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生物材料异物反应的调控策略

中国组织工程研究 2025年第16期29卷 3513-3520页

作者：叶超刘晓红海军军医大学附属长海医院心血管外科上海市200433

背景:生物材料植入体内后引发的异物反应会导致其被纤维组织包裹,阻碍植入物与宿主组织的相互作用,损害植入物的功能,进而缩短其寿命。目的:重点讨论生物材料异物反应的调控策略进展,包括基于生物材料表面改性、药物递送和仿生表面修饰... 详细信息

背景:生物材料植入体内后引发的异物反应会导致其被纤维组织包裹,阻碍植入物与宿主组织的相互作用,损害植入物的功能,进而缩短其寿命。目的:重点讨论生物材料异物反应的调控策略进展,包括基于生物材料表面改性、药物递送和仿生表面修饰的策略,同时探讨了这些方法的优势和局限性。方法:应用计算机在PubMed、Wiley、EBSCOhost、ScienceDirect和Elsevier数据库检索2000年1月至2024年3月期间的相关文献,以“biological materials,foreign body reaction,fibrosis,macrophage,myofibroblasts,inflammation,regulation,tissue repair”为检索词,最终纳入69篇文献进行分析。结果与结论:通过调整生物材料的表面特性(例如尺寸、形状、粗糙度、表面电荷、亲水性以及机械刚度等)能够减轻其对免疫系统的刺激,进而降低发生异物反应的风险;通过可控量的药物刺激产生持久的化学反应,结合使用可控降解的载体材料,可以减轻异物反应;生物材料仿生表面修饰(如两性离子涂层、蛋白质分子涂层等生物活性分子涂层)在短期能有效减轻异物反应。由于植入物和组织再生的免疫反应具有复杂性,在设计和制造植入物时也应考虑异物反应和组织再生之间的整体平衡。

关键词：生物材料异物反应纤维化巨噬细胞肌成纤维细胞炎症调控组织修复

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa Shen Chang Cheng Yu-Han Wang Wen-chao Cheng De-Zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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轮毂电动机驱动车辆并联式复合制动策略

江苏大学学报（自然科学版） 2025年第1期46卷 9-17页

作者：付翔肖帅徐超武汉理工大学汽车工程学院湖北武汉430070

基于并联式轮毂电动机驱动实车构型,分析影响制动能量回收效率的主要因素,采用联邦卡尔曼滤波纵向车速估计算法,提出了三层式复合制动控制策略.该策略中的制动决策层根据踏板输入信号和行驶状态来识别制动工况,并进入相应的制动模式.制... 详细信息

基于并联式轮毂电动机驱动实车构型,分析影响制动能量回收效率的主要因素,采用联邦卡尔曼滤波纵向车速估计算法,提出了三层式复合制动控制策略.该策略中的制动决策层根据踏板输入信号和行驶状态来识别制动工况,并进入相应的制动模式.制动控制层根据制动决策层的指令,在常规制动工况下通过粒子群优化(PSO)算法优化前、后轮电制动力矩分配,实现电池有效回收效率最大化;紧急制动工况下,通过模糊自整定PID算法实现车辆在不同附着路面上各轮滑移率的安全有效控制,优化了制动防抱死控制的鲁棒性,提高制动安全性.制动执行层响应制动控制层的指令,设计了电制动补偿机制,以迅速补偿调节各轮轮缸的压力误差,提高车辆制动稳定性.最后实车验证了该复合控制策略的有效性.

关键词：轮毂电动机驱动车辆并联式复合制动粒子群优化制动能量回收模糊自整定PID

Machine learning design of 400 MPa grade biodegradable Zn-Mn based alloys with appropriate corrosion rates

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International Journal of Minerals,Metallurgy and Materials 2024年第12期31卷 2727-2736页

作者： Wangzhang Chen Wei Gou Yageng Li Xiangmin Li Meng Li Jianxin Hou Xiaotong Zhang zhangzhi Shi Luning Wang Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China School of Computer and Communication Engineering Shunde Innovation SchoolUniversity of Science and Technology BeijingShunde 528399China

The commonly used trial-and-error method of biodegradable Zn alloys is costly and *** this study,based on the self-built database of biodegradable Zn alloys,two machine learning models are established by the first time to predict the ultimate tensile strength(UTS)and immersion corrosion rate(CR)of biodegradable Zn alloys.A real-time visualization interface has been established to design Zn-Mn based alloys;a representative alloy is *** tensile mechanical properties and immersion corrosion rate tests,its UTS reaches 420 MPa,and the prediction error is only 0.95%.CR is 73μm/a and the prediction error is 5.5%,which elevates 50 MPa grade of UTS and owns appropriate corrosion ***,influences of the selected features on UTS and CR are discussed in *** combined application of UTS and CR model provides a new strategy for synergistically regulating comprehens-ive properties of biodegradable Zn alloys.

