检索结果-南通市图书馆

Understanding enhancing mechanism of Pr_(6)O_(11) and Pr(OH)_(3) in methanol electrooxidation

Journal of Rare Earths 2022年第1期40卷 85-92页

作者： Yang Yang Zhenyu Li Ying Yu xueqiong zhang Hang Wei Haibin Chu Inner Mongolia Engineering and Technology Research Center for Catalytic Conversion and Utilization of Carbon Resource Molecules College of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhot 010021China

The presence of oxygen vacancies and hydroxyl groups are both favorable for the methanol electrooxidation on Pt-based *** and differentiating the enhancing mechanism between oxygen vacancies and hydroxyl groups for high activity of Pt catalysts in methanol oxidation reaction(MOR)is essential but still ***,we developed two kinds of co-catalyst for Pt/CNTs,Pr_(6)O_(11)is rich in oxygen vacancies but contains substantially no hydroxyl groups,while Pr(OH)_(3) possesses abundant hydroxyl groups without oxygen *** a seque nce of designed experiments,it can be found that both oxygen vacancies and hydroxyl groups can improve the performance of Pt/CNTs electrocatalysts,but the enhancing mechanism and improving degree of oxygen vacancies and hydroxyl groups for the MOR are *** the oxygen vacancies are more conducive to increasing the intrinsic activity of the Pt catalyst,and the hydroxyl groups play a decisive role in dehydrogenation and deproto nation of methanol,the co-catalysts with both oxygen vacancies and hydroxyl groups mixed with Pt/CNTs have higher catalytic ***,hydroxyl-rich Pr_(6)O_(11)·xH_(2)O was prepared and used as MOR electrocatalyst after mixed with Pt/*** from the synergistic effect of oxygen vacancies and hydroxyl groups,the Pr_(6)O_(11)·xH_(2)O/Pt/CNTs shows a high peak current density of 741 mA/mg,which is three times higher than that of Pt/*** new discoveries serve as a promising strategy for the rational design of MOR catalysts with low cost and high activity.

关键词： Oxygen vacancies Hydroxyl groups Pr_(6)O_(11) Pr(OH)_(3) Methanol oxidation reaction Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation of Gallic Acid-chitosan Copolymer and Its Antibacterial Activity against Staphylococcus Aureus and Escherichia Coli

引用

Journal of Wuhan University of Technology(Materials Science) 2021年第6期36卷 934-941页

作者： YAN Chunchao XIAO Feng QIU Tong zhang xueqiong ZHAN Siwen LU Mengli YANG Mengjia zhang Juan College of Pharmacy Hubei University of Chinese MedicineWuhan 430065China Department of Pharmacy Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430060China School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China Maternal and Child Health Hospital of Hubei Wuhan 430070China

To synthesize three different grafting ratios of gallic acid(GA)-chitosan(CS)copolymer by a free radical mediated grafting method,which is further applied to the field of antibacterial materials,crosslinking structures of the compound GA-CS copolymer were characterized,fully indicating that gallic acid is resoundingly grafted onto *** grafting ratios of three copolymers GA-CS are 45.71%(Ⅰ),36.12%(Ⅱ),and 18.96%(Ⅲ)were determined by UV-Vis *** minimum inhibitory concentrations of three GA-CS copolymers are 30μg/mL against Escherichia coli and are ranged from 250 to 550μg/mL against Staphylococcus *** counting viable bacterial colonies,it can be found that antibacterial property is preferable by increasing the grafting ratio of GA-CS *** of investigation on aforementioned bacteria experiment indicate that the CFU/mL values of GA-CS(Ⅰ,Ⅱ,Ⅲ)are 2.04×10^(6),7.56×10^(6),1.48×10^(7) to Staphylococcus aureus,and 2.96×10^(6),1.01×10^(7),2.14×10^(7) to Escherichia coli after 12 h *** addition,the interaction process between GA-CS copolymer and bacteria can be observed through a transmission electron *** specific manifestation is that the bacterial cell membranes are ruptured after being treated with the copolymer,which causes the cell contents to flow out,and the cell morphology is shrunk and out ofshape.

