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Efficacy and safety of triple-antiplatelet therapy after percutaneous coronary intervention： a meta-analysis

Chinese Medical Journal 2013年第9期126卷 1750-1754页

作者： zhang yong tang hai-qin li jin fu zhao-xin Department of Geriatrics First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 China

Background The combination of cilostazol, aspirin and clopidogrel （triple antiplatelet therapy, TAT） after a percutaneous coronary intervention has been used as an alternative therapy. We performed a meta-analysis to evaluate the efficacy and safety of TAT for patients after percutaneous coronary intervention （PCI）. Methods We systematically searched Pubmed, Embase and Web of Science databases to identify all randomized controlled trials （RCTs） that compared dual antiplatelet therapy （DAT） with and without cilostazol after PCI. All analyses were conducted using Review Manager 5.0. Results The final analysis consisted of 4474 patients from ten studies. The combined results suggested that there was a lower risk of cardiac death （relative risk （RR）=0.55, 95% confidence interval （Cl）： 0.31-0.98, P 〈0.05） and major adverse cardiac events （MACEs）（RR=0.63, 95% Cl： 0.54-0.74, P 〈0.05） in patients treated with TAT as compared to those with DAT follow-ups after six months to one year; no significant difference was observed in bleeding and non-fatal myocardial infarction （MI）（RR=1.14, 95% Cl： 0.80-1.64, P 〉0.055 RR=0.87, 95% Cl： 0.42-1.83, P 〉0.05）. However, the rate of adverse drug reaction was higher in patients receiving TAT than in patients receiving DAT （RR=2.21, 95% Cl： 1.84-2.66, P 〈0.05）. Moreover, there was a lower risk of stent thrombosis in patients treated with TAT as compared to those treated with DAT （RR=0.44, 95% Cl： 0.21-0.94, P 〈0.05）. The TAT group had a reduced risk of target lesion revascularization （TLR）（RR=0.60, 95% Cl： 0.43-0.82, P=-0.001） and target vessel revascularization （TVR） than the DAT group （RR=0.56, 95% Cl： 0.45-0.71, P 〈0.05）. The number of MACEs was lower for patients in the TAT group than in the DAT group with diabetes mellitus sub-analysis （RR=0.41, 95% Cl： 0.28-0.61, P 〈0.05）. But no significant difference was observed between the two groups regarding MACEs in patients with drug-eluting stent implantations （RR=0.82, 95% Cl： 0.65-1.03, P

关键词： triple antiplatelet therapy dual antiplatelet therapy percutaneous coronary intervention meta-analysis

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Innovative coaxial high-temperature thin-film sensor with core-shell structure surpassing traditional multilayer films

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Rare Metals 2024年第8期43卷 3854-3867页

作者： Chao Wu Guo-Chun Chen fu-xin zhao Fan lin Ying-Jun Zeng Yan-zhang fu Yan-Song zhang li-Da Xu qin-Nan Chen Rui tang Dao-Heng Sun Zhen-Yin hai Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China AECC Shenyang Engine Institute Shenyang 110015China School of Aerospace Engineering Xiamen UniversityXiamen 361005China

High-temperature thin-film sensors(TFSs)often suffer from inadequate tolerance to elevated *** this study,an innovative approach is presented to fabricate in situ integrated TFSs with a core-shell structure on alloy components using coaxial multi-ink printing *** method replaces traditional layerby-layer(LbL) deposition and LbL sintering processes and achieves simplified one-step *** coaxial TFS includes a conductive Pt core for conducting and sensing and a dielectric shell for electrical isolation and high-temperature *** coaxial Pt resistance grid demonstrates excellent high-temperature stability,with a resistance drift rate of only 0.08%·h^(-1) at 800 ℃,significantly lower than traditional Pt *** employing this method,a Pt thin-film strain gauge(TFSG) is fabricated that boasts remarkable high-temperature electromechanical *** effectively addresses the problem of sensitivity degradation experienced by traditional LbL Pt TFSGs when subjected to high *** demonstrate the system integration potential of the technique by printing and verifying the functionality of a long-path thinfilm resistance grid on turbine blades,which can withstand butane flame up to ~1300℃.These results showcase the potential of core-shell structure of the coaxial TFS for high-temperature applications,providing a novel approach to develop high-performance TFS beyond traditional multilayer structure.

