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Constructal design of a rectangular parallel phase change microchannel in a three-dimensional electronic device

Science China(Technological Sciences) 2024年第5期67卷 1381-1390页

作者： zhang jiwen FENG HuiJun CHEN LinGen GE YanLin Institute of Thermal Science and Power Engineering Wuhan Institute of TechnologyWuhan430205China College of Power Engineering Naval University of EngineeringWuhan430033China Hubei Provincial Engineering Technology Research Center of Green Chemical Equipment Wuhan430205China School of Mechanical&Electrical Engineering Wuhan Institute of TechnologyWuhan430205China

Based on constructal theory,a rectangular parallel phase change microchannel model in a three-dimensional electronic device(TDED)is established with R134a as the cooling *** on the minimization of a complex function(CF)composed of linear weighting sum of maximum temperature difference and pumping power consumption,constructal design of the TDED is conducted first;and then,maximum temperature difference and pumping power consumption are minimized by non-dominated sorting genetic algorithm-II *** results reveal that there exist an optimal mass flow rate(0.0012 kg/s)and a quadratic optimal aspect ratio(AR)(0.39)of the microchannel which lead to quadratic minimum CF(0.817).Compared with the original value,the CF after optimization is reduced by 18.34%.Reducing the inlet temperature of cooling fluid and microchannel number appropriately can help to enhance the overall performance of *** using the artificial neural network and genetic algorithms in the toolboxes of Matlab software,the optimal AR gained in the Pareto solution set is located between 0.2–*** smallest deviation index among three discussed strategies is 0.346,and the corresponding optimal AR is 0.413,which is selected as the optimal design strategy of the microchannel in the TDED under multiple *** findings in this study can serve as theoretical guides for thermal designs of electronic devices.

关键词： constructal theory parallel microchannel evaporation phase change three-dimensional electronic device multi-objective optimization artificial neural network

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Establishment of an indirect immunofluorescence assay for the detection of African swine fever virus antibodies

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Journal of Integrative Agriculture 2024年第1期23卷 228-238页

作者： Wan Wang Zhenjiang zhang Weldu Tesfagaber jiwen zhang Fang Li Encheng Sun Lijie Tang Zhigao Bu Yuanmao Zhu Dongming Zhao State Key Laboratory for Animal Disease Control and Prevention National African Swine Fever Para-reference LaboratoryNational High Containment Facilities for Animal Diseases Control and PreventionHarbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150069China

African swine fever(ASF)continues to cause enormous economic loss to the global pig *** there is no safe and effective vaccine,accurate and timely diagnosis of ASF is essential to implement control *** immunofluorescence assay(IFA)is a gold standard serological method recommended by the World Organization for Animal Health(WOAH).In this study,we used primary fetal kidney cells to establish a wild boar cell line(BK2258)that supported the efficient replication of ASF virus(ASFV)SD/DY-I/21 and showed visible cytopathic effect(CPE).Moreover,using BK2258,we established a sensitive and specific IFA for ASFV antibody *** standardize and evaluate the performance of this assay,we used serum samples from pigs infected with the low virulent genotype I SD/DY-I/21 and genotype II HLJ/HRB1/20,and immunized with the vaccine candidate HLJ/18-7GD,field samples,and negative serum *** IFA reacted with the ASFV-positive sera and displayed bright fluorescence *** was no non-specific green fluorescence due to cellular senescence or other cell damage-causing *** to a commercial indirect enzyme-linked immunosorbent assay(iELISA),ASFV antibodies were detected 1–4 days earlier using our *** detection limits of the IFA and iELISA for the same ASFV-antibody positive serum samples were 1:25,600 and 1:6,400,respectively,indicating that the IFA is more sensitive than *** newly established IFA was highly specific and did not cross-react with sera positive for six other important porcine pathogens(i.e.,Classical swine fever virus(CSFV),Porcine reproductive and respiratory syndrome virus(PRRSV),Porcme circovirus type 2(PCV2),Pseudorabies virus(PRV),Foot-and-Mouth disease virus type O(FMDV/O),and Porcine epidemic diarrhea virus(PEDV)).This study thus provides a sensitive,specific,and reliable detection method that is suitable for the serological diagnosis of ASF.

