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Synthetic and Systems Biotechnology 2024年第2期9卷 380-387页

作者： Xinye Wang Yiyi Huang weiyan zhang Kangjie Lv Xiaoying Li Zhixin Wang Li zhang Tom Hsiang Lixin zhang Liming Ouyang Xueting Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237China Department of Chemistry Boston UniversityBostonMAUSA School of Environmental Sciences University of Guelph50 Stone Road EastGuelphOntarioN1G 2W1Canada

Fungal bifunctional terpene synthases(BFTSs)catalyze the formation of numerous di-/sester-/tri-terpenes ***,the mechanism in controlling the cyclization pattern of terpene scaffolds is rarely deciphered for further application of tuning the catalytic promiscuity of terpene synthases for expanding the chemical *** this study,we expanded the catalytic promiscuity of Fusarium oxysporum fusoxypene synthase(FoFS)by a single mutation at L89,leading to the production of three new *** computational analysis revealed that the reconstitution of the hydrogen-bond(H-bond)network of second-shell residues around the active site of FoFS influences the orientation of the aromatic residue W69 within the first-shell catalytic ***,the dynamic orientation of W69 alters the carbocation transport,leading to the production of diverse ring system *** findings enhance our knowledge on understanding the molecular mechanisms,which could be applied on protein engineering terpene synthases on regulating the terpene skeletons.

关键词： Bifunctional terpene synthase Sesterterpene Carbocation transportation Density functional theory calculations Molecular dynamics simulations

Equation of state for boron nitride along the principal Hugoniot to 16 Mbar

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Matter and Radiation at Extremes 2024年第5期9卷 77-86页

作者： Huan zhang Yutong Yang Weimin Yang Zanyang Guan Xiaoxi Duan Mengsheng Yang Yonggang Liu Jingxiang Shen Katarzyna Batani Diluka Singappuli Ke Lan Yongsheng Li Wenyi Huo Hao Liu Yulong Li Dong Yang Sanwei Li Zhebin Wang Jiamin Yang Zongqing Zhao weiyan zhang Liang Sun Wei Kang Dimitri Batani National Key Laboratory of Plasma Physics Laser Fusion Research CenterChina Academy of Engineering PhysicsMianyang 621900China HEDPS Center for Applied Physics and Technologyand College of PhysicsPeking UniversityBeijing 100871China HEDPS Center for Applied Physics and Technologyand School of EngineeringPeking UniversityBeijing 100871China Institute of Plasma Physics and Laser Microfusion Hery 2301-497 WarszawaPoland Universitéde Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications)UMR 5107F-33405 TalenceFrance Institute of Applied Physics and Computational Mathematics Beijing 100094China

The thermodynamic properties of boron nitride under extreme pressures and temperatures are of great interest and importance for materials science and inertial confinement fusion physics,but they are poorly understood owing to the challenges of performing experiments and realizing ab initio ***,we report the first shock Hugoniot data on hexagonal boron nitride at pressures of 5–16 Mbar,using hohlraum-driven shock waves at the SGIII-p laser facility in *** density functional theory molecular dynamics calculations closely match experimental data,validating the equations of state for modeling the shock response of boron nitride and filling a crucial gap in the knowledge of boron nitride properties in the region of multi-Mbar pressures and eV *** results presented here provide fundamental insights into boron nitride under the extreme conditions relevant to inertial confinement fusion,hydrogen–boron fusion,and high-energy-density physics.

关键词： boron Hugoniot extreme

Carrier frequency and symbol rate estimation based on cyclic spectrum

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Journal of Systems Engineering and Electronics 2020年第1期31卷 37-44页

作者： CAO Sisi zhang weiyan Institute of Computer Applications China Academy of Engineering Physics

Carrier frequency and symbol rate estimation are the main contents of parameter estimation,which is the basis of modulation recognition and further processing of signals especially in non-cooperative *** the development of wireless communication,the signal transmission environment has become increasingly bad,causing more difficulties in parameter *** is well known that the signal cycle spectrum is robust to noises and signal parameters are closely *** practice,it is impossible to calculate the cyclic spectrum of infinite length data *** using finite length data to obtain a cycle spectrum,the truncation noise is induced,resulting in *** is necessary to overcome the influence of noises in order to improve the detection ability of discrete spectral *** improved method of the discrete spectral line extraction algorithm is proposed by reflecting the amplitude advantage of discrete spectral lines through salient features of continuous noises in discrete spectral line neighborhood.

