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Coronary spasm, a pathogenic trigger of vulnerable plaque rupture

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Chinese Medical Journal 2011年第23期124卷 4071-4078页

作者： WANG li-xin LU Shu-zheng zhang Wei-jun SONG Xian-tao CHEN Hui zhang li-jie Department of Cardiology Beijing Anzhen Hospital Capital University of Medical Sciences Beijing 100029 China

Objective This coronary artery spasm review aimed to explore the most possible pathogenic trigger mechanism of vulnerable plaque rupture. Data sources Data used in this coronary artery spasm review were mainly from Medline and Pubmed in English. Study selection These reports from major review on coronary artery spasm .and these research included coronary artery conception, pathogenesis of spasm, mechanisms of plaque rupture, epidemiological evidence, clinical manifestation and the relationship between coronary artery spasm and vulnerable plaque rupture. Results Coronary artery spasm is somehow related to the presence of atherosclerotic intima disease in the coronary artery. However, chronic low-grade inflammation causes coronary vessel smooth muscle cell hypersensitivity, which can directely cause coronary artery spasm. Myocardial infarction and sudden cardiac death may be initiated by a sudden intense localized contraction of coronary artery smooth muscle. Conclusion Coronary artery spasm may be one trigger that can initiate and exacerbate vulnerable plaque rupture.

关键词： coronary spasm vulnerable plaque rupture pathogenic trigger

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian Lu Mingcong Tang jie Wu Kouer zhang Wenzhi li Yunxia Hu Xiaomin Xu Xiao zhang Zongping Shao liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： lifang Zhao Mingkai zhang Qimeng li Xuemin Wang jie Lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

A study on the reaction of 2'-hydroxychalcones with I_2-H_2SO_4-DMSO system

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Chinese Journal of Chemistry 1994年第1期12卷 73-78页

作者： zhang, Fang-jie li, Yu-linState Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University , Lanzhou, Gansu 73000, China State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou University Lanzhou Gansu 73000 China

The reaction of 2'-hydroxychalcones with I_2-H_2SO_4-DMSO system has been studied. The results obtained by us are entirely different from those reported in the literature. The mechanism of this reaction has also been ... 详细信息

关键词： Reaction 2'-hydroxychalcone I_2-H_2SO_4-DMSO system.

Comparision of high sensitivity C-reactive protein and matrix metalloproteinase 9 in patients with unstable angina between with and without significant coronary artery plaques

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Chinese Medical Journal 2011年第11期000卷 1657-1661页

作者： WANG li-xin LU Shu-zheng zhang Wei-jun SONG Xian-tao CHEN Hui zhang li-jie Department of Cardiology Beijing Anzhen Hospital CapitalMedical University Beijing 100029 China Institute of Biomedical Engineering Capital Medical UniversityBeijing 100069 China

Background Inflammation within vulnerable coronary plaques may cause unstable angina by promoting rupture and erosion. C-reactive protein （CRP） is the most reliable and accessible test method for clinical use for identifying coronary artery disease event. Matrix metalloproteinase 9 （MMP-9） is highly over-expressed in the vulnerable regions of a plaque. Our aim was to evaluate the plasma levels of MMP-9 and hsCRP in subjects with both unstable angina and coronary plaques, as well as in those with unstable angina without coronary plaques.

关键词： unstable angina high sensitivity C-reactive protein matrix metalloproteinase 9 coronary artery stenosis angiography

Preparation and adsorption properties of macroporous tannin resins

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Forestry Studies in China 2006年第3期8卷 51-55页

作者： zhang li-ping Du jie liu Jian College of Materials Science and Technology Beijing Forestry University Beijing 100083 P. R. China

In this paper, a new kind of adsorption resin with multi-phenolic hydroxyl was created by immobilizing black wattle bark tannins to chloromethyl polystyrene resin. Its adsorption capacity to cation dye was tested. With an orthogonal test the optimal conditions of synthesis were determined： the concentration of sodium hydroxide solution 1.0 mol.L^-1; the reaction time is one hour and the mass concentration of tannins 5%. With single factorial experiment the optimal conditions of adsorption were confirmed： a solidified pH of 5.0; an adsorption temperature of 25℃ and a cation dye concentration of 100 mg.L^-1. The adsorption for cation dye can be similar to Langmuir isotherms.

关键词： macroporous resin plant tannins adsorption

Therapeutic options for intermediate-advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第13期17卷 1685-1689页

作者： Zong-Ming zhang Jin-Xing Guo Zi-Chao zhang Nan ]iang Zhen-Ya zhang li-jie Pan Department of General Surgery Digestive Medical Center The First Affiliated Hospital Schoolof Medicine Tsinghua University Beijing 100016 China

Hepatocellular carcinoma (HCC) is one of the most common malignancies, ranking the sixth in the world, with 55% of cases occurring in China. Usually, patients with HCC did not present until the late stage of the disease, thus limiting their therapeutic options. Although surgical resection is a potentially curative modality for HCC, most patients with intermediate-advanced HCC are not suitable candidates. The current therapeutic modalities for intermediate-advanced HCC include: (1) surgical procedures, such as radical resection, palliative resection, intraoperative radiofrequency ablation or cryosurgical ablation, intraoperative hepatic artery and portal vein chemotherapeutic pump placement, two-stage hepatectomy and liver transplantation; (2) interventional treatment, such as transcatheter arterial chemoembolization, portal vein embolization and image-guided locoregional therapies; and (3) molecularly targeted therapies. So far, how to choose the therapeutic modalities remains controversial. Surgeons are faced with the challenge of providing the most appropriate treatment for patients with intermediate-advanced HCC. This review focuses on the optional therapeutic modalities for intermediateadvanced HCC.

关键词： Hepatocellular carcinoma Intermediateadvanced Surgical procedure Interventional treatment Molecularly targeted therapy

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哈尔滨市松北区水库雍水浸没评价

吉林大学学报（地球科学版） 2010年第1期40卷 134-139页

作者：秦雨张立杰吉林大学水资源与环境研究所长春130026 黑龙江省水利厅哈尔滨150080

浸没问题是平原型水库主要地质灾害之一。在分析了哈尔滨市松北区雍水浸没成控因素的基础上,采用地下水流数值模拟技术对研究区在不同开采方案下的雍水浸没进行评价,并综合考虑区内的地表覆盖情况、建筑物地基形式等因素,提出了适合研... 详细信息

浸没问题是平原型水库主要地质灾害之一。在分析了哈尔滨市松北区雍水浸没成控因素的基础上,采用地下水流数值模拟技术对研究区在不同开采方案下的雍水浸没进行评价,并综合考虑区内的地表覆盖情况、建筑物地基形式等因素,提出了适合研究区水文地质条件的浸没标准:农田区为粉质粘土2.50 m,粉细砂1.50 m;建筑物区为粉质粘土3.50 m,粉细砂3.00 m。将研究区划分为可能浸没区、过渡浸没区和不发生浸没区,并确定了各浸没区的范围。

关键词：水库雍水浸没地下水临界深度评价标准

The application of a proportional difference type iterative learning control in active vibration control

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通讯和计算机（中英文版） 2008年第2期5卷 37-41页

作者： HAO Xiao-hong zhang Lei li Heng-jie School of Electrical Engineering and Information Engineering Lanzhou University of Technology Lanzhou 730050 China