关键词： African swine fever antibody IFA serological method

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基于机器人建模的航空装配测控仿真分析方法

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清华大学学报（自然科学版） 2024年第4期64卷 724-737页

作者：王斌张继文吴丹清华大学机械工程系高端装备界面科学与技术全国重点实验室北京100084

在航空飞机数字化装配过程中,需要对装配环境中的运动调姿机构的运动能力和靶标测量机构的测量能力进行仿真,以确保调姿机构实现给定运动空间的灵活调姿及测量机构实现对目标测量点的无遮挡、高精度测量,从而测控结合完成装配。而航空... 详细信息

在航空飞机数字化装配过程中,需要对装配环境中的运动调姿机构的运动能力和靶标测量机构的测量能力进行仿真,以确保调姿机构实现给定运动空间的灵活调姿及测量机构实现对目标测量点的无遮挡、高精度测量,从而测控结合完成装配。而航空领域常用的仿真平台如DELMIA、CATIA和SA等,目前无法实现结合设备位置规划、运动控制评估和测量场分析的综合仿真。为了在同一体系下实现航空装配数字化测控系统的综合仿真,该文提出一种基于机器人建模的航空装配测控仿真分析方法。将数字化装配环境中的零部件及工装、调姿机构、测量机构、环境干扰物体等关键要素在机器人仿真平台中分别建模为不同的机器人,进而按照装配需求编写控制程序,使系统按照需求控制各个机器人联合运动执行仿真分析,以完成测控算法验证,并可进一步设置动态优化问题对测调参数、测量设备站位等现有仿真平台难仿信息进行优化。以高遮挡环境下的多个激光跟踪仪对大量测量点的联合测量可达性仿真分析和多激光跟踪仪站位仿真规划为例,阐述了测量机构的机器人建模方法、仿真系统的搭建方法、仿真激光测量系统的原理和站位规划的实施方式,验证了所提方法的可行性。该方法简单、高效,当环境改变时可快速重规划。

关键词：航空数字化装配测控仿真方法激光跟踪仪测量可达性站位优化

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Visualization of nasal powder distribution using biomimetic human nasal cavity model

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Acta Pharmaceutica Sinica B 2024年第1期14卷 392-404页

作者： Jiawen Su Yan Liu Hongyu Sun Abid Naeem Huipeng Xu Yue Qu Caifen Wang Zeru Li Jianhua Lu Lulu Wang Xiaofeng Wang Jie Wu Lixin Sun jiwen zhang Zhigang Wang Rui Yang Li Wu Key Laboratory of Modern Preparation of TCM Ministry of EducationJiangxi University of Chinese MedicineNanchang 330004China Key Laboratory of Molecular Pharmacology and Drug Evaluation School of PharmacyMinistry of EducationYantai UniversityYantai 264005China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201210China Nantong Haimen People’s Hospital Nantong 226199China Yangtze Delta Drug Advanced Research Institute Nantong 226126China Shenyang Pharmaceutical University Shenyang 110016China National Institutes for Food and Drug Control Beijing 100000China Nanjing University of Chinese Medicine Nanjing 210023China

Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal ***,no reliable method is currently available to assess its impact on delivery *** this study,a biomimetic nasal model based on three-dimensional(3D)reconstruction and three-dimensional printing(3DP)technology was developed for visualizing the deposition of drug powders in the nasal *** results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and *** nasal cavity model was modified with dimethicone and validated to be suitable for the deposition *** experimental device produced the most satisfactory results with five spray ***,particle sizes and spray angles were found to significantly affect the experimental device’s performance and alter drug distribution,***,mometasone furoate(MF)nasal spray(NS)distribution patterns were investigated in a goat nasal cavity model and three male goat noses,confirming the in vitro and in vivo *** conclusion,the developed human nasal structure biomimetic device has the potential to be a valuable tool for assessing nasal drug delivery system deposition and distribution.

关键词： Nasal drug deposition Nasal drug distribution Nasal drug delivery Biomimetic nasal model Nasal powder Three-dimensional reconstruction Three-dimensional printing Nasal drug distribution

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中国式现代化话语体系建构的三维论析

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福州党校学报 2024年第1期 48-53页

作者：张继文广东开放大学马克思主义学院广东广州510091

构建中国式现代化话语体系是认识中国特色社会主义实践、实现社会主义现代化奋斗目标、构建可信可敬可爱中国形象的重要方式。在时代快速发展的背景下,我们既面临西方话语霸权压力,又需应对话语概念范畴表述不清、话语对外传播水平不高... 详细信息

构建中国式现代化话语体系是认识中国特色社会主义实践、实现社会主义现代化奋斗目标、构建可信可敬可爱中国形象的重要方式。在时代快速发展的背景下,我们既面临西方话语霸权压力,又需应对话语概念范畴表述不清、话语对外传播水平不高等问题。要加快建构话语体系,通过充实话语内容、优化话语表达和促进话语认同等策略,进一步加深对中国式现代化话语体系的理解,推动其认同和传播,为中国式现代化进程提供坚实的话语支撑。

