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绿色化学工程(英文) 2023年第3期4卷 303-311页

作者： Yu Chen Yanlong Wang Yue Bai Minghui Feng Fengyi Zhou Yanhong Lu Yuting Guo yixuan zhang Tiancheng Mu Department of Chemistry and Material Science Langfang Normal UniversityLangfang065000China Hebei Regional Geological Survey Institute Langfang065000China Department of Chemistry Renmin University of ChinaBeijing100872China

Dissolution of lithium cobalt oxide(LCO)is the key step for the recovery of valuable metals(e.g.,Co and Li)from spent LCO-based lithium-ion batteries(LIBs).However,the dissolution process of LCO either needs toxic solvents,and high temperature,or shows low *** eutectic solvents(DESs)are potential green solvents to dissolve ***,DESs with polyethylene glycol(PEG)as hydrogen bond acceptor and ascorbic acid(AA)as hydrogen bond donor are found to dissolve LCO with 84.2%Co leaching efficiency at 80℃ and 72 h,which is higher than that from the reported references by common ***,both DESs components(i.e.,PEG and AA)are cheap,biodegradable,and *** could be easily and abundantly extracted from natural fruits or *** provides a new guide for the green,mild,and efficient dissolution of LCO aiming at sustainable recovery of spent LIBs.

关键词： Low cost Mild condition New energy Green chemistry Green solvents Ascorbic acid

Analyses of active faults, seismic activities and sea floor unstable factors of the Zhujiang River Mouth Basin and its adjacent areas

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Acta Oceanologica Sinica 1990年第3期9卷 413-428页

作者： Liu yixuan, zhang Yixiang, Zhou Jialun , Xie yixuan, Lu Chengbing, Zhong Jianqiang and Zhan Wenhuan South China Sea Institute of Oceanology, Academia Sinica, Guangzhou, China

-On the basis of the data of geophysics and seismic activities, the analyses of the active faults, seismic activities and the sea floor unstable factors of the Zhujiang River Mouth Basin have been made so as to study the characteristics of the compressional subactive continental margin of Cathaysian system, arc littoral strongly active fracture zone, the division of seismic subzone and seismic zone of the continental margin of northern South China Sea, the potential focal area, and to analyze the regional stability. We consider that the Zhujiang River Mouth Basin belongs to a stable or a moderately stable region.

关键词： In high NEE Analyses of active faults

More Than Lightening:A Self-Supervised Low-Light Image Enhancement Method Capable for Multiple Degradations

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 622-637页

作者： Han Xu Jiayi Ma yixuan Yuan Hao zhang Xin Tian Xiaojie Guo the Electronic Information School Wuhan UniversityWuhan 430072China IEEE the Department of Electronic Engineering Chinese University of Hong KongHong Kong 999077China the College of Intelligence and Computing Tianjin UniversityTianjin 300350China

Low-light images suffer from low quality due to poor lighting conditions,noise pollution,and improper settings of *** enhance low-light images,most existing methods rely on normal-light images for guidance but the collection of suitable normal-light images is *** contrast,a self-supervised method breaks free from the reliance on normal-light data,resulting in more convenience and better *** self-supervised methods primarily focus on illumination adjustment and design pixel-based adjustment methods,resulting in remnants of other degradations,uneven brightness and *** response,this paper proposes a self-supervised enhancement method,termed as *** can handle multiple degradations including illumination attenuation,noise pollution,and color shift,all in a self-supervised *** attenuation is estimated based on physical principles and local neighborhood *** removal and correction of noise and color shift removal are solely realized with noisy images and images with color ***,the comprehensive and fully self-supervised approach can achieve better adaptability and *** is applicable to various low light conditions,and can reproduce the original color of scenes in natural *** experiments conducted on four public datasets demonstrate the superiority of SLIE to thirteen state-of-the-art *** code is available at https://***/hanna-xu/SLIE.

关键词： Color correction low-light image enhancement self-supervised learning.

Conditional Generative Adversarial Network Enabled Localized Stress Recovery of Periodic Composites

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 957-974页

作者： Chengkan Xu Xiaofei Wang yixuan Li Guannan Wang He zhang Transportation and Municipal Engineering Institute Powerchina Huadong Engineering CorporationHangzhou310014China College of Civil Engineering and Architecture Zhejiang UniversityHangzhou310058China Anhui Transport Consulting&Design Institute Co. Ltd.Hefei230088China Center for Balance Architecture Zhejiang UniversityHangzhou310058China

