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Recent Advances in Artificial Sensory Neurons: Biological Fundamentals, Devices, Applications, and Challenges

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NANO-MICRO LETTERS 2025年第1期17卷 1-49页

作者： Zhong, Shuai Su, Lirou Xu, Mingkun Loke, Desmond Yu, Bin Zhang, Yishu Zhao, rong Guangdong Inst Intelligence Sci & Technol Zhuhai 519031 Hengqin Peoples R China Zhejiang Univ Coll Integrated Circuits Hangzhou 3112000 Peoples R China ZJU Hangzhou Global Sci & Technol Innovat Ctr Hangzhou 310027 Peoples R China Singapore Univ Technol & Design Dept Sci Math & Technol Singapore 487372 Singapore Tsinghua Univ Dept Precis Instruments Beijing 100084 Peoples R China Tsinghua Univ Ctr Brain Inspired Comp Res Beijing 100084 Peoples R China Tsinghua Univ IDG McGovern Inst Brain Res Beijing 100084 Peoples R China

Biological fundamentals and recent progress of artificial sensory neurons are systematically *** device, performance metrics, and potential applications of artificial sensory neurons are *** for the future development of artificial sensory neurons are discussed. Spike-based neural networks, which use spikes or action potentials to represent information, have gained a lot of attention because of their high energy efficiency and low power consumption. To fully leverage its advantages, converting the external analog signals to spikes is an essential prerequisite. Conventional approaches including analog-to-digital converters or ring oscillators, and sensors suffer from high power and area costs. Recent efforts are devoted to constructing artificial sensory neurons based on emerging devices inspired by the biological sensory system. They can simultaneously perform sensing and spike conversion, overcoming the deficiencies of traditional sensory systems. This review summarizes and benchmarks the recent progress of artificial sensory neurons. It starts with the presentation of various mechanisms of biological signal transduction, followed by the systematic introduction of the emerging devices employed for artificial sensory neurons. Furthermore, the implementations with different perceptual capabilities are briefly outlined and the key metrics and potential applications are also provided. Finally, we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第01期 377-384页

作者： Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

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Lanthanocene Diolate Complexes: Synthesis, Structures and Catalytic Property for ε-Caprolactone Polymerization

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Chinese Journal of Chemistry 2015年第5期33卷 563-567页

作者： zhanghai Gu Li Li Qianwen Bao Fugen Yuan School of Chemistry and Biochemistry Suzhou University of Science and TechnologySuzhouJiangsu 215009China

Reaction of LnCl3 first with three equivalent of C5H5Na in THF,then with one equivalent of N-phenyldiethanolamine in THF-DME afforded complexes of{[(C_(5)H_(5))Ln(μ-OCH_(2)CH_(2))_(2)N(C_(6)H_(5))]4(μ_(4)-C_(l))}[Na(DME)_(4)](Ln=Sm(1),Yb(2)),being characterized by infrared spectra,elemental analyses and X-ray *** are ionic pair *** anionic part is a cluster,which can be viewed as a cyclic tetramer with four(C5H5)Ln units bridged by four pairs of OR groups,forming a pinwheel *** the complexes can catalyze the ring-opening polymerization ofε-caprolactone under mild conditions,and complex 1 is more active than complex *** polymerization accords with one order reaction kinetics for monomer *** molecular weight increases with the yield increasing,and the molecular weight distribution is rather narrow(1.19

关键词： lanthanide alkoxide catalytic activity caprolactone

BIOLOGICAL INVASION PROBLEM WITH FREE BOUNDARY NONLOCAL DIFFUSION EQUATION

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数学杂志 2025年第1期45卷 48-56页

作者： HE Yu-rong ZHANG Ya-rong School of Science Xi'an University of Architecture and TechnologyXi'an 710055China Xi'an Special Equipment Inspection Institute Xi'an 710065China School of Power and Energy Northwestern Polytechnical UniversityXi'an 710072China

In order to better describe the phenomenon of biological invasion,this paper introduces a free boundary model of biological ***,the right free boundary is added to the equation with logistic ***,the existence and uniqueness of local solutions are proved by the Sobolev embedding theorem and the comparison ***,according to the relevant research data and contents of red fire ants,the diffusion area and nest number of red fire ants were simulated without external *** paper mainly simulates the early diffusion process of red fire *** the early diffusion stage,red fire ants grow slowly and then spread over a large area after reaching a certain number.

