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Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in Colorectal Cancer Cells

Chinese Journal of Integrative Medicine 2024年第1期30卷 25-33页

作者： GAO Quan LI Lin zhang Qi-man SHENG Qin-song zhang ji-liang jiN Li-jun SHANG Rui-yan School of Pharmacy and Department of Medical Oncology the Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Department of Colorectal Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Beijing Tong Ren Tang Chinese Medicine Co. Ltd.Beijing(100000)China Department of Traditional Chinese Medicine Hangzhou Shangcheng District People's HospitalHangzhou(310006)China Department of Gynecology Hangzhou Women's HospitalHangzhou(310008)China

Objective: To determine whether monotropein has an anticancer effect and explore its potential mechanisms against colorectal cancer(CRC) through network pharmacology and molecular docking combined with experimental verification. Methods: Network pharmacology and molecular docking were used to predict potential targets of monotropein against CRC. Cell counting kit assay, plate monoclonal assay and microscopic observation were used to investigate the antiproliferative effects of monotropein on CRC cells HCT116, HT29 and LoVo. Flow cytometry and scratch assay were used to analyze apoptosis and cell cycle, as well as cell migration, respectively in HCT116, HT29, and LoVo cells. Western blotting was used to detect the expression of proteins related to apoptosis, cell cycle, and cell migration, and the expression of proteins key to the Akt pathway. Results: The Gene Ontology and Reactome enrichment analyses indicated that the anticancer potential of monotropein against CRC might be involved in multiple cancer-related signaling pathways. Among these pathways, RAC-beta serine/threonine-protein kinase(Akt1, Akt2), cyclin-dependent kinase 6(CDK6), matrix metalloproteinase-9(MMP9), epidermal growth factor receptor(EGFR), cell division control protein 42 homolog(CDC42) were shown as the potential anticancer targets of monotropein against CRC. Molecular docking suggested that monotropein may interact with the 6 targets(Akt1, Akt2, CDK6, MMP9, EGFR, CDC42). Subsequently, cell activity of HCT116, HT29 and LoVo cell lines were significantly suppressed by monotropein(P<0.05). Furthermore, our research revealed that monotropein induced cell apoptosis by inhibiting Bcl-2 and increasing Bax, induced G_1–S cycle arrest in colorectal cancer by decreasing the expressions of CyclinD1, CDK4 and CDK6, inhibited cell migration by suppressing the expressions of CDC42 and MMP9(P<0.05), and might play an anticancer role through Akt signaling pathway. Conclusions: Monotropein exerts its antitumor

关键词： monotropein Chinese medicine anticancer activity colorectal cancer cells network pharmacology

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社区网格化治理效能提升中的社会资本功能探究

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哈尔滨市委党校学报 2024年第5期 52-57页

作者：王映雪张继亮黑龙江大学政府管理学院哈尔滨150080

社区网格化治理是多元主体共同参与的基层社会治理创新实践。治理效能作为评估治理行动的重要指标,直接关系到社区网格化治理价值目标的实现。实践表明,社区网格化治理效能往往受到多元主体价值共识不足、交流沟通不畅、伦理规范弱化、... 详细信息

社区网格化治理是多元主体共同参与的基层社会治理创新实践。治理效能作为评估治理行动的重要指标,直接关系到社区网格化治理价值目标的实现。实践表明,社区网格化治理效能往往受到多元主体价值共识不足、交流沟通不畅、伦理规范弱化、主体性缺失等因素制约,因而陷入效率与成本同步累进或逆向反比的困境。社会资本是一种关系嵌入型的能产性资源。将其植入社区网格化治理行动过程将推动生成社区治理共同体、促进主体互信交往、补齐理性行动短板、弥补管理技术网格不足,从而全面提升社区网格化治理效能。

关键词：社区治理网格化治理社会资本治理效能共识信任

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基于路径延迟故障序列的硬件木马检测方法

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计算机工程与设计 2024年第1期45卷 1-9页

作者：伍远翔唐明胡一凡张吉良武汉大学国家网络安全学院空天信息安全与可信计算教育部重点实验室湖北武汉430072 湖南大学半导体学院(集成电路学院) 湖南长沙410082

