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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu wen-Jia Chen Xin-Ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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Physiological Differences Between Yellow-Seeded and Black-Seeded Rapeseeds (Brassica napus L.) with Different Testa Characteristics During Artificial Ageing

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Agricultural Sciences in China 2005年第5期4卷 355-361页

作者： zhangxue-kun YANGGui-tang CHENLi LIJia-na TANGZhang-lin CollegeofAgronomicandLifeScience SouthwestAgriculturalUniversityChongqing400716P.R.China

Yellow-seeded rapeseed (Brassica napus L.) is a new kind of breeding resources with yellow color, increased oil and protein content and less unwanted crude fiber content due to the thinner and transparent testa compared with traditional black or brown-seeded rapeseed. To analyze the longevity of the yellow-seeded rapeseed during storage, the physiological differences between the yellow and black-seeded near-isogenic lines were studied by artificial ageing method. The testa rate, anthocyanin content and melanin content of yellow-seeded rapeseeds decreased by 20.1, 25.2, and 80.4% respectively than black-seeded rapeseed. During artificial ageing, the yellow-seeded rapeseed showed significantly different effect of ageing compared with the black-seeded, as demonstrated by faster deterioration with lower germination percentage, seed vigour index, reducing sugar and soluble protein contents than the black-seeded, as well as a drastic increase in electrical conductivity, malnodialdehyde (MDA) content and a rapid decrease in activities of antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD). The results suggested that the transparent testa of the yellow-seeded rapeseed lost some abilities to protect the embryo against adverse environmental conditions and thus led to a poor storability.

关键词： Brassica napus L. Yellow-seeded Artificial ageing Deterioration

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初中生认知控制对替代性攻击行为的影响:激惹和触发的情境边界条件

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心理学报 2025年第1期57卷 36-57页

作者：林爽程塨渌刘文白学军天津师范大学心理学部天津300387 辽宁师范大学心理学院大连116029 广西师范大学教育学部桂林541004

本研究通过3个实验探索了初中生认知控制对替代性攻击行为的影响以及认知控制影响替代性攻击行为的激惹和触发情境边界条件。实验1考察了一般性认知控制对替代性攻击行为的影响,结果发现一般性认知控制不能有效降低替代性攻击行为的攻... 详细信息

本研究通过3个实验探索了初中生认知控制对替代性攻击行为的影响以及认知控制影响替代性攻击行为的激惹和触发情境边界条件。实验1考察了一般性认知控制对替代性攻击行为的影响,结果发现一般性认知控制不能有效降低替代性攻击行为的攻击比例。实验2探讨了特异性认知控制对替代性攻击行为的有效抑制作用,结果发现无论在高激惹情境还是低激惹情境,主动控制和反应性控制启动条件下的替代性攻击行为均显著低于基线水平。实验3则探究了特异性认知控制抑制替代性攻击行为的激惹和触发情境边界条件,结果发现特异性认知控制、激惹情境、触发情境三者的交互作用显著,激惹和触发情境能够有效调节特异性认知控制对替代性攻击行为的影响。而且,在高激惹高触发和高激惹低触发情境下,主动性控制减基线的攻击比例显著高于反应性控制减基线,但在低激惹高触发和低激惹低触发情境下主动性控制减基线的攻击比例与反应性控制减基线不存在显著差异。此外,高激惹高触发情境下主动性控制减基线的攻击比例是所有条件下最高的。以上结果说明,特异性认知控制能够有效抑制初中生的替代性攻击行为,其中主动性控制的情境边界出现在高激惹高触发情境。

