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护理学杂志 2024年第7期39卷 118-121页

作者：孙鑫章孙瑞梁欣上官张科周红长江大学医学部湖北荆州434100 南阳市第一人民医院长江大学艺术学院湖北荆州434100

本文介绍共识性质性研究的发展及哲学基础、关键特征及基本原则和4个主要的应用步骤,阐述共识性质性研究在临床护理实践领域的应用进展,以期为护理同仁运用多元化质性研究方法提供参考。

关键词：共识性质性研究质性研究护理心理学方法论综述文献

新文科视域下应用型高校跨学科课程建设路径研究

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北京联合大学学报 2024年第2期38卷 6-10页

作者：肖章柯齐再前北京联合大学教务处北京100101

随着我国社会经济的快速发展,跨学科课程建设成为应用型高校教育教学改革的重要发展方向。基于新文科建设的新内涵,分析应用型高校开展跨学科课程建设的必要性和面临的挑战,厘清应用型高校开设跨学科课程存在的问题,从价值引领、技术赋... 详细信息

随着我国社会经济的快速发展,跨学科课程建设成为应用型高校教育教学改革的重要发展方向。基于新文科建设的新内涵,分析应用型高校开展跨学科课程建设的必要性和面临的挑战,厘清应用型高校开设跨学科课程存在的问题,从价值引领、技术赋能、顶石课程建设、教学方式改革、制度建设等方面,提出应用型高校跨学科课程建设策略,以期为应用型高校开展跨学科课程建设、培养应用型复合型人才提供参考。

关键词：新文科应用型高校跨学科课程

In silico analysis and experimental validation of active compounds from Rhodiola rosea L. ameliorating pulmonary fibrosis

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中国药理学通报 2015年第B11期31卷 143-143页

作者： zhangke HUANGJian LIGuo-yu WANGHang-yu WANGJin-hui SchoolofTraditionalChineseMateriaMedica ShenyangPharmaceuticalUniversitySheyangLiaoning110016 SchoolofPharmacy ShiheziUniversityShiheziXijiang832002

Aim Rhodiola rosea L. possesses a wide range of pharmacological properties including lung-protective, and it has been implemented in folk medicine for several 100 years. However, the accurate mechanisms of its lung- protective activity remain unclear. This study aimed at investigating the possible mechanisms of lung-protective activity of Rhodiola rosea L. in pulmonary fibrosis model. Methods Pathological observation, ROS detection and measure- ments of biochemical indexes on rat models proved lung-protective effect of Rhodiola rosea L. Identification of active compounds in Rhodiola rosea L. was executed through several methods including UPLC-TOF-MS. SEA docking, too- lecular modeling, molecular docking, and molecular dynamics （MD） simulation were applied in this study to explore possible mechanisms of the lung-protective potential of Rhodiola rosea L. Furthermore, in vitro cytological examina- tion and Western blot were used for validating the efficacy of the selected compounds. Results Experiments on rat models showed a potent lung-protective effect of Rhodiola rosea L. Then we analyzed the chemical composition of Rhodiola rosea L. and found out their key targets. Moreover, in silico analysis results testified good interaction be- tween selected compound 13 and key targets Akt-1/Caspase-1, and compound 10 also interacts well with Akt-1. Fur- ther Western blot analysis proved changed expression levels of those target proteins, indicating that selected small compounds indeed acted on those targets. Conclusion In silico analysis and experimental validation together demon- strated that selected compound 10 in Rhodiola rosea L. targeted Akt-1 in hepatocytes. Besides, compound 13 targeted both Caspase-1 and Akt-1. These small compounds may ameliorate pulmonary fibrosis by acting on their targets which are related to apoptosis or autophagy. The conclusions above may shed light on the complex molecular mechanisms of Rhodiola rosea L. acting on pneumonocyte and ameliorating pulmonary fibrosis.

关键词： Rhodiola rosea L. in silico analysis pulmonary fibrosis target Akt-1 Caspase-1.

Comparison of Fully 3-D,Simplified 3-D and 2-D Numerical Simulations on a Circulating Fluidized Bed Boiler

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热科学学报:英文版 2023年第5期32卷 1832-1848页

作者： LI Kun CHENG Leming MA zhangke LUO Guanwen LI Liyao ZHANG Qingyu GUO Qiang ZHAO Liang Institute for Thermal Power Engineering State Key Laboratory of Clean Energy UtilizationZhejiang UniversityHangzhou 310027China Dongfang Boiler Group Co. Ltd.Zigong 611731China

Based on the fully three-dimensional(3-D)and two-dimensional(2-D)comprehensive CFD(Computational Fluid Dynamics)combustion models for a circulating fluidized bed boiler,a simplified 3-D computational domain considering the corrections of furnace side wall openings is proposed.It aims to compensate for the deficiencies of the large amount of computation in the fully 3-D model and improve the air and gas flow treatments at the openings in the simplified 2-D model.Three different computational domains,named as the fully 3-D model,simplified 3-D model and 2-D model,were implemented to perform a comparative CFD analysis in an ultra-supercritical circulating fluidized bed boiler including the hydrodynamics,penetration depth of secondary air,temperature and species distribution.The simulation results computed by the simplified3-D model yield better agreement with the fully 3-D simulation results than those of the 2-D model.The simplified 3-D model is recommended as an alternative computational domain for the conventional 2-D model in the numerical simulation of large-scale circulating fluidized bed boiler.