针对基于侧信道信号的硬件木马检测普遍面临的两类问题,即需要黄金芯片和信号测量成本大,提出一种利用路径延迟故障序列的检测方法。基于时序冲突时电路路径产生延迟故障的先后顺序,间接利用路径延迟之间相对大小关系产生芯片检测ID;检... 详细信息

针对基于侧信道信号的硬件木马检测普遍面临的两类问题,即需要黄金芯片和信号测量成本大,提出一种利用路径延迟故障序列的检测方法。基于时序冲突时电路路径产生延迟故障的先后顺序,间接利用路径延迟之间相对大小关系产生芯片检测ID;检测不依赖于黄金芯片,且在大范围的环境变化和工艺偏差下具有稳定性;故障序列在芯片设计阶段仿真获得,无需额外硬件开销。对ISCAS-89基准和AES-128电路实例验证了检测的有效性,其可成功检测插入的两种类型硬件木马。

关键词：集成电路硬件木马检测方法侧信道黄金芯片路径延迟故障输出

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基于动态阈值的稳态模拟量异常预警方法

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机电产品开发与创新 2024年第3期37卷 169-171页

作者：张吉亮陈姝凡曹浩中国工业互联网研究院北京100020 江苏省工业互联网发展研究中心江苏苏州215000

在对生产生活中常见的电压、电流、温度等稳态模拟量进行异常预警分析时,当前监测类系统存在阈值维护工作量大、算法模型技术复杂和因单点异常判定导致了频繁预警和漏预警等问题。针对上述问题,本文提出了一种基于动态阈值和滑动窗口式... 详细信息

在对生产生活中常见的电压、电流、温度等稳态模拟量进行异常预警分析时,当前监测类系统存在阈值维护工作量大、算法模型技术复杂和因单点异常判定导致了频繁预警和漏预警等问题。针对上述问题,本文提出了一种基于动态阈值和滑动窗口式分析的稳态模拟量异常预警方法。该方法能提高监测类系统预警功能的易维护性和预警有效性。

关键词：稳态模拟量动态阈值滑动窗口异常预警

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Robust Correlation Clustering Problem with Locally Bounded Disagreements

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Tsinghua Science and Technology 2024年第1期29卷 66-75页

作者： Sai ji Min Li Mei liang Zhenning zhang Institute of Mathematics Hebei University of TechnologyTianjin 300401China School of Mathematics and Statistics Shandong Normal UniversityJinan 250358China College of Statistics and Data Science Beijing University of TechnologyBeijing 100124China Department of Operations Research and Information Engineering Beijing University of TechnologyBeijing 100124China

Min-max disagreements are an important generalization of the correlation clustering problem(CorCP).It can be defined as *** a marked complete graph G=(V,E),each edge in the graph is marked by a positive label"+"or a negative label"_"based on the similarity of the connected *** goal is to find a clustering C of vertices V,so as to minimize the number of disagreements at the vertex with the most ***,the disagreements are the positive cut edges and the negative non-cut edges produced by clustering *** paper considers two robust min-max disagreements:min-max disagreements with outliers and min-max disagreements with *** parameter δ∈(0,1/14),we first provide a threshold-based iterative clustering algorithm based on LP-rounding technique,which is a(1/δ,7/(1-14δ))-bi-criteria approximation algorithm for both the min-max disagreements with outliers and the min-max disagreements with outliers on one-sided complete bipartite ***,we verify that the above algorithm can achieve an approximation ratio of 21 for min-max disagreements with penalties when we set parameter δ=1/21.

