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G-protein beta 3 subunit polymorphisms and essential hypertension： a case-control association study in northern Han Chinese

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Journal of Geriatric Cardiology 2015年第2期12卷 127-134页

作者： Mei li Bei zhang Chuang li jie-lin liU li-Juan WANG Ya liU Zuo-Guang WANG Shao-Jun WEN Department of Hypertension Research Beijing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel DiseasesBeijing 100029 China

Objective To explore the association between the three polymorphisms [ C825T, C1429T and G（-350）A] of the gene encoding the G protein beta 3 subunit （GNB3） and hypertension by performing a case-control study in the northern Han Chinese population. Methods We recnaited 731 hypertensive patients and 673 control subjects （the calculated power value was 〉 0.8）. Genotyping was performed to identify C825T, C1429T and G（-350）A polymorphisms using the TaqMan assay. Comparisons of allelic and genotypic frequencies between cases and controls were made by using the chi-square test. Logistic regression analyses were performed to investigate the relationships between the three polymorphisms of GNB3 gene under different genetic models （additive, dominant and recessive models）. Results The genotype dis- tribution and allele frequencies of C825T, C1429T and G（-350）A polymorphisms did not differ significantly between hypertensive patients and control subjects, either when the full sample was assessed, or when the sample was stratified by gender. No significant association was observed between C825T, C 1429T and G（-350）A polymorphisms and the risk of essential hypertension in any genetic model. linkage dis- equilibrium was only detected between C825T and C 1429T polymorphisms. Haplotype analyses observed that none of the three estimated haplotypes significantly increased the risk of hypertension. Conclusions Our study suggested that the GNB3 gene polymorphisms [C825T, C 1429T and G（-350）A] were not significantly associated with essential hypertension in northern Han Chinese population.

关键词： G protein beta 3 subunit gene Haplotype Hypertension Polymorphism

Antithrombotic and antiplatelet therapies in relation to risk stratification in patients with non-ST elevation acute coronary syndrome： insights from the Sino-Global Registry of Acute Coronary Events

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Chinese Medical Journal 2009年第5期122卷 502-508页

作者： zhang li-jie CHEN Yun-dai SONG Xian-tao ZHAO Fu-hai Lü Shu-zheng Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Cardiology Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Cardiology Xiyuan Hospital of China Academy of Chinese Medical Science Beijing 100091 China

Background Antithrombotic and antiplatelet therapies have been proposed to treat non-ST elevation acute coronary syndrome （NSTEACS）, yet limited information is available about their applications from a multicenter ＂real-world＂ clinical procedure, especially in China. This study was undertaken to characterize the use of antithrombotic and antiplatelet agents in relation to the risk levels of the NSTEACS patients who were enrolled in Sino-Global Registry of Acute Coronary Events （GRACEs） registry study. Methods We analyzed the data from 618 Chinese NSTEACS patients stratified into low-（n=151）, intermediate-（n=233）, and high-risk groups （n=-234） based on GRACE risk scores. The baseline characteristics, clinical presentations, antithrombotic and antiplatelet agents were recorded and compared among the three groups. Results The administration rates of low-molecular-weight heparins （LMWHs）（86.08%） and thienopyridines （85.92%） were higher whereas the administration rate of glycoprotein Ⅱb/Ⅲa inhibitor （1.78%） was much lower than those reported previously. Meanwhile, within the first 24 hours of admission, the use of heparin/LMWHs in the high-risk group was more than that in the intermediate- and low-risk groups （73.50% vs 63.09% vs 55.63%, P=0.001）. Furthermore, the combination of antithrombotic and antiplatelet medications showed no significant differences in all groups. Conclusions In the ＂real world＂ practice of China, the antithrombotic and antiplatelet therapies on NSTEACS are well adherent to the current guidelines except for several gaps, such as the very low use of glycoprotein Ⅱb/Ⅲa inhibitor. Moreover, these antithrombotic and antiplatelet treatments usually tend to be underused for the high-risk ones.

