检索结果-南通市图书馆

Microdeletion on Xq27.1 in a Chinese VACTERL-like Family with Kidney and Anal Anomalies

Biomedical and Environmental Sciences 2024年第5期37卷 503-510页

作者： li Min zhang Yu Lan zhang kai li li Ping Ping LYU Yu Han liANG Ya Xin YU Yue Department of Gynecology and Obstetrics Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing HospitalBeijing 100730China The Key Laboratory of Geriatrics Beijing Institute of GeriatricsBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective VATER/VACTERL-like association is associated with adverse pregnancy *** evidence of this disorder is *** this study,we aimed to provide genetic insights to improve the diagnosis of *** We have described a Chinese family in which four members were affected by renal defects or agenesis,anal atresia,and anovaginal fistula,which is consistent with the diagnosis of a VACTERL-like *** and genetic analyses were conducted using genome and exome *** Segregation analysis revealed the presence of a recessive X-linked microdeletion in two living affected individuals,harboring a 196–380 kb microdeletion on Xq27.1,which was identified by familial exome *** sequencing was performed on the affected male,confirming a-196 kb microdeletion in Xq27.1,which included a 28%loss of the CDR-1 *** family members were included in the co-segregation analysis,and only VACTERL-like cases with microdeletions were reported in *** These results suggest that the 196–380 kb microdeletion in Xq27.1 could be a possible cause of the VATER/VACTERL-like ***,further genetic and functional analyses are required to confirm or rule out genetic background as the definitive cause of the VACTERL association.

关键词： Prenatal diagnosis VACTERL whole-genome sequencing whole-exome sequencing X-linked

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于铝基含能配合物及CL-20含能微芯片的制备及表征

引用

火炸药学报 2024年第5期47卷 438-444,I0004页

作者：孟珂娟马小霞李宇翔张开黎香港城市大学工学院机械工程系中国香港999077 北京理工大学机电学院北京100081

为提高含能微芯片的能量特性和燃烧特性,推进其在微推进器、微驱动器、微毁伤器等装置中的应用,通过在铜箔上原位生长含能配位聚合物(ECP)、电子束沉积n-Al及重结晶CL-20的方法制备了ECP@Al@CL-20的含能阵列,采用SEM、XRD、TG/DSC及高... 详细信息

为提高含能微芯片的能量特性和燃烧特性,推进其在微推进器、微驱动器、微毁伤器等装置中的应用,通过在铜箔上原位生长含能配位聚合物(ECP)、电子束沉积n-Al及重结晶CL-20的方法制备了ECP@Al@CL-20的含能阵列,采用SEM、XRD、TG/DSC及高速摄影等表征方法对其微观形貌、物相组成、热分解特性、燃烧性能及贮存寿命进行了测试与分析。在此基础上,将其与微机电系统(MEMS)集成制得了功能性的ECP@Al@CL-20含能微芯片,并对含能微芯片进行了电容点火测试。结果表明,由于ECP的导热系数低,使ECP@Al@CL-20含能阵列从外到内的传热效率降低,导致放热峰温相比纯CL-20提高了8.5℃,从而提高了ECP@Al@CL-20的热稳定性;ECP@Al@CL-20含能阵列具有优异的燃烧性能,自持燃烧时间(340 ms)远大于ECP@Al的自持燃烧时间(120 ms),含能微芯片可在15 mJ的输入能量下激发。

关键词：含能配位聚合物微机电系统纳米铝 CL-20 微加热器含能微芯片 ECP MEMS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SQUAMOSA Promoter-Binding Protein-like Transcription Factors:Star Players for Plant Growth and Development

引用

Journal of Integrative Plant Biology 2010年第11期52卷 946-951页

作者： Xiaobo Chen Zenglin zhang Danmei liu kai zhang Aili li Long Mao National Key Facility for Crop Gene Resources and Genetic Improvement (NFCRI) MOA Key Laboratory of Crop Germplasm & BiotechnologyInstitute of Crop ScienceChinese Academy of Agricultural Sciences (CAAS)Beijing 100081China

