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Prognostic value of PEA3 subfamily gene expression in cholangiocarcinoma

World Journal of Gastrointestinal Oncology 2024年第9期16卷 4014-4027页

作者： Li Wang Zhe zhang hai-zhang Ma Department of Emergency The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Emergency Medicine The First People’s Hospital of Linping District HangzhouHangzhou 311100Zhejiang ProvinceChina Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina

BACKGROUND Cholangiocarcinoma(CCA)is a lethal malignancy with limited treatment options and poor *** PEA3 subfamily of E26 transformation specific genes:ETV1,ETV4,and ETV5 are known to play significant roles in various cancers by influencing cell proliferation,invasion,and *** To analyze PEA3 subfamily gene expression levels in CCA and their correlation with clinical parameters to determine their prognostic value for *** The expression levels of PEA3 subfamily genes in pan-cancer and CCA data in the cancer genome atlas and genotype-tissue expression project databases were analyzed with R language *** curve and receiver operating characteristic analyses were performed using the SurvMiner,Survival,and Procr language *** gene expression profiling interactive analysis 2.0 database was used to analyze the expression levels of PEA3 subfamily genes in different subtypes and stages of *** Gestalt was used to perform the gene ontology/Kyoto encyclopedia of genes and genomes(GO/KEGG)analysis,and STRING database analysis was used to determine the genes and proteins related to PEA3 subfamily *** ETV1,ETV4,and ETV5 expression levels were significantly increased in *** were significant differences in ETV1,ETV4,and ETV5 expression levels among the different subtypes of CCA,and predictive analysis revealed that only high ETV1 and ETV4 expression levels were significantly associated with shorter overall survival in patients with ***/KEGG analysis revealed that PEA3 subfamily genes were closely related to transcriptional misregulation in *** vitro and in vivo experiments revealed that PEA3 silencing inhibited the invasion and metastasis of CCA *** The expression level of ETV4 may be a predictive biomarker of survival in patients with CCA.

关键词： PEA3 subfamily Cholangiocarcinoma The cancer genome atlas ETV4 The prognosis Prognostic biomarker

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鱼雷外形低阻、低噪和高机动性的多学科优化设计方法

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兵工学报 2012年第2期33卷 186-191页

作者：赵加鹏张云海任翀中船重工710研究所102室湖北宜昌443003

为了解决鱼雷外形低阻、低噪和高机动性综合优化设计问题,基于MDO理论,利用两级综合优化算法和并行子空间优化算法,提出了一种适用于鱼雷外形综合优化设计的多学科优化算法,建立了系统级优化模型,利用二次响应面近似技术,解决了学科级... 详细信息

为了解决鱼雷外形低阻、低噪和高机动性综合优化设计问题,基于MDO理论,利用两级综合优化算法和并行子空间优化算法,提出了一种适用于鱼雷外形综合优化设计的多学科优化算法,建立了系统级优化模型,利用二次响应面近似技术,解决了学科级与系统级之间的耦合问题。最后,通过实际算例,对多学科分析与优化方法及模型的有效性进行了验证,获得了一种综合性能较优的方案。

关键词：系统工程方法论鱼雷外形多学科设计优化

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Optimized Selection Method of Air Combat Course of Action under Stochastic Uncertainty

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 494-518页

作者： yun Zhong Jieyong zhang Peng Sun Lujun Wan Kepeng Wang Information and Navigation College Air Force Engineering UniversityXi’an710077China Equipment Management and Unmanned Aerial Vehicle Engineering College Air Force Engineering UniversityXi’an710051China Air Traffic Control and Navigation College Air Force Engineering UniversityXi’an710051China Unit 94040 of PLA Korla841000China

Aiming at the design problem of aviation swarm combat course of action(COA),considering the influence of stochastic parameters in the causal relationship model and optimization problem model,according to the dynamic influence net(DIN)theory,stochastic simulation technique,feedforward neural network(FNN)function approximation technique and multi-objective artificial fish school algorithm(MOAFSA),this paper proposed a COA optimized method based on DIN and multi-objective stochastic chance constraint optimization for aviation swarm ***,on the basis of establishing the overall framework of the model and defining the elements of causal relationship modeling,the static and dynamic causal relationship modeling and optimization problem modeling were carried out ***,the probability propagation mechanism of DIN was established,which mainly included two aspects,i.e.,the overall process and the specific ***,input and output data were generated based on stochastic *** to these data,FNN was adopted for function approximation,and MOAFSA was adopted for iterative ***,the rationality of the model,and the effectiveness and superiority of the algorithm were verified through multiple sets of simulation cases.