关键词：中国式现代化话语体系必要性中国形象文化软实力

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硬式内窥镜检测仪评估硬式内窥镜光学性能的研究

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中国医学装备 2024年第2期21卷 33-36页

作者：颜培巧张伟张继文国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院消毒供应中心北京100021 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院护理部北京100021

目的:应用硬式内窥镜检测仪检测法和目测检测法检测评估硬式内窥镜的导光性能和成像性能,探讨硬式内窥镜检测仪检测硬式内窥镜光学性能的应用效果。方法:选取2022年5月至2023年5月北京协和医学院肿瘤医院膀胱镜手术使用的174件硬式内窥... 详细信息

目的:应用硬式内窥镜检测仪检测法和目测检测法检测评估硬式内窥镜的导光性能和成像性能,探讨硬式内窥镜检测仪检测硬式内窥镜光学性能的应用效果。方法:选取2022年5月至2023年5月北京协和医学院肿瘤医院膀胱镜手术使用的174件硬式内窥镜,分别采用目测法和检测仪法对174件硬式内窥镜进行清洗消毒后的检测。根据检测方式不同,将其分为目测组(90件)和检测仪组(84件)。对比分析两种检测硬式内窥镜导光性能和成像性能的方法,比较两种检测方法的检测效果。结果:检测仪组和目测组光通量不合格检出率分别为11.9%(10/84)和0(0/90),两组硬式内窥镜导光性能的光通量检测比较,差异有统计学意义(x^(2)=9.276,P<0.05)。硬式内窥镜成像性能检测中检测仪组和目测组的成像质量不合格检出率分别为9.5%(8/84)和1.11%(1/90),两组比较差异有统计学意义(x^(2)=6.269,P<0.05)。结论:应用硬式内窥镜检测仪可提高消毒供应中心工作人员检测硬式内窥镜光学性能的准确率,完善硬式内窥镜的质控管理,降低硬式内窥镜损耗率,延长硬式内窥镜的使用寿命,为临床提供更加安全有效的医疗器械,保障医疗安全。

关键词：硬式内窥镜检测光学性能成像性能导光性能

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清热利咽汤对行放化疗鼻咽癌患者口腔黏膜炎发生率的影响

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四川中医 2024年第7期42卷 175-178页

作者：蔡琰张霁雯龚齐上海市宝山区罗店医院耳鼻咽喉科上海201908 上海市宝山区罗店医院消化内科上海201908 上海市宝山区中西医结合医院(上海中医药大学附属曙光医院宝山分院)耳鼻咽喉科上海201900

目的:研究清热利咽汤对行放化疗鼻咽癌患者口腔黏膜炎发生率的影响。方法:本文选取2018年5月~2023年6月在我院放射科治疗的鼻咽癌患者110例,按随机数字法将患者分为对照组、观察组,各55例。对照组放化疗后给予还原型谷胱甘肽钠;观察组... 详细信息

目的:研究清热利咽汤对行放化疗鼻咽癌患者口腔黏膜炎发生率的影响。方法:本文选取2018年5月~2023年6月在我院放射科治疗的鼻咽癌患者110例,按随机数字法将患者分为对照组、观察组,各55例。对照组放化疗后给予还原型谷胱甘肽钠;观察组在对照组的基础上给予清热利咽汤。检测CD4^(+)/CD8^(+)、CD19^(+)/CD69^(+)、骨型碱性磷酸酶(B-ALP)、血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP-2)、生命质量表-头颈癌(QLICP-HN)、症状积分。统计治疗有效率、口腔黏膜炎发生率。结果:观察组治疗后CD4^(+)/CD8^(+)、CD19^(+)/CD69^(+)水平高于对照组治疗后,B-ALP水平低于对照组治疗后(P<0.05)。观察组治疗后VEGF、MMP-2水平及QLICP-HN评分低于对照组治疗后(P<0.05)。观察组治疗后溃疡、咽痛灼热、脓涕腥臭及咽干口渴积分低于对照组治疗后(P<0.05)。观察组治疗后总有效率高于对照组(P<0.05)。两组患者治疗后,观察组口腔黏膜炎发生率低于对照组(P<0.05)。结论:清热利咽汤对行放化疗鼻咽癌患者的治疗效果显著,可降低口腔黏膜炎发生率,减轻患者炎症反应,提高生活质量,有利于患者恢复。

关键词：清热利咽汤放化疗鼻咽癌口腔黏膜炎发生率

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ASFV transcription reporter screening system identifies ailanthone as a broad antiviral compound

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Virologica Sinica 2023年第3期38卷 459-469页