SQUAMOSA Promoter-Binding Protein-like （SPL） genes encode plantspecific transcription factors that play important roles in plant phase transition,flower and fruit development,plant architecture,gibberellins signaling,sporogenesis,and response to copper and fungal *** Arabidopsis,many SPL genes are post-transcriptionally regulated by the microRNA （miRNA） miR156,among which AtSPL9 in turn positively regulates the expression of the second miRNA *** miR156AtSPL9-miR172 regulatory pathway plays critical roles during juvenile to adult leaf development and the miR156-SPLs feedback interaction persists all through the plant development,which may be conserved in other *** the present paper,we provide a concise review on the most recent progress in the regulatory mechanisms associated with plant SPL transcription factors,especially in relation to *** potential application of these discoveries in agriculture is briefly discussed.

关键词： Transcription factors Transcription Plants Planting Genes Regulations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correlation of genes associated with drug response to prognosis of large cell lung carcinoma

引用

Chinese Journal of Cancer 2011年第7期30卷 497-504页

作者： Cheng Chen Xiang-li Jiang Cui-Cui zhang kai li Department of Medical Thoracic Oncology TianjinMedical University Cancer Institute and Hospital Tianjin 300060 P. R.China.

Platinum-based chemotherapy remains the main treatment of advanced lung cancer. However, platinum resistance has become a major treatment obstacle. Novel therapies, particularly tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKI) and agents that target vascular endothelial growth factor (VEGF), have improved the treatment. Both chemotherapy and targeted therapy have their molecular mechanisms. This study aimed to determine the mutation, amplification, or expression status and interrelationships of the epidermal growth factor receptor (EGFR), K-Ras proto-oncogene, excision repair cross-complementation group 1 (ERCC1), and VEGF genes as well as their correlations to prognosis of large cell lung carcinoma (LCLC) after EGFR-targeted therapy, chemotherapy, and anti-VEGF therapy. EGFR and K-Ras mutations in 60 specimens of LCLC were detected by direct DNA sequencing. EGFR, ERCC1, and VEGF protein expression was detected by immunohistochemistry (IHC). EGFR gene copy number was detected by fluorescence in situ hybridization (FISH). One (1.7%) patient had an EGFR L858M point mutation in exon 21, 3 (5.0%) had K-Ras mutations, and 10 (19.6%) had EGFR amplification (FISH positive). Positive rates of EGFR, ERCC1, and VEGF proteins were 38.3%, 56.7%, and 70.0%, respectively. EGFR amplification was positively correlated to EGFR protein expression (r = 0.390, P = 0.005). The positive rate of VEGF protein was significantly higher in patients with lymph node metastasis than in those without (84.6% vs. 58.8%, P = 0.046). No significant correlations were observed among the EGFR, K-Ras, ERCC1, and VEGF genes. EGFR gene amplification and the low rate of EGFR mutation suggest that patients with LCLC are likely to obtain little benefit from anti-EGFR therapies.

关键词：相关基因表皮生长因子受体血管内皮生长因子药物反应肺癌预后细胞基因突变检测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高职动物检疫技术在线开放课程建设探析

引用

新疆职业教育研究 2024年第3期15卷 32-34页

作者：刘晓娜李泽宇张凯丽新疆农业职业技术大学新疆昌吉831100

在当前高等职业教育中,在线开放课程成为一种新兴的教学模式。本研究选取新疆某高职院校动物检疫技术在线开放课程,深入分析课程内容建设的现状、必要性及实施方法等,为高职院校在线开放课程建设提供参考。

关键词：高职在线开放课程动物检疫技术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Engineered spidroin-derived high-performance fibers for diverse applications

引用

Nano Research 2024年第2期17卷 492-502页

作者： Dawen Qin Jingjing li Huanrong li Hongjie zhang kai liu National-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization Tianjin Key Laboratory of Chemical Process SafetySchool of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Engineering Research Center of Advanced Rare Earth Materials Ministry of EducationDepartment of ChemistryTsinghua UniversityBeijing 100084China University of Science and Technology of China Hefei 230026China

Spider silks are well known for their exceptional mechanical properties that are tougher than Kevlar and ***,the restricted production amounts from their native sources limit applications of spider *** the decades,there have been significant interests in fabricating man-made silk fibers with comparable performance to natural silks,inspiring many efforts both for biosynthesizing recombinant spider silk proteins(spidroins)in amenable heterologous hosts and biomimetic spinning of artificial spider *** strategies provide promising routes to produce high-performance and functionally optimized fibers with diverse ***,we summarize the hosts that have been applied to produce recombinant *** addition,the fabrication and mechanical properties of recombinant spidroin fibers and their composite fibers are also ***,we demonstrate the applications of recombinant spidroin-based ***,facing the challenges in biosynthesis,scalable production,and hierarchical assembly of high-performance recombinant spidroins,we give a summary and perspective on future development.