关键词： gallic acid chitosan antibacterial activity antibacterial material

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In-situ Gelation of Sodium Alginate-chitosan for Oral Delivery of Probiotics

引用

Journal of Wuhan University of Technology(Materials Science) 2024年第6期39卷 1621-1627页

作者： LI Jie QI Yingxia SONG Feiyu DAI Fuli QIU Tong zhang xueqiong School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China School of Chinese Medicine Macao University of Science and TechnologyMacao 999078China

We developed a new preparation to protect probiotic cells from adverse environmental conditions and improve their livability,which is called Lactobacillus casei-Sodium alginate-Chitosan (LSC).The LSC was prepared by mixing probiotics with sodium alginate-chitosan *** preparation contained complex calcium ions,which were released in the acidic environment of gastric juice,thus crosslinking to form in-situ *** proportions of sodium alginate-chitosan were prepared to add to simulate gastrointestinal fluid to get the best *** optimal ratio of LSC preparation was compared with traditional gel microspheres to observe the survival effect of probiotics in gastrointestinal fluid *** with sodium alginate sol,the porosity of sodium alginate-chitosan sol is lower,which is beneficial to the protection of *** the ratio of chitosan to sodium alginate is 1.5:1.5 (w/v),the protective effect is the *** protective ability of LSC is 64 times that of traditional microspheres,and it has the potential of synergistic anti-tumor.A probiotic preparation with simple preparation process and better protection effect compared with traditional microspheres was prepared,which has joint anti-tumor potential.

关键词： sodium alginate in-situ gelation LSC oral administration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and Evaluation of Dual Targeting Nanoparticles for Oral Cancer

引用

Journal of Wuhan University of Technology(Materials Science) 2019年第6期34卷 1495-1504页

作者： WU Shanshan XIONG Fuliang zhang xueqiong QIU Tong TANG Mingxiu YE Xiaojing CHEN Zhijun ZHOU Gang Department of Phamaceutical Engineering School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China Biomedical Materials and Engineering Center Wuhan University of TechnologyWuhan 430070China The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhan 430072China Department of stomatology Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070China Department of Oral Medicine School and Hospital of StomatologyWuhan UniversityWuhan 430072China

A dual-receptor targeting delivery system based on acid-cleavage hydrazone bond was developed in the study. The characters of CMCS-hyd-CUR-EGFR-mAb were identified. The in vitro release studies revealed that this drug delivery system was acid-sensitive, and the self-assembled nanoparticles which were spherical. The in vitro results indicated that the dual-receptor targeting nanoparticles could be faster internalized into the Cal-27 cells via receptor-mediated endocytosis, which exhibited better antitumor activity than the one-receptor nanoparticles. The experimental results clearly reveal that CMCS-hyd-CUR-EGFR mAb provides a novel way for drug delivery in oral cancer treatment.

关键词： hydrazone bond dual-receptor targeting self-assembly nanoparticle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

pH-sensitive Nanoparticles for High Loading and Efficient Delivery of Doxorubicin

引用

Journal of Wuhan University of Technology(Materials Science) 2023年第4期38卷 929-937页

作者：鲁孟丽黄丽华 ZHAN Siwen LI Juncan QIU Tong YANG Mengjia LI Jie TONG Miao zhang xueqiong 施川 School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan430070China Tongji Medical College Huazhong University of Science and TechnologyWuhan430030China Wuhan Aimin Pharmaceutical Co.Ltd Ezhou436070China Hubei Li Shizhen Pharmaceutical Research Co.Ltd Ezhou436070China

An acid-sensitive delivery system based on acylhydrazone bond was developed for high loading and efficient delivery of ***(DOX)was covalently combined with dihydrazide adipate to form acid-sensitive hydrazone bond based on Schiff base reaction,then the intermediate was covalently combined with carboxymethyl chitosan through amide bond to form polymeric prodrugs,and nanoparticles were formed through ***,the structural and particle properties of CMCS-ADH-DOX were characterized by ultraviolet visible near infrared spectrophotometry(UV),nuclear magnetic resonance spectroscopy(^(1)H-NMR),fourier transform infrared spectroscopy(FT-IR),dynamic light scattering(DLS),and transmission electron microscopy(TEM).The mean diameter of the self-assembled nanoparticles is 165 nm,while the morphology is a relatively uniform spherical ***,these DOXloaded nanoparticles showed pH-triggered drug release *** with free DOX,CAD NPs showed lower toxic side effects in L929 cells and similar toxicity in 4T1 *** experimental results indicate that the CMCS-ADH-DOX nanoparticles may be used as an acid-sensitive targeted delivery system with good application prospect for cancer.