关键词： Coaxial printing Core-shell structure Thinfilm strain gauge High-temperature stability

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Design and evaluation of prototype readout electronics for nuclide detector in Very Large Area Space Telescope

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Nuclear Science and Techniques 2022年第5期33卷 154-166页

作者： hai-Bo Yang Xian-qin li Yu-Hong Yu yong Chen Jie Kong yong-Jie zhang Shu-Wen tang Jian-Hua Guo Bing Yang Feng-Jiao Su Wen-Jian Sun jin-Xiang Wang Cheng-xin zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Harbin Institute of Technology Harbin 150001China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210000China Harbin University of Science and Technology Harbin 150080China Northwest Normal University Harbin 150080China

China plans to develop the next generation dark matter particle explorer satellite,referred to as the Very Large Area Space Telescope(VLAST).As an essential step in this process,the prototype design of detectors and electronics for the VLAST is currently *** nuclide detector is a core detector in the *** mainly measures nuclides’charges and distinguishes high-energy gamma rays and *** paper will discuss the prototype readout electronics for the VLAST’s nuclide detector,which accurately measures the charge signal of the photomultiplier tubes using the VATA160 applicationspecific integrated circuit chip;furthermore,we consider a series of critical problems,including radiation-hardening and environment *** test results show that the system exhibits stable operation,good performance,and good technical ***,each electronic channel achieves a dynamic range of 0-12.5 pC,the random noise level exceeds 1.6 fC,and the integral nonlinearity exceeds 0.35%.

关键词： Dark matter VLAST Nuclidedetector Prototype readout electronics VATA160 Large dynamic range Irradiationtest Performance test

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Rapid screening of Zr-containing particles from Chang’e-5 lunar soil samples for isotope geochronology:Technical roadmap for future study

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Geoscience Frontiers 2022年第3期13卷 68-78页

作者： jin-Hua li Qiu-li li liang zhao jin-hai zhang Xu tang li-xin Gu Qian Guo Hong-Xia Ma qin Zhou Yan liu Pei-Yu liu Hao Qiu Gang li lin Gu Shun Guo Chun-Lai li Xian-Hua li fu-Yuan Wu yong-xin Pan Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Lunar and Deep Space Exploration National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100012China Institute of High Energy Physics Chinese Academy of ScienceYuquan Road 19BShijingshan DistrictBeijing 100049China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

New samples returned by China Chang’e-5(CE-5)mission offer an opportunity for studying the lunar geologic longevity,space weathering,and regolith *** age determination of the CE-5 samples was among the first scientific questions to be ***,the precious samples,most in the micrometer size range,challenge many traditional analyses on large single crystals of zircon developed for massive bulk ***,we developed a non-destructive rapid screening of individual zirconium-containing particle for isotope geochronology based on a Micro X-ray fluorescence analysis(μXRF).The selected particles were verified via scanning electron microscopy(SEM),3D X-ray microscopy(XRM),and focused ion beam scanning electron microscopy(FIB-SEM)techniques,which showed that zirconium-bearing minerals with several microns were precisely positioned and readily suitable for site-specific isotopic dating by second ion mass spectrometry(SIMS).Such protocol could be also appli-cable in non-destructively screening other types of particles for different scientific *** there-fore proposed a correlative workflow for comprehensively studying the CE-5 lunar samples from single particles on nanometer to atomic *** various microscopic and spectromicroscopic instru-ments together,this workflow consists of six steps:(1)single-particle selection with non-destructive μXRF technique,(2)2D/3D morphological and structural characterization with a correlative submicron 3D XRM and nanoscale resolution FIB-SEM imaging methods,(3)SEM analysis of the surface morphology and chemistry of the selected particle,(4)a series of microscopic and microbeam analyses(e.g.,SEM,electron probe microanalysis,and SIMS)on the cross-section of the selected particle to obtain structural,mineralogical,chemical,and isotopic features from the micron to nanometer scale,(5)advanced 2D/3D characterization and site-specific sample preparation of thin foil/tip specimens on a microregion of inter-est in

关键词： Chang’e-5 lunar samples Zr-containing particles mXRF Correlative workflow Technical roadmap Extraterrestrial samples

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Toward real-time digital pulse process algorithms for CsI(Tl)detector array at external target facility in HIRFL-CSR

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Nuclear Science and Techniques 2023年第9期34卷 8-20页

作者： Tao liu hai-Sheng Song Yu-Hong Yu Duo Yan Zhi-Yu Sun Shu-Wen tang Fen-Hua Lu Shi-Tao Wang Xue-Heng zhang Xian-qin li hai-Bo Yang Fang Fang yong-Jie zhang Shao-Bo Ma Hooi-jin Ong Cheng-xin zhao Northwest Normal University Lanzhou 730070China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

A fully digital data acquisition system based on a field-programmable gate array(FPGA) was developed for a CsI(Tl) array at the external target facility(ETF) in the Heavy Ion Research Facility in Lanzhou(HIRFL). To process the CsI(Tl) signals generated by γ-rays and light-charged ions, a scheme for digital pulse processing algorithms is proposed. Every step in the algorithms was benchmarked using standard γ and α sources. The scheme, which included a moving average filter, baseline restoration, leading-edge discrimination, moving window deconvolution, and digital charge comparison, was subsequently implemented on the FPGA. A good energy resolution of 5.7% for 1.33-MeV γ-rays and excellent α-γ identification using the digital charge comparison method were achieved, which satisfies CsI(Tl) array performance requirements.

