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Research landmarks on the 60th anniversary of Epstein-Barr virus

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Science China(life Sciences) 2025年第2期68卷 354-380页

作者： lan-Yi zhong Chu Xie le-le zhang Yan-lin Yang yuan-Tao liu Ge-Xin Zhao Guo-long Bu Xian-Shu Tian Zi-Ying Jiang Bo-yu yuan Peng-lin li Pei-huang Wu Wei-hua Jia Christian Münz Benjamin E.Gewurz Qian zhong Cong Sun Mu-sheng zeng State Key laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Viral Immunobiology Institute of Experimental ImmunologyUniversity of ZürichZürich 8092Switzerland Division of Infectious Diseases Department of MedicineBrigham and Women’s HospitalBoston MA 02115USA Department of Microbiology Harvard Medical SchoolBoston MA 02115USA Harvard Program in Virology Boston MA 02115USA Broad Institute of Harvard and MIT Cambridge MA 02142USA

Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human *** we commemorate the 60th anniversary of EBV's discovery,it is an opportune moment to reflect on the major advancements in our understanding of this complex *** this review,we highlight key milestones in EBV research,including its virion structure and life cycle,interactions with the host immune system,association with EBV-associated diseases,and targeted intervention strategies.

关键词： Epstein-Barr virus oncovirus immune response epidemiology vaccines antibodies

A high fidelity general purpose 3-D Monte Carlo particle transport program JMCT3.0

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Nuclear Science and Techniques 2022年第8期33卷 175-192页

作者： li Deng Gang li Bao-Yin zhang Rui li ling-yu zhang Xin Wang yuan-Gang Fu Dun-Fu Shi Peng liu Yan Ma Dan-Hu Shangguan ze-hua Hu sheng-Cheng Zhou Jing-Wen Shen Institute of Applied Physics and Computational Mathematics(IAPCM) Beijing 100094China CAEP Software Centre for High Performance Numerical Simulation(CAEP-SCNS) Beijing 100088China

JMCT is a large-scale,high-fidelity,three-dimensional general neutron–photon–electron–proton transport Monte Carlo software *** was developed based on the combinatorial geometry parallel infrastructure JCOGIN and the adaptive structured mesh infrastructure *** is equipped with CAD modeling and visualizes the image *** supports the geometry of the body and the structured/unstructured *** has most functions,variance reduction techniques,and tallies of the traditional Monte Carlo particle transport *** energy models,multi-group and continuous,are *** recent years,some new functions and algorithms have been developed,such as Doppler broadening on-thefly(OTF),uniform tally density(UTD),consistent adjoint driven importance sampling(CADIS),fast criticality search of boron concentration(FCSBC)domain decomposition(DD),adaptive control rod moving(ACRM),and random geometry(RG)*** JMCT is also coupled with the discrete ordinate SNcode JSNT to generate source-biasing factors and weight-window *** present,the number of geometric bodies,materials,tallies,depletion zones,and parallel processors are sufficiently large to simulate extremely complicated device *** can be used to simulate reactor physics,criticality safety analysis,radiation shielding,detector response,nuclear well logging,and dosimetry calculations *** particular,JMCT can be coupled with depletion and thermal-hydraulics for the simulation of reactor nuclear-hot feedback *** paper describes the progress in advanced modeling,high-performance numerical simulation of particle transport,multiphysics coupled calculations,and large-scale parallel computing.

关键词： Advanced modeling High-performance numerical simulation Multi-physics coupled calculation large-scale parallel computing JMCT

In-beam gamma rays of CSNS Back-n characterized by black resonance filter

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Nuclear Science and Techniques 2024年第10期35卷 149-160页

作者： Jin-Cheng Wang jie Ren Wei Jiang Xi-Chao Ruan Ying-Yi liu Hao-lan Yang Kuo-zhi Xu Xin-Yi Pan Qi Sun jie Bao Han-Xiong huang Hao-Fan Bai Jiang-Bo Bai Ping Cao Qi-Ping Chen Yong-Hao Chen Wen-Hao Duan An-Chuan Fan Rui-Rui Fan Chang-Qing Feng Min-Hao Gu Chang-Cai Han Zi-jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu zhi-jie Jiang ling Kang Chang-lin lan Bo li Feng li Qiang li Xiao li Yang li jie liu Rong liu Shu-Bin liu Yi-Na liu Guang-yuan luan Chang-Jun Ning Yi-Jia Qiu Wen-Kai Ren zhi-Zhou Ren Zhao-Hui Song Kang Sun zhi-Xin Tan Jing-yu Tang sheng-Da Tang li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang zhong-Wei Wen Xiao-Guang Wu Xuan Wu ze-Peng Wu Cong Xia li-Kun Xie Han Yi Tao yu Yong-Ji yu Guo-Hui zhang Hang-Chang zhang Qi-Wei zhang Xian-Peng zhang yu-liang zhang zhi-Yong zhang Mao-yuan Zhao zhi-Hao Zhou Ke-Jun Zhu Chong Zou Key laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China State Key laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China USTC Archaeometry lab University of Science and Technology of ChinaHefei 230026China State Key laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Institute of Advanced Technology University of Science and Technology of ChinaHefei 230027China