关键词： min-max disagreements outliers penalties approximation algorithm LP-rounding

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Compensation temperatures and hysteresis behaviors of a graphene-like trilayer

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Communications in Theoretical Physics 2024年第5期76卷 166-179页

作者： Ying An ji liang Wei Wang Mei-mei Du Feng-ge zhang School of Science Shenyang University of TechnologyShenyang 110870China School of Electrical Engineering Shenyang University of TechnologyShenyang 110870China

This work focuses on the ground-state phase diagram,the compensation temperatures and the critical behaviors of a ferrimagnetic graphene-like trilayer induced by crystal fields and exchange *** simulation results show that a negative decrease in crystal field or an increase in exchange coupling can increase the critical *** importantly,an M curve with double compensation temperatures can be observed,which is not predicted by the Neel *** remarkable compensation phenomenon has potential application value in the field of magnetic recording.

关键词： graphene-like trilayer mixed-spin Ising model magnetization double compensation temperatures triple-loop hysteresis monte Carlo

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Electrical discharge and arc milling with automatic tracking of optimal flushing direction:A novel high-efficiency compound machining method

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Chinese Journal of Aeronautics 2024年第3期37卷 351-364页

作者： Xinlei WU Yonghong LIU Pengxin zhang liang QI Dege LI Chi MA Renjie ji College of Mechanical and Electronic Engineering China University of Petroleum(East China)Qingdao 266580China School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing 211816China

The arc milling method has the advantages of high machining efficiency and low cost and is independent of the strength and hardness of machined ***,frequent electrode back-offs and the risk of workpiece burning may occur if erosion products are not removed *** this study,it was found that the flushing method of the working medium had a significant impact on the machining performance of arc *** on this,a novel highefficiency compound machining method of electrical discharge and arc milling with automatic tracking of the optimal flushing direction was *** automatic tracking optimizer for external working medium injection was designed to determine the optimal external flushing direction according to the feed *** influence of flushing methods,working mediums,and machining parameters on the machining efficiency,tool electrode wear rate,machining error,and surface integrity of titanium alloys were *** results indicated that better machining performance and environmental friendliness were achieved using the compound flushing method of outer compressed air and inner deionized ***,the automatic tracking flushing method in the opposite direction of the feed direction showed superior results compared to other *** material removal rate with the opposite direction injection could be increased up to 1.62 times that of the same direction,and the relative electrode wear rate could be reduced by 14.76%.This novel method has broad application prospects for machining parts with difficult-to-cut materials in aerospace and military industries.

关键词： Arc milling Dielectric Difficult-to-cut materials Electric discharge machining Erosion Material removal rate

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Retrieval of Antarctic sea ice freeboard and thickness from HY-2B satellite altimeter data

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Acta Oceanologica Sinica 2024年第3期43卷 87-101页

作者： Yizhuo Chen Xiaoping Pang Qing ji Zhongnan Yan Zeyu liang Chenlei zhang Chinese Antarctic Center of Surveying and Mapping Wuhan UniversityWuhan 430079China Key Laboratory of Polar Surveying and Mapping Science Ministry of Natural ResourcesWuhan 430079China Key Laboratory of Polar Environment Monitoring and Public Governance Ministry of EducationWuhan 430079China 4 School of Geography and Tourism Anhui Normal UniversityWuhu 241002China

Antarctic sea ice is an important part of the Earth’s atmospheric system,and satellite remote sensing is an important technology for observing Antarctic sea *** Chinese Haiyang-2B(HY-2B)satellite altimeter data could be used to estimate sea ice freeboard and provide alternative Antarctic sea ice thickness information with a high precision and long time series,as other radar altimetry satellites can,needs further *** paper proposed an algorithm to discriminate leads and then retrieve sea ice freeboard and thickness from HY-2B radar altimeter *** first collected the Moderate-resolution Imaging Spectroradiometer ice surface temperature(IST)product from the National Aeronautics and Space Administration to extract leads from the Antarctic waters and verified their accuracy through Sentinel-1 Synthetic Aperture Radar ***,a surface classification decision tree was generated for HY-2B satellite altimeter measurements of the Antarctic waters to extract leads and calculate local sea surface *** then estimated the Antarctic sea ice freeboard and thickness based on local sea surface heights and the static equilibrium ***,the retrieved HY-2B Antarctic sea ice thickness was compared with the CryoSat-2 sea ice thickness and the Antarctic Sea Ice Processes and Climate(ASPeCt)ship-based observed sea ice *** results indicate that our classification decision tree constructed for HY-2B satellite altimeter measurements was reasonable,and the root mean square error of the obtained sea ice thickness compared to the ship measurements was 0.62 *** proposed sea ice thickness algorithm for the HY-2B radar satellite fills a gap in this application domain for the HY-series satellites and can be a complement to existing Antarctic sea ice thickness products;this algorithm could provide long-time-series and large-scale sea ice thickness data that contribute to research on global climate change.