关键词： spider silk recombinant spidroin heterologous expression fiber fabrication mechanical property

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evolution hydrothermal aging resistance mechanism study of zirconium and manganese doped CeO_(2)catalysts in soot catalytic combustion based on low Miller indices crystal surface effect

引用

Journal of Rare Earths 2024年第7期42卷 1272-1281,I0003页

作者： Zonglin li Pan Wang Hong Ni Chengcheng Ao lidong zhang Hefeng zhang kai li School of Automotive and Traffic Engineering Jiangsu UniversityZhenjiang212013China State Environmental Protection Key Laboratory of Vehicle Emission Control and Simulation Chinese Research Academy of Environmental ScienceBeijing100012China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei230026China

The thermogravimetric analysis(TGA)experiments were carried out to reveal the mechanism of Zr and Mn doping on catalytic activity of CeO_(2)catalyst both fresh and after hydrothermal aging,and the lattice morphology and valence changes were characterized by means of Brunauer-Emmett-Teller(BET)method,X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and H_(2)-temperature programmed reduction(H_(2)-TPR).Density functional theory(DFT)and molecular thermodynamics calculations were applied to investigate the change in catalytic activity,crystal surface energy and crystal morphology caused by hydrothermal *** maximum reaction rate temperature of fresh Mn/CeO_(2)(389℃)is similar to that of CeO_(2)(371℃)and lower than that of Zr/CeO_(2)(447℃),but the catalytic performance of CeO_(2)decreases more severely after hydrothermal *** catalyst crystals show different degrees of crystal surface migration after hydrothermal aging,which leads to the reduction of Ce^(3+)/Ce^(4+) ratio and the active sites *** calculations indicate that the doping of Zr and Mn reduces the surface energy of the low Miller indices surface and increases the oxygen vacancy formation energy,leading to better thermal stability and lower catalytic *** Zr and Mn doping also changes the adsorption energy and Gibbs free energy of H_(2)O,which dominates the migration of(111)to(110)and(100)in the vapor *** crystal surface migration mechanism of CeO_(2)catalysts doped with Zr and Mn induced by H_(2)O molecules at high temperature obtained in this study can provide a valuable addition to the regeneration of CeO_(2)catalysts in the after-treatment systems of diesel engines.

关键词： Soot CeO_(2)-based catalyst CDPF Rare earth metal oxides DFT calculations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中老年脑卒中患者多维衰弱发展轨迹及其影响因素研究

引用

护理学报 2024年第6期31卷 6-12页

作者：薛荣张开利陈保云马荣慧张雨欣徐州医科大学护理学院江苏徐州221000 徐州市中心医院护理部江苏徐州221009 徐州市中心医院神经内科江苏徐州221009

目的探讨中老年脑卒中患者多维衰弱发展轨迹及其影响因素,为临床医护人员开展衰弱干预提供理论依据。方法选取2022年10—12月徐州市某三级甲等医院神经内科住院的中老年脑卒中患者为研究对象,采用一般资料调查表、Zung焦虑自评量表和Z... 详细信息

