响最为显著,而变刚度支座与普通支座受轴压影响较小。通过算例表明,可通过调整变刚度支座实现竖向刚度的优化。综合而言,变刚度支座对力和变形的承载能力较好,为三维隔震(振)提供了一种简单实用的解决方案。

关键词：变刚度橡胶支座刚度矩阵分析法厚层橡胶支座三维隔震(振) P-Δ效应

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磁场处理对面团发酵特性的影响及作用机制

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食品科学 2024年第3期45卷 110-116页

作者：张艳艳张斯琦孙萌辉刘兴丽张华郑州轻工业大学食品与生物工程学院河南郑州450001 郑州轻工业大学食品生产与安全河南省协同创新中心河南省冷链食品质量安全控制重点实验室中原食品实验室河南郑州450001

磁场可通过影响水分子的排布改变食品内部水分分布进而改善食品的品质。本研究分别在0、0.5、1.0、1.5、2.0mT的磁场强度条件下发酵面团1h,通过低场核磁、原位拉曼光谱等技术研究了磁场处理对面团发酵特性、水分分布及蛋白分子结构的影... 详细信息

磁场可通过影响水分子的排布改变食品内部水分分布进而改善食品的品质。本研究分别在0、0.5、1.0、1.5、2.0mT的磁场强度条件下发酵面团1h,通过低场核磁、原位拉曼光谱等技术研究了磁场处理对面团发酵特性、水分分布及蛋白分子结构的影响,以期为开发高品质的中式美食提供理论基础。结果显示:随着磁场强度的增大,面团的发酵能力呈先上升后下降的趋势,在磁场强度为1.5 mT时对发酵力的影响最为显著;馒头的比容呈现先上升后下降的趋势,在磁场强度在1.0 mT时,馒头的比容为2.24 mL/g;馒头的硬度、黏性、咀嚼性呈现先下降后上升的趋势,弹性、内聚性、回复性没有明显的变化;强结合水与自由水含量呈先下降后上升趋势,弱结合水含量呈先上升后下降的趋势,在磁场强度为1.0 mT时,对水分分布的影响最为显著;α-螺旋相对含量呈先上升后下降的趋势,无规卷曲呈先下降后上升的趋势,在磁场强度为0.5 mT时α-螺旋相对含量最高,为54%,无规卷曲相对含量最低,为21%。适当的磁场处理可以提高面团的发酵力、馒头的比容和质构特性,加速面团中的水分分布,提高面筋网络的稳定性。综上,磁场处理可以通过改善面团中水分的分布、提高水分均匀度以及改变面筋蛋白的分子结构,提高面团的发酵特性以及馒头的质构特性。

关键词：磁场面团发酵水分迁移蛋白结构

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信息化与性别工资差距——来自中国的经验证据

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财经科学 2024年第1期 134-148页

作者：胡善成张云矿张彦彦南开大学经济学院中共天津市委党校马克思主义学院

基于2011—2018年中国流动人口动态监测调查(CMDS)和城市数据,分析了信息化发展对性别工资差距的影响。研究发现,信息化发展显著扩大了不同技能水平下的性别工资差距。通过借助工具变量和“宽带中国”准自然实验克服内生性问题以后,所... 详细信息

基于2011—2018年中国流动人口动态监测调查(CMDS)和城市数据,分析了信息化发展对性别工资差距的影响。研究发现,信息化发展显著扩大了不同技能水平下的性别工资差距。通过借助工具变量和“宽带中国”准自然实验克服内生性问题以后,所得结论依然稳健。研究还发现,信息化对性别工资差距的影响存在地区、中心城市和城市规模的异质性。为此,应通过制度创新引导数字经济带来生产效率变革的同时兼顾收入公平,加快劳动力市场化改革,保障女性劳动力获得岗位的机会平等,推进信息和数字要素均等化,使“数字红利”覆盖更广泛群体。

关键词：信息化性别工资差距准自然实验

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基于转录组学和代谢组学联合分析草珊瑚萜类化合物生物合成的组织特异性分布

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生物工程学报 2024年第2期40卷 542-561页

作者：吴迪张燕燕林楠魏艺聪福建中医药大学药学院福建福州350122

本研究旨在探究草珊瑚叶和根中萜类化合物的组织特异性分布差异,解析其药效品质差异形成的分子机制。采用液相色谱-质谱联用技术(liquid chromatography-mass spectrometry, LC-MS)和Illumina HiSeq~(TM)高通量测序技术获得草珊瑚[Sarca... 详细信息

本研究旨在探究草珊瑚叶和根中萜类化合物的组织特异性分布差异,解析其药效品质差异形成的分子机制。采用液相色谱-质谱联用技术(liquid chromatography-mass spectrometry, LC-MS)和Illumina HiSeq~(TM)高通量测序技术获得草珊瑚[Sarcandra glabra(thunb) naka]叶和根的代谢组学和转录组学数据。代谢组学结果表明参与叶和根中萜类合成的差异代谢物有50个,包括法尼西基半胱氨酸、甘油醛-3-磷酸、甲羟戊酸-5-磷酸等。转录学结果表明差异代谢酶基因有57条,包括ACTC、HMGCR、MVK、DXS与KS等,并预测了MYB、C2H2、AP2/ERF-ERF等7个转录因子参与调控草珊瑚不同组织部位中萜类的合成和积累差异。实时荧光定量PCR(quantitative real-time polymerase chain reaction, qRT-PCR)结果显示,随机选取的8个参与萜类合成的酶基因在草珊瑚不同组织部位中的表达趋势与转录组学测序结果一致。本研究有助于阐明草珊瑚叶和根临床疗效差异形成的分子机制,同时为草珊瑚的资源开发利用奠定基础。

关键词：草珊瑚萜类代谢组学转录组学

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