关键词： HY-2B satellite altimeter classification decision tree sea ice freeboard and thickness Antarctic waters

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Studies on Intramolecular Stacking Interaction of Ternary Complexes M（Ⅱ）（ATP）￣（2－） with Heteroaromatic N－Base Ligands

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Chemical Research in Chinese Universities 1994年第3期10卷 167-174页

作者： WU Fu-liai, SONG Bin, zhang jie and ji liang-nian (Chemistiy Department , Biotechnology Research Center, Zhongshan University, Guangzhou, 510275)

o understand the driving forces leading to mixed-ligand complexes in biologi-cal *** complexes of M (ATP(L￣(2-) type, where M = Cu￣(2+), Ni￣(2+) orCo￣(2+) , and L= pyridine(Py) , 4-picoline, 3, 5-lutidine, isoquinoline (lq) or benzimi-dazole(Bi) in aqueous solution were studied by spectropliotometry, some of them(M=Cu￣(2+), L = isoquinoline or benzimidazole) were also separately studied hy po-tentiometric pH titration. The results show that an intramolecular stacking interac-tion exists between the heteroaromatic ring of the ligands and the purine moiety ofATP.

关键词： Stacking interaction Ternary complexes Heteroaromatic N-base ATP

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胰胆管型胆管内乳头状瘤影像表现与病理对照

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医药论坛杂志 2024年第2期45卷 221-224,F0003页

作者：许晨阳张继良朱绍成宁培钢郭濴文泽军河南省人民医院放射科郑州450003

目的通过胰胆管型胆管内乳头状瘤(pbIPNB)的影像学表现与病理对照分析,提高对该病的认识及影像诊断水平。方法回顾性分析2020年1月至2023年9月河南省人民医院收治的经手术病理学证实的pbIPNB患者15例,将影像学(CT及MRCP)表现与病理对照... 详细信息

目的通过胰胆管型胆管内乳头状瘤(pbIPNB)的影像学表现与病理对照分析,提高对该病的认识及影像诊断水平。方法回顾性分析2020年1月至2023年9月河南省人民医院收治的经手术病理学证实的pbIPNB患者15例,将影像学(CT及MRCP)表现与病理对照。结果15例患者中,13例患者胆管内显示乳头状肿瘤,2例患者胆管内未见肿瘤显示;13例肿瘤均边界清楚,CT平扫为软组织密度,CT增强扫描均表现为动脉期轻中度强化,静脉期强化程度稍减低;10例患者表现为肿瘤上下游胆管扩张,3例患者表现为上游胆管扩张;7例患者CT平扫表现为胆管内密度增高;胆管扩张分型,Ⅰ型3例,Ⅱ型3例,Ⅲ型2例,Ⅳ型7例;6例患者有肝实质异常灌注,15例患者均无肝实质萎缩;3例患者MRCP表现为螺纹征,3例患者表现为肝左叶肝内胆管、肝总管及胆总管团状充盈缺损。病理学表现:镜下见细而薄的分枝和乳头被立方或低柱状上皮覆盖,胞浆呈嗜酸或嗜双色性,外观黏液较少,核圆、深染,核仁突出,包括不规则的乳头状结构,细胞核分层较多,实性或粉刺样结构,细胞和细胞核不典型。结论pbIPNB在CT及MRCP上有一定的影像学特征,且有相应的病理学基础作为支撑,基于病理基础,并结合影像学征象进行分析,有助于提高该病诊断准确率。

关键词：胰胆管型胆管内乳头状瘤磁共振胰胆管成像计算机断层扫描病理学

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