关键词： CFB(circulating fluidized bed) numerical simulation simplified 3-D model 2-D model

Straw bio-degradation by acidogenic bacteria and composite fungi

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Journal of Environmental Sciences 2004年第4期16卷 690-693页

作者： zhangke-qiang CHENXiu-wei JIMin NINGAn-rong FANHuan ZHOUKe China.CollegeofEnvironmentalScienceandEngineering TianjinUniversityTianjin300072 TianjinAgro-biologicalTechniqueResearchCenter Tianjin300192China AgriculturalEnvironmentProtectionInstitute M.O.A.Tianjin300191China

A composite microbial system, including a strain of Candida tropicalis(W3), a strain of Lactobacillus plantarm(WY3) and three strains of basidiomycete pL104, pL113 and C33, was chosen to degrade corn straw. The final pH was acid owing to the inoculation of acidogenic bacteria, and under this condition the composite fungi system could produce complex enzyme to destroy the compact structure of corn straw. The experimental results showed that the biomass of composite fungi could reach up to maximum when the pH value was 4.5. Through the bio-degradation by combining acidogenic bacteria with the composite fungi system, the cellulose, hemi-cellulose and lignin degradation rates of corn straw powder were 26.36%, 43.30% and 26.96%, respectively. And the gross crude protein content increased 60.41%. This study provided the evidence for the feasibility of developing a composite microbial system with high capability of degrading straw lignocelluloses in order to make reasonable use of straw resource and protect rural eco-environment.

关键词： lignocellulose bio-degradation acidogenic bacteria composite fungi system

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药浴治疗小儿肺系疾病研究进展

光明中医 2024年第10期39卷 2098-2101页

作者：沈张可孙易娜湖北中医药大学中医临床学院湖北中医药大学中医临床学院

肺系疾病为小儿最常见、最多发疾病，发病率居儿科疾病之首，严重影响小儿健康成长。药浴疗法作为一种操作简便、不良反应少、疗效良好、胃肠道刺激小、易于为小儿接受的中医外治法，临床应用逐渐扩大。笔者通过检索药浴、小儿肺系疾病... 详细信息

肺系疾病为小儿最常见、最多发疾病，发病率居儿科疾病之首，严重影响小儿健康成长。药浴疗法作为一种操作简便、不良反应少、疗效良好、胃肠道刺激小、易于为小儿接受的中医外治法，临床应用逐渐扩大。笔者通过检索药浴、小儿肺系疾病相关临床文献，发现近年来，有关药浴疗法的历史源流与作用原理及其治疗小儿肺系疾病的研究正不断开展，鉴于此，此文试对药浴疗法治疗小儿肺系疾病研究进展做一综述，以期为推广药浴治疗小儿肺系疾病的临床应用作参考。

关键词：咳嗽小儿肺系疾病药浴中医外治法以外治内

Antibacterial Activities of Neolignans Isolated from the Seed Endotheliums of Trewia nudiflora

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Acta Botanica Sinica 2004年第9期46卷 1122-1127页

作者： LIGuo-Hong ZHAOPei-Ji SHENYue-Mao zhangke-Qin LaboratoryforConservationandUtilizationofBio-resource YunnanUniversityKunming650091China StateKeyLaboratoryofPhytochemistryandPlantResourcesinWestChina KunmingInstituteofBotanyTheChineseAcademyofSciencesKunming650204China

Five neolignans including four new ones were obtained from the seed endotheliums of Trewia nudiflora L. Their structures were determined to be 9'-methyl americanol A(1), 9'-methyl isoamericanol A(2), 9'-ethyl americanol A(3), 9'-butyl americanol A(4), and americanin (5). Two acetylated products 3,4-diacetyl americanin (5a) and 3,4,9-triacetyl americanin (5b) had been prepared from compound 5. All of these compounds were investigated on antibacterial assays when carbenicillin sodium, streptomycin sulfate and rifampicin were used as positive controls. Compounds 4 and 5 exhibited antibacterial activities against gram-positive bacterium Staphylococcus aureus and gram-negative bacterium Mycobacterium tuberculosis at the minimum inhibitory concentrations (MIC) of 50μg/mL and 100μg/mE respectively, but 5a and 5b did not exhibit antibacterial activity at 200μg/disk.