关键词： nanoparticles acylhydrazone bond polymeric prodrug acid-sensitive

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and Evaluation of Novel Chitosan Derivatives for Gene Delivery

引用

Journal of Wuhan University of Technology(Materials Science) 2015年第4期30卷 852-858页

作者：付芳 LIU Xiong 吕波 QU Guoyi ZHENG Hua HUANG Zhijun XU Peihu XU Haixing YIN Yihua LIU Xia zhang xueqiong School of Chemistry Chemical Engineering and Life Sciences Wuhan University of Technology Luo Tian Wan Mizhai Hospital

A series of novel water soluble chitosan derivatives as gene vectors was synthesized. The delivery systems were tested for their ability to form complexes with plasmid DNA by utilizing agarose gel electrophoresis, particle size analysis, zeta potential measurement and scanning electron microscopy. Furthermore, cytotoxicity of chitosan derivatives and transfection efficiency of polyplexes were evaluated in vitro. The experimental results showed that the novel chitosan derivatives had lower cytotoxicity, good DNA condensation, and higher transfection efficiencies compared to chitosan in both 293T and HeLa cell lines. It was indicated that these chitosan derivatives were promising candidates for non-viral gene vectors.

关键词： gene vector transfection efficiency chitosan non-viral vector

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and Evaluation of Insulin-loaded Nanoparticles based on Hydroxypropyl-β-cyclodextrin Modified Carboxymethyl Chitosan for Oral Delivery

引用

Journal of Wuhan University of Technology(Materials Science) 2016年第6期31卷 1394-1400页

作者：宋豪源马晓玲 XIONG Fuliang HONG Hui LI Chunfu LI Lianghong WU Shanshan zhang xueqiong 张娟胡建华 Department of Pharmaceutical Engineering School of Chemistry Chemical Engineering and Life Sciences Wuhan University of Technology Wuhan 430070 China Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients Hubei University of Education Wuhan 430000 China Maternal and Child Health Hospital of Hubei Wuhan 430070 China Beijing You'an Hospital attached to the Capital University of Medical Science Beijin 100069 China

Novel insulin-loaded nanoparticles based on hydroxypropyl-β-cyclodextrin modified carboxymethyl chitosan（CMC-HP-β-CD） were prepared to improve the oral bioavailability of insulin. The CMC-HP-β-CD was characterized by FT-IR spectroscopy and 1H-NMR spectra. The insulin-loaded nanoparticles were prepared through crosslinking with calcium ions, and the morphology and size of the prepared nanoparticles were characterized by transmission electron microscopy（TEM） and dynamic light scattering（DLS）. Cumulative release in vitro study was performed respectively in simulated gastric medium fluid（SGF, p H=1.2）, simulated intestinal fluid（SIF, p H=6.8） and simulated colonic fluid（SCF, p H=7.4）. The encapsulation efficiency of insulin was up to 87.14 ± 4.32% through high-performance liquid chromatography（HPLC）. Statistics indicated that only 15% of the encapsulated insulin was released from the CMC-HP-β-CD nanoparticles in 36 h in SGF, and about 50% of the insulin could be released from the nanoparticles in SIF, whereas more than 80% was released in SCF. In addition, the solution containing insulin nanoparticles could effectively reduce the blood glucose level of diabetic mice. The cytotoxicity test showed that the samples had no cytotoxicity. CMC-HP-β-CD nanoparticles are promising candidates as potential carriers in oral insulin delivery systems.