关键词： digital modulation signal carrier frequency symbol rate cyclic spectrum noise control

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环境因素对水痘发病影响的研究进展

中华疾病控制杂志 2024年第1期28卷 101-107页

作者：栾桂杰张伟燕刘少楠陈萌孙靓山东省疾病预防控制中心免疫预防管理所济南250014

目的综合分析气象因素和大气污染等环境因素对水痘发病的影响。方法在中国知网、万方、Web of Science、PubMed等数据库检索2021年12月31日前发表的环境因素与水痘发病关系的文献,对纳入研究的基本信息、方法和结果等进行整理分析。结... 详细信息

目的综合分析气象因素和大气污染等环境因素对水痘发病的影响。方法在中国知网、万方、Web of Science、PubMed等数据库检索2021年12月31日前发表的环境因素与水痘发病关系的文献,对纳入研究的基本信息、方法和结果等进行整理分析。结果共纳入19项气象因素研究和3项大气污染研究。气温、相对湿度和降水的变化会造成水痘发病的增多,大气压、风速、日照等与水痘发病之间的相关性存在地区差异;PM2.5、PM10和NO2等大气污染物会增加水痘发病的风险。结论气象因素和大气污染等环境因素暴露会影响水痘的发病,需采取针对性的防护措施。

关键词：环境因素气象因素大气污染水痘

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基于跨层级多视角特征的多语言事件探测

计算机科学 2024年第5期51卷 208-215页

作者：张志远张维彦宋雨秋阮彤华东理工大学信息工程与科学学院上海200237

多语言事件探测任务的目标是将多种语言的新闻文档集合组织成不同的关键事件,其中每个事件可以包含不同语言的新闻文档。该任务有助于各种下游任务应用,如多语言知识图谱构建、事件推理、信息检索等。目前,多语言事件探测主要分为先翻... 详细信息

多语言事件探测任务的目标是将多种语言的新闻文档集合组织成不同的关键事件,其中每个事件可以包含不同语言的新闻文档。该任务有助于各种下游任务应用,如多语言知识图谱构建、事件推理、信息检索等。目前,多语言事件探测主要分为先翻译再事件探测与先单语言检测再跨多种语言对齐两种方法,前者依赖翻译的效果,后者需要为每种语言单独训练模型。为此,提出了一种名为基于跨层级多视角特征融合的多语言事件探测方法,端到端地进行多语言事件探测任务。该方法从不同层级利用文档的多视角特征,获得了高可靠性的多语言事件探测结果并提升了低资源语言事件探测的泛化性能。在9种语言混合的新闻数据集上进行的实验表明,所提方法的BCubed F1值提升了4.63%。

关键词：多语言预训练模型多语言事件探测新闻文档聚类加权相似度增量聚类

山东省8月龄儿童麻腮风联合减毒活疫苗与乙型脑炎减毒活疫苗同时接种的不良反应监测分析

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中国疫苗和免疫 2024年第1期30卷 83-86页

作者：谢萌冯蕾张伟燕许青刘少楠孙辉峰孙靓张丽山东省疾病预防控制中心山东济南250014

目的分析8月龄儿童麻腮风联合减毒活疫苗(Measles,mumps and rubella combined attenuated live vaccine,MMR)与乙型脑炎减毒活疫苗(Japanese encephalitis attenuated live vaccine,JEV-L)同时接种的不良反应。方法通过山东省免疫规划信息系统和中国疑似预防接种异常反应监测系统收集山东省2020年出生且满8月龄儿童MMR和JEV-L同时或单独接种的剂次数和不良反应个案,采用泊松回归模型计算不良反应报告发生率的95%置信区间(Confidence interval,CI)。结果山东省8月龄儿童MMR与JEV-L同时接种、MMR单独接种、JEV-L单独接种一般反应报告发生率(/10万剂)分别为103.90(95%CI:92.01-117.32)、119.49(95%CI:109.40-130.50)、49.29(95%CI:42.85-56.69),异常反应分别为3.20(95%CI:1.60-6.29)、4.11(95%CI:2.56-6.61)、0.50(95%CI:0.13-2.01)。结论8月龄儿童同时接种MMR和JEV-L同时接种或单独接种的不良反应发生率均在预期范围内,同时接种未增加不良反应的发生风险。