关键词：认知控制替代性攻击行为激惹情境触发情境情境边界条件

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智慧医疗情境下四方主体隐私行为的交互机理及演化趋势研究

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现代情报 2025年第1期45卷 135-149页

作者：朱光吴晗逸刘雯南京信息工程大学风险治理与应急决策研究院江苏南京210044 南京信息工程大学管理工程学院江苏南京210044

[目的/意义]本文针对智慧医疗情境下隐私行为研究在博弈主体、模型参数等方面的不足,探寻患者、医疗机构、智慧医疗平台和政府四方主体之间的隐私行为交互机理与演化趋势。[方法/过程]基于演化博弈理论,构建患者、医疗机构、智慧医疗平... 详细信息

[目的/意义]本文针对智慧医疗情境下隐私行为研究在博弈主体、模型参数等方面的不足,探寻患者、医疗机构、智慧医疗平台和政府四方主体之间的隐私行为交互机理与演化趋势。[方法/过程]基于演化博弈理论,构建患者、医疗机构、智慧医疗平台和政府四方博弈模型。根据不同参数调节下各方行为策略的收益、成本、损失等计算收益矩阵,求解主体的演化稳定策略,并考虑不同因素对主体行为策略及系统稳定状态的影响。[结果/结论]患者的隐私披露行为与披露隐私后获得的服务收益密切相关,医疗机构的隐私保护投入成本和隐私泄露概率对其隐私保护行为有显著影响,智慧医疗平台的政府奖惩、罚款收益和投入成本是影响其严格管理行为的关键因素,政府的监管行为与奖惩机制等因素密切相关。通过应用本文模型和方法,可以动态调整隐私保护机制,明确各方职责,推动智慧医疗可持续健康发展。

关键词：智慧医疗演化博弈隐私行为患者医疗机构智慧医疗平台政府

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan Gao Xia Li wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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基于微流控芯片评估富血小板血浆促进子宫内膜细胞的增殖

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中国组织工程研究 2025年第10期29卷 2091-2096页

作者：闻哲嘉吕芳苏州大学附属第二医院生殖中心江苏省苏州市215004

背景:富血小板血浆可促进薄型子宫内膜细胞的增殖,但存在剂量难以控制、取样困难等问题。微流控芯片具有高通量、低消耗、操作简便等优点,为模拟子宫内膜细胞在体微环境提供了新途径。目的:利用三通道微流控芯片构建富血小板血浆促进子... 详细信息

背景:富血小板血浆可促进薄型子宫内膜细胞的增殖,但存在剂量难以控制、取样困难等问题。微流控芯片具有高通量、低消耗、操作简便等优点,为模拟子宫内膜细胞在体微环境提供了新途径。目的:利用三通道微流控芯片构建富血小板血浆促进子宫内膜细胞增殖的研究模型。方法:从1名女性外周静脉血中提取富血小板血浆。采用含不同浓度[0%(对照),0.5%,1%,2%]富血小板血浆的无血清细胞培养基培养人子宫内膜间质细胞,采用划痕实验检测细胞迁移,CCK-8法检测细胞增殖。利用聚二甲基硅氧烷胶制备微流控芯片,该微流控芯片设计有3个通道,中间通道为细胞外基质水凝胶通道,左右两侧分别为人子宫内膜间质细胞及富血小板血浆通道,3个通道之间保存有可以相互沟通以及实现物质交换的面积,实验组两侧通道分别加入人子宫内膜间质细胞(绿色荧光蛋白GFP标记)和含0.5%富血小板血浆的无血清培养基,对照组两侧通道分别加入人子宫内膜间质细胞(绿色荧光蛋白GFP标记)和无血清细胞培养基,共培养48 h后,采用Ki67免疫荧光染色观察细胞增殖与迁移。结果与结论:(1)细胞划痕实验和CCK-8检测结果显示,与对照组相比,0.5%,1%,2%浓度的富血小板血浆可促进人子宫内膜间质细胞的迁移与增殖(P <0.05),并且0.5%浓度富血小板血浆的促进细胞迁移与增殖作用强于其他2个浓度(P <0.05);(2)Ki67免疫荧光染色结果显示,与对照组相比,实验组人子宫内膜间质细胞的增殖和迁移能力更强;(3)实验证实通过三通道微流控芯片可以模拟子宫内膜细胞的微环境,同时利用该系统验证了富血小板血浆可显著促进子宫内膜间质细胞的增殖与迁移。

