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Humulus lupulus L. Extract Prevents Ovariectomy-Induced Osteoporosis in Mice and Regulates Activities of Osteoblasts and Osteoclasts

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Chinese Journal of Integrative Medicine 2021年第1期27卷 31-38页

作者： XIA Tian-shuang LIN Liu-yue zhang qiao-yan JIANG Yi-ping LI Chang-hui LIU Xiao-yan QIN Lu-ping XIN Hai-liang Department of Pharmacognosy School of PharmacySecond Military Medical UniversityShanghai(200433)China Schoolof Pharmacy Fujian University of Traditional Chinese MedicineFuzhou(350108)China School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou(310053)China

Objective:To systematically evaluate the protective effects of Humulus lupulus ***(HLE)on osteoporosis ***:In vivo experiment,a total of 3512-week-old female ICR mice were equally divided into 5 groups:the sham control group(sham);the ovariectomy with vehicle group(OVX);the OVX with estradiol valerate[EV,0.2 mg/(kg·d)];the OVX with low-or high-dose HLE groups[HLE,1 g/(kg·d)and 3 g/(kg·d)],7 in each *** began 1 week after the ovariectomized surgery and lasted for 12 *** mass and trabecular bone mircoarchitecture were evaluated by micro computed tomography,and bone turnover markers in serum were evaluated using enzyme-linked immunosorbent assay(ELISA)*** vitro experiment,osteoblasts and osteoclasts were treated with HLE at doses of 0,4,20 and 100μg/*** for bone formation in osteoblasts and bone resorption in osteoclasts were ***:Compared with the OVX group,HLE exerted bone protective effects by the increase of estradiol(P<0.05),the improvement of cancellous bone structure,bone mineral density(P<0.01)and the reduction of serum alkaline phosphatase(ALP),tartrate resistant acid phosphatase(TRAP),bone gla-protein,c-terminal telopeptides of typeⅠcollagen(CTX-Ⅰ)and deoxypyridinoline levels(P<0.01 for all).In vitro experiment,compared with the control group,HLE at 20μg/mL promoted the cell proliferation(P<0.01),and increased the expression of bone morphogenetic protein-2 and osteopontin levels in osteoblasts(both P<0.05).HLE at 100μg/mL increased the osteoblastic ALP activities,and HLE at all dose enhanced the extracellular matrix mineralization(both P<0.01).Furthermore,compared with the control group,HLE at 20μg/m L and 100μg/m L inhibited osteoclastic TRAP activity(P<0.01),and reduced the expression of matrix metalloproteinase-9 and cathepsin K(both P<0.05).Conclusion:HLE may protect against bone loss,and have potentials in the treatment of osteoporosis.

关键词： Humulus lupulus L. osteoporosis ovariectomy-induced mice osteoblasts osteoclasts

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Rubus chingii Hu: an overview of botany, traditional uses,phytochemistry, and pharmacology

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Chinese Journal of Natural Medicines 2020年第6期18卷 401-416页

作者： SHENG Jia-Yun WANG Si-Qi LIU Kao-Hua ZHU Bo zhang qiao-yan QIN Lu-Ping WU Jian-Jun School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou 310053China

Rubus chingii Hu, a member of the rosaceae family, is extensively distributed in China and Japan. Its unripe fruits(Fupenzi in Chinese) have a long history of use as an herbal tonic in traditional Chinese medicine for treating various diseases commonly associated with kidney deficiency, and they are still in use today. Phytochemical investigations on the fruits and leaves of R. chingii indicate the presence of terpenoids, flavonoids, steroids, alkaloids, phenylpropanoids, phenolics, and organic acids. Extracts or active substances from this plant are reported to have various pharmacological properties, including antioxidant, anti-inflammatory, antitumor, antifungal, antithrombotic, antiosteoporotic, hypoglycemic, and central nervous system-regulating effects. This review provides up-to-date information on the botanical characterizations, traditional usages, chemical constituents, pharmacological activities, toxicity,and quality control of R. chingii. Possible directions for future research are also briefly proposed. This review aims to supply fundamental data for the further study of R. chingii and contribute to the development of its clinical use.