关键词： carboxymethyl chitosan hydroxypropyl-β-cyclodextrin nanoparticles insulin oral delivery bioavailability cytotoxicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inclusion-Interaction Assembly Strategy for Constructing pH/Redox Responsive Micelles for Controlled Release of 6-Mercaptopurine

引用

Materials Sciences and Applications 2015年第7期6卷 605-616页

作者： Mingyuan Tan Hua Zheng xueqiong zhang Zhiyan Yu Zhao Ye Liyan Shi Kaikai Ding Department of Pharmaceutical Engineering School of Chemistry Chemical Engineering and Life Sciences Wuhan University of Technology Wuhan China

An inclusion-interaction assembly strategy was used to construct novel pH/redox responsive core-shell micelles with hydrophobic drug as the core and hydrophilic polymer as the shell. At first, a dimer of hydrophobic drug 6-mercaptopurine and a hydrophilic β-CD grafted carboxymethyl chitosan were synthesized. Then, a novel amphiphilic inclusion complex was prepared with the dimer being partially embedded into the cavity of β-CD moiety. It self-assembled into pH/redox responsive core-shell micelles in distilled water. TEM confirmed that the micelles possessed a spherical core-shell configuration with a mean size of about 160 nm. DLS showed that the micelles were stable in aqueous solution. Their particle diameters altered with pH values as well as glutathione (GSH) concentrations and respectively attained a maximum value at pH 6.0 and 20 mM GSH. Release profiles of 6-mercaptopurine showed a low release rate (about 27 wt% after 48 h) in pH 7.4 medium with 10 μM GSH, and a marked increase (over 88 wt% after 48 h) in pH 5.0 medium with 20 mM GSH. In vitro cytotoxicity test showed that the micelles had a dose-dependent toxicity for HeLa cells, indicating a great potential for controlled release of 6-mercaptopurine in tumor cells.

关键词： Chitosan Cyclodextrin 6-Mercaptopurine pH-Sensitive Redox-Responsive Controlled Release

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用布洛芬混悬液与对乙酰氨基酚混悬液对高热患儿进行治疗的效果对比

引用

当代医药论丛 2020年第12期18卷 122-123页

作者：张雪琼四川省甘孜藏族自治州人民医院四川甘孜626000

目的:探讨用布洛芬混悬液和对乙酰氨基酚混悬液对高热患儿进行治疗的临床效果。方法:选择2018年3月至2019年3月期间四川省甘孜藏族自治州人民医院收治的62例高热患儿作为研究对象。将这62例患儿分为布洛芬组(n=31)和对乙酰氨基酚组(n=31... 详细信息

目的:探讨用布洛芬混悬液和对乙酰氨基酚混悬液对高热患儿进行治疗的临床效果。方法:选择2018年3月至2019年3月期间四川省甘孜藏族自治州人民医院收治的62例高热患儿作为研究对象。将这62例患儿分为布洛芬组(n=31)和对乙酰氨基酚组(n=31)。为布洛芬组患儿使用布洛芬混悬液进行治疗,为对乙酰氨基酚组患儿使用对乙酰氨基酚混悬液进行治疗。然后,比较两组患儿不良反应的发生率及其在治疗前、治疗1 h时、治疗2 h时、治疗3 h时其体温的情况。结果:治疗后,与对乙酰氨基酚组患儿相比,布洛芬组患儿不良反应的发生率更低,差异有统计学意义(P0.05,t=0.0794)。与对乙酰氨基酚组患儿相比,布洛芬组患儿在治疗1 h时、治疗后2 h时及治疗3 h时其体温均更低,差异有统计学意义(P<0.05)。结论:与使用对乙酰氨基酚混悬液相比,使用布洛芬混悬液对高热患儿进行治疗的临床效果更好,其不良反应的发生率更低。

关键词：布洛芬混悬液对乙酰氨基酚混悬液小儿高热

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于博弈论的入侵检测模型

引用

网络安全技术与应用 2006年第2期 20-22,11页

作者：张雪琼华中科技大学图像识别与人工智能研究所湖北430074

入侵检测系统是保障网络动态安全的一个重要组成部分,但现有的入侵检测技术仍然存在着不容忽视的虚警和漏警,如何制订响应决策成了入侵检测系统的一大难题。将博弈论的思想引入入侵检测系统的决策过程中,提出了一个基于博弈论的入侵检... 详细信息

入侵检测系统是保障网络动态安全的一个重要组成部分,但现有的入侵检测技术仍然存在着不容忽视的虚警和漏警,如何制订响应决策成了入侵检测系统的一大难题。将博弈论的思想引入入侵检测系统的决策过程中,提出了一个基于博弈论的入侵检测模型及其分析方法,并给出了实验分析。

关键词：入侵检查网络安全博弈论

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：