The back-streaming white-neutron beamline(Back-n)of the China Spallation Neutron Source is an essential neutronresearch platform built for the study of nuclear data,neutron physics,and neutron *** types of cross-sectional neutron-reaction measurements have been performed at Back-n since early *** measurements have shown that a significant number of gamma rays can be transmitted to the experimental stations of Back-n along with the neutron *** gamma rays,commonly referred to as in-beam gamma rays,can induce a non-negligible experimental background in neutron-reaction *** the characteristics of in-beam gamma rays is important for understanding the experimental ***,measuring in-beam gamma rays is challenging because most gamma-ray detectors are sensitive to neutrons;thus,discriminating between neutron-induced signals and those from in-beam gamma rays is *** this study,we propose the use of the black resonance filter method and a CeBr_(3) scintillation detector to measure the characteristics of the in-beam gamma rays of *** types of black resonance filters,^(181)Ta,^(59)Co,^(nat)Ag,and^(nat)Cd,were used in this *** time-of-flight(TOF)technique was used to select the detector signals remaining in the absorption region of the TOF spectra,which were mainly induced by in-beam gamma *** energy distribution and flux of the in-beam gamma rays of Back-n were determined by analyzing the deposited energy spectra of the CeBr_(3) scintillation detector and using Monte Carlo *** on the results of this study,the background contributions from in-beam gamma rays in neutron-reaction measurements at Back-n can be reasonably evaluated,which is beneficial for enhancing both the experimental methodology and data analysis.

关键词： In-beam gamma rays Back-n CeBr_(3)scintillator Black filter resonance technique

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang li li‑Jiao Wang Xiang‑Biao Qiu Jing‑Wen li Wei Xu Tao li ze‑Bin lin Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun Jing‑yu Tang Rong zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai jie Bao Ping Cao Qi‑Ping Chen Zhen Chen zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong huang Wei‑hua Jia Hao‑yu Jiang Wei Jiang zhi‑jie Jiang Zheng‑Yao Jin ling Kang Bo li Chao li Gong li Jia‑Wen li Xiao li Yang li jie liu Rong liu Shu‑Bin liu Guang‑yuan luan Bin‑Bin Qi jie Ren zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song zhi‑Xin Tan sheng‑Da Tang Peng‑Cheng Wang Zhao‑Hui Wang zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji yu Guo‑Hui zhang lin‑Hao zhang Mo‑Han zhang Qi‑Wei zhang Xian‑Peng zhang yu‑liang zhang yue zhang zhi‑Yong zhang Mao‑yuan Zhao lu‑Ping Zhou zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation

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Nuclear Science and Techniques 2023年第1期34卷 51-85页

作者： Nan‑Shun huang Zi‑Peng liu Bang‑jie Deng Zi‑Han Zhu Shao‑hua li Tao liu Zheng Qi Jia‑Wei Yan Wei zhang sheng‑Wang Xiang Yang‑Yang lei Ya Zhu Yong‑Zhou He Qi‑Bing yuan Fei Gao Rong‑Bing Deng Sen Sun zhi‑Di lei zhi‑Qiang Jiang Meng‑Qi Duan yuan Zhuan Xue‑Fang huang Peng‑Cheng Dong zhong‑liang li Shang‑yu Si lian Xue Si Chen Yong‑Fang liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao zhangjiang laboratory Shanghai 201210China School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China European XFEl Schenefeld 22869Germany ShanghaiTech University Shanghai 201210China

The cavity-based X-ray free-electron laser(XFEl)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEl is capable of generating ultra-short pulses with chaotic *** general,a cavity-based XFEl can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific *** the development of superconducting MHz repetition-rate XFEl facilities such as FlASH,European-XFEl,lClS-II,and SHINE,practical cavity-based XFEl operations are becoming increasingly *** this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEl facility-SHINE,which we refer to as MING@SHINE.

