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Total Saponin Fraction of Dioscorea Nipponica Makino Improves Gouty Arthritis Symptoms in Rats via M1/M2 Polarization of Monocytes and Macrophages Mediated by Arachidonic Acid Signaling

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Chinese Journal of Integrative Medicine 2023年第11期29卷 1007-1017页

作者： ZHOU Qi SUN Hui-juan zhang xi-wu Research Institute of Chinese Medicine Heilongjiang University of Chinese MedicineHarbin(150040)China Graduate School Heilongjiang University of Chinese MedicineHarbin(150040)China

Objective:To explore the mechanism of effects of total saponin fraction from Dioscorea Nipponica Makino(TSDN)on M1/M2 polarization of monocytes/macrophages and arachidonic acid(AA)pathway in rats with gouty arthritis(GA).Methods:Seventy-two Sprague Dawley rats were randomly divided into 4 groups(n=18 in each):normal,model,TSDN at 160 mg/kg,and celecoxib at 43.3 mg/*** urate crystal(MSU)was injected into the rats’ankle joints to induce an experimental GA *** and tissue samples were collected on the 3rd,5th,and 8th days of drug *** changes in the synovium of joints were observed via hematoxylin and eosin(HE)*** expression levels of arachidonic acid(AA)signaling pathway were assessed via real-time polymerase chain reaction(q PCR)and Western *** cytometry was used to determine the proportion of M1 and M2 macrophages in the peripheral *** enzyme-linked immunosorbent assay(ELISA)was used to detect interleukine(IL)-1β,tumor necrosis factoralpha(TNF-α),IL-4,IL-10,prostaglandin E_(2)(PGE_(2)),and leukotriene B4(LTB4).Results:HE staining showed that TSDN improved the synovial tissue.q PCR and Western blot showed that on the 3rd,5th and 8th days of drug administration,TSDN reduced the m RNA and protein expressions of cyclooxygenase(COX)2,microsomal prostaglandin E synthase-1 derived eicosanoids(m PGES-1),5-lipoxygenase(5-LOX),recombinant human mothers against decapentaplegic homolog 3(Smad3),nucleotide-binding oligomerization domain-like receptor protein 3(NALP3),and inducible nitric oxide synthase(i NOS)in rats’ankle synovial tissues(P<0.01).TSDN decreased COX1 m RNA and protein expression on 3rd and 5th day of drug administration and raised it on the 8th day(both P<0.01).It lowered CD68 protein expression on days 3(P<0.01),as well as m RNA and protein expression on days 5 and 8(P<0.01).On the 3rd,5th,and 8th days of drug administration,TSDN elevated the m RNA and protein expression of Arg1 and CD163(P<0.01).F

关键词： Smad3 Blood mother

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Differential mRNA expression levels and gene sequences of carboxylesterase in both deltamethrin resistant and susceptible strains of the cotton aphid, Aphis gossypii

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Insect Science 2008年第3期15卷 209-216页

作者： Chuan-Wang Cao Jing zhang xi-wu Gao Pei Liang Hui-Lin Guo Department of Entomology China Agricultural University Beijing China

Extensive use of insecticides on cotton has prompted resistance development in the cotton aphid, Aphis gossypii （Glover） in China, A deltamethrin-selected population of cotton aphids from xinjiang Uygur Autonomous Region, China with 228,59-fold higher resistance to deltamethrin was used to examine how carboxylesterase conferred resistance to this pyrethroid insecticide. The carboxylesterase activity in the deltamethrin-resistant strain was 3.67-, 2,02- and 1.16-fold of the susceptible strain when using α-naphthyl acetate （α-NA）, β-naphthyl acetate （β-NA） and α-naphthyl butyrate （α-NB） as substrates, respectively, Carboxylesterase cDNA was cloned and sequenced from both deltamethrinresistant and susceptible strains. The cDNA contained 1581 bp open reading frames （ORFs） coding a 526 amino acid protein. Only one amino acid substitution （Val^87-Ala） was observed between deltamethrin-resistant and susceptible strains but it is not genetically linked to resistance by the catalytic triad and signature motif analysis. The real-time polymerase chain reaction analysis indicated that the resistant strain had a 6.61-fold higher level of carboxylesterase mRNA than the susceptible strain. The results revealed that up-regulation of the carboxylesterase gene, not modified gene structure, may be responsible for the development of resistance in cotton aphids to deltamethrin.