关键词： non-ST elevation acute coronary syndromes risk stratification antithrombotic antiplatelet

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一种免装配微惯性测量单元的研制与开发

中国惯性技术学报 2011年第6期19卷 664-669页

作者：张丽杰常佶内蒙古工业大学电力学院呼和浩特010051

以柔性材料和高精度六面体作为惯性传感器的安装载体和基准,设计了一种免装配、安装误差小、体积小、功耗低且便于标定的微惯性测量单元。给出了安装误差小角度前提下的传感器的测量方程和标定方法;利用微控制器的并行工作机制,提出了... 详细信息

以柔性材料和高精度六面体作为惯性传感器的安装载体和基准,设计了一种免装配、安装误差小、体积小、功耗低且便于标定的微惯性测量单元。给出了安装误差小角度前提下的传感器的测量方程和标定方法;利用微控制器的并行工作机制,提出了一种快速有效的基于均值滤波和FIR滤波的组合滤波方案。实验结果表明:MIMU可以100 Hz的频率更新测量输出,加速度测量噪声小于2.5 mg、测量误差小于0.8 mg,旋转角速度测量噪声小于0.15 o/s、测量误差小于0.2 o/s,可满足微小型惯性导航系统的功耗、体积、测量精度和响应速度的应用需求。

关键词：微惯性测量单元柔性电路板滤噪标定

安装误差对球齿轮姿态调整机构指向精度的影响分析

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兵工学报 2009年第7期30卷 962-966页

作者：李婷潘存云李强张立杰国防科技大学机电工程与自动化学院湖南长沙410073

球齿轮是两自由度齿轮传动机构,将其应用于星载天线姿态调整机构具有结构紧凑、承载能力大等优点,安装误差是影响其指向精度的重要因素之一。在对球齿轮指向机构进行运动分析和啮合模型推导的基础上,建立了球齿轮机构的指向误差模型。... 详细信息

球齿轮是两自由度齿轮传动机构,将其应用于星载天线姿态调整机构具有结构紧凑、承载能力大等优点,安装误差是影响其指向精度的重要因素之一。在对球齿轮指向机构进行运动分析和啮合模型推导的基础上,建立了球齿轮机构的指向误差模型。分析计算了不同安装误差对其输出轴指向误差的影响。研究结果对球齿轮姿态调整机构的实际应用具有理论指导意义。

关键词：机械设计球齿轮姿态调整机构运动分析指向精度安装误差指向误差

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微小型航姿测量系统及其数据融合方法

中国惯性技术学报 2011年第3期19卷 307-311页

作者：张丽杰常佶内蒙古工业大学电力学院呼和浩特010051

以小型无人机航姿测量系统的微小型化为背景,利用MEMS惯性测量元件研制了一种低成本微型航姿测量系统。针对MEMS器件用于载体航姿测量时精度低、易发散的问题,提出一种计算量小、实时性强的加速度信息、磁场强度信息、陀螺信息的融合方... 详细信息

以小型无人机航姿测量系统的微小型化为背景,利用MEMS惯性测量元件研制了一种低成本微型航姿测量系统。针对MEMS器件用于载体航姿测量时精度低、易发散的问题,提出一种计算量小、实时性强的加速度信息、磁场强度信息、陀螺信息的融合方法。采用卡尔曼滤波器对系统的俯仰角、滚转角和航向角的误差进行最优估计;设计数据融合的判别准则,并根据判据的判断结果调整卡尔曼滤波器中的量测信息,使系统可用于小型无人机的定高自主飞行。实验结果表明,系统输出航姿的更新频率可达100 Hz,航姿测量误差小于0.6°,航姿标准差小于0.09°;将其应用于某小型固定翼飞行器的飞行控制系统中进行自主飞行实验,完成了预定的飞行任务。