关键词： Free boundary biological invasion differential equation

Optical and electronic properties of single modulation doped GaAs/AlGaAs V-grooved quantum wire modified by ion implantation

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Science China(Physics,Mechanics & Astronomy) 2005年第3期48卷 361-370页

作者： HUANG Shaohua CHEN zhanghai BAI Lihui WANG Fangzhen SHEN Xuechu Surface Physics Laboratory Department of Physics Fudan University Shanghai 200433 China Surface Physics Laboratory Department of Physics Fudan University Shanghai 200433 China Surface Physics Laboratory Department of Physics Fudan University Shanghai 200433 China Surface Physics Laboratory Department of Physics Fudan University Shanghai 200433 China Surface Physics Laboratory Department of Physics Fudan University Shanghai 200433 China

Single GaAs/Al0.5Ga0.5As V-grooved quantum wire modified by selective ion-implantation and rapid thermally annealing was investigated by spatially-resolved microphotoluminescence and magneto-resistance measurement. Spatially-resolved photoluminescence results indicate that the ion-implantation induced quantum well intermixing raises significantly the electron subband energies of the side quantum wells and vertical quantum wells, and more efficient accumulation of electrons in the quantum wires is achieved. Furthermore, the polarization properties of the photoluminescence from the quantum wires show large linear polarization degree up to 63%. Magneto- transport investigation on the ion implanted quantum wire samples presents the quasi-one dimensional intrinsic motion of electrons, which is important for the design and optimization of one dimensional electronic devices.

关键词： GaAs/AlGaAs V-grooved quantum wire, ion-implantation, photoluminescence, polarization,magneto-resistance

Effects on the Hadron Propagators due to κμκυ Terms in the Vector Meson Propagator

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Communications in Theoretical Physics 2003年第3X期40卷 357-362页

作者： zhanghai-Xia WUShi-Shu CenterforTheoreticalPhysics CollegeofPhysicsJilinUniversityChangchun130023China

In an approximation where the baryon current conservation is violated, the contribution of the κμκυ terms in the vector meson propagator may not vanish. Their effects on the baryon and meson spectral functions and on the consequences of self-consistency are studied in the relativistic self-consistent Hartree-Fock approximation by means of the σ-ω model. Two cases where the κμκυ terms are and are not neglected are compared. It is found that there is a marked change in the baryon spectral function which becomes more peaked in the latter case. Such a change remains even by a proper readjustment of parameters. The effects of self-consistency in the σ-ω model are qualitatively the same in both cases, though quantitatively there is some significant difference.

关键词：自相容性强子传播矢量介子传播光谱函数 Hartree-Fock近似

Estimation of Critical Rate of Temperature Rise for Thermal Explosion of First Order Autocatalytic Decomposition Reaction Systems by Using Non-isothermal DSC

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Chemical Research in Chinese Universities 2004年第2期20卷 163-165页

作者： GUOPeng-jiang HUrong-zu zhanghai XIAZhi-ming SONGJi-rong GAOSheng-li NINGBin-ke SHIQi-zhen LIUrong LUGui-e JIANGJi-you SchoolofChemistryandChemicalEngineering SouthwesternNormalUniversityChongqing400715P.R.China ShaanxiKeyLaboratoryofPhysico-InorganicChemistryandDepartmentofChemistry Xi''anModernChemistryResearchInstitute Xi''an710065P.R.China DepartmentofMathematics NorthwestUniversityXi''an710069P.R.China DepartmentofFoodEngineering NanchangUniversityNanchang330047P.R.China OrdnanceEngineeringInstitute Shijiazhuang050000P.R.China

A method of estimating the critical rate of temperature rise for the thermal explosion of first order autocatalytic decomposition reaction systems by using non-isothermal DSC is presented. The information was obtained on the increasing rate of temperature for the first order autocatalytic decomposition of nitrocellulose containing 13.86% nitrogen converting into the thermal explosion.

关键词： DSC Critical rate of temperature rise NC Non-isothermal change Thermal explosion

E-Commerce-Objected E-Stamp Systems

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The Journal of China Universities of Posts and Telecommunications 2002年第1期9卷 72-76页

作者： HUXiang-dong zhanghai-sheng 等 InstituteofPostalAutomaion ChongqingUniversityofPostsandTelecommunicationsChongqing400065P.R.China ChengduInstituteofComputerApplicationAcademiaSinica Chengdu610041P.R.China

Bioosting e-stamp's advantages are conduced to promote logisticsto go forward and help postal depart- ments to improve the quality ofservice, many other businesses add-valued can be developed in e-stampsystems. This p... 详细信息

关键词： e-commerce e-stamp logistics tracking and tracing