关键词： Rubus chingii Hu Botany Traditional uses Phytochemistry Pharmacology Review

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Evaluation of coronary plaque and stent deployment by intravascular optical coherence tomography in elderly patients with unstable angina and non-ST-elevation myocardial infarction

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Journal of Geriatric Cardiology 2007年第1期4卷 3-9页

作者： Caiyi LU Shiwen WANG Wei yan Xingli WU Yuxiao zhang qiao XUE Muyang yan Peng LIU Rui CHEN Jinyue ZHAI Institute of Geriatric Cardiology Chinese PLA General HospitalBeijing 100853China

Objective To evaluate the feasibility and efficacy of intravascular optical coherence tomography(OCT)in the assessment of plaque characteristics and drug eluting stent deployment quality in the elderly patients with unstable angina(UA)and non-ST segment elevation myocardial infarction(NSTEMI).Methods OCT was used in elderly patients undergoing percutaneous coronary *** patients,9 males and 6 females with mean age of 72.6±5.3 years(range 67-92 years)were enrolled in the *** were obtained before initial balloon dilatation and following stent *** plaque characteristics before dilation,vessel dissection,tissue prolapse,stent apposition and strut distribution after stent implantation were *** Fifteen lesions were selected from 32 angiographic lesions as study lesions for OCT imaging after diagnostic coronary *** were 7 lesions in the left anterior descending artery,5 lesions in the right coronary artery and 3 lesions in the left circumflex coronary *** them,12(80.0%)were lipid-rich plaques,and 10(66.7%)were vulnerable plaques with fibrous cap thickness 54.2±7.3μ*** ruptured culprit plaques(46.7%)were found;4 in UA patients and 3 in NSTEMI *** prolapse was observed in 11 lesions(73.3%).Irregular stent strut distribution was detected in 8 lesions(53.3%).Vessel dissections were found in 5 lesions(33.3%).Incomplete stent apposition was observed in 3 stents(20%)with mean spacing between the struts and the vessel wall 172±96 mm(range 117-436 mm).Conclusions 1)It is safe and feasible to perform intravascular OCT to differentiate vulnerable coronary plaque and monitor stent deployment in elderly patients with UA and USTEMI.2)Coronary plaques in elderly patients with UA and USTEMI could be divided into acute ruptured plaque,vulnerable plaque,lipid-rich plaque,and stable plaque.3)Minor or critical plaque rupture is one of the mechanisms of UA in elderly patients.4)Present drug eluting stent

关键词： optical coherence tomography acute coronary syndrome percutaneous coronary intervention stent elderly

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Dynamic changes of flavonoids in Actinidia valvata leaves at different growing stages measured by HPLC-MS/MS

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Chinese Journal of Natural Medicines 2016年第1期14卷 66-72页

作者： DU qiao-Hui zhang qiao-yan HAN Ting JIANG Yi-Ping PENG Cheng XIN Hai-Liang Department of Pharmacognosy School of PharmacySecond Military Medical University Key Laboratory of Standardization of Chinese Herbal Medicines of the Ministry of Education College of PharmacyChengdu University of Traditional Chinese Medicine

Flavonoids are a large group of phenolic secondary metabolites havinga wide range of biochemical and pharmacological *** analysis of flavonoid profiles in the genus Actinidia,which has not been intensively conducted,is useful to a better understanding of the pattern and distribution of *** the present work,a liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI-MS/MS)method was developed to profile the flavonoids,which was then used to determine the dynamic change of 17 biologically active flavonoids in the leaves of Actinidia valvata at the main growing stages,including glucuronides and acylated di-and triglycosides of *** contents of flavonoid triglycosides were significantly higher than other *** highest concentrations of kaemperol glycosides were observed in June,while other flavonoids showed highest concentrations in *** the other hand,the contents of four isorhamnetin glycosides were increased sharply in September to *** flavonoid profiles seem to be related to temperature,UV-B,and water *** studies are required to examine the functions of flavonoids in the Actinidia valvata and the underlying molecular mechanisms of actions.