关键词：麻腮风联合减毒活疫苗乙型脑炎减毒活疫苗同时接种不良反应监测

Ice sheet controls on fine-grained deposition at the southern Mendeleev Ridge since the penultimate interglacial

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Acta Oceanologica Sinica 2020年第9期39卷 86-95页

作者： Liming Ye Xiaoguo Yu weiyan zhang Rong Wang Key Laboratory of Submarine Geosciences Ministry of Natural ResourcesHangzhou 310012China Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China

Clay minerals deposited at the southern Mendeleev Ridge in the Arctic Ocean have a unique provenance,which can be used to reconstruct changes in the local sedimentary *** show that sediments in core ARC7-E23 record high-frequency changes in clay minerals since the penultimate *** clay minerals,grain size,and ice-rafted debris indicate the extent of the East Siberia Ice Sheet(ESIS).During the glacial periods of Marine Isotope Stage 2(MIS2)and MIS4,the southern Mendeleev Ridge was likely covered by an ESIS-extended ice shelf,blocking almost all sediment input from the Canadian Arctic and Laptev Sea,but allowing transport of fine-grained sediments from the East Siberian and Chukchi Sea *** ESIS retreat,the Beaufort Gyre and Transpolar Drift became the primary transport mechanism for the distally sourced *** conditions in MIS3 enhanced both the oceanic circulation and sediment transport.

关键词： Arctic Ocean Mendeleev Ridge East Siberian Ice Sheet clay minerals

山东省预防接种单位工作人员成人疫苗知识和态度及行为调查分析

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中华预防医学杂志 2024年第8期58卷 1252-1255页

作者：胡苏兰于洋张伟燕张英洁李仁鹏徐爱强杨正辉乳山市疾病预防控制中心乳山264500 威海市卫生健康服务中心威海264200 山东省疾病预防控制中心免疫预防管理所济南250014 山东省疾病预防控制中心人力资源部济南250014 山东省地方病防治研究所济南250014 山东大学预防医学研究院、山东省传染病预防控制重点实验室济南250014 威海市疾病预防控制中心威海264200

为了解山东省预防接种单位工作人员对流感、肺炎球菌、人乳头瘤病毒、带状疱疹、新型冠状病毒、乙肝等成人疫苗接种知识、态度、行为(KAP),于2022年8—9月,对山东省12县(市、区)797名成人预防接种单位工作人员进行了调查分析。结果显示... 详细信息

为了解山东省预防接种单位工作人员对流感、肺炎球菌、人乳头瘤病毒、带状疱疹、新型冠状病毒、乙肝等成人疫苗接种知识、态度、行为(KAP),于2022年8—9月,对山东省12县(市、区)797名成人预防接种单位工作人员进行了调查分析。结果显示,调查对象新型冠状病毒疫苗知识和态度总得分最高,M(Q_(1),Q_(3))为23(20,25)分和10(10,10)分,带状疱疹疫苗得分最低,分别为19(15,22)分和8(8,10)分。疫苗知识点"疫苗适用人群"得分最高,M(Q_(1),Q_(3))为26(23,30)分,"禁忌证/不良反应"及"不良反应处置"得分较低,总得分M(Q_(1),Q_(3))分别为24(20,29)分和24(20,28)分。89.71%调查对象2年内至少接种1种成人疫苗,53.58%接种者为自身内在认知驱动接种,认为"有必要接种",66.00%未接种任何成人疫苗的调查对象对接种必要性认知不足,认为"自己身体健康,没必要接种疫苗"。综上,山东省成人预防接种单位工作人员在疫苗方面对带状疱疹疫苗总体认知不足,在成人预防接种知识点方面,对"禁忌证/不良反应及处置"认知相对较差。

关键词：医务人员成人疫苗知识态度行为横断面研究

Mineralogy and Chemistry of Sulfides from the Longqi and Duanqiao Hydrothermal Fields in the Southwest Indian Ridge

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Acta Geologica Sinica(English Edition) 2018年第5期92卷 1798-1822页

作者： zhang Baisong LI Zhenqing HOU Zengqian zhang weiyan XU Bo China University of Geosciences Beijing 100083 Institute of Mineral Resources Chinese Academy of Geological Sciences Beijing 100037 Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 Second Institute of Oceanography State Oceanic Administration Hangzhou 310012