关键词： Aphis gossypii (Glover) carboxylesterase deltamethrin resistance genesequence mRNA expression

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空间曲面纤维网格制作及加固水下混凝土柱试验研究

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土木工程学报 2017年第10期50卷 45-53,90页

作者：魏洋张希吴刚纪军张敏南京林业大学江苏南京210037 东南大学混凝土及预应力混凝土结构教育部重点实验室江苏南京210096 北京特希达技术研发有限公司北京100011

平面纤维(FRP)网格以其卓越的性能在特定结构加固方面具有较好的应用优势,但其对小尺寸曲面、异形混凝土结构构件的约束加固并不适用。提出了空间曲面纤维网格制作工艺,制作了曲面纤维网格制品,测试了纤维网格拉伸的力学性能;提出了空... 详细信息

平面纤维(FRP)网格以其卓越的性能在特定结构加固方面具有较好的应用优势,但其对小尺寸曲面、异形混凝土结构构件的约束加固并不适用。提出了空间曲面纤维网格制作工艺,制作了曲面纤维网格制品,测试了纤维网格拉伸的力学性能;提出了空间曲面纤维网格加固水下混凝土柱的施工工艺,并进行了轴压试验研究,试验结果表明:空间曲面纤维网格加固水下混凝土试件的轴压性能明显优于未加固混凝土圆柱试件,随着纤维网格纤维用量的增加,加固试件的承载能力和变形能力能有效提高,并取得和陆上试件相近的加固效果,根据纤维网格约束量的不同,水下加固试件的应力-应变曲线表现为软化、强化与临界行为,采用现有FRP约束混凝土模型能够较好地预测空间曲面纤维网格加固水下混凝土的极限应力与极限应变。

关键词：混凝土结构空间曲面水下加固技术纤维网格力学性能

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Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations: A Review

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Structural Durability & Health Monitoring 2025年第1期19卷 25-54页

作者： Chao zhang Shang-xi Lai Hua-Ping Wang School of Civil Engineering and Mechanics Lanzhou UniversityLanzhou730000China Key Laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou730000China

Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the ***,it is particularly signiﬁcant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientiﬁc basis for structural damage identiﬁcation and dynamic model modiﬁ*** view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and brieﬂy describes how to identify structural damages based on the derived modal *** paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),brieﬂy describes damage identiﬁcation methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artiﬁcial intelligence(AI)methods in the direction of modal parameter recognition and damage identiﬁcation is further *** on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identiﬁcation methods are given to provide scientiﬁc references for the optimized design and functional upgrading of SHM systems.

关键词： Structural health monitoring data information modal parameters damage identiﬁcation AI method

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Smart Cellulose‑Based Janus Fabrics with Switchable Liquid Transportation for Personal Moisture and Thermal Management

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Nano-Micro Letters 2025年第1期17卷 333-347页

作者： Jianfeng xi Yanling Lou Liucheng Meng Chao Deng Youlu Chu Zhaoyang Xu Huining xiao Weibing wu Jiangsu Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsJiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass MaterialsNanjing Forestry UniversityNanjing 210037People’s Republic of China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering University of New BrunswickFrederictonNB E3B 5A3Canada Macromolecular Chemistry and Bavarian Polymer Institute University of BayreuthBayreuth 95440Germany

The Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human ***,the development of smart and dynamic fabrics capable of managing personal moisture/thermal comfort in response to changing external environments remains a ***,a smart cellulose-based Janus fabric was designed to dynamically manage personal moisture/*** cotton fabric was grafted with N-isopropylacrylamide to construct a temperature-stimulated transport ***,hydrophobic ethyl cellulose and hydrophilic cellulose nanofiber were sprayed on the bottom and top sides of the fabric to obtain wettability *** fabric exhibits anti-gravity directional liquid transportation from hydrophobic side to hydrophilic side,and can dynamically and continuously control the transportation time in a wide range of 3–66 s as the temperature increases from 10 to 40℃.This smart fabric can quickly dissipate heat at high temperatures,while at low temperatures,it can slow down the heat dissipation rate and prevent the human from becoming too *** addition,the fabric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic *** smart fabric offers an innovative approach to maximizing personal comfort in environments with significant temperature variations.

