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Application of Blockchain Sharding Technology in Chinese Medicine Traceability System

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Computers, Materials & Continua 2023年第7期76卷 35-48页

作者： Fuan Xiao Tong Lai Yutong Guan Jiaming Hong honglai zhang Guoyu Yang Zhengfei Wang School of Medical Information Engineering Guangzhou University of Chinese MedicineGuangzhou510006China Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou510006China

Traditional Chinese Medicine(TCM)is one of the most promising programs for disease prevention and ***,the quality of TCM has garnered much *** ensure the quality of TCM,many works are based on the blockchain scheme to design the traceability scheme of TCM to trace its *** these schemes can ensure the integrity,sharability,credibility,and immutability of TCM more effectively,many problems are exposed with the rapid growth of TCM data in blockchains,such as expensive overhead,performance bottlenecks,and the traditional blockchain architecture is unsuitable for TCM data with dynamic *** by the aforementioned problems,we propose a novel and lightweight TCM traceability architecture based on the blockchain using sharding(LBS-TCM).Compared to the existing blockchain-based TCM traceability system,our architecture utilizes sharding to develop a novel traceability mechanism that supports more convenient traceability operations for TCM requirements such as uploading,querying,and ***,our architecture consists of a leader shard blockchain layer as its main component,which employs a sharding mechanism to conveniently TCM *** evaluations demonstrated that our architecture showed better performance in many aspects compared to traditional blockchain architectures,such as TCM transaction processing,TCM transaction querying,TCM uploading,*** our architecture,tracing TCM has become a very efficient operation,which ensures the quality of TCM and provides great convenience for subsequent TCM analysis and retrospective research.

关键词： Blockchain sharding traceability traditional chinese medicine

ACCELERATED LIFE TEST STUDIES OF NEW COATED DISPENSER CATHODES

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Journal of Electronics(China) 2007年第5期24卷 717-720页

作者： zhang Mingchen zhang honglai Liu Pukun Su Xiaobao Li Yutao Institute of Electronics Chinese Academy of Sciences Beijing 100080 China

The life of impregnated Ba-W cathodes with a new construction have been evaluated using an accelerated life test at three different temperatures (1170℃,1130℃,1090℃) and constant current density (2A/cm^2).According to the relationship of life with operating temperatures,an accelerated equation has been set *** cathode life at normal operating temperature is deducted based on the accelerated *** results show that life of the novel cathode exceeds 190,000 hour at a current density of 2A/cm^2.

关键词： Dispenser cathodes Accelerated life test

Cloning, expression and mapping of the full-length cDNA of human CCTβ subunit

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Chinese Science Bulletin 2000年第22期45卷 2034-2041页

作者： Juxiang Jiang Wei Lin honglai zhang Zheng Chen Qiang Tu Ying Jiang Long Yu Shouyuan Zhao State Key Laboratory of Genetic Engineering Institute of Genetics. School of Life Science Fudan University Shanghai China Department of Biochemistry College of Medical Science Suzhou University Suzhou China

Chaperonins assist the proper folding of target proteins without being a part of the substrates. The eukaryotic cytosolic chaperonin, CCT-Chaperonin Containing TCP-1 (tailless complex polypeptide-1), is mainly involved in the formation of cytoskeletal proteins and is essential for cell viability. Mammalian CCT is commonly a protein complex composed of 7-9 subunit species. We have isolated a novel full-length cDNA from human testis cDNA library. This cDNA of 1935 bp contains a 1605 bp open reading frame (ORF) encoding 535 amino acids (aa). The deduced protein of the cDNA is highly homologous to the CCTβ subunit of saccharomyces cerevisiae, schizosaccharomyces pombe, caenorhabditis elegans and mouse, etc. Especially high homology (97%) is found between the deduced protein and mouse CCTβhomology, the protein encoded by the new gene was proposed to be a human CCTβ subunit. Northern hybridization showed that human CCTβ gene is expressed as a transcript of about 2.0 kb in various tissues. Overexpression

关键词： CCTP subunit cDNA cloning tissue expression pattern human chromosome 12q14.