关键词：微流控芯片富血小板血浆子宫内膜间质细胞子宫内膜增殖迁移细胞外基质薄型子宫内膜子宫内膜相关疾病

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马克思“机器论片段”语境下的数字技术再反思

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海南大学学报（人文社会科学版） 2025年第1期43卷 60-67页

作者：王文陶厚兴中国人民大学重阳金融研究院北京100872 兰州大学马克思主义学院甘肃兰州730000

马克思“机器论片段”重点论述了机器体系的产生及其在社会生产中的应用所引起的劳动资料技术化、一般智力对象化、固定资本扩大化、人机关系异化等一系列深刻变革。数字技术具有物质技术与社会历史双重属性,其一方面作为人造的“物体系... 详细信息

马克思“机器论片段”重点论述了机器体系的产生及其在社会生产中的应用所引起的劳动资料技术化、一般智力对象化、固定资本扩大化、人机关系异化等一系列深刻变革。数字技术具有物质技术与社会历史双重属性,其一方面作为人造的“物体系”,克服与弥补人类自身劳动力的不足,另一方面作为生产关系与资本权力的物性表达。数字技术的广泛应用导致工业时代的“机器悖论”演化为数字时代的“智能悖论”,集中表现为“劳动悖论”“时间悖论”与“解放悖论”。马克思“机器论片段”的机器技术思想对我们在数字时代审思数字技术,探索扬弃技术的权力与宰制,消解人与技术的异化关系,使技术真正摆脱压迫、剥削人的工具地位,成为提高劳动生产率,缩短必要劳动时间和增加自由支配时间,促进人类劳动解放与自由全面发展的现实路径依然具有理论与实践价值。

关键词：马克思机器论片段一般智力固定资本数字技术

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Is it possible to foot reflexology for infants with sensorineural hearing loss?

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World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： Min Ai Hang-Hang Zhang Jun-Bang Feng Chuan-Ming Li wen-Jing Wang Meng-Die Hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss Future perspectives Limitations Neural conduction

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缺陷对单层硅烯纳米梁振动频率的影响

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原子与分子物理学报 2025年第6期42卷 76-82页

作者：张文博王静新疆大学物理科学与技术学院乌鲁木齐830017

由于硅纳米谐振器在量子计算、传感器、医学等方面存在广泛的应用,使其物理性质的研究具有重要意义.本文通过分子动力学模拟方法研究了掺杂元素、空位缺陷、掺杂浓度对单层硅烯纳米梁振动特性的影响.研究结果表明,单层硅烯纳米梁的振动... 详细信息

由于硅纳米谐振器在量子计算、传感器、医学等方面存在广泛的应用,使其物理性质的研究具有重要意义.本文通过分子动力学模拟方法研究了掺杂元素、空位缺陷、掺杂浓度对单层硅烯纳米梁振动特性的影响.研究结果表明,单层硅烯纳米梁的振动频率随着纳米梁长度的增加而减小.单元素、双元素掺杂均会导致单层硅烯纳米梁的振动频率的增加,且随着掺杂浓度的增加纳米梁的振动频率整体呈现增大的趋势.此外,单空位缺陷会导致单层硅烯纳米梁的振动频率随着缺陷浓度的增加而减小.掺杂-单空位缺陷的单层硅烯纳米梁的振动频率则呈现了随着掺杂浓度的增加先减小后增加的变化趋势.这些变化规律均是由掺杂元素、空位缺陷以及它们共同作用的结果.此研究结果对硅烯纳米谐振器,振荡器等纳米器件的设计具有一定的理论指导意义.

关键词：硅烯掺杂振动频率分子动力学

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu Ke Wang Jia-Zhu wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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