Structural damage in heterogeneousmaterials typically originates frommicrostructures where stress concentration ***,evaluating the magnitude and location of localized stress distributions within microstructures under external loading is *** unit cells(RUCs)are commonly used to represent microstructural details and homogenize the effective response of *** work develops a machine learning-based micromechanics tool to accurately predict the stress distributions of extracted *** locally exact homogenization theory efficiently generates the microstructural stresses of RUCs with a wide range of parameters,including volume fraction,fiber/matrix property ratio,fiber shapes,and loading ***,the conditional generative adversarial network(cGAN)is employed and constructed as a surrogate model to establish the statistical correlation between these parameters and the corresponding localized *** stresses predicted by cGAN are validated against the remaining true data not used for training,showing good *** work demonstrates that the cGAN-based micromechanics tool effectively captures the local responses of composite *** can be used for predicting potential crack initiations starting from microstructures and evaluating the effective behavior of periodic composites.

关键词： Periodic composites localized stress recovery conditional generative adversarial network

不同感染方式对狂犬病病毒在人二倍体细胞中增殖的影响

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沈阳药科大学学报 2024年第2期41卷 177-181页

作者：甄祖刚周荔葆王野刘春雨张怡轩沈阳药科大学生命科学与生物制药学院辽宁沈阳110016 辽宁成大生物股份有限公司辽宁沈阳110179

目的考察带毒传代感染、直接吸附感染、混种传代感染三种方式感染人二倍体细胞对狂犬病病毒增殖的影响。方法不同方式感染后,经过细胞工厂生产,获取狂犬病病毒收获液,经过滤澄清、浓缩、纯化、灭活制备疫苗原液。根据《中华人民共和国... 详细信息

目的考察带毒传代感染、直接吸附感染、混种传代感染三种方式感染人二倍体细胞对狂犬病病毒增殖的影响。方法不同方式感染后,经过细胞工厂生产,获取狂犬病病毒收获液,经过滤澄清、浓缩、纯化、灭活制备疫苗原液。根据《中华人民共和国药典》(2020版)检测方法检测收获液病毒滴度及原液抗原含量。结果带毒传代组的收获液病毒滴度为(6.40±0.33)lgLD50·mL^(-1),原液抗原含量为(34.8±1.5)IU·mL^(-1);混种传代感染组的收获液病毒滴度为(6.35±0.18)lgLD50·mL^(-1),原液抗原含量为(34.3±2.1)IU·mL^(-1);直接吸附感染组收获液病毒滴度为(4.71±0.39)lgLD50·mL^(-1),原液抗原含量为(12.6±2.0)IU·mL^(-1)。结论试验证明狂犬病病毒PV株采用混种传代感染的方式感染人二倍体细胞MRC-5细胞,病毒增殖效果良好,毒种代次明确,工艺操作简单,更适合于狂犬疫苗的生产。

关键词：狂犬病病毒人二倍体细胞感染方式抗原含量

生物制药拔尖创新复合型人才培养模式的探索与实践——以沈阳药科大学为例

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高等药学教育研究 2024年第2期 72-75页

作者：陈羽倪现朴吴莹莹隋毅张怡轩沈阳药科大学生命科学与生物制药学院辽宁沈阳110016

中国正在积极推进由制造大国向制造强国、由中国制造向中国智造转变,这就需要高等院校在科技创新领域对工程教育理念、人才培养模式、专业学科结构等方面开展一系列改革。笔者以沈阳药科大学生命基地班为例,探索在新工科背景下,基于OBE... 详细信息

中国正在积极推进由制造大国向制造强国、由中国制造向中国智造转变,这就需要高等院校在科技创新领域对工程教育理念、人才培养模式、专业学科结构等方面开展一系列改革。笔者以沈阳药科大学生命基地班为例,探索在新工科背景下,基于OBE为核心的工程教育理念,实施以“导师制”实现五位一体“3+x”多元拔尖创新复合型人才培养方案,为将来生物制药领域造就拔尖创新高质量工程技术复合型人才奠定基础。

关键词：生物制药拔尖创新人才培养模式

A Tibetan Opera Master

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The Journal of Human Rights 2007年第3期6卷 36-37页

作者： zhang yixuan

At nine o＇clock on the morning of January 19, 2007, bright sunshine covers Quzong, a village in Rinbung County in Tibet＇s Gyangze Prefecture. Ci Ren, 79, leaves home after having buttered tea. He is going to visit Pian Duo, head of the village＇s Jiang Ga Er Tibetan Opera Troupe, to discuss borrowing costumes from the county＇s opera troupe. They plan to perform Tibetan Opera for the villagers for two days. For Ci Ren and his fellow performers, offering theatrical performance has been a routine activity to usher in the Tibetan New Year.