关键词： Directional water transport Cotton fabric Anti-gravity directional liquid transportation Janus wettability

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A quantum-search-based multi-classifier for image recognition

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 21-31页

作者： Lu Liu xingyu wu Lufan zhang Chuan Wang School of Artificial Intelligence Beijing Normal University Applied Optics Beijing Area Major Laboratory Beijing Normal University

The multi-class classification of images is a pivotal challenge within the realm of image processing. As the volume of visual data continues to expand, there is a burgeoning interest in harnessing the unique capabilities of quantum computation to augment the efficiency of classification tasks. However, many existing methods for training quantum image multi-classifiers parallel classical machine learning techniques, where the requisite circuit measurements increase linearly with the volume of training data. This work introduces a novel approach for training a quantum image multi-classifier based on the quantum search algorithm. We have meticulously conducted rigorous experiments on a handwritten digit dataset, a classic benchmark in the field. The results have been meticulously compared with previous works, and the comparative analysis not only validates the efficiency of our proposed approach, requiring only O(N/b) measurements during training, but also highlights a significant quadratic speedup of the algorithm.

关键词： quantum computation image recognition quantum search algorithm

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综采加长工作面技术研究及实践

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煤炭科学技术 2007年第8期35卷 14-17+21页

作者：张喜武神华集团有限责任公司北京100011

在分析国内外综采加长工作面技术发展现状的基础上,从理论和实践2方面就综采工作面加长后工作面矿压规律的变化和工作面配套设备参数的选择等进行了系统研究,结合神东矿区应用情况,对加长工怍面技术应用效果进行了分析,提出该技术的应... 详细信息

在分析国内外综采加长工作面技术发展现状的基础上,从理论和实践2方面就综采工作面加长后工作面矿压规律的变化和工作面配套设备参数的选择等进行了系统研究,结合神东矿区应用情况,对加长工怍面技术应用效果进行了分析,提出该技术的应用前景和发展方向。

关键词：煤矿综采加长工作面矿压规律配套设备

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坚持自主创新,实现本质安全——神华创建煤矿本质安全型企业的探索与实践

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煤炭工程 2006年第8期 36-39页

作者：张喜武神华集团有限责任公司北京100011

论文科学地分析了煤矿本质安全型企业的特征和支撑体系,并结合神华近年来“四坚持、四强化”的基本探索与实践,提出了建立本质安全型管理系统的基本思路,从系统管理的角度提出了自主创新安全理念、创新安全技术、创新安全管理、创新安... 详细信息

论文科学地分析了煤矿本质安全型企业的特征和支撑体系,并结合神华近年来“四坚持、四强化”的基本探索与实践,提出了建立本质安全型管理系统的基本思路,从系统管理的角度提出了自主创新安全理念、创新安全技术、创新安全管理、创新安全教育培训等实现本质安全的途径。

关键词：本质安全自主创新神华特色系统管理

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微小RNA心肌缺血后心脏保护机制的研究进展

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中华心血管病杂志 2011年第6期39卷 568-570页

作者：解冰张锡武何斌第二军医大学附属长海医院烧伤外科上海200433

微小RNA（microRNA,miRNA）是一类含约22个核苷酸的非编码小分子单链RNA,其序列高度保守,可以在转录后水平特异性识别靶基因的3′非翻译区（3′UTR）上的相应靶位点,通过抑制或降解特定的靶基因而发挥调节蛋白质合成的作用[1].自从1993... 详细信息

微小RNA（microRNA,miRNA）是一类含约22个核苷酸的非编码小分子单链RNA,其序列高度保守,可以在转录后水平特异性识别靶基因的3′非翻译区（3′UTR）上的相应靶位点,通过抑制或降解特定的靶基因而发挥调节蛋白质合成的作用[1].自从1993年第一个miRNA lin-4被发现以来,短短十几年间已经有近千种miRNA陆续被发现.大量研究表明,其几乎参与人类生命活动及疾病进程各个方面的调控[2].特别是近些年来,随着冠心病的发病率及死亡率日趋升高,miRNA在心血管疾病的病理生理过程中的调控机制已成为当前研究的热点,尤其在心肌缺血再灌注损伤（ischemia/reperfusion injury）的心肌保护机制方面,其可能发挥非常关键的作用,正成为各国学者研究的主要方向.

关键词：心肌缺血再灌注损伤微小RNA 心脏保护机制缺血后 miRNA 病理生理过程特异性识别蛋白质合成

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan Li xi Liu Wenping Liang Yu Li Liyong wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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