Recent investigations found that hydrothermal activity and sulfide mineralization occurs along the Southwest Indian Ridge（SWIR）. The Longqi and Duanqiao hydrothermal fields between 49° E and 53° E of the SWIR are two prospective mineralization areas discovered by Chinese scientists. With the aim to determine the mineralogical and chemical characteristics of sulfide minerals, we have conducted detailed studies for samples from the two areas using an optical microscope, X-ray diffractometer, scanning electron microscope, and electron microprobe. The mineralization processes in the Longqi area are divided into three main stages：（1） the low-medium-temperature stage： colloform pyrite（Py I）＋ marcasite → euhedral pyrite（Py II）,（2） the high-temperature stage： isocubanite（±exsolved chalcopyrite）＋ pyrrhotite → coarse-grained chalcopyrite（Ccp I）, and（3） the medium–low-temperature stage： sphalerite ＋ fine-grained chalcopyrite inclusions（Ccp II） → aggregates of anhedral pyrite（Py III） ± marcasite → Fe-oxide（-hydroxide）＋ amorphous silica. The mineralization processes in the Duanqiao area are divided into two main stages：（1） the medium–high-temperature stage： subhedral and euhedral pyrite（Py I′） → coarse-grained chalcopyrite（Ccp I′） and（2） the medium–low-temperature stage： sphalerite → fine-grained chalcopyrite（Ccp II′）＋ chalcopyrite inclusions（Ccp II′） → silica-cemented pyrite（Py II′）＋ marcasite → Fe-oxide ＋ amorphous silica. We suggest that the fine-grained chalcopyrite inclusions in sphalerite from Longqi and Duanqiao were formed by co-precipitation and replacement mechanisms, respectively. Primary sphalerites from both fields are enriched in Fe（avg. 5.84 wt% for the Longqi field vs. avg. 3.69 wt% for the Duanqiao field）, Co（avg. 185.56 ppm for the Longqi field vs. 160.53 ppm for the Duanqiao field）, and Cd（avg. 1950 ppm for the Longqi field vs. avg. 525.26 ppm for the Duanqiao field）. Cu contents in pyrite from the Duanqiao field（Py I′： avg. 849.23 ppm and Py II′： avg. 11

关键词： mineralogy mineralogical chemistry Longqi Duanqiao Southwest Indian Ridge(SWIR)

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山东省疫苗冷链监测平台建设与应用评价

中国疫苗和免疫 2024年第2期30卷 225-230页

作者：栾桂杰刘少楠孙靓刘尧储凌孙辉峰张伟燕山东省疾病预防控制中心山东济南250014 苏州市伏泰信息科技股份有限公司江苏苏州215004

目的分析山东省疫苗冷链监测平台建设和运行情况。方法采用5G、大数据、物联网等先进技术,利用5G温湿度记录设备采集数据,建设覆盖全省疾病预防控制机构(Center for disease control and prevention,CDC)和预防接种单位的疫苗冷链监测平... 详细信息

目的分析山东省疫苗冷链监测平台建设和运行情况。方法采用5G、大数据、物联网等先进技术,利用5G温湿度记录设备采集数据,建设覆盖全省疾病预防控制机构(Center for disease control and prevention,CDC)和预防接种单位的疫苗冷链监测平台,评价2023年平台运行效果。结果山东省冷链监测平台覆盖了省级CDC、16个市级CDC、152个县级CDC和4202个预防接种单位,配备了5313个温湿度记录设备。平台的核心业务功能包括冷链设备温度实时监测、异常状况报警、管理质量评价等。2023年冷链设备(以某普通冷库为例)温度稳定值范围为0.33-0.56,稳定性好;平均每台设备月异常温度报警数为1.4条,其中省级、市级、县级CDC和预防接种单位分别为0.6条、1.4条、1.7条和1.4条;各单位冷链设备档案完整率、数据上传及时率、冷链云注册率、单位审核完整率和报警处置及时率分别为99.98%-100%、99.45%-100%、98.11%-100%、98.33%-100%和89.70%-100%。结论山东省疫苗冷链监测平台实现了疫苗储存运输全过程温度监测,提升了疫苗冷链管理水平,保障了疫苗安全性和有效性。

关键词：疫苗冷链监测平台建设应用