关键词： Actinidia valvata LC—MS/MS Flavonoids Dynamic change Kaempferol triglycosides Growing stage

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Estrogenic activity of osthole and imperatorin in MCF-7 cells and their osteoblastic effects in Saos-2 cells

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Chinese Journal of Natural Medicines 2016年第6期14卷 413-420页

作者： JIA Min LI Yuan XIN Hai-Liang HOU Ting-Ting zhang Nai-Dai XU Hong-Tao zhang qiao-yan QIN Lu-Ping Department of Pharmacognosy School of Pharmacy Second Military Medical University

There is an increasing interest in phytoestrogens due to their potential medical usage in hormone replacement therapy(HRT). The present study was designed to investigate the in vitro effects of estrogen-like activities of two widespread coumarins, osthole and imperatorin, using the MCF-7 cell proliferation assay and their alkaline phosphatase(ALP) activities in osteoblasts Saos-2 cells. The two compounds were found to strongly stimulate the proliferation of MCF-7 cells. The estrogen receptor-regulated ERα, progesterone receptor(PR) and PS2 m RNA levels were increased by treatment with osthole and imperatorin. All these effects were significantly inhibited by the specific estrogen receptor antagonist ICI182, 780. Cell cycle analysis revealed that their proliferation stimulatory effect was associated with a marked increase in the number of MCF-7 cells in S phase, which was similar to that observed with estradiol. It was also observed that they significantly increased ALP activity, which was reversed by ICI182,780. These results suggested that osthole and imperatorin could stimulate osteoblastic activity by displaying estrogenic properties or through the ER pathway. In conclusion, osthole and imperatorin may represent new pharmacological tools for the treatment of osteoporosis.

关键词： Osthole Imperatorin MCF-7 Estrogenic activity Estrogen receptors Osteoblasts Alkaline phosphatase

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随机结构面切割岩质边坡空间块体模型及关键块体分析

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东北大学学报（自然科学版） 2011年第3期32卷 431-434页

作者：王述红张航张艳桥张靖杰东北大学资源与土木工程学院辽宁沈阳110819 沈阳市环境保护局辽宁沈阳110011

在现场结构面非接触摄影技术采集的基础上,提出基于虚拟网格的、采用随机结构面切割岩体的方法,建立了岩质边坡空间块体模型.并将该模型接入作者团队自主开发研制的三维数值分析系统GeoSMA-3D,进行岩质边坡关键块体搜索和分析.算例表明... 详细信息

在现场结构面非接触摄影技术采集的基础上,提出基于虚拟网格的、采用随机结构面切割岩体的方法,建立了岩质边坡空间块体模型.并将该模型接入作者团队自主开发研制的三维数值分析系统GeoSMA-3D,进行岩质边坡关键块体搜索和分析.算例表明:该模型具有可以动态添加结构面、易于建立复杂岩体边坡几何模型等优点,并对辽宁某边坡进行了关键块体分析.

关键词：岩体随机不连续面 GeoSMA-3D 关键块体边坡

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JAK-STAT信号传导通路在肿瘤中的研究进展

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基础医学与临床 2011年第4期31卷 463-466页

作者：洪璇张艳桥哈尔滨医科大学附属第三医院肿瘤内科黑龙江哈尔滨150081

JAK-STAT信号传导通路由多种细胞因子以及受体所激活,在实体瘤及血液系统肿瘤中参与肿瘤细胞的增殖、分化、血管生成以及机体免疫调节等过程,该通路的异常表达及活化对促进肿瘤的发生发展具有重要的作用。近几年,以阻断JAK-STAT信号传... 详细信息