关键词： Zn alloys machine learning alloy design performance prediction

从“敬天畏命”视角论绎传统武术技击发展之道

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哈尔滨体育学院学报 2025年第1期43卷 25-32页

作者：武超陕西师范大学体育学院陕西西安710119

受中华文明“敬天畏命”思想内核的影响,传统武术的技击发展有其与众不同的历史逻辑与目标追求。运用文献资料、自身体悟等方法从“敬天畏命”视角论绎传统武术技击观的目标变迁与求道进路。研究认为:“敬天畏命”观念对传统武术技击发... 详细信息

受中华文明“敬天畏命”思想内核的影响,传统武术的技击发展有其与众不同的历史逻辑与目标追求。运用文献资料、自身体悟等方法从“敬天畏命”视角论绎传统武术技击观的目标变迁与求道进路。研究认为:“敬天畏命”观念对传统武术技击发展影响深远,从时间上看,促使传统武术技击发展经历了由原始社会的“交通天人”和“备战御敌”两种功能形态向热兵器时代“求道砺器”二元结构的转变过程;从空间上看,促使传统武术技击发展形成了技击技理追求与“自然之天”的“天人一体”、技击伦理追求与“道德之天”的“天人合德”、技击心理追求与“神灵之天”的“天人感应”三位一体求道进路,从而拓展了传统武术技击表现形式多样化的发展空间,开启了传统武术技击功能价值多元化的发展路径,提升了传统武术技击的文化张力,激发了传统武术技击的文化活力。

关键词：传统武术敬天畏命技击天人合一

EFFECTIVE NUMERICAL METHODS FOR ELASTO-PLASTIC CONTACT PROBLEMS WITH FRICTION

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Acta Mechanica Sinica 1990年第4期6卷 349-356页

作者： Wang Xucheng Chang Liangming Cen zhangzhi (Department of Engineering Mechanics,Tsinghua University) Department of Engineering Mechanics Tsinghua University Beijing China

Several effective numerical methods for solving the elasto-plastic contact problems with friction are pres- ***,a direct substitution method is employed to impose the contact constraint conditions on condensed finite ele- ment equations,thus resulting in a reduction by half in the dimension of final governing ***,an algorithm composed of contact condition probes and elasto-plastic iterations is utilized to solve the governing equation,which distinguishes two kinds of nonlinearities,and makes the solution *** addition,Positive-Negative Sequence Modifica- tion Method is used to condense the finite element equations of each substructure and an analytical integration is intro- duced to determine the elasto-plastic status after each time step or each iteration,hence the computational efficiency is en- hanced to a great ***,several test and practical examples are pressented showing the validity and versatility of these methods and algorithms.

关键词： elasto-plasticity contact problem finite element method

Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao chao-Min Xu Ke Wang Jia-Zhu Wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

浑水入渗对粗粒土柱孔隙及渗透性影响试验研究

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岩土工程学报 2025年第1期47卷 173-183页

作者：毛海涛张超袁古城何涛谷易山西农业大学城乡建设学院山西太原030000 重庆三峡学院土木工程学院重庆404120

浑水渗流在水利工程的反滤设计、浑水浇灌、堤坝渗流控制等方面都有较大影响,目前理论多采用稳定渗流计算方法,忽略了渗流过程中粗细颗粒与水力的耦合作用。自制渗流装置,将不同控制粒径浑水、不均匀系数粗粒土柱和水头等作为基本控制因... 详细信息

浑水渗流在水利工程的反滤设计、浑水浇灌、堤坝渗流控制等方面都有较大影响,目前理论多采用稳定渗流计算方法,忽略了渗流过程中粗细颗粒与水力的耦合作用。自制渗流装置,将不同控制粒径浑水、不均匀系数粗粒土柱和水头等作为基本控制因素,研究不同工况下浑水中悬浮颗粒对粗粒土土柱中的渗透特性影响;推导了变渗透系数浑水渗流计算微分方程,通过对比验证和公式修正,结果表明:粗粒土中颗粒淤积率与控制粒径C_(0.075)含量符合Boltzmann函数关系;C_(0.075)是重要的影响因子,浑水颗粒在粗粒土柱的运移、沉积和淤堵形态过程大致可分为4种形态:表层堆积淤堵形态(S型);表层-内部双重淤堵形态(S-I型);内部孔隙淤堵形态(I型);暂态孔隙淤堵形态(P型)。土柱C_(u)越大,孔隙度越小,浑水颗粒在粗粒土中运移也越困难,土柱填充性就越差;水头加剧了颗粒在土柱内部运移的速度,但也加速了其在顶部的沉积并封堵;S型时土柱0~2cm渗透系数下降速率最大,封堵时总体渗透系数最小,2cm以下相对孔隙率及随深度逐渐减小;S-I和I型土柱下部渗透系数明显滞后于上部,相对孔隙率存在临界深度(约为4~6cm);P型时土柱整体相对孔隙率基本无变化。

关键词：颗粒渗流粗粒土浑水堵塞

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面向工业互联网的语义编码传输方法及应用

中山大学学报（自然科学版）（中英文） 2025年第1期64卷 51-60页

作者：牛凯鲁延鹏董超北京邮电大学人工智能学院北京100876 泛网无线通信教育部重点实验室北京100876 鹏城实验室广东深圳518055

通过将语义通信技术引入工业网络,构建了一个面向工业互联网的语义编码传输系统。系统中设计了语义编解码器以提取信源中的语义信息,相对于传统通信系统,基于语义信息的通信有更高的信息压缩效率与更高的符号差错容忍能力。同时引入信... 详细信息

通过将语义通信技术引入工业网络,构建了一个面向工业互联网的语义编码传输系统。系统中设计了语义编解码器以提取信源中的语义信息,相对于传统通信系统,基于语义信息的通信有更高的信息压缩效率与更高的符号差错容忍能力。同时引入信源信道联合编解码器,以信源信道联合编码的方式将语义信息转化为信道符号传输,进一步提升系统对工业网络通信资源的利用效率。所有编解码器均构建在深度神经网络架构Transformer上,确保了编解码器对语义信息的理解能力及系统的泛化能力。在工业药品生产场景中,对该系统进行测试,结果显示:相较于传统通信方案,该语义编码传输系统在图像重建质量和传输处理速度方面均有显著提升。且系统对下游任务的性能影响极小,保证了工业生产中如缺陷检测等关键任务的准确性。

关键词：工业互联网数据压缩与传输语义通信深度学习