Cloning, characterization and mapping of human SPIN to human chromosome 9q22.1-22.3

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Chinese Science Bulletin 2000年第10期45卷 909-914页

作者： zhang honglai YU Long WANG Xiaoke CHEN Zheng TU Qiang CHEN Jinqiu DING Jianbo GAO Jie ZHAO Shouyuan State Key Laboratory of Genetic Engineering Institute of GeneticsFudan UniversityShanghai 200433China Department of Biochemistry Suzhou Medical CollegeSuzhou 215007China

Spindle is a specific substructure in cell during meiosis and gamete maturity division and its structure and function directly influence the development, differentiation, growth and reproduction of individuals. Recent researches also show that mouse Mos/MAPK pathway is tightly related to spindiin phosphorylation. We report that (i) a novel gene encoding a putative human spindlin (SPIN) has been cloned, which is highly homologous to mouse Spin; (ii) tissue expression pattern of SPIN shows that SPIN is highly expressed as a 4.8 kb transcript in ovary, testis, heart, brain, kidney, pancreas, placenta and spleen, also with a specific 2.0 kb transcript in testis, but there is no hybridization band in thymus and small intestine, and (iii) SPIN has been mapped to human chromosome 9q22.1-22.3 by Radiation Hybrid Mapping. This novel gene was registered in GenBank as SPIN with accession number AF087864.

关键词： human spindlin cDNA cloning chromosome 9q22.1-22.3 tissue expression pattern.

IMPROVEMENT OF THE PERFORMANCE OF THE DISPENSER CATHODE WITH Re AS A MIDDLE LAYER

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Journal of Electronics(China) 2006年第3期23卷 473-475页

作者： Li Yutao zhang honglai Liu Pukun zhang Mingchen Institute of Electronics Chinese Academy of Sciences Beijing 100080 China

A new type of dispenser cathode with dual-layer (Os-W/Re) is developed. The cathode coated with Os-W/Re shows better emission performance than the cathode coated with Os-W alloy. X-ray Photoelectron Spectroscopy (XPS) spectra demonstrate that ternary alloy coating (Os-W-Re) formed on the surface of the cathode with dual-layer (Os-W/Re) after full activation is the major reason why it has better emission than the cathode with Os-W alloy. The surface of each variety of the cathode is characterized with Scanning Electron Microscope (SEM) before and after activation: the emitting surface of the cathode with Os-W alloy after ageing appeared non-adherence (flaking) in localized areas, which is one of the reasons for non-uniform emission. However, the surface of the cathode with dual-layer (Os-W/Re) does not present film peeling under the same conditions. Thus it ensures better emission uniformity and functional reliability for the dispenser cathode.

关键词： Dispenser cathode Dual-layer Os-W/Re Os-W Emission uniformity

低剂量电离辐射对小鼠肺,胸腺和脾细胞分泌CSF的影响

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中华放射医学与防护杂志 1992年第3期12卷 162-165页

作者：张鸿来张铭 130021

本实验采用X射线对小鼠全身照射，剂量率为12.5mGy/min，剂量为25～250mGy。发现低剂量辐射能明显刺激肺和胸腺细胞分泌造血细胞集落刺激因子（Colony-stimulating factors，CSF）。胸腺细胞反应较为敏感，50mGy即能明显促进CSF分泌，25... 详细信息

本实验采用X射线对小鼠全身照射，剂量率为12.5mGy/min，剂量为25～250mGy。发现低剂量辐射能明显刺激肺和胸腺细胞分泌造血细胞集落刺激因子（Colony-stimulating factors，CSF）。胸腺细胞反应较为敏感，50mGy即能明显促进CSF分泌，250mGy时胸腺细胞分泌CSF活性水平仍明显高于对照（ P <0.01），且以50mGy剂量照射对其分泌CSF的刺激作用最强；肺组织细胞反应较弱，仅在75mGy剂量照射后，CSF分泌量明显增加（ P <0.05）；低剂量照射对脾细胞分泌CSF未见有明显的促进作用。75mGy照射后不同时间检测CSF，发现照射后2天肺和胸细胞分泌CSF量明显增加，直到照射后7天，CSF活性水平仍明显高于对照（ P <0.01），说明低剂量X射线全身照射能明显促进肺和胸腺细胞分泌CSF，这对促进机体造血和免疫功能，增强机体抵抗力有重要的意义。

关键词：集落刺激因子肺胸腺电离辐射

Investigation of recovery characteristics after ion bombardment on scandate cathode

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Investigation of recovery characteristics after ion bombardm...