关键词： Stochastic uncertainty aviation swarm stochastic simulation course of action feedforward neural network multi-objective artificial fish school algorithm

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Targeting synaptic pathology in Alzheimer’s disease

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Zoological Research 2024年第4期45卷 875-876页

作者： Jing Cao yun-Wu zhang Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China

Alzheimer’s disease(AD)is a neurodegenerative disorder characterized by memory and cognitive *** two primary pathological hallmarks of AD include the accumulation ofβ-amyloid(Aβ)plaques and formation of neurofibrillary tangles(NFTs)composed predominantly of hyperphosphorylated tau protein(zhang et al.,2023).Moreover,synaptic dysfunction is considered another crucial factor in AD pathogenesis and is closely associated with cognitive ***,synaptic damage,loss,and dysfunction manifest earlier than the pathological features of Aβplaques and NFTs(Knopman et al.,2021).Therefore,understanding the mechanisms underlying synaptic dysfunction in AD is vital for providing insights into disease mechanisms and developing novel therapeutic strategies.

关键词： Alzheimer Aβ tau

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Ultimately Bounded Output Feedback Control for Networked Nonlinear Systems With Unreliable Communication Channel: A Buffer-Aided Strategy

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1566-1578页

作者： Yuhan zhang Zidong Wang Lei Zou yun Chen Guoping Lu the College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China IEEE the Department of Computer Science Brunel UniversityUB83PHUnited Kingdom the College of Information Science and Technology Donghua UniversityShanghai 201620 the Engineering Research Center of Digitalized Textile and Fashion Technology Ministry of EducationShanghai 201620China the School of Automation Hangzhou Dianzi UniversityHangzhou 310018China the School of Electrical Engineering Nantong UniversityNantong 226019China

This paper concerns ultimately bounded output-feedback control problems for networked systems with unknown nonlinear dynamics. Sensor-to-observer signal transmission is facilitated over networks that has communication *** transmissions are carried out over an unreliable communication channel. In order to enhance the utilization rate of measurement data, a buffer-aided strategy is novelly employed to store historical measurements when communication networks are inaccessible. Using the neural network technique, a novel observer-based controller is introduced to address effects of signal transmission behaviors and unknown nonlinear *** the application of stochastic analysis and Lyapunov stability, a joint framework is constructed for analyzing resultant system performance under the introduced controller. Subsequently, existence conditions for the desired output-feedback controller are delineated. The required parameters for the observerbased controller are then determined by resolving some specific matrix inequalities. Finally, a simulation example is showcased to confirm method efficacy.

关键词： Buffer-aided strategy neural networks nonlinear control output-feedback control unreliable communication channel

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Organic Brønsted Acid-Catalyzed Stereoselective Cationic RAFT Polymerization:The Effect of RAFT Agents

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Chinese Journal of Polymer Science 2024年第6期42卷 711-717页

作者： Zheng-Yi zhang Zan Yang yun Liao Sai-Hu Liao Key Laboratory of Molecule Synthesis and Function Discovery(Fujian Province University) College of ChemistryFuzhou UniversityFuzhou350108China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China Beijing National Laboratory for Molecular Sciences Beijing100190China

The tacticity of vinyl polymers is a key factor affecting the properties of ***,organic Brønsted acids have been demonstrated as effective catalysts for the development of highly stereoselective cationic reversible addition-fragmentation chain transfer(RAFT)polymerizations of vinyl ethers,in which the use of RAFT agents could allow the control the molecular weight and tacticity of polymer products ***,the effect of RAFT agents on the tacticity-regulation remains elusive and lacks of *** this study,we synthesized four types of RAFT agents and evaluated their influence in the stereoselective cationic polymerization of isobutyl vinyl ether in the presence of PADI as a Brønsted acid catalyst,which unveils that the Z group of RAFT agents could not only affect the polydispersity of the products,but also exert a profound effect on the *** extensive screening of the RAFT agents,high stereoregularity(isotacticity,90%m)was obtained when using dithiocarbonate ester-type RAFT agents with a benzyloxy Z group.