作者： Yuhang zhang Zhenjiang zhang Fan zhang jiwen zhang Jun Jiao Min Hou Nianchao Qian Dongming Zhao Xiaofeng Zheng Xu Tan College of Veterinary Medicine Hunan Agricultural UniversityChangsha 410128China State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China Beijing Advanced Innovation Center for Structural Biology Beijing Frontier Research Center for Biological StructureMOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologySchool of Pharmaceutical SciencesTsinghua-Peking Center for Life SciencesTsinghua UniversityBeijing 100084China Institute of Health and Medicine Hefei Comprehensive National Science CenterHefei 230601 China

African swine fever(ASF)is an acute,highly contagious and deadly viral disease in swine that jeopardizes the worldwide pig ***,there are no authoritative vaccine and antiviral drug available for ASF *** swine fever virus(ASFV)is the etiological agent of *** the ASFV proteins,p72 is the most abundant component in the virions and thus a potential target for anti-ASFV drug ***,we con-structed a luciferase reporter system driven by the promoter of p72,which is transcribed by the co-transfected ASFV RNA polymerase *** this system,we screened over 3200 natural product compounds and obtained three potent candidates against *** further evaluated the anti-ASFV effects and proved that among the three candidates,ailanthone(AIL)inhibits the replication of ASFV at the nanomolar concentration(IC_(50)=15 nmol/L).Our in vitro experiments indicated that the antiviral effect of AIL is associated with its inhibition of the HSP90-p23 ***,we showed the antiviral activity of AIL on Zika virus and hepatitis B virus(HBV),which supports that AIL is a potential broad-spectrum antiviral agent.

关键词： African swine fever virus(ASFV) Replication inhibition Broad-spectrum antiviral drugs Ailanthone(AIL)

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Machine Learning Analysis of Impact of Western US Fires on Central US Hailstorms

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Advances in Atmospheric Sciences 2024年第7期41卷 1450-1462页

作者： Xinming LIN jiwen FAN Yuwei zhang ZJason HOU Pacific Northwest National Laboratory RichlandWA 99354USA Argonne National Laboratory LemontIL 60439USA

Fires,including wildfires,harm air quality and essential public services like transportation,communication,and *** fires can also influence atmospheric conditions,including temperature and aerosols,potentially affecting severe convective ***,we investigate the remote impacts of fires in the western United States(WUS)on the occurrence of large hail(size:≥2.54 cm)in the central US(CUS)over the 20-year period of 2001–20 using the machine learning(ML),Random Forest(RF),and Extreme Gradient Boosting(XGB)*** developed RF and XGB models demonstrate high accuracy(>90%)and F1 scores of up to 0.78 in predicting large hail occurrences when WUS fires and CUS hailstorms coincide,particularly in four states(Wyoming,South Dakota,Nebraska,and Kansas).The key contributing variables identified from both ML models include the meteorological variables in the fire region(temperature and moisture),the westerly wind over the plume transport path,and the fire features(i.e.,the maximum fire power and burned area).The results confirm a linkage between WUS fires and severe weather in the CUS,corroborating the findings of our previous modeling study conducted on case simulations with a detailed physics model.

关键词： wildfire severe convective storm hailstorm machine learning

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Shanghai center project excavation induced ground surface movements and deformations

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Frontiers of Structural and Civil Engineering 2018年第1期12卷 26-43页

作者： Guolin XU jiwen zhang Huang LIU Changqin REN Department of Civil Engineering Southwest Forestry University Kunming 650224 China Department of Civil Engineering University of Kentucky Lexington KY 40506-0281 USA Shanghai Geotechnical Investigations & Design Institute Company Limited Shanghai 200032 China

Empirical data on deep urban excavations can provide designers a significant reference basis for assessing potential deformations of the deep excavations and their impact on adjacent structures. The construction of the Shanghai Center involved excavations in excess of 33-m-deep using the top-down method at a site underlain by thick deposits of marine soft clay. A retaining system was achieved by 50-m-deep diaphragm walls with six levels of struts. During construction, a comprehensive instrumentation program lasting 14 months was conducted to monitor the behaviors of this deep circular excavation. The following main items related to ground surface movements and deformations were collected：（1） walls and circumferential soils lateral movements; （2） peripheral soil deflection in layers and ground settlements; and （3） pit basal heave. The results from the field instrumentation showed that deflections of the site were strictly controlled and had no large movements that might lead to damage to the stability of the foundation pit. The field performance of another 21 cylindrical excavations in top-down method were collected to compare with this case through statistical analysis. In addition, numerical analyses were conducted to compare with the observed data. The extensively monitored data are characterized and analyzed in this paper.

关键词： deep excavation foundation pit soft clay top-down method field observation ground surface movements,ground deformations

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