JAK-STAT信号传导通路由多种细胞因子以及受体所激活,在实体瘤及血液系统肿瘤中参与肿瘤细胞的增殖、分化、血管生成以及机体免疫调节等过程,该通路的异常表达及活化对促进肿瘤的发生发展具有重要的作用。近几年,以阻断JAK-STAT信号传导通路为机制的药物已经成为肿瘤治疗研究的热点,许多该通路抑制剂在体内外实验中均体现出抗肿瘤效果。

关键词： Janus STAT 肿瘤治疗

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我国水稻黑条矮缩病和玉米粗缩病研究进展

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植物保护学报 2005年第1期32卷 97-103页

作者：陈声祥张巧艳浙江省农业科学院农业部病毒学与生物技术重点开放实验室杭州310021

上世纪60年代初我国华东和华北地区分别发现了水稻黑条矮缩病和玉米粗缩病,后来都分别发生了2次大流行,同时都以病害防治为目标分别开展了研究,探明了当地病害发生规律,提出了相应的防治方法,获得了不同程度的防病效果。80年代以来,水... 详细信息

上世纪60年代初我国华东和华北地区分别发现了水稻黑条矮缩病和玉米粗缩病,后来都分别发生了2次大流行,同时都以病害防治为目标分别开展了研究,探明了当地病害发生规律,提出了相应的防治方法,获得了不同程度的防病效果。80年代以来,水稻黑条矮缩病的发生报道仅限于华东地区局部地市,玉米粗缩病的发生涉及华北、东北、西北、西南和华中地区13个省市。根据各地对两病病原形态、寄主及症状、介体昆虫及传病特性等方面相似性的报道,提出了我国玉米粗缩病与水稻黑条矮缩病病原异同性问题。经近10年来对两病用生物学和分子生物学方法进行比较鉴定,证明我国玉米粗缩病和水稻黑条矮缩病病原同属水稻黑条矮缩病毒(RBSDV)。同时基本探明了水稻黑条矮缩病在浙江杂交稻区和华北玉米区的再次流行成灾的原因,提出了相应的防治措施.并有效地控制了病害的流行危害。

关键词：玉米粗缩病研究进展水稻黑条矮缩病毒分子生物学方法病害发生规律 60年代病害防治防治方法防病效果 80年代华东地区华中地区病原形态介体昆虫比较鉴定防治措施华北流行相似性寄主成灾稻区

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang yanyu zhang yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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沙格列汀合成路线的改进

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中国新药杂志 2018年第2期27卷 203-206页

作者：曹文婷贺欢张俏艳张勇河北科技大学化学与制药工程学院石家庄050018 河北省药用分子化学重点实验室省部共建国家重点实验室培育基地石家庄050018

目的:改进沙格列汀的合成路线。方法:以(S)-N-叔丁氧羰基-(3-羟基金刚烷-1-基)甘氨酸和2,2'-二硫化二苯并噻唑为原料,在亚磷酸三乙酯的还原作用下生成(S)-N-叔丁氧羰基-(3-羟基金刚烷-1-基)甘氨酸苯并[d]噻唑-2-硫酯;该硫醇活性酯与(1S,... 详细信息

目的:改进沙格列汀的合成路线。方法:以(S)-N-叔丁氧羰基-(3-羟基金刚烷-1-基)甘氨酸和2,2'-二硫化二苯并噻唑为原料,在亚磷酸三乙酯的还原作用下生成(S)-N-叔丁氧羰基-(3-羟基金刚烷-1-基)甘氨酸苯并[d]噻唑-2-硫酯;该硫醇活性酯与(1S,3S,5S)-2-氮杂双环[3.1.0]己烷-3-甲腈对甲苯磺酸盐发生缩合反应,再经盐酸脱氨基保护基等步骤得到抗糖尿病药物沙格列汀。结果:所得目标产物总收率35.6%,产品纯度在99.9%以上。结论:改进后的工艺操作简单,产率较高,产品纯度高,适合工业化生产。

关键词：沙格列汀 2 2'-二硫化二苯并噻唑合成

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