关键词： Bronsted acid catalysis Stereoselective cationic polymerization RAFT polymerization Chain transfer agents Tacticity

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影像志与“青海学”交叉研究的探讨

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青海民族研究 2012年第4期23卷 48-52页

作者：张海云青海民族大学青海西宁810007

"青海学"正处于起步阶段",青海学"的进一步发展有赖于各相关学科的合作。影像表达自上世纪至今有了长足的发展,并成为文化研究的另一支"笔"。本文对贾宁教授提出的文化命题"青海学"做出了正面回应,并试图通过无处不在的青海学影像,探讨... 详细信息

"青海学"正处于起步阶段",青海学"的进一步发展有赖于各相关学科的合作。影像表达自上世纪至今有了长足的发展,并成为文化研究的另一支"笔"。本文对贾宁教授提出的文化命题"青海学"做出了正面回应,并试图通过无处不在的青海学影像,探讨史志和影像交叉研究的可能性,提出青海学影像志在文化重建和意义符号的传递时应遵循的理论基准。

关键词：影像志青海学交叉研究

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英国古堡、古镇和古城文化旅游教育研究——以刘易斯小镇为主要考察对象

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青海民族研究 2020年第4期31卷 79-83页

作者：张海云青海民族大学科学管理处青海西宁810007

通过对英国刘易斯镇的旅游规划与设计的探讨,本文试图从人类学的视角去探讨旅游的终极意义、旅游业在国家文化软实力中的作用、旅游教育如何成功实施等问题,以期对我国旅游业后发地区的旅游规划与设计有所参考。

关键词：英国文化传播旅游教育

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基于校本测试的大学英语阅读群体及个性化诊断研究

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外语电化教学 2020年第5期 79-85,12页

作者：张海云石运章山东农业大学外国语学院山东省泰安市271018

认知诊断评估在语言测试尤其是英语阅读领域的应用得到了越来越多的关注。该研究基于大学英语校本期末测试开展了认知诊断评估,运用认知诊断模型G-DINA对构建的阅读认知属性Q矩阵和6,242名被试在阅读理解部分的作答数据进行了诊断分析,... 详细信息

认知诊断评估在语言测试尤其是英语阅读领域的应用得到了越来越多的关注。该研究基于大学英语校本期末测试开展了认知诊断评估,运用认知诊断模型G-DINA对构建的阅读认知属性Q矩阵和6,242名被试在阅读理解部分的作答数据进行了诊断分析,得到了被试的认知属性掌握概率、潜质类型分布情况、试题答对概率等诊断信息,探索对被试进行阅读技能掌握情况的群体和个性化诊断,以期为教育管理者、教师和学生充分发挥大学英语校本期末测试的积极反拨作用提供启示。

关键词：校本测试阅读认知诊断评估个性化诊断

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Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy

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Chinese Journal of Chemistry 2024年第10期42卷 1175-1189页

作者： Guo-Feng Luo Wei-hai Chen Xian-Zheng zhang state Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei KeyLaboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanHubei 430079China Key Laboratoryof Biomedical Polymers of Ministry of Education&Departmentof Chemistry Wuhan UniversityWuhanHubei 430072China

Tumor stroma composing diverse extracellular matrixes(ECM)and stromal cells shapes a condensed physical barrier,which severely hampers the efficient accessibility of nanomedicine to tumor cells,especially these deep-seated in the core of *** barrier significantly compromises the antitumor effects of drug-loaded nanomedicine,revealing the remarkable importance of disrupting stromal barrier for improved tumor therapy with deep penetration *** achieve this goal,various nanoparticle-based strategies have been developed,including direct depleting ECM components via delivering anti-fibrotic agents or targeting stromal cells to suppress ECM expression,dynamic regulation of nanoparticles’physicochemical properties(i.e.,size,surface charge,and morphology),mechanical force-driven deep penetration,natural/biomimetic self-driven nanomedicine,and transcytosis-inducing *** these nanostrategies were systemically summarized in this review,and the design principles for obtaining admirable nanomedicine were *** the rapid development of nanotechnology,elaborate design of multifunctional nanomedicine provides new opportunities for overcoming the critical stromal barriers to maximize the therapeutic index of various therapies,such as chemotherapy,photodynamic therapy,and immunotherapy.

关键词： Nanomedicine Tumor stroma Deep penetration Enhanced drug perfusion Cancer therapy Drug carriers Biomaterials Nanotechnology

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