目的探讨中老年脑卒中患者多维衰弱发展轨迹及其影响因素,为临床医护人员开展衰弱干预提供理论依据。方法选取2022年10—12月徐州市某三级甲等医院神经内科住院的中老年脑卒中患者为研究对象,采用一般资料调查表、Zung焦虑自评量表和Zung抑郁自评量表收集患者的基线资料,采用Tilburg衰弱量表调查患者入院48 h、出院后3个月和出院后6个月多维衰弱得分情况,使用潜类别增长模型探究中老年脑卒中患者多维衰弱发展轨迹类别,采用无序多分类Logistic回归及决策树模型分析识别轨迹类别的影响因素。结果中老年脑卒中患者多维衰弱发展轨迹可分为3种类别:非衰弱稳定组(42.8%)、低水平衰弱快速加重组(36.3%)和高水平衰弱缓慢加重组(20.9%)。Logistic回归分析结果显示,年龄、婚姻状况、文化程度、卒中严重程度评分、共病评分、日常生活活动能力评分和焦虑为中老年脑卒中患者多维衰弱发展轨迹的影响因素(P<0.05);决策树模型进一步分析结果显示,日常生活活动能力评分为最主要影响因素,其后依次为焦虑和卒中严重程度评分。结论本研究识别出3种类别中老年脑卒中患者多维衰弱发展轨迹,验证了衰弱发展异质性的特点。未来医护人员可通过筛查识别不同类别患者多维衰弱发展轨迹,制定针对性衰弱干预和居家衰弱管理方案,延缓甚至逆转多维衰弱。

关键词：中老年脑卒中多维衰弱轨迹潜类别增长模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Data complexity-based batch sanitization method against poison in distributed learning

引用

Digital Communications and Networks 2024年第2期10卷 416-428页

作者： Silv Wang kai Fan Kuan zhang Hui li Yintang Yang State Key Laboratory of Integrated Service Networks Xidian UniversityXi'an710126China Department of Electrical and Computer Engineering University of Nebraska-LincolnLincolnNE68588USA Key Lab.of the Minist.of Educ.for Wide Bandgap Semiconductor Materials and Devices Xidian UniversityXi'an710071China

The security of Federated Learning(FL)/Distributed Machine Learning(DML)is gravely threatened by data poisoning attacks,which destroy the usability of the model by contaminating training samples,so such attacks are called causative availability indiscriminate *** the problem that existing data sanitization methods are hard to apply to real-time applications due to their tedious process and heavy computations,we propose a new supervised batch detection method for poison,which can fleetly sanitize the training dataset before the local model *** design a training dataset generation method that helps to enhance accuracy and uses data complexity features to train a detection model,which will be used in an efficient batch hierarchical detection *** model stockpiles knowledge about poison,which can be expanded by retraining to adapt to new *** neither attack-specific nor scenario-specific,our method is applicable to FL/DML or other online or offline scenarios.

关键词： Distributed machine learning security Federated learning Data poisoning attacks Data sanitization Batch detection Data complexity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficient nitrite-to-ammonia electroreduction over Zr-Ni frustrated Lewis acid-base pairs

引用

Science China Chemistry 2024年第5期67卷 1707-1714页

作者： Ying zhang Zhuohang li Wenyu Du kai Chen Ke Chu School of Materials Science and Engineering Lanzhou Jiaotong UniversityLanzhou 730070China

Electrochemical NO_(2)~--to-NH_(3) conversion(NO_(2)RR) offers a green route to NH_(3) electrosynthesis, while developing efficient NO_(2)RR catalysis systems at high current densities remains a grand challenge. Herein, we report an efficient Zr-NiO catalyst with atomically dispersed Zr-dopants incorporated in NiO lattice, delivering the exceptional NO_(2)RR performance with industriallevel current density(>0.2 A cm^(-2)). In situ spectroscopic measurements and theoretical simulations reveal the construction of ZrNi frustrated Lewis acid-base pairs(FLPs) on Zr-Ni O, which can substantially increase the number of absorbed nitrite(NO_(2)~-),promote the activation and protonation of NO_(2)~- and concurrently hamper the H coverage, boosting the activity and selectivity of Zr-NiO towards the NO_(2)RR. Remarkably, Zr-NiO exhibits the exceptional performance in a flow cell with high Faradaic efficiency for NH_(3) of 94.0% and NH_(3)yield rate of 1,394.1 μmol h^(-1)cm^(-2) at an industrial-level current density of 228.2 m A cm^(-2),placing it among the best NO_(2)RR electrocatalysts for NH_(3) production.

关键词： electrochemical nitrite-to-ammonia conversion frustrated Lewis acid-base pairs(FLPs) in situ spectroscopy theoretical computations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：