关键词： CsI(Tl)array On-line digital algorithms Moving average filter Moving window deconvolution On-line particle identification algorithms

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Characteristics and Time-Dependent Instability of Ga-Doped ZnO Thin Film Transistor Fabricated by Radio Frequency Magnetron Sputtering

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Chinese Physics Letters 2011年第12期28卷 297-299页

作者： HUANG hai-qin SUN Jian liU Feng-Juan zhao Jian-Wei HU Zuo-fu li Zhen-Jun zhang Xi-qing WANG yong-Sheng Key Laboratory of Luminescence and Optical Information(Ministry of Education) Institute of Optoelectronic TechnologyBeijing Jiaotong UniversityBeijing 100044 Beijing BOE Optoelectronics Technology CO. LTDBeijing 100176

We report on the fabrication and electrical characteristics of Ga-doped ZnO thin film transistors(TFTs).Low Ga-doped(0.7wt%)ZnO thin films were deposited on SiO_(2)/p−Si substrates by rf magnetron *** GZO TFTs show a mobility of 1.76 cm2/V⋅s,an on/off ratio of 1.0×10^(6),and a threshold voltage of 35 *** time−dependent instability of the TFT is *** VTH shifts *** addition,the device shows a decrease of the on/off ratio,mainly due to the increase of the *** mechanisms of instability are discussed.

关键词： TFTs film instability

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linear dipole behavior of single quantum dots encased in metal oxide semiconductor nanoparticles films

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Frontiers of physics 2019年第2期14卷 97-104页

作者： Guo-Feng zhang yong-Gang Peng hai-qing Xie Bin li Zhi-Jie li Chang-Gang Yang Wen-li Guo Cheng-Bing qin Rui-Yun Chen Yan Gao Yu-Jun Zheng lian-Tuan Xiao Suo-tang Jia State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China School of Physics Shandong UniversityJinan 250100China Department of Physics Taiyuan Normal UniversityJinzhong 030619China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Understanding of charge/energy exchange processes and interfacial interactions that occur between quantum dots (QDs) and the metal oxides is of critical importance to these QD-based optoelectronic devices. This work reports on linear dipole behavior of single near-infrared emitting CdSeTe/ZnS core/shell QDs which are encased in indium tin oxide (ITO) semiconductor lianoparticles films. A strong polarization anisotropy in photohiminescence emission is observed by defocused wide-field imaging and polarization measuremen11echniques, and the average polarization degree is up to 0.45. A possible mechanism for the observation is presented in which the electrons, locating at single QD surface from ITO by electron transfer due to the equilibration of the Fermi levels, result in a significant Stark distortion of the QD electron/hole wavefunctions. The Stark distortion results in the linear polarization property of the single QDs. The investigation of linear dipole behavior for single QDs encased in ITO films would be helpful for further improving QD-based device performance.

关键词： single quantum dots linear dipole behavior electron transfer polarization property metal oxide nanoparticles

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Establishment of a rat model of chronic thoracolumbar cord compression with a flat plastic screw

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Neural Regeneration Research 2016年第6期11卷 963-970页

作者： yong Sun li-hai zhang Yang-mu fu Zhi-rui li Jian-heng liu Jiang Peng Bin liu Pei-fu tang Department of Orthopedics Chinese PLA General Hospital Department of Orthopedics Research Institute Chinese PLA General Hospital

Previous studies of animal models of chronic mechanical compression of the spinal cord have mainly focused on cervical and thoracic lesions, but few studies have investigated thoracolumbar injury. The specific pathophysiological mechanism of chronic thoracolumbar cord injury has not yet been elucidated. The purpose of this study was to improve animal models of chronic thoracolumbar cord compression using the progressive screw. A custom-designed flat plastic screw was implanted in the spinal cord between thoracic vertebrae 12 and lumbar 1 of rats. The screw was tightened one complete turn（0.5 mm） every 7 days for 4 weeks to create different levels of chronic spinal cord compression. Following insertion of the screw, there was a significant decline in motor function of the hind limbs, and severe stenosis of micro-computed tomography parameters in the spinal cord. Cortical somatosensory evoked potential amplitudes were reduced remarkably, and latencies were prolonged at 30 minutes after surgery. The loss of motor neurons in the gray matter was marked. Demyelination and cavitation were observed in the white matter. An appropriate rat model of chronic thoracolumbar cord compression was successfully created using the progressive screw compression method, which simulated spinal cord compression injury.