关键词：小型无人机航姿测量微机电系统数据融合卡尔曼滤波

ON BIO-EFFECTS ON KARST LANDSCAPE IN JIUZHAIGOU CONSERVATION, SICHUAN PROVINCE, CHINA—WITH SPECIAL REFERENCE TO A MICROMORPHOLOFICAL APPROACH

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Journal of Geographical Sciences 1997年第3期7卷 1-15页

作者： zhang jie li Shengfeng Zhou Yinkang Du Jinkang Department of Geography, Nanjing University, Nanjing 210093 People’s Republic of China

Jiuzhaigou Conservation is a typical karst region with scenic tufa constructive landscape. With observation in situ and optical microscope as well as scanning electronic microscope, a series minor and micro biokarst solution features and related agents were identified and described related to local environmental condition, and also the bioeffect on karst deposition in formation of the local tufa dammed lakes were elucidated and *** is shown in the cycle model proposed in the paper that many organisms (algae,mosses,and bushes etc.) with various effects (assimilation,interception,encrustation,trapping and binding etc.)on tufa deposition play an important role throughout the compound cycle process of the tufa dam gradation,*** formation of the tufa dammed lakes in the stream channels which are character of local karst landscape.

关键词： biokarst micro pits erosion tufa karst dammed lake Jiuzhaigou.

Parametric Instability of a liquid Metal Sessile Drop Under a High Frequency Amplitude-Modulate Magnetic Field

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Journal of Iron and Steel Research International 2012年第S1期19卷 491-494页

作者： LEI Zuo-sheng zhang li-jie CHEN Chao-yue GUO Jia-hong REN Zhong-ming FAUTRELLE Yves ETAY Jecqueline Shanghai Key Laboratory of Modern Metallurgy and Material Processing Shanghai University Shanghai Institute of Applied Mathematics and Mechanics Shanghai University SIMAP-EPM laboratory Grenoble Institute of Technology/CNRS UMR 526638402 St-Martin d'HeresFrance

The parametric instability behavior of a liquid mercury sessile drop under high frequency Amplitude-Modulate Magnetic Field(AMMF),i.e.a high frequency magnetic field(carder wave)modulated by a low frequency sine wave(modulate wave),is investigated *** free surface contour of the mercury drop is observed by a CCD camera while varying the frequency and amplitude of the high frequency *** a given frequency and amplitude,the edge deformations with an azimuthal wave numbers(modes n=3,4,5,6)were excited.

关键词： high frequency Amplitude-Modulate Magnetic Field liquid metal sessile drop parametric instability

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo zhang jie Dang Jia Guo Hanghang Zhou Xuewei Lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

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颅骨修补材料的临床应用及研究现状

中国组织工程研究与临床康复 2008年第10期12卷 1939-1942页

作者：张立杰营口经济技术开发区中心医院脑外科辽宁省营口市115007

不同种类颅骨修补材料性能及临床应用效果不尽相同。有机玻璃曾经被普遍应用但生物相容性差皮下积液感染率高,现在已经很少应用;骨水泥组织相容性好但不易被吸收,只应用于部分颅骨的修补;医用硅胶涤纶丝网格便宜,疗效好,但局部感染、材... 详细信息

不同种类颅骨修补材料性能及临床应用效果不尽相同。有机玻璃曾经被普遍应用但生物相容性差皮下积液感染率高,现在已经很少应用;骨水泥组织相容性好但不易被吸收,只应用于部分颅骨的修补;医用硅胶涤纶丝网格便宜,疗效好,但局部感染、材料裸露,术后外观欠佳;作为高分子材料之一的钛和钛合金因其良好的生物相容性及理化特性成为目前临床应用最广泛的颅骨缺损修补材料,但也存在很多不足之处。随着社会的发展,患者的要求也逐步提高,很多修补材料因自身的种种缺点已经被淘汰,颅骨修补材料的选择需要根据不同的个体和不同的情况,文章通过对不同种类颅骨修补材料性能及临床应用的比较,寻找生物相容性良好,临床效果最佳的颅骨修补材料。

关键词：颅骨修补材料钛合金生物相容性