小剂量辐射刺激小鼠骨髓细胞G—CSF受体表达

The 5th International Vacuum Electron Sources Conference(IVESC2004)

作者： Mingchen zhang,honglai zhang,Pukun Liu,Yutao Li Institute of Electronics,Chinese Academy of Sciences,Beijing 100080,PRChina

The scandate cathode has excellent electron emission capability. However applications in vacuum electron devices are limited because of nonuniform emission and weak resistance to ion bombardment. A new method has been adopted for making scandate cathode. This type of scandate cathode showed more uniform emission and fast recovery characteristics after ion bombardment comparing with conventional impregnated scandate cathode. The results of XPS analysis before and after ion bombardment are presented.

关键词： top-layer scandate cathode Ion bombardment and X-ray analysis

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中华放射医学与防护杂志 1993年第5期13卷 308-310页

作者：张鸿来刘树铮北京医科大学基础病理室，100083 白求恩医科大学放射生物学重点实验室，长春　130021

利用＾１２５Ｉ标记的Ｇ－ＣＳＦ（＾１２５Ｉ－Ｇ－ＣＳＦ）检测小鼠骨髓细胞表面Ｇ－ＣＳＦ受体表达，发现＾１２５Ｉ－Ｇ－ＣＳＦ与其受体的结合在３７℃，６０分钟内完成，３×１０＾６骨髓细胞表面的最大结合量（Ｂｍａｘ）为１５... 详细信息

利用＾１２５Ｉ标记的Ｇ－ＣＳＦ（＾１２５Ｉ－Ｇ－ＣＳＦ）检测小鼠骨髓细胞表面Ｇ－ＣＳＦ受体表达，发现＾１２５Ｉ－Ｇ－ＣＳＦ与其受体的结合在３７℃，６０分钟内完成，３×１０＾６骨髓细胞表面的最大结合量（Ｂｍａｘ）为１５．１ｐｍｏｌ，解离常数（Ｋｄ）７８．６ｐｍｏｌ，推算细胞表面Ｇ－ＣＳＦ受体数为３１００个左右；小剂量辐射（５０－２５０ｍＧｙ）照射小鼠后４８小时，检测骨髓细胞表面Ｇ－ＣＳＦ受体数，发…

关键词：小剂量辐射 G-CSF 受体骨髓细胞

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自动舌诊技术的研究进展

中国中医基础医学杂志 2023年第5期29卷 871-874,F0003,F0004页

作者：张林子周武张洪来广州中医药大学医学信息工程学院广州510006

近年来,舌诊的客观化发展如自动采集、舌图处理和分析等技术均有了长足进步,且相关研究成果正逐步应用于临床进行辅助诊断,促进了中医诊断客观化的发展。本文通过文献调研和对比分析等方法,从自动化舌诊的硬件采集设备和舌象特征分析技... 详细信息

近年来,舌诊的客观化发展如自动采集、舌图处理和分析等技术均有了长足进步,且相关研究成果正逐步应用于临床进行辅助诊断,促进了中医诊断客观化的发展。本文通过文献调研和对比分析等方法,从自动化舌诊的硬件采集设备和舌象特征分析技术两方面对中医舌诊的客观化研究进展进行了系统性的探讨与总结,并讨论了当前存在的一些问题以及对发展前景的展望,从而为后续临床研发提供理论基础,并为自动化舌诊技术的进一步发展提供参考。

关键词：自动舌诊客观化舌图分析