关键词： screw thoracic lumbar vertebral minutes evoked stenosis progressive custom prolonged

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Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

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World Journal of Pediatrics 2024年第9期20卷 901-914页

作者： Ying-Shuo Wang Yun-lian Zhou Guan-Nan Bai Shu-Xian li Dan Xu li-Na Chen xing Chen Xiao-Yan Dong Hong-Min fu Zhou fu Chuang-li Hao Jian-Guo Hong En-Mei liu Han-Min liu Xiao-Xia Lu Zheng-Xiu Luo Lan-Fang tang Man Tian yong Yin Xiao-Bo zhang Jian-Hua zhang hai-lin zhang De-Yu zhao Shun-Ying zhao Guo-Hong Zhu Ying-Xue Zou Quan Lu Yuan-Yuan zhang Zhi-Min Chen Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Pulmonology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Department of Pulmonary and Critical Care Medicine Kunming Children’s HospitalKunming 650034China Department of Respiratory Medicine Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Pulmonology Children’s Hospital of Soochow UniversitySuzhou 215003China Department of Pediatrics Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200080China Department of Respiratory Medicine Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Respiratory Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Respiratory Medicine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Respiratory Medicine Children’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Pulmonology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 201102China Department of Pediatric Respiratory Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Respiratory Diseases Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Departmen

Background Mycoplasma pneumoniae(***)is a significant contributor to community-acquired pneumonia among *** 1968,when a strain of *** resistant to macrolide antibiotics was initially reported in Japan,macrolide-resistant ***(MRMP)has been documented in many countries worldwide,with varying incidence *** infections lead to a poor response to macrolide antibiotics,frequently resulting in prolonged fever,extended antibiotic treatment,increased hospitalization,intensive care unit admissions,and a significantly higher proportion of patients receiving glucocorticoids or second-line *** 2000,the global incidence of MRMP has gradually increased,especially in East Asia,which has posed a serious challenge to the treatment of *** infections in children and attracted widespread attention from ***,there is still no global consensus on the diagnosis and treatment of MRMP in *** We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world’s first consensus on the diagnosis and treatment of pediatric MRMP pneumonia,based on evidence *** evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,CNKI,Medline,and the Cochrane *** used variations in terms for“macrolide-resistant”,“Mycoplasma pneumoniae”,“MP”,“***”,“pneumonia”,“MRMP”,“lower respiratory tract infection”,“Mycoplasma pneumoniae infection”,“children”,and“pediatric”.Results Epidemiology,pathogenesis,clinical manifestations,early identification,laboratory examination,principles of antibiotic use,application of glucocorticoids and intravenous immunoglobulin,and precautions for bronchoscopy are *** and rapid identification of gene mutations associated with MRMP is now available by polymerase chain reaction and fluorescent probe techniques in respiratory *** the resistance rate to mac

关键词： Child Macrolide-resistant Mycoplasma pneumoniae Recommendation Diagnosis Treatment

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Genetic Structure and Diversity of Parental Cultivars Involved in China Mainland Sugarcane Breeding Programs as Inferred from DNA Microsatellites

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Journal of Integrative Agriculture 2012年第11期11卷 1794-1803页

作者： QI yong-wen PAN yong-bao LAO Fang-ye zhang Chui-ming FAN li-na HE Hui-yi liU Ruin WANG qin-nan liU Shao-mou liU fu-ye li Qi-wei DENG hai-hua Guangdong Key Laboratory of Sugarcane Improvement and Biorefinery Guangzhou Sugarcane Industry Research Institute Guangzhou 510316 P.R.China USDA-ARS Mid-South Area Sugarcane Research Laboratory Houma 70360 USA

To understand genetic structure and diversity of parental cultivars involved in China Mainland sugarcane breeding programs, 92 elite parents and 4 wild relatives were genotyped with 18 microsatellite DNA markers. The genetic similarity （GS） values among the cultivars ranged from 0.346 to 0.960 with an average of 0.533. Among the introduced cultivars, India accessions had the closest genetic distance to China Mainland accessions （0.447）, while Australia accessions have the furthest distance （0.503）. A comparison of allelic diversity among geographical origins showed that there were 22 China Mainland specific alleles, of which 28% were derived from native S. spontaneaum germplasm in China. Model-based genetic structure, clustering, and principal components analyses consistently revealed there were five groups within the 96 accessions. Groups 1, 2, 4, and 5 consisted of all cultivars and group 3 only contained wild germplasm. Group 2 was characterized as the Introduction group with 46 cultivars predominantly introduced from Australia, Taiwan of China, India, and USA. Groups 1, 4, and 5 consisted of cultivars mostly originated from China Mainland, defined as the Complex group, Yacheng lines group, and F134/CP72-1210 group, respectively, upon their pedigree. By understanding the genetic relationships among the parental cultivars, breeders can gain a rational basis for expanding the gene pool and select the best parental accessions for crossing.

关键词： genetic diversity microsatellite DNA marker population structure sugarcane

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