关键词：新木脂素种皮抗菌活性大戟科革兰氏阳性菌

Calcium looping heat storage performance and mechanical property of CaO-based pellets under fluidization

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Chinese Journal of Chemical Engineering 2021年第8期34卷 170-180页

作者： zhangke Ma Yingjie Li Boyu Li Zeyan Wang Tao Wang Wentao Lei School of Energy and Power Engineering Shandong UniversityJinan 250061China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China Shandong Naxin Electric Power Technology Co. Ltd.Jinan 250101China

The CaO-based pellets were fabricated using extrusion-spheronization method for calcium looping thermochemical heat storage under the fluidization.The effects of adhesive,biomass-based pore-forming agent,binder and particle size on the heat storage performance and mechanical property of the CaObased pellets were investigated in a bubbling fluidized bed reactor.The addition of 2%(mass)polyvinylpyrrolidone as an adhesive not only helps granulate,but also improves the heat storage capacity of the pellets.All biomass-templated CaO-based pellets display higher heat storage capacity than biomass-free pellets,indicating that the biomass-based pore-forming agent is beneficial for heat storage under the fluidization.Especially,bagasse-templated pellets show the highest heat storage conversion of 0.61 after 10 cycles.Moreover,Al_(2)O_(3)as a binder for the pellets helps obtain high mechanical strength.The CaO-based pellets doped with 10%(mass)bagasse and 5%(mass)Al_(2)O_(3)reach the highest heat storage density of 1621 kJ·kg^(-1) after 30 cycles and the highest crushing strength of 4.98 N.The microstructure of the bagasse-templated pellets appears more porous than that of biomass-free pellets.The bagassetemplated CaO-based pellets doped with Al_(2)O_(3)seem promising for thermochemical heat storage under the fluidization,owing to the enhanced heat storage capacity,excellent mechanical strength,and simplicity of the synthesis procedure.

关键词： Calcium looping heat storage Fluidization CaO-based pellets Mechanical property

浅谈细胞产品开发用人诱导多能干细胞的建株要求

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中国新药杂志 2022年第21期31卷 2101-2108页

作者：张可华纳涛孟淑芳中国食品药品检定研究院生物制品检定所细胞资源保藏研究中心卫生部生物技术产品检定方法及其标准化重点实验室北京100050

人诱导多能干细胞(human induced pluripotent stem cells, hiPSC)自从问世以来一直是干细胞和再生医学领域研究的热点,在国内干细胞产品临床转化研究高速发展的今天,随着hiPSC重编程技术、多能干细胞培养技术、干细胞诱导分化技术以及... 详细信息

人诱导多能干细胞(human induced pluripotent stem cells, hiPSC)自从问世以来一直是干细胞和再生医学领域研究的热点,在国内干细胞产品临床转化研究高速发展的今天,随着hiPSC重编程技术、多能干细胞培养技术、干细胞诱导分化技术以及多能干细胞质量研究技术的不断深化,以hiPSC为基础开发的衍生产品开始从实验室逐渐走向临床产品开发及研究阶段。本文以基于hiPSC开发药品为出发点和思路,参考相关法规和指南,简述hiPSC的建株以及细胞株的质量要求,为开发以hiPSCs为基础的细胞治疗产品提供参考,以期在细胞产品开发的重要源头hiPSC细胞株尽可能满足药品监管的要求。

关键词：细胞治疗干细胞治疗诱导多能干细胞建株质量控制

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摄影机的“故乡”就是世界--贾樟柯访谈

电影评介 2022年第3期 28-32页

作者：王兵兵贾樟柯中国传媒大学不详

时间:2021年12月10日地点:贾樟柯工作室从故乡与文学开始王兵兵(以下简称王):《一直游到海水变蓝》以18个章节讲述出1949年以来长达70年的中国往事。为什么用电影讲述“文学的故乡”?贾樟柯(以下简称贾):从2015年开始,我在汾阳贾家庄住... 详细信息

时间:2021年12月10日地点:贾樟柯工作室从故乡与文学开始王兵兵(以下简称王):《一直游到海水变蓝》以18个章节讲述出1949年以来长达70年的中国往事。为什么用电影讲述“文学的故乡”?贾樟柯(以下简称贾):从2015年开始,我在汾阳贾家庄住的时间长了,会较多地思考城市与乡村的关系。我认为其中最重要的一个问题是,现在中国的城市化进程很快,但人们做事的准则和生活习惯、思维习惯依然受中国5000年农耕文化的影响。

关键词：农耕文化贾樟柯城市与乡村工作室生活习惯思维习惯摄影机