关键词： A Tibetan Opera Master

Let-7i miRNA and platinum loaded nano-graphene oxide platform for detection/reversion of drug resistance and synergetic chemical-photothermal inhibition of cancer cell

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Chinese Chemical Letters 2022年第2期33卷 767-772页

作者： Jianhua Yan yixuan zhang Lijuan Zheng Yuwei Wu Ting Wang Ting Jiang Xiaoqin Liu Dongming Peng Yanfei Liu Zhenbao Liu Department of Pharmaceutics Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha 410013China Department of Pharmaceutical Engineering College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China Department of Medicinal Chemistry School of PharmacyHunan University of Chinese MedicineChangsha 410208China Molecular Imaging Research Center of Central South University Changsha 410008China

The drug resistance of chemotherapy is a major challenge to overcome for antineoplastic agents and the reverse of drug resistant is essential for cancer therapy. Herein, we developed a drug delivery system which can simultaneously detect/reverse the drug resistance and perform synergetic treatment of cancer. In this work, we integrated cyanine5(Cy5) modified mi RNA(let-7 i)(Cy5-mi RNA) and platinum onto nano-graphene oxide(NGO)(30-50 nm) platform to achieve simultaneously detection/reversion of drug resistance and synergetic treatment of cisplatin resistant SKOV3 cells(SKOV3 DDP cells). The Cy5-mi RNA adsorbed on NGO could selectively bind the drug resistance related m RNA follow by suppress the expression of drug resistance m RNA, and the binding simultaneously induced the release of Cy5-mi RNA from the NGO, thus the fluorescence signal of Cy5 recovered and could be used for drug resistance ***, the mi RNA suppressed the Cyclin D1 protein expressions thus reversed the drug resistance. The loaded platinum(Ⅳ)(Pt(Ⅳ)) was converted to the therapeutic platinum(Ⅱ)(Pt(Ⅱ)) in both tumor acidic and reductive environment responsive behavior. NGO furtherly performed photothermal therapy under near infrared(NIR) laser irradiation and enhanced the therapeutic effect. All in all, this nanoplatform realized detection/reversion of the drug resistance as well as synergetic chemical-photothermal treatment of ovarian cancer cells, which holds great promise in the treatment of drug resistant cancer cells.

关键词： Nano-graphene oxide Drug resistance Synergetic chemical-photothermal therapy miRNA Platinum

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农村饮用水菌落总数的测量不确定度评定

食品安全导刊 2024年第25期 79-82,86页

作者：范治东刘丽王丹张亦璇齐曼馨龙文艺邵阳学院医学技术学院湖南邵阳422000

目的:对农村饮用水菌落总数进行测量不确定度评定。方法:采集农村饮用水,采用平板计数法对水样菌落总数进行检测和计数,按照国家计量技术规范相关方法,分析菌落总数的不确定度来源,并评定菌落总数的测量不确定度。结果:重复测定和培养... 详细信息

目的:对农村饮用水菌落总数进行测量不确定度评定。方法:采集农村饮用水,采用平板计数法对水样菌落总数进行检测和计数,按照国家计量技术规范相关方法,分析菌落总数的不确定度来源,并评定菌落总数的测量不确定度。结果:重复测定和培养基配制引入的不确定度贡献较大,其次是样品吸取和稀释体积引入的不确定度;计算得出扩展不确定结果为0.0154,基于该不确定度值计算农村城郊和山区4种水源水(溪水、地下水、水库水和河水)的菌落总数,获得检测结果为170~380 CFU·mL^(-1),均低于500 CFU·mL^(-1),符合《生活饮用水卫生标准》(GB 5749—2022)要求。

关键词：农村饮用水菌落总数不确定度评定

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电力隧道渗漏水成因分析及治理措施研究

农村电气化 2024年第9期 10-13页

作者：张成李上国赵明刘遥张益轩崔奕铭李金涛宋庆贺国网北京市电力公司北京西城100031

电力隧道内电缆数量较多,电缆及其他电力设施对水非常敏感,如果积水淹没电缆(尤其是电缆接头部位),可能会造成事故和损失。文章详细分析了暗挖、盾构等结构形式隧道的渗漏水成因,对管片、环梁、沉降缝、墙体及管孔等部位渗漏水治理措施... 详细信息

电力隧道内电缆数量较多,电缆及其他电力设施对水非常敏感,如果积水淹没电缆(尤其是电缆接头部位),可能会造成事故和损失。文章详细分析了暗挖、盾构等结构形式隧道的渗漏水成因,对管片、环梁、沉降缝、墙体及管孔等部位渗漏水治理措施进行研究,提出了针对性的治理建议并进行了试点应用,为电力隧道渗漏水治理工作提供参考。

关键词：电力隧道渗漏水管片环梁管孔沉降缝