关键词： X-ray free-electron laser Free electron laser oscillator Fully coherent X-ray

Towards the full realization of the RIBll2 beam line at the HIRFl-CSR complex

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Science Bulletin 2018年第2期63卷 78-80页

作者： Bao-hua Sun Jian-Wei Zhao Xue-Heng zhang li-Na sheng zhi-yu Sun Isao Tanihata Satoru Terashima Yong Zheng li-hua Zhu li-Min Duan liu-Chun He Rong-Jiang Hu Guang-Shuai li Wen-Jian lin Wei-Ping lin Chuan-Ye liu zhong liu Chen-Gui lu Xin-Wen Ma li-Jun Mao Yi Tian Feng Wang Meng Wang Shi-Tao Wang Jia-Wen Xia Xiao-Dong Xu Hu-Shan Xu zhi-Guo Xu Jian-Cheng Yang Da-yu Yin You-Jin yuan Wen-long Zhan yu-Hu zhang Xiao-Hong Zhou School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China International Research Center for Nuclei and Particles in the Cosmos Beijing 100191 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

More than 99%of the mass in the visible universe—the material that makes up ourselves,our planet,stars—is in the atomic *** the matter has existed for billions of years,only over the past few decades have we had the tools and the knowledge necessary to get a basic understanding of the structure and dynamic of *** physicists around the world have made tremendous strides by initiating a broad range of key

关键词： HIRFl-CSR 横梁建筑群排队原子核物理学家试验性世界

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： sheng-Da Tang Yong-Hao Chen Jing-yu Tang Rui-Rui Fan Qiang li Gong li Dong liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong liu Han Yi Yang li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai jie Bao Ping Cao Qi-Ping Chen Zhen Chen zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong huang Wei-hua Jia Hao-yu Jiang Wei Jiang zhi-jie Jiang ling Kang Bo li Chao li Jia-Wen li Xiao li jie liu Shu-Bin liu Guang-yuan luan Chang-Jun Ning Bin-Bin Qi jie Ren zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun zhi-Xin Tan li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang zhong-Wei Wen Xiao-Guang Wu Xuan Wu li-Kun Xie Yong-Ji yu Guo-Hui zhang lin-Hao zhang Mo-Han zhang Qi-Wei zhang Xian-Peng zhang yu-liang zhang yue zhang zhi-Yong zhang Mao-yuan Zhao lu-Ping Zhou zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

Feasibility of controlling hepatitis E in Jiangsu Province, China: a modelling study

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Infectious Diseases of Poverty 2021年第3期10卷 116-117页

作者： Meng Yang Xiao-Qing Cheng ze-yu Zhao Pei-hua li Jia Rui sheng-Nan lin Jing-Wen Xu yuan-Zhao Zhu Yao Wang Xing-Chun liu li luo Bin Deng Chan liu jie-Feng huang Tian-long Yang Zhuo-Yang li Wei-Kang liu Wen-Dong liu Ben-hua Zhao yue He Qi Yin Si-Ying Mao Yan-hua Su Xue-Feng zhang Tian-Mu Chen State Key laboratory of Molecular Vacci no logy and Molecular Diagnostics School of Public HealthXiamen University4221-117 South Xiang'an RoadXiang'an DistrictXiamen City 361102Fujian ProvincePeople's Republic of China Jiangsu Center for Disease Control and Prevention Nanjing CityJiangsu ProvincePeople's Republic of China

Background:Hepatitis E,an acute zoonotic disease caused by the hepatitis E virus(HEV),has a relatively high burden in developing *** current research model on hepatitis E mainly uses experimental animal models(such as pigs,chickens,and rabbits)to explain the transmission of *** studies have developed a multi-host and multiroute transmission dynamic model(MHMRTDM)to explore the transmission feature of ***,this study aimed to explore its transmission and evaluate the effectiveness of intervention using the dataset of Jiangsu Province.

关键词： Hepatitis E Transmission dynamic model Meteorological factor Intervention Transmissibility

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： huaNG Hao-yue liN yu-ping WEI hua FU yu ZHOU yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei li Qing-bo li Shan-shan WANG Shi-dong DAI Fang liu Zhen-jie ZHAO ling WEN Jian-xuan WU li-yan zeNG Hui-yan zhang Jin-ming lU Qi-yun HE liu SONG Wei SUN lu lUO lu-lu HE Jia-li XIE Wen-wen liANG Qing-shun huaNG yuan ZHU sheng-ling lONG jie-er GAO zhi-juan WEN ze-huai li Chun-ji OUYANG Wen-wei li Geng WU Ming-hui li An-xiang huaNG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(Pl group were greater than those in the intervention group(Ply between groups(P>0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction