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Di(2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats

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Biomedical and Environmental Sciences 2019年第6期32卷 406-418页

作者： zhang Yue Zhu zhang zhao ming ZHOU Li Ting ZHU Jian zhang Xiao Han QI Wen DING Shuang XU Qi HAN Xu zhao Ya ming SONG Xin Yue zhao Tian Yang YE Lin Department of Occupational and Environmental Health School of Public Health Jilin University

Objective Previous studies have indicated that the plasticizer di(2-ethylhexyl) phthalate(DEHP) affects lipid accumulation;however, its underlying mechanism remains unclear. We aim to clarify the effect of DEHP on lipid metabolism and the role of TYK2/STAT1 and autophagy. Methods In total, 160 Wistar rats were exposed to DEHP [0, 5, 50, 500 mg/(kg·d)] for 8 weeks. Lipid levels, as well as mRNA and protein levels of TYK2, STAT1, PPARγ, AOX, FAS, LPL, and LC3 were detected. Results The results indicate that DEHP exposure may lead to increased weight gain and altered serum lipids. We observed that DEHP exposure affected liver parenchyma and increased the volume or number of fat cells. In adipose tissue, decreased TYK2 and STAT1 promoted the expression of PPARγ and FAS. The mRNA and protein expression of LC3 in 50 and 500 mg/(kg·d) groups was increased significantly. In the liver, TYK2 and STAT1 increased compensatorily;however, the expression of FAS and AOX increased, while LPL expression decreased. Joint exposure to both a high-fat diet and DEHP led to complete disorder of lipid metabolism. Conclusion It is suggested that DEHP induces lipid metabolism disorder by regulating TYK2/STAT1. Autophagy may play a potential role in this process as well. High-fat diet, in combination with DEHP exposure, may jointly have an effect on lipid metabolism disorder.

关键词： DEHP TYK2 STAT1 High-fat diet Autophagy Lipid metabolism

Synthesis and Antioxidant Activity of Sapriparaquinone Analogues

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Chinese Chemical Letters 2006年第9期17卷 1177-1180页

作者： Fei DENG Fu Jun zhang ming zhao Yi Ping WANG Jin Sheng zhang State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203

Twenty two sapriparaquinone derivatives were synthesized and their antioxidant activities were evaluated in vitro. Many of this kind of compounds demonstrated potent antioxidant activity against lipid peroxidation, especially compound 7 （IC50 = 3.7 μg/mL）. The preliminary structure-activity relationship of sapriparaquinone derivatives was discussed.

关键词： Synthesis sapriparaquinone antioxidant activity.

Microstructure,Properties and Heat Treatment Process of Powder Metallurgy Superalloy FGH95

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Journal of Iron and Steel Research International 2006年第5期13卷 65-68页

作者： GUO Wei-min WU Jian-tao zhang Feng-ge zhao ming-han High Temperature Materials Research Institute Central Iron and Steel Research Institute Beijing 100081 China

Microstructure and properties of nickel based powder metallurgy （PM） superalloy were presented. Effects of nonmetallic inclusions and heat treatment on microstructure and properties were. discussed. Development tend... 详细信息

关键词： microstructure property PM superalloy heat treatment

Activation of Growth-associated Protein by Intragastric Brazilein in Motor Neuron of Spinal Cord Connected with Injured Sciatic Nerve in Mice

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Chemical Research in Chinese Universities 2011年第2期27卷 254-257页

作者： CAO Jian LI Li-sen LIU Biao LIU Hao-yu zhang Hui zhao ming-ming YIN Wei-tian China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China

The purpose of this study is to explore the expression of growth-associated protein（GAP-43） in spinal cord segments connected with injured sciatic nerve by the treatment with brazilein in mice. Unilateral sciatic nerve interruption and anastomosis were performed. Physiological saline（blank group）, high dose, middle dose and low dose of brazilein were administrated intragastrically to healthy adult BALB/c mice in separate groups. L4―6 spinal segments connected with the sciatic nerve were harvested. Real-time PCR（Polymerase chain reaction） and Western blot analysis were performed to detect the expression of GAP-43 in spinal segments. Histological staining on myelin and the electrophysiology were performed to examine the sciatic nerve recovery. GAP-43 was activated in spinal cord L4―6 connected with injured sciatic nerve. In the survival time of 12 h, 24 h, 3 d, 5 d, 7 d and 14 d, GAP-43 expression in the motor neurons of spinal cord of the high dose group and that in the middle dose group were significantly higher than those on the low dose and blank groups. Myelin in the high dose group and that in the middle dose group were more mature and the potential amplitude and MNCV（motor nerve conduction velocity） in the high and middle dose groups were obviously higher than those in the low dose group and blank group. Brazilein facilitates the expression of GAP-43 in neurons in spinal cord L4―6 segments connected with injured sciatic nerve, which promotes nerve regeneration.

关键词： Brazilein Growth-associated protein(GAP-43) Injury of sciatic nerve Regeneration

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弹性变形对柔性飞艇气动特性的影响

实验流体力学 2010年第3期24卷 59-62页

作者：陈华张召明南京航空航天大学空气动力学系南京210016

设计加工具有相同几何外形的刚性飞艇模型和可变内压的柔性飞艇模型,并进行了低速风洞实验。研究了内压变化对柔性模型阻力和俯仰力矩特性的影响,比较了柔性模型和刚性模型气动特性的差异。实验结果表明,随着内压的增加柔性模型的阻力... 详细信息

设计加工具有相同几何外形的刚性飞艇模型和可变内压的柔性飞艇模型,并进行了低速风洞实验。研究了内压变化对柔性模型阻力和俯仰力矩特性的影响,比较了柔性模型和刚性模型气动特性的差异。实验结果表明,随着内压的增加柔性模型的阻力呈下降趋势;对于具有相同几何外形的柔性和刚性模型,柔性模型的阻力明显大于刚性模型;刚性模型的尾翼对俯仰力矩的影响较大。

关键词：柔性飞艇模型弹性变形风洞实验

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汽车冲撞刚性护栏冲击力的计算

土木工程学报 1995年第6期28卷 37-42页

作者：张誉赵鸣同济大学

本文对国内外常用的计算冲击力的方法进行了讨论.针对其不足之处,提出一种将汽车和护栏作为连续系统的动力计算方法,并与作者所做的载重汽车直接冲撞钢筋混凝土护栏足尺模型试验结果进行了比较,计算结果良好.

关键词：汽车高速公路护栏刚性护栏冲撞冲击力计算

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光合细菌防治高脂家兔动脉粥样硬化的研究

营养学报 2006年第5期28卷 412-414页

作者：熊琦张肇铭山西大学生命科学与技术学院光合细菌研究室太原030006

目的:研究光合细菌对动脉粥样硬化的防治作用。方法:用高脂饲料建立实验性高脂家兔模型;以螺旋藻作为阳性对照;设立空白对照、高脂对照,以肝脏总胆固醇含量(TC)、主动脉斑块面积百分比(PA)及冠状动脉堵塞情况等为指标,观察光合细菌对动... 详细信息

目的:研究光合细菌对动脉粥样硬化的防治作用。方法:用高脂饲料建立实验性高脂家兔模型;以螺旋藻作为阳性对照;设立空白对照、高脂对照,以肝脏总胆固醇含量(TC)、主动脉斑块面积百分比(PA)及冠状动脉堵塞情况等为指标,观察光合细菌对动脉粥样硬化的防治作用。结果:光合细菌组的肝脏TC含量、肝系数、PA分别比高脂组降低了63.99%、21.96%、70.10%,都具有非常显著性差异(P<0.01),同时也显著低于螺旋藻组。病理学检查表明,光合细菌组肝脏上的脂质沉积和冠状动脉的病变也明显轻于高脂组和螺旋藻组。结论:光合细菌对高脂家兔的动脉粥样硬化具有很好的防治作用,效果优于螺旋藻。

关键词：光合细菌高脂家兔动脉粥样硬化

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光合细菌转化槲寄生制剂抗肿瘤活性初步研究

微生物学通报 2006年第2期33卷 40-43页

作者：杨官娥张肇铭山西大学生命科学与技术学院

通过急性毒性实验比较各制剂组的毒性,MTT法考查各制剂组对人体外癌细胞的生长抑制率,体内实验考查各制剂组对移植性肿瘤的抗肿瘤作用。结果表明,光合细菌(PSB)制剂组、光合细菌转化槲寄生(PSBT)制剂组无毒,PSBT降低了槲寄生的毒性;PSB... 详细信息

通过急性毒性实验比较各制剂组的毒性,MTT法考查各制剂组对人体外癌细胞的生长抑制率,体内实验考查各制剂组对移植性肿瘤的抗肿瘤作用。结果表明,光合细菌(PSB)制剂组、光合细菌转化槲寄生(PSBT)制剂组无毒,PSBT降低了槲寄生的毒性;PSBT制剂组对人体外癌细胞BGC-803、A2780、KB和小鼠体内S180肉瘤、H22肝癌、Lewis肺癌均具有明显抑制作用,且抗肿瘤活性高于其他制剂组。

关键词：光合细菌槲寄生急性毒性抗肿瘤活性生物转化

利用球形红细菌降低小麦、油菜幼苗中镉积累的研究

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山西大学学报(自然科学版) 2007年第3期30卷 394-399页

作者：郭凌张肇铭山西大学生命科学与技术学院

采用水培试验,研究了光合细菌球形红细菌（Rhodobacter sphaeroides）菌液对重金属镉胁迫下小麦（Triticum aestivum）和油菜（Brassica campestris）幼苗生长及富集镉的效应.结果表明,镉的添加浓度为0.5 mg/L、10 mg/L、20 mg/L,菌液... 详细信息

采用水培试验,研究了光合细菌球形红细菌（Rhodobacter sphaeroides）菌液对重金属镉胁迫下小麦（Triticum aestivum）和油菜（Brassica campestris）幼苗生长及富集镉的效应.结果表明,镉的添加浓度为0.5 mg/L、10 mg/L、20 mg/L,菌液的浓度为35 mg/L、70 mg/L（湿重）时,小麦和油菜幼苗生长受到的镉抑制都有不同程度的缓解,几项生长指标都有一定的增长,其中小麦茎叶长度,根系长度和鲜重的增长率范围依次为3.16%11.26%、2.46%6.85%、11.34%65.82%;油菜相应的增长率为0.98%14.71%,5.80%34.42%,3.93%27.63%;加入菌液后两种植物各部分镉积累也有不同的程度的降低,小麦茎叶,根系,整株镉的降低率范围依次为8.30%16.36%、3.78%31.70%、3.38%15.04%;油菜相应的降低率为1.05%12.30%、50.59%58.48%、0.89%25.19%.同浓度镉处理下,加入菌液与未加入菌液的处理之间存在差异.

关键词：球形红细菌镉小麦油菜生长镉积累